The network for 'positive regulation of histone modification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of histone modification

Any process that activates or increases the frequency, rate or extent of the covalent alteration of a histone.

Mus musculus
Name Description Probability Func Analog Organism
Ezh2 enhancer of zeste homolog 2 (Drosophila) 0.980
Trp53 transformation related protein 53 0.879
Kdm2b lysine (K)-specific demethylase 2B 0.662
Jarid2 jumonji, AT rich interactive domain 2 0.658
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.535
Ptgs2 prostaglandin-endoperoxide synthase 2 0.441
Hdac1 histone deacetylase 1 0.437
Lep leptin 0.412
Skil SKI-like 0.388
Eed embryonic ectoderm development 0.362
Trim28 tripartite motif-containing 28 0.343
Il10 interleukin 10 0.341
Dnmt3a DNA methyltransferase 3A 0.334
Col1a1 collagen, type I, alpha 1 0.304
Zeb1 zinc finger E-box binding homeobox 1 0.298
Rb1 retinoblastoma 1 0.287
Brca1 breast cancer 1 0.275
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.274
Trim24 tripartite motif-containing 24 0.263
Jun Jun oncogene 0.242
Pparg peroxisome proliferator activated receptor gamma 0.242
Cav1 caveolin 1, caveolae protein 0.226
Hist1h3g histone cluster 1, H3g 0.223
Tnf tumor necrosis factor 0.212
Esr1 estrogen receptor 1 (alpha) 0.206
Egr1 early growth response 1 0.205
Runx1 runt related transcription factor 1 0.193
Mdm2 transformed mouse 3T3 cell double minute 2 0.173
Arrb2 arrestin, beta 2 0.166
Sin3a transcriptional regulator, SIN3A (yeast) 0.165
Plin1 perilipin 1 0.161
Crebbp CREB binding protein 0.150
Nos1 nitric oxide synthase 1, neuronal 0.140
Kdm1a lysine (K)-specific demethylase 1A 0.139
Pax3 paired box gene 3 0.125
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.123
Ncoa6 nuclear receptor coactivator 6 0.115
Vdr vitamin D receptor 0.111
Atf3 activating transcription factor 3 0.103
Stk38 serine/threonine kinase 38 0.102
Fos FBJ osteosarcoma oncogene 0.099
Parp1 poly (ADP-ribose) polymerase family, member 1 0.099
Rbbp4 retinoblastoma binding protein 4 0.098
Daxx Fas death domain-associated protein 0.096
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.094
Pax7 paired box gene 7 0.084
Mapk1 mitogen-activated protein kinase 1 0.083
Fosl2 fos-like antigen 2 0.079
Rara retinoic acid receptor, alpha 0.079
Rxra retinoid X receptor alpha 0.077
Mstn myostatin 0.077
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.076
Pten phosphatase and tensin homolog 0.075
Mdm4 transformed mouse 3T3 cell double minute 4 0.073
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.073
Ptpn13 protein tyrosine phosphatase, non-receptor type 13 0.072
Huwe1 HECT, UBA and WWE domain containing 1 0.071
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.071
Ren1 renin 1 structural 0.070
Aebp2 AE binding protein 2 0.069
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.068
Junb Jun-B oncogene 0.067
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.065
Brca2 breast cancer 2 0.065
Nsfl1c NSFL1 (p97) cofactor (p47) 0.064
Sp1 trans-acting transcription factor 1 0.064
Wfikkn2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.063
Trp73 transformation related protein 73 0.063
Srf serum response factor 0.063
Egr2 early growth response 2 0.062
Gli2 GLI-Kruppel family member GLI2 0.060
Brd4 bromodomain containing 4 0.059
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.059
Clk1 CDC-like kinase 1 0.058
Ifng interferon gamma 0.056
Plaur plasminogen activator, urokinase receptor 0.056
Ncor1 nuclear receptor co-repressor 1 0.056
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.054
Mll1 myeloid/lymphoid or mixed-lineage leukemia 1 0.053
Rnf2 ring finger protein 2 0.053
Ep300 E1A binding protein p300 0.052
Gli3 GLI-Kruppel family member GLI3 0.052
E2f1 E2F transcription factor 1 0.052
Cdk1 cyclin-dependent kinase 1 0.049
Atm ataxia telangiectasia mutated homolog (human) 0.048
Arid2 AT rich interactive domain 2 (ARID, RFX-like) 0.048
Ruvbl1 RuvB-like protein 1 0.048
Thbs1 thrombospondin 1 0.048
Thoc2 THO complex 2 0.047
Hdac7 histone deacetylase 7 0.047
Kdm5a lysine (K)-specific demethylase 5A 0.046
H2afx H2A histone family, member X 0.046
Kitl kit ligand 0.046
Msx1 homeobox, msh-like 1 0.045
Thra thyroid hormone receptor alpha 0.044
Kit kit oncogene 0.044
Uhrf1 ubiquitin-like, containing PHD and RING finger domains, 1 0.044
Cyr61 cysteine rich protein 61 0.043
D4Wsu53e DNA segment, Chr 4, Wayne State University 53, expressed 0.043
Ctcf CCCTC-binding factor 0.043
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
rif1 RAP1 interacting factor homolog (yeast) 0.310
sephs1 selenophosphate synthetase 1 0.166
pcna proliferating cell nuclear antigen 0.161
dnmt1 DNA (cytosine-5-)-methyltransferase 1 0.115
slc2a10 solute carrier family 2 (facilitated glucose transporter), member 10 0.113
mpx myeloid-specific peroxidase 0.106
hdac1 histone deacetylase 1 0.102
tcea1 transcription elongation factor A (SII), 1 0.101
znf703 zinc finger protein 703 0.100
ube2i ubiquitin-conjugating enzyme E2I 0.099
hirip3 HIRA interacting protein 3 0.095
mapk1 mitogen-activated protein kinase 1 0.093
nasp nuclear autoantigenic sperm protein (histone-binding) 0.089
csf3r colony stimulating factor 3 receptor (granulocyte) 0.087
twist1a twist1a 0.083
apex1 APEX nuclease (multifunctional DNA repair enzyme) 1 0.078
gins2 GINS complex subunit 2 0.077
cse1l chromosome segregation 1-like (S. cerevisiae) 0.071
zgc:92139 zgc:92139 0.070
pola2 polymerase (DNA directed), alpha 2 0.068
wnk1 WNK lysine deficient protein kinase 1 0.065
pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.064
dnmt3 DNA (cytosine-5-)-methyltransferase 3 0.064
orc5 origin recognition complex, subunit 5 0.063
akap12b A kinase (PRKA) anchor protein (gravin) 12b 0.062
rx1 retinal homeobox gene 1 0.061
dntt deoxynucleotidyltransferase, terminal 0.060
lyz lysozyme 0.059
ahctf1 AT hook containing transcription factor 1 0.059
ilf3a interleukin enhancer binding factor 3a 0.058
agtr2 angiotensin II receptor, type 2 0.054
aurkb aurora kinase B 0.053
cbx1a chromobox homolog 1a (HP1 beta homolog Drosophila) 0.053
usp1 ubiquitin specific protease 1 0.053
runx1 runt-related transcription factor 1 0.051
stil TAL1 (SCL) interrupting locus 0.050
rpa1 replication protein A1 0.050
gata1a GATA binding protein 1a 0.050
chek1 CHK1 checkpoint homolog (S. pombe) 0.050
rarga retinoic acid receptor gamma a 0.050
rhag Rhesus blood group-associated glycoprotein 0.049
cdc23 CDC23 (cell division cycle 23, yeast, homolog) 0.048
srm spermidine synthase 0.048
pax7a paired box gene 7a 0.048
zgc:110113 zgc:110113 0.047
foxi2 forkhead box I2 0.045
sema3aa semaphorin 3aa 0.045
wu:fv91b12 wu:fv91b12 0.045
tra2b transformer 2 beta homolog (Drosophila) 0.044
pnp4a purine nucleoside phosphorylase 4a 0.044
snai1a snail homolog 1a (Drosophila) 0.044
smo smoothened homolog (Drosophila) 0.042
vps35 vacuolar protein sorting 35 (yeast) 0.042
ccnd1 cyclin D1 0.042
msh2 mutS homolog 2 (E. coli) 0.042
rfc4 replication factor C (activator 1) 4 0.042
ssrp1a structure specific recognition protein 1a 0.042
kita kit receptor a 0.041
prmt5 protein arginine methyltransferase 5 0.041
pola1 polymerase (DNA directed), alpha 1 0.041
eya2 eyes absent homolog 2 (Drosophila) 0.040
lmx1b.2 LIM homeobox transcription factor 1, beta 2 0.040
cstf1 cleavage stimulation factor, 3' pre-RNA, subunit 1 0.040
ash2l ash2 (absent, small, or homeotic)-like (Drosophila) 0.039
mtmr8 myotubularin related protein 8 0.039
rpa3 replication protein A3 0.039
myod1 myogenic differentiation 1 0.038
pax3a paired box gene 3a 0.037
foxe3 forkhead box E3 0.036
sass6 spindle assembly 6 homolog (C. elegans) 0.036
chek2 CHK2 checkpoint homolog (S. pombe) 0.036
spc24 SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae) 0.035
zgc:174506 zgc:174506 0.035
ptpra protein tyrosine phosphatase, receptor type, A 0.034
efnb2a ephrin B2a 0.034
crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.034
cbx5 chromobox homolog 5 (HP1 alpha homolog, Drosophila) 0.033
zgc:123326 zgc:123326 0.033
hells helicase, lymphoid-specific 0.033
ybey ybeY metallopeptidase 0.033
adnp2b ADNP homeobox 2b 0.032
chp2 calcineurin B homologous protein 2 0.032
fsta follistatin a 0.032
myst2 MYST histone acetyltransferase 2 0.032
zgc:112980 zgc:112980 0.032
mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.032
foxn1 forkhead box N1 0.032
znf346 zinc finger protein 346 0.031
lpp LIM domain containing preferred translocation partner in lipoma 0.031
zgc:66472 zgc:66472 0.031
atoh8 atonal homolog 8 0.031
ighz immunoglobulin heavy constant zeta 0.031
ywhabb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b 0.030
psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.030
ripply2 ripply2 0.030
nrp1b neuropilin 1b 0.030
ung uracil-DNA glycosylase 0.030
bactin1 bactin1 0.029
zgc:112083 zgc:112083 0.029
cbx2 chromobox homolog 2 (Drosophila Pc class) 0.029
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Chc Clathrin heavy chain 0.020
BicD Bicaudal D 0.013
Aats-ile Isoleucyl-tRNA synthetase 0.013
baz bazooka 0.012
mRpL33 mitochondrial ribosomal protein L33 0.012
CG11583 CG11583 gene product from transcript CG11583-RA 0.012
CG11076 CG11076 gene product from transcript CG11076-RB 0.011
Abi Abelson interacting protein 0.011
CkIIbeta Casein kinase II beta subunit 0.010
Atpalpha Na pump alpha subunit 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.841
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.813
MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.719
WDR5 WD repeat domain 5 0.614
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) 0.379
EED embryonic ectoderm development 0.300
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.293
EZH2 enhancer of zeste homolog 2 (Drosophila) 0.282
UHRF1 ubiquitin-like with PHD and ring finger domains 1 0.273
EP300 E1A binding protein p300 0.271
HDAC3 histone deacetylase 3 0.267
HDAC2 histone deacetylase 2 0.258
RB1 retinoblastoma 1 0.241
PML promyelocytic leukemia 0.234
NCOR2 nuclear receptor corepressor 2 0.233
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 0.225
HIST1H3B histone cluster 1, H3b 0.215
ZNF496 zinc finger protein 496 0.194
SUZ12 suppressor of zeste 12 homolog (Drosophila) 0.194
TGIF1 TGFB-induced factor homeobox 1 0.191
RBBP5 retinoblastoma binding protein 5 0.191
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.188
HCFC1 host cell factor C1 (VP16-accessory protein) 0.184
RBBP4 retinoblastoma binding protein 4 0.179
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.178
DHX30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 0.161
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.133
PIAS4 protein inhibitor of activated STAT, 4 0.127
HDAC1 histone deacetylase 1 0.127
LIN9 lin-9 homolog (C. elegans) 0.125
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.116
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.112
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.112
TSC22D1 TSC22 domain family, member 1 0.111
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.101
HIPK2 homeodomain interacting protein kinase 2 0.100
IRF2BP1 interferon regulatory factor 2 binding protein 1 0.093
NR2E3 nuclear receptor subfamily 2, group E, member 3 0.090
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.090
ADNP activity-dependent neuroprotector homeobox 0.088
EEF2K eukaryotic elongation factor-2 kinase 0.088
PARP1 poly (ADP-ribose) polymerase 1 0.088
GSK3B glycogen synthase kinase 3 beta 0.084
NRIP1 nuclear receptor interacting protein 1 0.081
CHAF1B chromatin assembly factor 1, subunit B (p60) 0.077
ATF3 activating transcription factor 3 0.072
RBBP7 retinoblastoma binding protein 7 0.065
STAG2 stromal antigen 2 0.065
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.063
NCOR1 nuclear receptor corepressor 1 0.062
HDAC7 histone deacetylase 7 0.061
DUSP1 dual specificity phosphatase 1 0.060
MBIP MAP3K12 binding inhibitory protein 1 0.059
CBX5 chromobox homolog 5 0.058
NRP1 neuropilin 1 0.058
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.050
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.050
MAP2K4 mitogen-activated protein kinase kinase 4 0.048
COASY CoA synthase 0.047
NCOA6 nuclear receptor coactivator 6 0.047
MED15 mediator complex subunit 15 0.045
COL4A1 collagen, type IV, alpha 1 0.042
HDGF hepatoma-derived growth factor 0.041
BRCA1 breast cancer 1, early onset 0.040
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.038
CHD8 chromodomain helicase DNA binding protein 8 0.037
CCNT1 cyclin T1 0.037
JUN jun proto-oncogene 0.037
MEN1 multiple endocrine neoplasia I 0.035
RAD51L1 RAD51-like 1 (S. cerevisiae) 0.035
HDAC9 histone deacetylase 9 0.034
CUL4A cullin 4A 0.034
CXXC1 CXXC finger protein 1 0.033
JUB jub, ajuba homolog (Xenopus laevis) 0.033
HIST2H3C histone cluster 2, H3c 0.032
CDCA4 cell division cycle associated 4 0.032
CTBP2 C-terminal binding protein 2 0.032
TONSL tonsoku-like, DNA repair protein 0.031
MAPK3 mitogen-activated protein kinase 3 0.031
TRIM28 tripartite motif containing 28 0.031
MYST1 MYST histone acetyltransferase 1 0.030
HTT huntingtin 0.029
DUSP3 dual specificity phosphatase 3 0.029
SUMO2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) 0.028
HEXIM1 hexamethylene bis-acetamide inducible 1 0.028
TP53 tumor protein p53 0.028
MAPK14 mitogen-activated protein kinase 14 0.028
LIN54 lin-54 homolog (C. elegans) 0.028
RICTOR RPTOR independent companion of MTOR, complex 2 0.027
HDAC5 histone deacetylase 5 0.027
MYST3 MYST histone acetyltransferase (monocytic leukemia) 3 0.027
HIST1H3A histone cluster 1, H3a 0.026
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 0.026
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.025
CTBP1 C-terminal binding protein 1 0.025
TLK1 tousled-like kinase 1 0.025
STAG1 stromal antigen 1 0.025
CREB1 cAMP responsive element binding protein 1 0.025
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 0.024
MAPK1 mitogen-activated protein kinase 1 0.023
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
CLB3 Clb3p 0.122
RTF1 Rtf1p 0.114
CTR9 Ctr9p 0.052
CKS1 Cks1p 0.045
CLB4 Clb4p 0.042
TRA1 Tra1p 0.028
SPT16 Spt16p 0.028
CDC6 Cdc6p 0.027
CLB1 Clb1p 0.027
LEO1 Leo1p 0.027
MSG5 Msg5p 0.020
SIC1 Sic1p 0.019
RTT109 Rtt109p 0.018
HIR1 Hir1p 0.018
CLB6 Clb6p 0.018
CDC28 Cdc28p 0.016
SET2 Set2p 0.015
CLB5 Clb5p 0.014
KSS1 Kss1p 0.014
TEC1 Tec1p 0.014
STE4 Ste4p 0.014
DIG1 Dig1p 0.013
SRD1 Srd1p 0.012
TAF8 Taf8p 0.012
YLR264C-A hypothetical protein 0.011
CUP1-1 Cup1-1p 0.011
PAF1 Paf1p 0.011
CDC20 Cdc20p 0.011
STE5 Ste5p 0.011
YLR162W hypothetical protein 0.011
LEU2 Leu2p 0.011
OPT2 Opt2p 0.011
SWC3 Swc3p 0.011
SPT5 Spt5p 0.011
ARP10 Arp10p 0.011
YOL038C-A hypothetical protein 0.011
TAF6 Taf6p 0.011
MRS6 Mrs6p 0.011
NGG1 Ngg1p 0.010
IES3 Ies3p 0.010
HXT3 Hxt3p 0.010
TYE7 Tye7p 0.010
MER1 Mer1p 0.010
FUS3 Fus3p 0.010
CLN2 Cln2p 0.010
SPL2 Spl2p 0.010