The network for 'adaptive immune response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

adaptive immune response

An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).

Mus musculus
Name Description Probability Func Analog Organism
Igh immunoglobulin heavy chain complex 1.000
Cd19 CD19 antigen 1.000
Tnf tumor necrosis factor 1.000
Lyz2 lysozyme 2 1.000
Cd40 CD40 antigen 1.000
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.999
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.998
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.995
Stat3 signal transducer and activator of transcription 3 0.995
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.993
Ifng interferon gamma 0.990
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.989
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.989
Fasl Fas ligand (TNF superfamily, member 6) 0.988
Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) 0.986
Il4 interleukin 4 0.986
Socs1 suppressor of cytokine signaling 1 0.984
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.982
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.982
Prf1 perforin 1 (pore forming protein) 0.978
Icos inducible T-cell co-stimulator 0.977
H2-Eb1 histocompatibility 2, class II antigen E beta 0.976
H2-Aa histocompatibility 2, class II antigen A, alpha 0.975
Ptprc protein tyrosine phosphatase, receptor type, C 0.972
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.971
Ccr1 chemokine (C-C motif) receptor 1 0.970
Ikzf1 IKAROS family zinc finger 1 0.968
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.967
Fas Fas (TNF receptor superfamily member 6) 0.959
Pten phosphatase and tensin homolog 0.959
Ccl2 chemokine (C-C motif) ligand 2 0.954
Cd44 CD44 antigen 0.954
Il2 interleukin 2 0.952
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.951
B2m beta-2 microglobulin 0.950
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.944
Irf8 interferon regulatory factor 8 0.938
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.938
Il1b interleukin 1 beta 0.938
Btk Bruton agammaglobulinemia tyrosine kinase 0.934
Pax5 paired box gene 5 0.933
Il2rb interleukin 2 receptor, beta chain 0.930
Cd22 CD22 antigen 0.927
Stat6 signal transducer and activator of transcription 6 0.923
Prdm1 PR domain containing 1, with ZNF domain 0.922
Ccr7 chemokine (C-C motif) receptor 7 0.921
Foxp3 forkhead box P3 0.917
Tlr4 toll-like receptor 4 0.915
Myd88 myeloid differentiation primary response gene 88 0.911
Irf4 interferon regulatory factor 4 0.909
C1qa complement component 1, q subcomponent, alpha polypeptide 0.909
Bcl6 B-cell leukemia/lymphoma 6 0.909
Ccl22 chemokine (C-C motif) ligand 22 0.898
Il6 interleukin 6 0.891
Il2rg interleukin 2 receptor, gamma chain 0.886
Zeb1 zinc finger E-box binding homeobox 1 0.877
Batf basic leucine zipper transcription factor, ATF-like 0.871
Rab27a RAB27A, member RAS oncogene family 0.870
Sh2d2a SH2 domain protein 2A 0.867
Cd4 CD4 antigen 0.864
Tapbp TAP binding protein 0.863
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.860
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.855
Efnb2 ephrin B2 0.854
Birc3 baculoviral IAP repeat-containing 3 0.854
Gzma granzyme A 0.853
Cyld cylindromatosis (turban tumor syndrome) 0.852
Il10 interleukin 10 0.851
H2-K1 histocompatibility 2, K1, K region 0.849
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.841
Il1r1 interleukin 1 receptor, type I 0.835
Foxn1 forkhead box N1 0.829
Gpr132 G protein-coupled receptor 132 0.825
Igk immunoglobulin kappa chain complex 0.824
Sfpi1 SFFV proviral integration 1 0.823
Cish cytokine inducible SH2-containing protein 0.822
Ifngr1 interferon gamma receptor 1 0.822
Traf2 TNF receptor-associated factor 2 0.816
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.805
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.802
Ccr6 chemokine (C-C motif) receptor 6 0.798
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.795
Fyn Fyn proto-oncogene 0.793
Ctsw cathepsin W 0.792
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.788
Atm ataxia telangiectasia mutated homolog (human) 0.783
Gdf3 growth differentiation factor 3 0.782
Ciita class II transactivator 0.782
Casp1 caspase 1 0.777
Fcrla Fc receptor-like A 0.777
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.775
Ccr2 chemokine (C-C motif) receptor 2 0.771
Cst7 cystatin F (leukocystatin) 0.769
Il6st interleukin 6 signal transducer 0.769
Clec4d C-type lectin domain family 4, member d 0.765
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.764
Tyrobp TYRO protein tyrosine kinase binding protein 0.764
Cxcl13 chemokine (C-X-C motif) ligand 13 0.761
Cd180 CD180 antigen 0.760
H2-D1 histocompatibility 2, D region locus 1 0.751
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
grna granulin a 0.534
csf1ra colony stimulating factor 1 receptor, a 0.408
zgc:64115 zgc:64115 0.240
c1qc complement component 1, q subcomponent, C chain 0.115
dnmt4 DNA (cytosine-5-)-methyltransferase 4 0.098
LOC557072 caspase recruitment domain-containing protein 11-like 0.085
itga2b integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B) 0.074
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.070
mef2a myocyte enhancer factor 2a 0.070
wasb Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b 0.068
irak4 interleukin-1 receptor-associated kinase 4 0.066
lndc1 ly6/neurotoxin domain containing 1 0.062
stat1b signal transducer and activator of transcription 1b 0.053
cd247l CD247 antigen like 0.053
ctssb.2 cathepsin S, b.2 0.052
tlr3 toll-like receptor 3 0.044
dlg2 discs, large (Drosophila) homolog 2 0.041
irf11 interferon regulatory factor 11 0.035
zgc:64051 zgc:64051 0.035
chtf18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae) 0.033
illr1 immune-related, lectin-like receptor 1 0.032
adipoql adiponectin, C1Q and collagen domain containing, like 0.032
nod1 nucleotide-binding oligomerization domain containing 1 0.031
ighm immunoglobulin heavy constant mu and immunoglobulin heavy constant mu 0.031
LOC100000934 hypothetical protein LOC100000934 0.030
msh2 mutS homolog 2 (E. coli) 0.024
cxcr3.2 chemokine (C-X-C motif) receptor 3.2 0.023
tlr9 toll-like receptor 9 0.023
tyrobp TYRO protein tyrosine kinase binding protein 0.022
ctsba cathepsin B, a 0.021
adipoql2 adiponectin, C1Q and collagen domain containing, like 2 0.021
il7r interleukin 7 receptor 0.021
ptger4b prostaglandin E receptor 4 (subtype EP4) b 0.020
spi1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.020
jag1b jagged 1b 0.019
grn1 granulin 1 0.019
fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.018
jam2a junctional adhesion molecule 2a 0.017
c1qa complement component 1, q subcomponent, A chain 0.017
adipor2 adiponectin receptor 2 0.017
tert telomerase reverse transcriptase 0.017
cd40lg CD40 ligand 0.017
il4r interleukin 4 receptor 0.016
polr2d polymerase (RNA) II (DNA directed) polypeptide D 0.016
coro1a coronin, actin binding protein, 1A 0.015
tbx21 T-box 21 0.015
ugt5c2 UDP glucuronosyltransferase 5 family, polypeptide C2 0.015
slc25a14 solute carrier family 25 (mitochondrial carrier, brain), member 14 0.015
tnfa tumor necrosis factor a (TNF superfamily, member 2) 0.014
calcr calcitonin receptor 0.014
nitr5 novel immune-type receptor 5 and immune-type receptor 5-like 0.014
pth1a parathyroid hormone 1a 0.013
foxp3a forkhead box P3a 0.013
lrrc33 leucine rich repeat containing 33 0.013
c1qb complement component 1, q subcomponent, B chain 0.013
il12bb interleukin 12B, b 0.013
LOC100534776 toll-like receptor 7-like 0.013
tph2 tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) 0.012
krml2.2 Kreisler (mouse) maf-related leucine zipper homolog 2.2 0.012
adrb2a adrenergic receptor, beta 2a 0.012
ighz immunoglobulin heavy constant zeta 0.012
hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 0.012
wt1b wilms tumor 1b 0.011
psap prosaposin 0.011
si:dkeyp-22b2.3 si:dkeyp-22b2.3 0.011
pdgfaa platelet-derived growth factor alpha a 0.011
si:ch211-195h23.3 si:ch211-195h23.3 0.011
dntt deoxynucleotidyltransferase, terminal 0.010
angptl1 angiopoietin-like 1 0.010
fcer1gl Fc receptor, IgE, high affinity I, gamma polypeptide like 0.010
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
TRAF1 TNF receptor-associated factor 1 0.999
BIRC3 baculoviral IAP repeat containing 3 0.998
B2M beta-2-microglobulin 0.992
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.979
HLA-A major histocompatibility complex, class I, A 0.979
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.977
HLA-C major histocompatibility complex, class I, C 0.969
TRAF2 TNF receptor-associated factor 2 0.968
CD40 CD40 molecule, TNF receptor superfamily member 5 0.955
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.943
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.908
HLA-DRA major histocompatibility complex, class II, DR alpha 0.892
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.887
IL2RG interleukin 2 receptor, gamma 0.881
IL4R interleukin 4 receptor 0.870
LCK lymphocyte-specific protein tyrosine kinase 0.868
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.842
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.838
BRCA1 breast cancer 1, early onset 0.831
CD80 CD80 molecule 0.819
CCL4 chemokine (C-C motif) ligand 4 0.801
TRAF3 TNF receptor-associated factor 3 0.796
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.779
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.765
TRAF6 TNF receptor-associated factor 6 0.736
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.708
TNF tumor necrosis factor 0.699
TRADD TNFRSF1A-associated via death domain 0.670
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.661
LTA lymphotoxin alpha (TNF superfamily, member 1) 0.659
TAPBP TAP binding protein (tapasin) 0.614
IRF1 interferon regulatory factor 1 0.607
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.597
STAT2 signal transducer and activator of transcription 2, 113kDa 0.581
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.580
HLA-DMB major histocompatibility complex, class II, DM beta 0.578
HLA-B major histocompatibility complex, class I, B 0.575
TANK TRAF family member-associated NFKB activator 0.551
CXCL9 chemokine (C-X-C motif) ligand 9 0.528
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.517
CD86 CD86 molecule 0.509
NOTCH1 notch 1 0.498
ICAM1 intercellular adhesion molecule 1 0.481
SNAP23 synaptosomal-associated protein, 23kDa 0.472
SYK spleen tyrosine kinase 0.467
HLA-G major histocompatibility complex, class I, G 0.456
SMAD3 SMAD family member 3 0.443
CCR7 chemokine (C-C motif) receptor 7 0.421
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.415
GRAP2 GRB2-related adaptor protein 2 0.412
CCL5 chemokine (C-C motif) ligand 5 0.406
CXCL10 chemokine (C-X-C motif) ligand 10 0.381
CD2 CD2 molecule 0.378
HLA-E major histocompatibility complex, class I, E 0.375
RNF11 ring finger protein 11 0.369
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.367
CCR5 chemokine (C-C motif) receptor 5 0.359
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.350
C1QA complement component 1, q subcomponent, A chain 0.349
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.347
THOC5 THO complex 5 0.346
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.343
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.337
MDC1 mediator of DNA-damage checkpoint 1 0.329
BCL3 B-cell CLL/lymphoma 3 0.326
BIRC2 baculoviral IAP repeat containing 2 0.311
CCL2 chemokine (C-C motif) ligand 2 0.302
CARD11 caspase recruitment domain family, member 11 0.280
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.276
HLA-F major histocompatibility complex, class I, F 0.272
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 0.271
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.265
TRAF5 TNF receptor-associated factor 5 0.255
NRP1 neuropilin 1 0.253
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.243
PML promyelocytic leukemia 0.238
CCL22 chemokine (C-C motif) ligand 22 0.218
DLG1 discs, large homolog 1 (Drosophila) 0.217
TRIM38 tripartite motif containing 38 0.217
C1QC complement component 1, q subcomponent, C chain 0.216
SLAMF1 signaling lymphocytic activation molecule family member 1 0.215
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 0.209
TLR2 toll-like receptor 2 0.206
NOTCH3 notch 3 0.205
IL2RB interleukin 2 receptor, beta 0.204
CCR1 chemokine (C-C motif) receptor 1 0.203
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.203
KAT2B K(lysine) acetyltransferase 2B 0.198
IRF4 interferon regulatory factor 4 0.195
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.195
IL23A interleukin 23, alpha subunit p19 0.181
CD163 CD163 molecule 0.178
SIGLEC7 sialic acid binding Ig-like lectin 7 0.171
CD22 CD22 molecule 0.165
IRF2 interferon regulatory factor 2 0.161
SRGN serglycin 0.159
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.156
BTN2A2 butyrophilin, subfamily 2, member A2 0.156
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.156
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 0.156
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-EC2 RT1 class Ib, locus EC2 0.227
RT1-Ba RT1 class II, locus Ba 0.096
Cd37 CD37 molecule 0.074
RT1-Da RT1 class II, locus Da 0.061
Gbp2 guanylate binding protein 2 0.056
RT1-S3 RT1 class Ib, locus S3 0.051
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.045
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.039
Cxcl10 chemokine (C-X-C motif) ligand 10 0.036
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.034
Apol3 apolipoprotein L, 3 0.032
Slfn2 schlafen 2 0.032
Hck hemopoietic cell kinase 0.031
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.028
Hsph1 heat shock 105/110 protein 1 0.027
Casp1 caspase 1 0.027
Cp ceruloplasmin 0.025
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.023
Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 0.019
Irf1 interferon regulatory factor 1 0.019
Plcg2 phospholipase C, gamma 2 0.018
Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 0.017
Aif1 allograft inflammatory factor 1 0.016
Ccl5 chemokine (C-C motif) ligand 5 0.016
Ciita class II, major histocompatibility complex, transactivator 0.015
B2m beta-2 microglobulin 0.014
Cd3g CD3 molecule, gamma 0.014
Epha2 Eph receptor A2 0.013
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.013
Icos inducible T-cell co-stimulator 0.013
Ctss cathepsin S 0.013
Bdkrb2 bradykinin receptor B2 0.013
Arhgap4 Rho GTPase activating protein 4 0.013
Mpeg1 macrophage expressed 1 0.013
Il2rb interleukin 2 receptor, beta 0.012
Rab20 RAB20, member RAS oncogene family 0.012
Cd5 Cd5 molecule 0.012
Tmem176b transmembrane protein 176B 0.012
Cd8a CD8a molecule 0.011
Rsad2 radical S-adenosyl methionine domain containing 2 0.011
Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain 0.011
Gja5 gap junction protein, alpha 5 0.011
C1qb complement component 1, q subcomponent, B chain 0.011
Nrg2 neuregulin 2 0.011
Chek2 CHK2 checkpoint homolog (S. pombe) 0.010
Il1b interleukin 1 beta 0.010
Inpp5d inositol polyphosphate-5-phosphatase D 0.010
Nkg7 natural killer cell group 7 sequence 0.010
Cd53 Cd53 molecule 0.010
Cd4 Cd4 molecule 0.010
Itih4 inter alpha-trypsin inhibitor, heavy chain 4 0.010
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism