The network for 'regulation of lymphocyte mediated immunity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of lymphocyte mediated immunity

Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity.

Mus musculus
Name Description Probability Func Analog Organism
Cd40 CD40 antigen 0.985
Tnf tumor necrosis factor 0.961
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.956
Igh immunoglobulin heavy chain complex 0.937
Fyn Fyn proto-oncogene 0.933
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.924
Il4 interleukin 4 0.908
Icos inducible T-cell co-stimulator 0.870
Ccr1 chemokine (C-C motif) receptor 1 0.853
Ncr1 natural cytotoxicity triggering receptor 1 0.842
Fasl Fas ligand (TNF superfamily, member 6) 0.815
Xcl1 chemokine (C motif) ligand 1 0.807
Foxp3 forkhead box P3 0.803
Prf1 perforin 1 (pore forming protein) 0.794
Klra9 killer cell lectin-like receptor subfamily A, member 9 0.792
Lta lymphotoxin A 0.775
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.756
Lyz2 lysozyme 2 0.741
B2m beta-2 microglobulin 0.738
Tapbp TAP binding protein 0.703
Stat3 signal transducer and activator of transcription 3 0.700
Cd19 CD19 antigen 0.691
Il6 interleukin 6 0.679
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.675
Stat5b signal transducer and activator of transcription 5B 0.649
H2-K1 histocompatibility 2, K1, K region 0.646
Noto notochord homolog (Xenopus laevis) 0.637
Traf6 TNF receptor-associated factor 6 0.631
Clec4d C-type lectin domain family 4, member d 0.612
Slamf1 signaling lymphocytic activation molecule family member 1 0.604
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.570
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.560
Cxcr5 chemokine (C-X-C motif) receptor 5 0.556
Cxcl13 chemokine (C-X-C motif) ligand 13 0.541
Pax5 paired box gene 5 0.536
Pnp2 purine-nucleoside phosphorylase 2 0.522
Klrc1 killer cell lectin-like receptor subfamily C, member 1 0.521
Il10 interleukin 10 0.511
Gzma granzyme A 0.510
Gzmk granzyme K 0.497
Socs1 suppressor of cytokine signaling 1 0.497
Ccr7 chemokine (C-C motif) receptor 7 0.491
Tbx21 T-box 21 0.480
C3 complement component 3 0.463
H2-D1 histocompatibility 2, D region locus 1 0.461
Ifng interferon gamma 0.448
Ikzf1 IKAROS family zinc finger 1 0.447
Cd40lg CD40 ligand 0.446
Irf9 interferon regulatory factor 9 0.434
H2-Q7 histocompatibility 2, Q region locus 7 0.420
Il1b interleukin 1 beta 0.413
Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.410
Pdcd1 programmed cell death 1 0.406
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.404
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.402
Irf1 interferon regulatory factor 1 0.386
Ltb lymphotoxin B 0.380
Arrb1 arrestin, beta 1 0.376
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.371
Ccl8 chemokine (C-C motif) ligand 8 0.348
Lag3 lymphocyte-activation gene 3 0.340
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.336
Stat5a signal transducer and activator of transcription 5A 0.331
Il2rg interleukin 2 receptor, gamma chain 0.330
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.329
Cd209a CD209a antigen 0.324
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.321
Ctla4 cytotoxic T-lymphocyte-associated protein 4 0.309
Mmp3 matrix metallopeptidase 3 0.309
Itk IL2-inducible T-cell kinase 0.299
Gzmb granzyme B 0.298
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.298
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.294
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.293
Pitx1 paired-like homeodomain transcription factor 1 0.283
Ccl4 chemokine (C-C motif) ligand 4 0.270
Ifnar2 interferon (alpha and beta) receptor 2 0.268
Aoah acyloxyacyl hydrolase 0.267
Cd96 CD96 antigen 0.266
Cd4 CD4 antigen 0.259
Clec4n C-type lectin domain family 4, member n 0.255
Sh2d2a SH2 domain protein 2A 0.254
Casp8 caspase 8 0.251
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.250
Cd209d CD209d antigen 0.249
Ccl22 chemokine (C-C motif) ligand 22 0.233
Hbb-b1 hemoglobin, beta adult major chain 0.233
Klrb1c killer cell lectin-like receptor subfamily B member 1C 0.231
Gpr132 G protein-coupled receptor 132 0.230
Cd22 CD22 antigen 0.228
Traf2 TNF receptor-associated factor 2 0.225
Ccl5 chemokine (C-C motif) ligand 5 0.222
Cd28 CD28 antigen 0.221
Ggt5 gamma-glutamyltransferase 5 0.220
Mefv Mediterranean fever 0.217
Cd247 CD247 antigen 0.216
Hspa9 heat shock protein 9 0.213
Il10ra interleukin 10 receptor, alpha 0.211
Fas Fas (TNF receptor superfamily member 6) 0.210
Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 0.208
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
nod1 nucleotide-binding oligomerization domain containing 1 0.027
tlr3 toll-like receptor 3 0.024
LOC100000934 hypothetical protein LOC100000934 0.020
zgc:64115 zgc:64115 0.019
LOC566708 FL cytokine receptor-like 0.018
irak4 interleukin-1 receptor-associated kinase 4 0.017
pkd2 polycystic kidney disease 2 0.016
defbl3 defensin, beta-like 3 0.016
pcsk9 proprotein convertase subtilisin/kexin type 9 0.015
im:7141132 im:7141132 0.014
fbln4 fibulin 4 0.014
pcsk7 proprotein convertase subtilisin/kexin type 7 0.014
hspa9 heat shock protein 9 0.013
lndc1 ly6/neurotoxin domain containing 1 0.013
angptl6 angiopoietin-like 6 0.013
foxp3a forkhead box P3a 0.013
angptl1 angiopoietin-like 1 0.013
lmx1b.2 LIM homeobox transcription factor 1, beta 2 0.012
furinb furin (paired basic amino acid cleaving enzyme) b 0.012
pdcd2 programmed cell death 2 0.012
tlr9 toll-like receptor 9 0.012
eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 0.012
itln3 intelectin 3 0.012
ugt5c2 UDP glucuronosyltransferase 5 family, polypeptide C2 0.012
wu:fc23b05 wu:fc23b05 0.012
nitr4a novel immune-type receptor 4a 0.012
slc4a2b solute carrier family 4, anion exchanger, member 2b 0.012
ren renin 0.012
tlr22 toll-like receptor 22 0.012
polr2d polymerase (RNA) II (DNA directed) polypeptide D 0.012
pcsk2 proprotein convertase subtilisin/kexin type 2 0.012
jak3 Janus kinase 3 (a protein tyrosine kinase, leukocyte) 0.011
pcsk1 proprotein convertase subtilisin/kexin type 1 0.011
c1qc complement component 1, q subcomponent, C chain 0.011
itln1 intelectin 1 0.011
tbx21 T-box 21 0.011
wu:fb80e01 wu:fb80e01 0.011
zgc:103710 zgc:103710 0.011
erbb3a v-erb-b2 erythroblastic leukemia viral oncogene homolog 3a 0.011
stc1l stanniocalcin 1, like 0.011
taf3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto 0.011
slc15a1b solute carrier family 15 (oligopeptide transporter), member 1b 0.011
zgc:153921 zgc:153921 0.011
hspa4a heat shock protein 4a 0.011
cd40lg CD40 ligand 0.011
dlg2 discs, large (Drosophila) homolog 2 0.011
smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.010
crb2a crumbs homolog 2a 0.010
c3c complement component c3c 0.010
tnfrsf18 tumor necrosis factor receptor superfamily, member 18 0.010
il10 interleukin 10 0.010
atp2b4 ATPase, Ca++ transporting, plasma membrane 4 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
HLA-A major histocompatibility complex, class I, A 0.979
B2M beta-2-microglobulin 0.977
TRAF3 TNF receptor-associated factor 3 0.938
HLA-C major histocompatibility complex, class I, C 0.917
HLA-G major histocompatibility complex, class I, G 0.907
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.902
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.851
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.849
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.811
TAPBP TAP binding protein (tapasin) 0.767
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.745
TRAF1 TNF receptor-associated factor 1 0.685
IL4R interleukin 4 receptor 0.616
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.608
CD40 CD40 molecule, TNF receptor superfamily member 5 0.596
CD84 CD84 molecule 0.504
CCR1 chemokine (C-C motif) receptor 1 0.485
HLA-E major histocompatibility complex, class I, E 0.478
CCL5 chemokine (C-C motif) ligand 5 0.458
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.455
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.453
SLAMF1 signaling lymphocytic activation molecule family member 1 0.432
IL2RG interleukin 2 receptor, gamma 0.417
CXCL9 chemokine (C-X-C motif) ligand 9 0.338
IL2RB interleukin 2 receptor, beta 0.330
HLA-F major histocompatibility complex, class I, F 0.310
SYK spleen tyrosine kinase 0.300
CCR5 chemokine (C-C motif) receptor 5 0.295
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.288
BIRC3 baculoviral IAP repeat containing 3 0.250
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 0.246
GRAP2 GRB2-related adaptor protein 2 0.239
GBA glucosidase, beta, acid 0.238
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.232
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.217
CCR7 chemokine (C-C motif) receptor 7 0.205
HLA-B major histocompatibility complex, class I, B 0.201
CCL4 chemokine (C-C motif) ligand 4 0.198
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.192
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.178
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.153
GZMK granzyme K (granzyme 3; tryptase II) 0.150
THOC5 THO complex 5 0.146
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.140
PILRA paired immunoglobin-like type 2 receptor alpha 0.130
SH2D1A SH2 domain containing 1A 0.112
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.106
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.100
IFNG interferon, gamma 0.100
HK3 hexokinase 3 (white cell) 0.098
LTA lymphotoxin alpha (TNF superfamily, member 1) 0.098
IL23A interleukin 23, alpha subunit p19 0.093
SIGLEC7 sialic acid binding Ig-like lectin 7 0.093
TGIF1 TGFB-induced factor homeobox 1 0.092
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.091
PVRL4 poliovirus receptor-related 4 0.087
CD2 CD2 molecule 0.086
PML promyelocytic leukemia 0.085
TRAF2 TNF receptor-associated factor 2 0.083
ENG endoglin 0.080
DPP4 dipeptidyl-peptidase 4 0.079
CCL19 chemokine (C-C motif) ligand 19 0.076
ARRB1 arrestin, beta 1 0.075
PVRL3 poliovirus receptor-related 3 0.074
NKG7 natural killer cell group 7 sequence 0.074
RIPK2 receptor-interacting serine-threonine kinase 2 0.072
KLRC3 killer cell lectin-like receptor subfamily C, member 3 0.071
ITM2B integral membrane protein 2B 0.070
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.068
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.067
CD48 CD48 molecule 0.064
IL8 interleukin 8 0.062
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.061
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 0.059
IL18RAP interleukin 18 receptor accessory protein 0.058
IDE insulin-degrading enzyme 0.058
HDAC9 histone deacetylase 9 0.058
CCL2 chemokine (C-C motif) ligand 2 0.056
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.056
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.054
FCN1 ficolin (collagen/fibrinogen domain containing) 1 0.054
CD80 CD80 molecule 0.054
TJP1 tight junction protein 1 (zona occludens 1) 0.053
MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 0.053
ITK IL2-inducible T-cell kinase 0.053
TNF tumor necrosis factor 0.053
CALCOCO2 calcium binding and coiled-coil domain 2 0.052
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 0.051
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.051
MBD4 methyl-CpG binding domain protein 4 0.051
IL1B interleukin 1, beta 0.050
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.050
VAMP4 vesicle-associated membrane protein 4 0.049
KLRC2 killer cell lectin-like receptor subfamily C, member 2 0.048
CCL22 chemokine (C-C motif) ligand 22 0.047
ARRB2 arrestin, beta 2 0.047
CD3G CD3g molecule, gamma (CD3-TCR complex) 0.047
IGSF6 immunoglobulin superfamily, member 6 0.046
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 0.045
CD86 CD86 molecule 0.044
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Rattus norvegicus
Name Description Probability Func Analog Organism
Hsph1 heat shock 105/110 protein 1 0.688
RT1-EC2 RT1 class Ib, locus EC2 0.062
Il1b interleukin 1 beta 0.046
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.039
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.038
Hspb1 heat shock protein 1 0.032
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.031
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.031
Igsf6 immunoglobulin superfamily, member 6 0.031
Aif1 allograft inflammatory factor 1 0.030
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.028
Gzmb granzyme B 0.028
Casp1 caspase 1 0.028
Kmo kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.027
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.024
RT1-S3 RT1 class Ib, locus S3 0.024
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.021
Spn sialophorin 0.021
Plcg2 phospholipase C, gamma 2 0.020
Apob apolipoprotein B 0.019
Oas1a 2'-5' oligoadenylate synthetase 1A 0.018
P2ry14 purinergic receptor P2Y, G-protein coupled, 14 0.016
Gzmk granzyme K 0.016
Cxcl9 chemokine (C-X-C motif) ligand 9 0.015
Plaur plasminogen activator, urokinase receptor 0.015
Cd2 Cd2 molecule 0.014
Prf1 perforin 1 (pore forming protein) 0.014
Grpr gastrin releasing peptide receptor 0.013
Dnajb1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.013
Fgg fibrinogen gamma chain 0.012
Cd247 Cd247 molecule 0.012
Il2rb interleukin 2 receptor, beta 0.012
Ccl4 chemokine (C-C motif) ligand 4 0.011
Mmp12 matrix metallopeptidase 12 0.011
Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 0.011
Ugt2a1 UDP glucuronosyltransferase 2 family, polypeptide A1 0.011
Trim47 tripartite motif-containing 47 0.011
Nkg7 natural killer cell group 7 sequence 0.010
Sell selectin L 0.010
Mmp8 matrix metallopeptidase 8 0.010
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.010
Dnase1l3 deoxyribonuclease 1-like 3 0.010
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism