The network for 'positive regulation of endopeptidase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of endopeptidase activity

Any process that increases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.

Homo sapiens
Name Description Probability Func Analog Organism
BCL2 B-cell CLL/lymphoma 2 1.000
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.997
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.994
BCL2L1 BCL2-like 1 0.993
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.960
BAX BCL2-associated X protein 0.953
RB1 retinoblastoma 1 0.914
CREBBP CREB binding protein 0.905
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.901
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.897
PYCARD PYD and CARD domain containing 0.839
XIAP X-linked inhibitor of apoptosis 0.838
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.833
BID BH3 interacting domain death agonist 0.831
SMAD1 SMAD family member 1 0.822
POU5F1 POU class 5 homeobox 1 0.815
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.802
S100B S100 calcium binding protein B 0.773
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.751
FAS Fas (TNF receptor superfamily, member 6) 0.751
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.703
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.700
TP53 tumor protein p53 0.668
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.663
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.660
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.654
CFLAR CASP8 and FADD-like apoptosis regulator 0.622
SMAD2 SMAD family member 2 0.605
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.595
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.542
RIPK2 receptor-interacting serine-threonine kinase 2 0.540
BCAP31 B-cell receptor-associated protein 31 0.540
CARD11 caspase recruitment domain family, member 11 0.530
SMN1 survival of motor neuron 1, telomeric 0.529
BIRC3 baculoviral IAP repeat containing 3 0.515
S100A6 S100 calcium binding protein A6 0.504
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.483
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.467
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.447
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.427
FMR1 fragile X mental retardation 1 0.419
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.405
COL4A2 collagen, type IV, alpha 2 0.401
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.394
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.392
SUMO2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) 0.390
POU3F2 POU class 3 homeobox 2 0.377
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.374
SP1 Sp1 transcription factor 0.368
DAXX death-domain associated protein 0.356
CAV1 caveolin 1, caveolae protein, 22kDa 0.349
HCK hemopoietic cell kinase 0.348
SOCS1 suppressor of cytokine signaling 1 0.348
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.346
FADD Fas (TNFRSF6)-associated via death domain 0.318
S100A14 S100 calcium binding protein A14 0.312
BMP2 bone morphogenetic protein 2 0.309
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.298
S100A1 S100 calcium binding protein A1 0.297
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.292
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.291
NCL nucleolin 0.268
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.264
MAPK8 mitogen-activated protein kinase 8 0.255
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.239
NCK1 NCK adaptor protein 1 0.239
HMGB2 high mobility group box 2 0.228
COL4A1 collagen, type IV, alpha 1 0.228
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.226
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 0.224
FKBP1A FK506 binding protein 1A, 12kDa 0.223
AR androgen receptor 0.219
HNF4A hepatocyte nuclear factor 4, alpha 0.216
NLRC4 NLR family, CARD domain containing 4 0.203
PML promyelocytic leukemia 0.202
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.198
S100A4 S100 calcium binding protein A4 0.191
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.189
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 0.180
SMAD7 SMAD family member 7 0.177
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.177
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.176
HMGB1 high mobility group box 1 0.169
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.164
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 0.162
FASLG Fas ligand (TNF superfamily, member 6) 0.156
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.153
HIPK2 homeodomain interacting protein kinase 2 0.152
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 0.149
TMSB10 thymosin beta 10 0.148
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.148
RAD23B RAD23 homolog B (S. cerevisiae) 0.148
TP53BP2 tumor protein p53 binding protein, 2 0.147
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.145
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.143
NMI N-myc (and STAT) interactor 0.136
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) 0.134
RXRA retinoid X receptor, alpha 0.134
HDAC1 histone deacetylase 1 0.132
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.129
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
gata5 GATA-binding protein 5 0.097
bcl2 B-cell leukemia/lymphoma 2 0.091
mcl1a myeloid cell leukemia sequence 1a 0.049
socs3a suppressor of cytokine signaling 3a 0.041
sulf1 sulfatase 1 0.040
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.036
plxnb2a plexin b2a 0.036
bida BH3 interacting domain death agonist 0.034
mcl1b myeloid cell leukemia sequence 1b 0.029
adipor1b adiponectin receptor 1b 0.025
irf6 interferon regulatory factor 6 0.025
caspa caspase a 0.025
ighz immunoglobulin heavy constant zeta 0.024
ahcy S-adenosylhomocysteine hydrolase 0.024
serpinb1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.024
col5a2l collagen, type V, alpha 2-like 0.023
bcl2l1 bcl2-like 1 0.023
hmgb1a high-mobility group box 1a 0.023
cmyb transcription factor cmyb 0.022
igfbp1a insulin-like growth factor binding protein 1a 0.022
psma6b proteasome (prosome, macropain) subunit, alpha type, 6b 0.022
gpia glucose phosphate isomerase a 0.019
socs1 suppressor of cytokine signaling 1 0.019
psmc1b proteasome (prosome, macropain) 26S subunit, ATPase, 1b 0.019
duox dual oxidase 0.019
bbc3 BCL2 binding component 3 0.018
ube2i ubiquitin-conjugating enzyme E2I 0.018
blf bloody fingers 0.018
mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.018
runx3 runt-related transcription factor 3 0.017
gadd45aa growth arrest and DNA-damage-inducible, alpha, a 0.017
psme2 proteasome activator subunit 2 0.017
epor erythropoietin receptor 0.016
hmgb2a high-mobility group box 2a 0.016
pccb propionyl Coenzyme A carboxylase, beta polypeptide 0.016
fech ferrochelatase 0.016
chac1 ChaC, cation transport regulator-like 1 0.016
LOC567131 calcitonin gene-related peptide type 1 receptor-like 0.015
tfe3b transcription factor binding to IGHM enhancer 3b 0.015
psmb4 proteasome (prosome, macropain) subunit, beta type, 4 0.015
foxn1 forkhead box N1 0.015
ptrfb polymerase I and transcript release factor b 0.014
sec23b Sec23 homolog B (S. cerevisiae) 0.014
tnfsf10l tumor necrosis factor (ligand) superfamily, member 10 like 0.014
ighz2 immunoglobulin heavy constant zeta2 0.014
foxn4 forkhead box N4 0.014
per2 period homolog 2 (Drosophila) 0.014
blmh bleomycin hydrolase 0.014
mcm5 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 0.014
s100a10b S100 calcium binding protein A10b 0.014
psma1 proteasome (prosome, macropain) subunit, alpha type, 1 0.014
cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.014
mych myelocytomatosis oncogene homolog 0.014
stc1l stanniocalcin 1, like 0.013
rnf17 ring finger protein 17 0.013
s100v2 S100 calcium binding protein V2 0.013
ptgs2a prostaglandin-endoperoxide synthase 2a 0.013
egr1 early growth response 1 0.013
psmd1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.013
ran ras-related nuclear protein 0.013
tnfsf10l2 tumor necrosis factor (ligand) superfamily, member 10 like 2 0.013
foxo3b forkhead box O3b 0.012
stab2 stabilin 2 0.012
card14 caspase recruitment domain family, member 14 0.012
copeb core promoter element binding protein 0.012
rag1 recombination activating gene 1 0.012
hbae1 hemoglobin alpha embryonic-1 0.012
hif1an hypoxia-inducible factor 1, alpha subunit inhibitor 0.011
wnt9a wingless-type MMTV integration site family, member 9A 0.011
bcl2l10 BCL2-like 10 (apoptosis facilitator) 0.011
col1a2 collagen, type I, alpha 2 0.011
psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.011
ighm immunoglobulin heavy constant mu and immunoglobulin heavy constant mu 0.011
pcna proliferating cell nuclear antigen 0.011
mmp2 matrix metalloproteinase 2 0.011
cct5 chaperonin containing TCP1, subunit 5 (epsilon) 0.011
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.011
crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.010
psma8 proteasome (prosome, macropain) subunit, alpha type, 8 0.010
ef1a elongation factor 1-alpha 0.010
pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 0.010
gata1a GATA binding protein 1a 0.010
eif3s2 eukaryotic translation initiation factor 3, subunit 2 beta 0.010
bactin1 bactin1 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
th thread 0.961
Dcp-1 Death caspase-1 0.884
Nc Nedd2-like caspase 0.856
rst roughest 0.826
alph alphabet 0.812
CG9772 CG9772 gene product from transcript CG9772-RB 0.798
Dredd Death related ced-3/Nedd2-like protein 0.780
jar jaguar 0.740
imd immune deficiency 0.728
grim CG4345 gene product from transcript CG4345-RA 0.722
Tbp-1 Tat-binding protein-1 0.657
Rpt1 CG1341 gene product from transcript CG1341-RA 0.650
Pli Pellino 0.627
Eip74EF Ecdysone-induced protein 74EF 0.565
BG4 CG12297 gene product from transcript CG12297-RA 0.525
Prosbeta3 Proteasome beta3 subunit 0.480
wts warts 0.460
yuri yuri gagarin 0.439
Rac1 CG2248 gene product from transcript CG2248-RA 0.423
scrib scribbled 0.413
hbs hibris 0.389
bchs blue cheese 0.376
p53 CG33336 gene product from transcript CG33336-RB 0.373
eyg eyegone 0.347
RnrL Ribonucleoside diphosphate reductase large subunit 0.327
X11L CG5675 gene product from transcript CG5675-RB 0.317
growl CG14648 gene product from transcript CG14648-RA 0.297
Cyt-c-d Cytochrome c distal 0.292
Rpt4 CG3455 gene product from transcript CG3455-RA 0.288
Ice CG7788 gene product from transcript CG7788-RA 0.287
Rpn6 Proteasome p44.5 subunit 0.275
Lasp CG3849 gene product from transcript CG3849-RB 0.269
betaTub85D beta-Tubulin at 85D 0.266
CG5384 CG5384 gene product from transcript CG5384-RA 0.255
CG5355 CG5355 gene product from transcript CG5355-RA 0.253
lmg lemming 0.251
CYLD cylindromatosis 0.249
sns sticks and stones 0.237
W Wrinkled 0.223
XNP CG4548 gene product from transcript CG4548-RA 0.215
kirre kin of irre 0.200
Trxr-1 Thioredoxin reductase-1 0.192
Ark Apaf-1-related-killer 0.191
ird5 immune response deficient 5 0.189
CG3875 CG3875 gene product from transcript CG3875-RA 0.185
CG13364 CG13364 gene product from transcript CG13364-RA 0.185
bon bonus 0.183
Chro Chromator 0.181
Gmd GDP-mannose 4,6-dehydratase 0.163
Mov34 CG3416 gene product from transcript CG3416-RA 0.156
Traf4 TNF-receptor-associated factor 4 0.155
dj don juan 0.153
ey eyeless 0.149
disco disconnected 0.137
B52 CG10851 gene product from transcript CG10851-RB 0.134
stwl stonewall 0.132
Art4 Arginine methyltransferase 4 0.132
RASSF8 CG5053 gene product from transcript CG5053-RA 0.129
AGO2 Argonaute 2 0.127
Pros26.4 Proteasome 26S subunit subunit 4 ATPase 0.125
Rpn3 Regulatory particle non-ATPase 3 0.118
msl-1 male-specific lethal 1 0.115
edl ETS-domain lacking 0.115
zfh1 Zn finger homeodomain 1 0.114
pyd polychaetoid 0.113
flfl falafel 0.113
msn misshapen 0.112
Sox14 Sox box protein 14 0.111
Unr Upstream of N-ras 0.111
Chrac-14 CG13399 gene product from transcript CG13399-RA 0.110
CG7998 CG7998 gene product from transcript CG7998-RA 0.110
hipk homeodomain interacting protein kinase 0.109
RanGap Ran GTPase activating protein 0.108
Hr38 Hormone receptor-like in 38 0.106
robo roundabout 0.105
CG6479 CG6479 gene product from transcript CG6479-RB 0.102
His3.3B Histone H3.3B 0.099
Pkd2 Polycystic kidney disease gene-2 0.097
park parkin 0.094
CG10576 CG10576 gene product from transcript CG10576-RA 0.091
nkd naked cuticle 0.086
CG5731 CG5731 gene product from transcript CG5731-RA 0.085
sty sprouty 0.083
CG9894 CG9894 gene product from transcript CG9894-RB 0.081
nocte no circadian temperature entrainment 0.077
CadN Cadherin-N 0.074
Galpha49B G protein alpha49B 0.074
Glut1 Glucose transporter 1 0.072
Bsg25D Blastoderm-specific gene 25D 0.072
mbt mushroom bodies tiny 0.071
sli slit 0.071
east enhanced adult sensory threshold 0.070
hkl hook-like 0.070
dmt dalmatian 0.067
key kenny 0.067
rno rhinoceros 0.067
rpr reaper 0.067
CG7033 CG7033 gene product from transcript CG7033-RC 0.066
CG5146 CG5146 gene product from transcript CG5146-RA 0.066
pr-set7 CG3307 gene product from transcript CG3307-RC 0.065
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Mus musculus
Name Description Probability Func Analog Organism
Tnf tumor necrosis factor 0.996
Trp53 transformation related protein 53 0.993
Cd44 CD44 antigen 0.957
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.905
Stat5b signal transducer and activator of transcription 5B 0.894
Casp1 caspase 1 0.880
Fas Fas (TNF receptor superfamily member 6) 0.865
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.852
Stat5a signal transducer and activator of transcription 5A 0.821
Pycard PYD and CARD domain containing 0.814
Gbp5 guanylate binding protein 5 0.780
Mcl1 myeloid cell leukemia sequence 1 0.734
Il10 interleukin 10 0.687
Mndal myeloid nuclear differentiation antigen like 0.592
Sfrp2 secreted frizzled-related protein 2 0.590
Lyz2 lysozyme 2 0.559
Skil SKI-like 0.538
Kit kit oncogene 0.532
Trp73 transformation related protein 73 0.518
Rara retinoic acid receptor, alpha 0.511
Lama5 laminin, alpha 5 0.510
Psme2 proteasome (prosome, macropain) 28 subunit, beta 0.508
S100a9 S100 calcium binding protein A9 (calgranulin B) 0.493
Wt1 Wilms tumor 1 homolog 0.491
Ptgs2 prostaglandin-endoperoxide synthase 2 0.446
Il2rg interleukin 2 receptor, gamma chain 0.436
Lepr leptin receptor 0.412
Cd151 CD151 antigen 0.357
S100a8 S100 calcium binding protein A8 (calgranulin A) 0.334
Bcl2 B-cell leukemia/lymphoma 2 0.330
Ltb lymphotoxin B 0.324
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.317
Stat6 signal transducer and activator of transcription 6 0.309
Nphs2 nephrosis 2 homolog, podocin (human) 0.306
Itga3 integrin alpha 3 0.305
Coro1b coronin, actin binding protein 1B 0.301
Il1r1 interleukin 1 receptor, type I 0.297
Socs1 suppressor of cytokine signaling 1 0.296
Ptpn2 protein tyrosine phosphatase, non-receptor type 2 0.283
Wnt3a wingless-related MMTV integration site 3A 0.276
Il6st interleukin 6 signal transducer 0.271
Ptprc protein tyrosine phosphatase, receptor type, C 0.270
Ncoa3 nuclear receptor coactivator 3 0.261
Bcl2l1 BCL2-like 1 0.249
Gdnf glial cell line derived neurotrophic factor 0.248
Irf9 interferon regulatory factor 9 0.231
Bax BCL2-associated X protein 0.230
Wnt4 wingless-related MMTV integration site 4 0.225
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.218
Htt huntingtin 0.216
Hoxa10 homeobox A10 0.215
Vhl von Hippel-Lindau tumor suppressor 0.214
Rb1 retinoblastoma 1 0.207
Xiap X-linked inhibitor of apoptosis 0.203
Psme1 proteasome (prosome, macropain) 28 subunit, alpha 0.202
Spna1 spectrin alpha 1 0.201
Ctgf connective tissue growth factor 0.201
Casp7 caspase 7 0.200
Cycs cytochrome c, somatic 0.199
Ilk integrin linked kinase 0.196
Igh immunoglobulin heavy chain complex 0.188
Stat1 signal transducer and activator of transcription 1 0.188
Mfn2 mitofusin 2 0.186
Notch2 Notch gene homolog 2 (Drosophila) 0.182
Ptch2 patched homolog 2 0.180
Npm1 nucleophosmin 1 0.171
Irgm1 immunity-related GTPase family M member 1 0.169
Tlr4 toll-like receptor 4 0.167
Cftr cystic fibrosis transmembrane conductance regulator homolog 0.165
Pax2 paired box gene 2 0.161
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.160
Ikzf1 IKAROS family zinc finger 1 0.156
Hbb-b1 hemoglobin, beta adult major chain 0.156
Esr2 estrogen receptor 2 (beta) 0.155
Rxra retinoid X receptor alpha 0.154
Tgfb1 transforming growth factor, beta 1 0.146
Mapk14 mitogen-activated protein kinase 14 0.142
Ar androgen receptor 0.142
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.137
Emx1 empty spiracles homolog 1 (Drosophila) 0.135
Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 0.135
Ccr1 chemokine (C-C motif) receptor 1 0.135
Gli2 GLI-Kruppel family member GLI2 0.125
Cd4 CD4 antigen 0.118
E2f1 E2F transcription factor 1 0.117
Cs citrate synthase 0.115
Sfrp1 secreted frizzled-related protein 1 0.113
Stc2 stanniocalcin 2 0.111
Il2rb interleukin 2 receptor, beta chain 0.110
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.109
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.109
Psma2 proteasome (prosome, macropain) subunit, alpha type 2 0.108
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.106
Hoxc6 homeobox C6 0.105
Inpp5d inositol polyphosphate-5-phosphatase D 0.105
Wnt7b wingless-related MMTV integration site 7B 0.105
Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 0.104
Exoc6 exocyst complex component 6 0.102
Il22 interleukin 22 0.100
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.100
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism