The network for 'positive regulation of lymphocyte differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of lymphocyte differentiation

Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation.

Mus musculus
Name Description Probability Func Analog Organism
Foxp3 forkhead box P3 0.898
Gli2 GLI-Kruppel family member GLI2 0.896
Rybp RING1 and YY1 binding protein 0.879
Rnf2 ring finger protein 2 0.863
Lck lymphocyte protein tyrosine kinase 0.860
Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) 0.849
Stat5a signal transducer and activator of transcription 5A 0.755
Jak2 Janus kinase 2 0.746
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.693
Egfr epidermal growth factor receptor 0.690
Ikzf1 IKAROS family zinc finger 1 0.674
Cd247 CD247 antigen 0.663
Lepr leptin receptor 0.643
Tgfb2 transforming growth factor, beta 2 0.616
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.586
Il10 interleukin 10 0.571
Pnp2 purine-nucleoside phosphorylase 2 0.550
Gata4 GATA binding protein 4 0.544
Tgfbr1 transforming growth factor, beta receptor I 0.539
Fyn Fyn proto-oncogene 0.534
Esr1 estrogen receptor 1 (alpha) 0.491
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.466
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.447
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.447
Cd80 CD80 antigen 0.443
Il1r1 interleukin 1 receptor, type I 0.409
Lat linker for activation of T cells 0.397
Gli3 GLI-Kruppel family member GLI3 0.382
Irf8 interferon regulatory factor 8 0.381
Ccl2 chemokine (C-C motif) ligand 2 0.375
Runx1 runt related transcription factor 1 0.372
Ccl7 chemokine (C-C motif) ligand 7 0.367
Gata6 GATA binding protein 6 0.362
Sox9 SRY-box containing gene 9 0.359
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.359
Il1b interleukin 1 beta 0.325
H2-Aa histocompatibility 2, class II antigen A, alpha 0.312
Tnf tumor necrosis factor 0.303
Stat5b signal transducer and activator of transcription 5B 0.301
H2-Eb1 histocompatibility 2, class II antigen E beta 0.297
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.293
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.291
Blnk B-cell linker 0.291
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.285
Il6st interleukin 6 signal transducer 0.281
Rarg retinoic acid receptor, gamma 0.276
Cd19 CD19 antigen 0.270
Was Wiskott-Aldrich syndrome homolog (human) 0.269
Plcg2 phospholipase C, gamma 2 0.263
Btk Bruton agammaglobulinemia tyrosine kinase 0.261
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.261
Cd44 CD44 antigen 0.257
Zfpm2 zinc finger protein, multitype 2 0.232
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.230
Ccl3 chemokine (C-C motif) ligand 3 0.228
Gata1 GATA binding protein 1 0.228
Rab27a RAB27A, member RAS oncogene family 0.223
Clec4d C-type lectin domain family 4, member d 0.219
Cxcl2 chemokine (C-X-C motif) ligand 2 0.218
Ar androgen receptor 0.213
Pitx1 paired-like homeodomain transcription factor 1 0.207
Grb2 growth factor receptor bound protein 2 0.207
Cbx7 chromobox homolog 7 0.202
Tnfrsf13c tumor necrosis factor receptor superfamily, member 13c 0.200
Ptgs2 prostaglandin-endoperoxide synthase 2 0.197
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.193
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.190
Itgax integrin alpha X 0.185
Ccr1 chemokine (C-C motif) receptor 1 0.184
Foxn1 forkhead box N1 0.183
Pcgf2 polycomb group ring finger 2 0.177
Hoxa11 homeobox A11 0.174
Cd5 CD5 antigen 0.174
Kiss1 KiSS-1 metastasis-suppressor 0.173
Hoxa10 homeobox A10 0.173
Kit kit oncogene 0.173
Igh immunoglobulin heavy chain complex 0.173
H2-DMa histocompatibility 2, class II, locus DMa 0.171
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.171
Ccr2 chemokine (C-C motif) receptor 2 0.169
Bcl6 B-cell leukemia/lymphoma 6 0.165
Ch25h cholesterol 25-hydroxylase 0.165
Inhba inhibin beta-A 0.162
Irf9 interferon regulatory factor 9 0.161
Bmp4 bone morphogenetic protein 4 0.158
S1pr3 sphingosine-1-phosphate receptor 3 0.156
Il10ra interleukin 10 receptor, alpha 0.153
Ptprc protein tyrosine phosphatase, receptor type, C 0.151
Ccr7 chemokine (C-C motif) receptor 7 0.145
Il1rap interleukin 1 receptor accessory protein 0.143
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.142
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.142
Plek pleckstrin 0.140
Il2 interleukin 2 0.137
Csf1 colony stimulating factor 1 (macrophage) 0.136
Hhex hematopoietically expressed homeobox 0.135
Batf basic leucine zipper transcription factor, ATF-like 0.135
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.134
Sh3kbp1 SH3-domain kinase binding protein 1 0.133
Phc2 polyhomeotic-like 2 (Drosophila) 0.132
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
HLA-C major histocompatibility complex, class I, C 0.998
HLA-F major histocompatibility complex, class I, F 0.996
HLA-G major histocompatibility complex, class I, G 0.995
HLA-B major histocompatibility complex, class I, B 0.995
B2M beta-2-microglobulin 0.992
HLA-A major histocompatibility complex, class I, A 0.981
HLA-E major histocompatibility complex, class I, E 0.883
IL4R interleukin 4 receptor 0.881
HLA-DRA major histocompatibility complex, class II, DR alpha 0.861
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.785
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.644
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.625
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.613
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.586
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.557
GAS6 growth arrest-specific 6 0.541
PILRA paired immunoglobin-like type 2 receptor alpha 0.419
HLA-DMB major histocompatibility complex, class II, DM beta 0.374
IL2RB interleukin 2 receptor, beta 0.367
HLA-DMA major histocompatibility complex, class II, DM alpha 0.352
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.283
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.206
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.202
MED25 mediator complex subunit 25 0.197
CD247 CD247 molecule 0.189
EPOR erythropoietin receptor 0.179
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.160
IL4 interleukin 4 0.127
IL15 interleukin 15 0.123
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.117
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.114
NCOR2 nuclear receptor corepressor 2 0.109
IL1R1 interleukin 1 receptor, type I 0.106
AXL AXL receptor tyrosine kinase 0.105
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 0.093
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.088
SLAMF1 signaling lymphocytic activation molecule family member 1 0.083
LAT linker for activation of T cells 0.077
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.074
BIRC3 baculoviral IAP repeat containing 3 0.069
TRAF1 TNF receptor-associated factor 1 0.067
SH3KBP1 SH3-domain kinase binding protein 1 0.066
IL6R interleukin 6 receptor 0.066
CXCR4 chemokine (C-X-C motif) receptor 4 0.065
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.061
TGIF1 TGFB-induced factor homeobox 1 0.060
RXRA retinoid X receptor, alpha 0.060
ESR1 estrogen receptor 1 0.059
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.058
HCK hemopoietic cell kinase 0.055
IL2RG interleukin 2 receptor, gamma 0.048
NOD2 nucleotide-binding oligomerization domain containing 2 0.047
TRAF3 TNF receptor-associated factor 3 0.047
NLK nemo-like kinase 0.047
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.043
INSR insulin receptor 0.043
IL15RA interleukin 15 receptor, alpha 0.041
CD40 CD40 molecule, TNF receptor superfamily member 5 0.040
BTN3A3 butyrophilin, subfamily 3, member A3 0.039
BTN3A1 butyrophilin, subfamily 3, member A1 0.039
CD164 CD164 molecule, sialomucin 0.039
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.035
CAV1 caveolin 1, caveolae protein, 22kDa 0.034
CD22 CD22 molecule 0.034
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.032
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.031
TGFB3 transforming growth factor, beta 3 0.031
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.031
PPARA peroxisome proliferator-activated receptor alpha 0.031
TPP1 tripeptidyl peptidase I 0.031
CSNK1G1 casein kinase 1, gamma 1 0.030
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 0.029
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.028
EGR2 early growth response 2 0.028
SIGLEC7 sialic acid binding Ig-like lectin 7 0.028
PSAP prosaposin 0.026
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.026
BTN2A1 butyrophilin, subfamily 2, member A1 0.026
LAPTM5 lysosomal protein transmembrane 5 0.026
JAK3 Janus kinase 3 0.024
CTBP1 C-terminal binding protein 1 0.024
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.024
TREM1 triggering receptor expressed on myeloid cells 1 0.023
CCR7 chemokine (C-C motif) receptor 7 0.022
PTAFR platelet-activating factor receptor 0.022
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.022
SLA Src-like-adaptor 0.022
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.021
BTN3A2 butyrophilin, subfamily 3, member A2 0.021
NCOA1 nuclear receptor coactivator 1 0.021
NCOR1 nuclear receptor corepressor 1 0.020
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.020
IFITM1 interferon induced transmembrane protein 1 (9-27) 0.019
CD48 CD48 molecule 0.019
FCN1 ficolin (collagen/fibrinogen domain containing) 1 0.019
IKZF3 IKAROS family zinc finger 3 (Aiolos) 0.019
SH2D2A SH2 domain containing 2A 0.018
IL1RN interleukin 1 receptor antagonist 0.018
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.018
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.018
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Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-DMb RT1 class II, locus DMb 0.433
RT1-Da RT1 class II, locus Da 0.277
RT1-Db1 RT1 class II, locus Db1 0.207
RT1-Bb RT1 class II, locus Bb 0.084
Cd37 CD37 molecule 0.066
Tcrb T-cell receptor beta chain 0.057
RT1-DMa RT1 class II, locus DMa 0.045
Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain 0.032
RT1-Ba RT1 class II, locus Ba 0.030
Cd247 Cd247 molecule 0.014
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism