The network for 'humoral immune response mediated by circulating immunoglobulin' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

humoral immune response mediated by circulating immunoglobulin

An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.

Mus musculus
Name Description Probability Func Analog Organism
Igh immunoglobulin heavy chain complex 1.000
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.995
Cd19 CD19 antigen 0.991
Tnf tumor necrosis factor 0.960
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.950
Lyz2 lysozyme 2 0.919
Cd40 CD40 antigen 0.903
Il4 interleukin 4 0.770
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.739
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.674
Il2 interleukin 2 0.653
Btk Bruton agammaglobulinemia tyrosine kinase 0.650
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.596
C1qb complement component 1, q subcomponent, beta polypeptide 0.552
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.516
Ikzf1 IKAROS family zinc finger 1 0.480
C1qa complement component 1, q subcomponent, alpha polypeptide 0.442
C1qc complement component 1, q subcomponent, C chain 0.352
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.290
Tyrobp TYRO protein tyrosine kinase binding protein 0.269
Fcgr2b Fc receptor, IgG, low affinity IIb 0.255
Ptprc protein tyrosine phosphatase, receptor type, C 0.255
Ccr1 chemokine (C-C motif) receptor 1 0.250
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.236
Cxcl13 chemokine (C-X-C motif) ligand 13 0.193
Il1b interleukin 1 beta 0.176
Grb2 growth factor receptor bound protein 2 0.174
H2-Aa histocompatibility 2, class II antigen A, alpha 0.170
Ltb lymphotoxin B 0.164
Cd22 CD22 antigen 0.153
Aif1 allograft inflammatory factor 1 0.143
Sfpi1 SFFV proviral integration 1 0.140
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.137
Clec4n C-type lectin domain family 4, member n 0.127
Fas Fas (TNF receptor superfamily member 6) 0.123
Icos inducible T-cell co-stimulator 0.115
Clec4d C-type lectin domain family 4, member d 0.111
Pycard PYD and CARD domain containing 0.106
Fyn Fyn proto-oncogene 0.102
Ifng interferon gamma 0.102
Ccr6 chemokine (C-C motif) receptor 6 0.101
Emr1 EGF-like module containing, mucin-like, hormone receptor-like sequence 1 0.095
Pou2af1 POU domain, class 2, associating factor 1 0.093
Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) 0.090
Il2rg interleukin 2 receptor, gamma chain 0.087
Inpp5d inositol polyphosphate-5-phosphatase D 0.086
Ccr7 chemokine (C-C motif) receptor 7 0.081
Il22 interleukin 22 0.080
Igk immunoglobulin kappa chain complex 0.079
Cxcr5 chemokine (C-X-C motif) receptor 5 0.078
Mefv Mediterranean fever 0.075
Csf1r colony stimulating factor 1 receptor 0.072
Ms4a1 membrane-spanning 4-domains, subfamily A, member 1 0.070
Il7 interleukin 7 0.066
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.062
Rag1 recombination activating gene 1 0.061
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.058
Ifngr1 interferon gamma receptor 1 0.055
Bcl6 B-cell leukemia/lymphoma 6 0.055
Cr2 complement receptor 2 0.053
Cyld cylindromatosis (turban tumor syndrome) 0.052
Plcg2 phospholipase C, gamma 2 0.051
Casp1 caspase 1 0.047
Clec4e C-type lectin domain family 4, member e 0.044
H2-Eb1 histocompatibility 2, class II antigen E beta 0.041
Ccl6 chemokine (C-C motif) ligand 6 0.041
Cd44 CD44 antigen 0.039
Prf1 perforin 1 (pore forming protein) 0.039
Prkcd protein kinase C, delta 0.038
Igl immunoglobulin lambda chain complex 0.038
Ly86 lymphocyte antigen 86 0.037
Cd72 CD72 antigen 0.036
C3 complement component 3 0.036
AF251705 cDNA sequence AF251705 0.036
Blnk B-cell linker 0.035
Unc93b1 unc-93 homolog B1 (C. elegans) 0.033
Csf3r colony stimulating factor 3 receptor (granulocyte) 0.031
Cd79b CD79B antigen 0.031
Lyz1 lysozyme 1 0.030
Cfp complement factor properdin 0.030
Cd5l CD5 antigen-like 0.030
Msr1 macrophage scavenger receptor 1 0.030
Lta lymphotoxin A 0.029
Tox thymocyte selection-associated high mobility group box 0.028
Rag2 recombination activating gene 2 0.028
Ms4a6d membrane-spanning 4-domains, subfamily A, member 6D 0.028
Cd86 CD86 antigen 0.027
Tcrd T-cell receptor delta chain 0.027
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.027
Itgb2 integrin beta 2 0.027
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.027
Ctss cathepsin S 0.027
Mrc1 mannose receptor, C type 1 0.024
Pax5 paired box gene 5 0.024
Tcrb T-cell receptor beta chain 0.024
Il10 interleukin 10 0.024
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.023
Rpe65 retinal pigment epithelium 65 0.022
Vav1 vav 1 oncogene 0.021
Aicda activation-induced cytidine deaminase 0.021
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
LOC566708 FL cytokine receptor-like 0.601
grna granulin a 0.489
adipoql adiponectin, C1Q and collagen domain containing, like 0.463
foxj1b forkhead box J1b 0.439
LOC557072 caspase recruitment domain-containing protein 11-like 0.405
adipoql2 adiponectin, C1Q and collagen domain containing, like 2 0.337
slc4a4b solute carrier family 4, sodium bicarbonate cotransporter, member 4b 0.204
foxd5 forkhead box D5 0.179
hbbe1.1 hemoglobin beta embryonic-1.1 0.175
rhcgl1 Rhesus blood group, C glycoprotein, like 1 0.166
cxcr3.2 chemokine (C-X-C motif) receptor 3.2 0.156
lrrc6 leucine rich repeat containing 6 0.155
zgc:92661 zgc:92661 0.139
gmfg glia maturation factor, gamma 0.126
vwf von Willebrand factor 0.125
cps1 carbamoyl-phosphate synthase 1, mitochondrial 0.119
rnasel1 ribonuclease like 1 0.100
pkd2 polycystic kidney disease 2 0.090
otc ornithine carbamoyltransferase 0.079
grn1 granulin 1 0.079
ccdc151 coiled-coil domain containing 151 0.074
coro1a coronin, actin binding protein, 1A 0.071
dact2 dapper homolog 2, antagonist of beta-catenin (xenopus) 0.069
wu:fc23b05 wu:fc23b05 0.069
adipor2 adiponectin receptor 2 0.068
nod1 nucleotide-binding oligomerization domain containing 1 0.066
pglyrp5 peptidoglycan recognition protein 5 0.063
caprin2 caprin family member 2 0.062
pcsk2 proprotein convertase subtilisin/kexin type 2 0.060
tlr9 toll-like receptor 9 0.056
LOC100000934 hypothetical protein LOC100000934 0.050
tmprss4b transmembrane protease, serine 4b 0.049
card9 caspase recruitment domain family, member 9 0.046
sepp1b selenoprotein P, plasma, 1b 0.046
gyltl1b glycosyltransferase-like 1b 0.045
cd40 CD40 antigen 0.045
si:dkeyp-22b2.3 si:dkeyp-22b2.3 0.044
LOC100330224 fatty acid binding protein 1b-like 0.043
cd40lg CD40 ligand 0.038
zgc:153921 zgc:153921 0.038
lipc lipase, hepatic 0.037
cd247l CD247 antigen like 0.036
ahsg alpha-2-HS-glycoprotein 0.035
nipblb novel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila) 0.035
c1qa complement component 1, q subcomponent, A chain 0.034
her3 hairy-related 3 0.033
s1pr3 sphingosine-1-phosphate receptor 3 0.033
ren renin 0.033
calcr calcitonin receptor 0.031
foxe3 forkhead box E3 0.030
pcsk9 proprotein convertase subtilisin/kexin type 9 0.030
racgap1 Rac GTPase-activating protein 1 0.030
c1qb complement component 1, q subcomponent, B chain 0.029
foxa2 forkhead box A2 0.029
notum3 notum 3 0.029
nkd1 naked cuticle homolog 1 (Drosophila) 0.028
fli1b friend leukemia integration 1b 0.027
rhag Rhesus blood group-associated glycoprotein 0.026
asl argininosuccinate lyase 0.026
osr2 odd-skipped related 2 (Drosophila) 0.025
ptger4b prostaglandin E receptor 4 (subtype EP4) b 0.025
gata1a GATA binding protein 1a 0.025
hs3st1l2 heparan sulfate (glucosamine) 3-O-sulfotransferase 1-like 2 0.025
retsatl retinol saturase (all-trans-retinol 13,14-reductase) like 0.024
si:dkey-22a1.3 si:dkey-22a1.3 0.024
cep55l centrosomal protein 55 like 0.024
pcsk1 proprotein convertase subtilisin/kexin type 1 0.023
tlr3 toll-like receptor 3 0.023
c1qc complement component 1, q subcomponent, C chain 0.023
lndc1 ly6/neurotoxin domain containing 1 0.023
cp ceruloplasmin 0.023
lmx1b.2 LIM homeobox transcription factor 1, beta 2 0.023
pdcd2 programmed cell death 2 0.023
fbp1b fructose-1,6-bisphosphatase 1b 0.023
slc12a10.2 solute carrier family 12 (sodium/potassium/chloride transporters), member 10.2 0.022
olig3 oligodendrocyte transcription factor 3 0.022
nitr5 novel immune-type receptor 5 and immune-type receptor 5-like 0.022
LOC100005232 Gig2-like protein DreD 0.021
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.021
pglyrp2 peptidoglycan recognition protein 2 0.021
wt1b wilms tumor 1b 0.021
foxi3a forkhead box I3a 0.021
si:ch211-195h23.3 si:ch211-195h23.3 0.021
ccna1 cyclin A1 0.021
illr1 immune-related, lectin-like receptor 1 0.020
lrrc33 leucine rich repeat containing 33 0.020
foxp3a forkhead box P3a 0.020
cd74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.019
LOC795916 mucolipin-1-like 0.019
zgc:103710 zgc:103710 0.019
crfb7 cytokine receptor family member b7 0.019
slc4a1b solute carrier family 4, anion exchanger, member 1b 0.019
zerg24 potassium voltage-gated channel zerg24 0.019
numbl numb homolog (Drosophila)-like 0.019
LOC100003330 melanocortin-2 receptor accessory protein 2-like 0.019
lgals2a lectin, galactoside-binding, soluble, 2a 0.019
si:ch211-255l12.1 si:ch211-255l12.1 0.018
ighm immunoglobulin heavy constant mu and immunoglobulin heavy constant mu 0.018
fzd10 frizzled homolog 10 0.018
chek2 CHK2 checkpoint homolog (S. pombe) 0.018
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.672
HLA-DRA major histocompatibility complex, class II, DR alpha 0.444
HLA-DMA major histocompatibility complex, class II, DM alpha 0.411
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.374
SYK spleen tyrosine kinase 0.237
HLA-DMB major histocompatibility complex, class II, DM beta 0.192
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.188
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.128
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.061
C1QC complement component 1, q subcomponent, C chain 0.051
C1QA complement component 1, q subcomponent, A chain 0.038
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.036
C1QB complement component 1, q subcomponent, B chain 0.025
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.020
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.016
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.015
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.012
CD22 CD22 molecule 0.012
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.012
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Rattus norvegicus
Name Description Probability Func Analog Organism
LOC100364265 ribosomal protein L19-like 0.027
LOC100363106 LRRG00130-like 0.016
RT1-Db1 RT1 class II, locus Db1 0.016
LOC100359522 LRRGT00191-like 0.016
Fgg fibrinogen gamma chain 0.014
Ctss cathepsin S 0.013
RT1-Ba RT1 class II, locus Ba 0.013
C1qb complement component 1, q subcomponent, B chain 0.012
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism