The network for 'positive regulation of smooth muscle cell migration' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of smooth muscle cell migration

Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.

Mus musculus
Name Description Probability Func Analog Organism
Kdr kinase insert domain protein receptor 0.995
Flt4 FMS-like tyrosine kinase 4 0.992
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.991
Nos3 nitric oxide synthase 3, endothelial cell 0.990
Csf1 colony stimulating factor 1 (macrophage) 0.986
Trp53 transformation related protein 53 0.959
Lepr leptin receptor 0.839
Src Rous sarcoma oncogene 0.837
Flt1 FMS-like tyrosine kinase 1 0.766
Tgfb1 transforming growth factor, beta 1 0.745
Kitl kit ligand 0.684
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.667
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.644
Mef2d myocyte enhancer factor 2D 0.640
Pdgfb platelet derived growth factor, B polypeptide 0.639
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.632
Plcg1 phospholipase C, gamma 1 0.625
Apc adenomatosis polyposis coli 0.601
Esr1 estrogen receptor 1 (alpha) 0.568
Amhr2 anti-Mullerian hormone type 2 receptor 0.566
Bcl2 B-cell leukemia/lymphoma 2 0.552
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.534
Lama5 laminin, alpha 5 0.521
Tgfbr2 transforming growth factor, beta receptor II 0.511
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.505
Ednrb endothelin receptor type B 0.481
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.470
Notch2 Notch gene homolog 2 (Drosophila) 0.452
Ptprb protein tyrosine phosphatase, receptor type, B 0.447
Cav1 caveolin 1, caveolae protein 0.435
Nrp1 neuropilin 1 0.421
Pxn paxillin 0.416
Nos1 nitric oxide synthase 1, neuronal 0.412
Ghr growth hormone receptor 0.410
Vhl von Hippel-Lindau tumor suppressor 0.398
Ptgs2 prostaglandin-endoperoxide synthase 2 0.395
Col1a1 collagen, type I, alpha 1 0.383
Dlg4 discs, large homolog 4 (Drosophila) 0.375
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.360
Itga3 integrin alpha 3 0.357
Smad3 MAD homolog 3 (Drosophila) 0.338
Ptk2 PTK2 protein tyrosine kinase 2 0.312
Pten phosphatase and tensin homolog 0.291
Vegfa vascular endothelial growth factor A 0.272
Bcar1 breast cancer anti-estrogen resistance 1 0.271
Slc9a3r2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.262
Mdm2 transformed mouse 3T3 cell double minute 2 0.259
C1qc complement component 1, q subcomponent, C chain 0.257
Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 0.251
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.247
Meox2 mesenchyme homeobox 2 0.244
Cdh5 cadherin 5 0.225
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.224
Bak1 BCL2-antagonist/killer 1 0.218
Ddr2 discoidin domain receptor family, member 2 0.216
Csf1r colony stimulating factor 1 receptor 0.198
Ret ret proto-oncogene 0.193
Stat3 signal transducer and activator of transcription 3 0.181
Bax BCL2-associated X protein 0.177
Sdc3 syndecan 3 0.175
H2-Eb1 histocompatibility 2, class II antigen E beta 0.171
Prlr prolactin receptor 0.164
Vdr vitamin D receptor 0.162
Plat plasminogen activator, tissue 0.158
Esr2 estrogen receptor 2 (beta) 0.151
Cbl Casitas B-lineage lymphoma 0.151
Tek endothelial-specific receptor tyrosine kinase 0.150
Mmp9 matrix metallopeptidase 9 0.147
Dmpk dystrophia myotonica-protein kinase 0.147
Sox10 SRY-box containing gene 10 0.144
Lif leukemia inhibitory factor 0.143
Gucy1b3 guanylate cyclase 1, soluble, beta 3 0.136
Gja1 gap junction protein, alpha 1 0.134
Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.133
Lrp1 low density lipoprotein receptor-related protein 1 0.127
Epas1 endothelial PAS domain protein 1 0.126
Wwtr1 WW domain containing transcription regulator 1 0.120
Gaa glucosidase, alpha, acid 0.115
Bbc3 BCL2 binding component 3 0.109
Runx2 runt related transcription factor 2 0.108
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.105
Smad4 MAD homolog 4 (Drosophila) 0.104
Ncoa3 nuclear receptor coactivator 3 0.103
Axl AXL receptor tyrosine kinase 0.103
She src homology 2 domain-containing transforming protein E 0.102
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.100
Zfp651 zinc finger protein 651 0.099
Ldb2 LIM domain binding 2 0.098
Spry4 sprouty homolog 4 (Drosophila) 0.098
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.097
Aplnr apelin receptor 0.095
Sema6d sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.094
Fyn Fyn proto-oncogene 0.094
Acvrl1 activin A receptor, type II-like 1 0.092
Tmem204 transmembrane protein 204 0.091
Plxna1 plexin A1 0.091
Tcirg1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 0.091
Eng endoglin 0.090
Mfn2 mitofusin 2 0.086
Il6 interleukin 6 0.085
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.999
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.998
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.995
VEGFA vascular endothelial growth factor A 0.962
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.926
NRP1 neuropilin 1 0.892
CCR5 chemokine (C-C motif) receptor 5 0.890
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.715
EGFR epidermal growth factor receptor 0.580
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.368
LAT linker for activation of T cells 0.301
BCAR1 breast cancer anti-estrogen resistance 1 0.250
CCL2 chemokine (C-C motif) ligand 2 0.247
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.236
CXCL9 chemokine (C-X-C motif) ligand 9 0.186
PDGFC platelet derived growth factor C 0.176
CCL5 chemokine (C-C motif) ligand 5 0.137
IGF1R insulin-like growth factor 1 receptor 0.135
FYN FYN oncogene related to SRC, FGR, YES 0.133
GAB1 GRB2-associated binding protein 1 0.123
CCL4 chemokine (C-C motif) ligand 4 0.115
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.114
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.108
PGF placental growth factor 0.100
BCL2L1 BCL2-like 1 0.097
PLAUR plasminogen activator, urokinase receptor 0.087
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.072
IDE insulin-degrading enzyme 0.057
CCL13 chemokine (C-C motif) ligand 13 0.057
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.057
PTPN23 protein tyrosine phosphatase, non-receptor type 23 0.056
MAPK8 mitogen-activated protein kinase 8 0.056
MMP1 matrix metallopeptidase 1 (interstitial collagenase) 0.053
CCL8 chemokine (C-C motif) ligand 8 0.052
BAD BCL2-associated agonist of cell death 0.049
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.048
NCOR2 nuclear receptor corepressor 2 0.047
IRS1 insulin receptor substrate 1 0.044
JDP2 Jun dimerization protein 2 0.044
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.043
EEA1 early endosome antigen 1 0.043
INHBA inhibin, beta A 0.043
CXCL11 chemokine (C-X-C motif) ligand 11 0.039
GRB2 growth factor receptor-bound protein 2 0.038
CDH5 cadherin 5, type 2 (vascular endothelium) 0.037
CCR1 chemokine (C-C motif) receptor 1 0.032
PDGFA platelet-derived growth factor alpha polypeptide 0.031
PLAT plasminogen activator, tissue 0.031
ITGB1BP3 integrin beta 1 binding protein 3 0.030
GNLY granulysin 0.030
IL6 interleukin 6 (interferon, beta 2) 0.030
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.029
DCN decorin 0.029
OSMR oncostatin M receptor 0.028
JAK2 Janus kinase 2 0.027
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.026
IL1B interleukin 1, beta 0.025
FGFR1 fibroblast growth factor receptor 1 0.024
LDLR low density lipoprotein receptor 0.024
CCL3 chemokine (C-C motif) ligand 3 0.023
VCAM1 vascular cell adhesion molecule 1 0.023
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.022
JAK1 Janus kinase 1 0.020
GAB2 GRB2-associated binding protein 2 0.019
STC1 stanniocalcin 1 0.018
IGFBP5 insulin-like growth factor binding protein 5 0.018
MMP12 matrix metallopeptidase 12 (macrophage elastase) 0.018
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.018
PXN paxillin 0.017
KITLG KIT ligand 0.017
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.017
MEF2A myocyte enhancer factor 2A 0.016
S100B S100 calcium binding protein B 0.016
PTPRB protein tyrosine phosphatase, receptor type, B 0.016
PIK3CA phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.016
CMIP c-Maf-inducing protein 0.016
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.016
IL8 interleukin 8 0.015
PLCG1 phospholipase C, gamma 1 0.015
CXCL13 chemokine (C-X-C motif) ligand 13 0.015
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.014
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.013
PIK3CB phosphoinositide-3-kinase, catalytic, beta polypeptide 0.013
DARC Duffy blood group, chemokine receptor 0.013
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.013
AXL AXL receptor tyrosine kinase 0.013
CCL7 chemokine (C-C motif) ligand 7 0.013
ENG endoglin 0.012
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.012
CD83 CD83 molecule 0.011
PPARA peroxisome proliferator-activated receptor alpha 0.011
FRS2 fibroblast growth factor receptor substrate 2 0.011
CCL11 chemokine (C-C motif) ligand 11 0.011
LIF leukemia inhibitory factor (cholinergic differentiation factor) 0.011
ICAM1 intercellular adhesion molecule 1 0.011
SLAMF8 SLAM family member 8 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.314
Dock8 dedicator of cytokinesis 8 0.182
Mmp10 matrix metallopeptidase 10 0.166
Hck hemopoietic cell kinase 0.165
Ptafr platelet-activating factor receptor 0.162
Mmp13 matrix metallopeptidase 13 0.137
Fcgr3a Fc fragment of IgG, low affinity IIIa, receptor 0.111
Hpgds hematopoietic prostaglandin D synthase 0.109
Vav1 vav 1 guanine nucleotide exchange factor 0.108
RGD1561143 similar to cell surface receptor FDFACT 0.099
Ccl4 chemokine (C-C motif) ligand 4 0.095
Ppp1cb protein phosphatase 1, catalytic subunit, beta isoform 0.092
Bsg basigin 0.081
Casp1 caspase 1 0.081
Cfp complement factor properdin 0.080
Col12a1 collagen, type XII, alpha 1 0.076
Il1b interleukin 1 beta 0.075
Gabrp gamma-aminobutyric acid (GABA-A) receptor, pi 0.074
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.074
Trim47 tripartite motif-containing 47 0.071
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.071
Cd38 CD38 molecule 0.069
Neurl3 neuralized homolog 3 (Drosophila) 0.061
Il1a interleukin 1 alpha 0.060
Gzmk granzyme K 0.057
Mmp12 matrix metallopeptidase 12 0.057
Prf1 perforin 1 (pore forming protein) 0.057
S1pr2 sphingosine-1-phosphate receptor 2 0.056
Arhgap4 Rho GTPase activating protein 4 0.053
C5ar1 complement component 5a receptor 1 0.052
Cd8a CD8a molecule 0.051
Ar androgen receptor 0.050
Cd4 Cd4 molecule 0.050
Anxa1 annexin A1 0.048
Clec9a C-type lectin domain family 9, member a 0.046
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.045
Cybb cytochrome b-245, beta polypeptide 0.044
LOC100360986 mCG1035404-like 0.044
Hivep1 human immunodeficiency virus type I enhancer binding protein 1 0.043
Cpa3 carboxypeptidase A3, mast cell 0.041
Ednrb endothelin receptor type B 0.041
Ly86 lymphocyte antigen 86 0.041
Fosl1 fos-like antigen 1 0.040
Tlr4 toll-like receptor 4 0.040
Klrb1a killer cell lectin-like receptor subfamily B, member 1A 0.040
Dnase1l3 deoxyribonuclease 1-like 3 0.040
Inpp5d inositol polyphosphate-5-phosphatase D 0.037
Arl11 ADP-ribosylation factor-like 11 0.037
Plau plasminogen activator, urokinase 0.037
Aif1 allograft inflammatory factor 1 0.036
Utrn utrophin 0.035
Cast calpastatin 0.033
Calcb calcitonin-related polypeptide, beta 0.032
Ccl3 chemokine (C-C motif) ligand 3 0.031
Stat6 signal transducer and activator of transcription 6 0.031
Arhgap25 Rho GTPase activating protein 25 0.031
Cga glycoprotein hormones, alpha polypeptide 0.030
Pebp1 phosphatidylethanolamine binding protein 1 0.030
Pld2 phospholipase D2 0.030
Snai1 snail homolog 1 (Drosophila) 0.030
Slco2b1 solute carrier organic anion transporter family, member 2b1 0.030
Elf1 E74-like factor 1 0.030
Cxcl13 chemokine (C-X-C motif) ligand 13 0.029
Calcrl calcitonin receptor-like 0.029
Csf1 colony stimulating factor 1 (macrophage) 0.028
Ptprc protein tyrosine phosphatase, receptor type, C 0.027
Ccr1 chemokine (C-C motif) receptor 1 0.027
Itgam integrin, alpha M 0.027
Ptma prothymosin alpha 0.027
Fcgr2a Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.026
Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 0.026
Cd37 CD37 molecule 0.026
Figf c-fos induced growth factor 0.026
Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.026
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 0.026
Met met proto-oncogene 0.025
Wnt5a wingless-type MMTV integration site family, member 5A 0.024
Arhgap10 Rho GTPase activating protein 10 0.024
Ly6al lymphocyte antigen 6 complex, locus A-like 0.024
Ptpre protein tyrosine phosphatase, receptor type, E 0.024
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.024
Nampt nicotinamide phosphoribosyltransferase 0.023
Olfml2b olfactomedin-like 2B 0.023
Snx18 sorting nexin 18 0.023
Marcks myristoylated alanine rich protein kinase C substrate 0.023
Scarf2 scavenger receptor class F, member 2 0.022
Csn1s1 casein alpha s1 0.022
Lst1 leukocyte specific transcript 1 0.022
Cd86 CD86 molecule 0.022
Purb purine rich element binding protein B 0.022
Lilrb3l leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like 0.022
Has2 hyaluronan synthase 2 0.022
Gzmb granzyme B 0.022
Atp2b4 ATPase, Ca++ transporting, plasma membrane 4 0.022
Mpeg1 macrophage expressed 1 0.022
Lcp2 lymphocyte cytosolic protein 2 0.022
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.022
Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 0.022
Tfec transcription factor EC 0.021
LOC100361706 lambda-chain C1-region-like 0.021
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism