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Homo sapiens

24 genes annotated in human

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regulation of b cell activation

GO:0050864

Any process that modulates the frequency, rate or extent of B cell activation.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of b cell activation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of b cell activation" (in gray)

Name	Description	Probability	Func Analog Organism
IL4R	interleukin 4 receptor	0.941
BCL2	B-cell CLL/lymphoma 2	0.862
BCL2L1	BCL2-like 1	0.661	Human
TICAM2	toll-like receptor adaptor molecule 2	0.484
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.388	Human
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.345
SYK	spleen tyrosine kinase	0.306	Mouse
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.286
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.213	Mouse
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.210
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.200	Mouse
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.195
SMN1	survival of motor neuron 1, telomeric	0.188
MYD88	myeloid differentiation primary response gene (88)	0.174
LAT	linker for activation of T cells	0.172
CD80	CD80 molecule	0.166
IRAK1	interleukin-1 receptor-associated kinase 1	0.157
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.143	Mouse
IL10RA	interleukin 10 receptor, alpha	0.141
SH3BP2	SH3-domain binding protein 2	0.141
XIAP	X-linked inhibitor of apoptosis	0.140
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.131
H2AFX	H2A histone family, member X	0.125
NCOA3	nuclear receptor coactivator 3	0.124
BLNK	B-cell linker	0.117
THOC4	THO complex 4	0.113
IL4	interleukin 4	0.112	Mouse
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.108
NBN	nibrin	0.107
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.107
BAK1	BCL2-antagonist/killer 1	0.100
HDAC9	histone deacetylase 9	0.097
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.092
TAL1	T-cell acute lymphocytic leukemia 1	0.092
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.088
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.087
TNFRSF13B	tumor necrosis factor receptor superfamily, member 13B	0.080
SH3KBP1	SH3-domain kinase binding protein 1	0.079
IL2RG	interleukin 2 receptor, gamma	0.078	Mouse
IL22RA2	interleukin 22 receptor, alpha 2	0.078
TFF1	trefoil factor 1	0.073
CDK6	cyclin-dependent kinase 6	0.072
MDC1	mediator of DNA-damage checkpoint 1	0.070
GRAP2	GRB2-related adaptor protein 2	0.067
EP300	E1A binding protein p300	0.065
INSR	insulin receptor	0.065
TP53BP1	tumor protein p53 binding protein 1	0.064
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.063
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.061	Mouse
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.060
IL2RB	interleukin 2 receptor, beta	0.058
TNIP1	TNFAIP3 interacting protein 1	0.058
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.056
IRS1	insulin receptor substrate 1	0.056
BAD	BCL2-associated agonist of cell death	0.055
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.055
SMC1A	structural maintenance of chromosomes 1A	0.054
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.054
GAS7	growth arrest-specific 7	0.053
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.052
HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	0.051
BID	BH3 interacting domain death agonist	0.049
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.048
LCK	lymphocyte-specific protein tyrosine kinase	0.046
THOC2	THO complex 2	0.042
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.041	Mouse
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.040
CD86	CD86 molecule	0.039
IL6R	interleukin 6 receptor	0.035
CXCR4	chemokine (C-X-C motif) receptor 4	0.035
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.035
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.034
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.034
ZNF830	zinc finger protein 830	0.033
IRAK4	interleukin-1 receptor-associated kinase 4	0.033
CYSLTR1	cysteinyl leukotriene receptor 1	0.033	Human
SH2D2A	SH2 domain containing 2A	0.032
PRKCQ	protein kinase C, theta	0.032
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.032
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.032
FASLG	Fas ligand (TNF superfamily, member 6)	0.031
MS4A1	membrane-spanning 4-domains, subfamily A, member 1	0.030
RNF144B	ring finger protein 144B	0.030
FOXP3	forkhead box P3	0.029	Mouse
FERMT2	fermitin family member 2	0.029
TNFRSF17	tumor necrosis factor receptor superfamily, member 17	0.029
ARNT	aryl hydrocarbon receptor nuclear translocator	0.029
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.028
PCDH9	protocadherin 9	0.028
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.028
PML	promyelocytic leukemia	0.028
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.027	Mouse
PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.027
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.027
LAPTM5	lysosomal protein transmembrane 5	0.027
SLAMF1	signaling lymphocytic activation molecule family member 1	0.026
ENG	endoglin	0.025
IRAK2	interleukin-1 receptor-associated kinase 2	0.025
HDAC1	histone deacetylase 1	0.025
JAK3	Janus kinase 3	0.024
THOC5	THO complex 5	0.024
ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	0.024	Mouse
IL8	interleukin 8	0.024
SP3	Sp3 transcription factor	0.024
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.023
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.023
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.023
PTPN7	protein tyrosine phosphatase, non-receptor type 7	0.022
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.022
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.021
CD247	CD247 molecule	0.021
ARHGAP15	Rho GTPase activating protein 15	0.021
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.021
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.021
AR	androgen receptor	0.020
SLA	Src-like-adaptor	0.020
CD22	CD22 molecule	0.020
IL22RA1	interleukin 22 receptor, alpha 1	0.020
GBP5	guanylate binding protein 5	0.020
TNIP2	TNFAIP3 interacting protein 2	0.019	Mouse
NLRC4	NLR family, CARD domain containing 4	0.019
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	0.019
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.019	Mouse
LY96	lymphocyte antigen 96	0.019
RUNX1	runt-related transcription factor 1	0.019
IRF4	interferon regulatory factor 4	0.019
NCOR2	nuclear receptor corepressor 2	0.019
CSNK1G1	casein kinase 1, gamma 1	0.018
CXCL2	chemokine (C-X-C motif) ligand 2	0.018
JAK1	Janus kinase 1	0.018
BCL10	B-cell CLL/lymphoma 10	0.018
DDX39B	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B	0.018
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.017
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.017
TLR4	toll-like receptor 4	0.017	Mouse
EPOR	erythropoietin receptor	0.017
CYSLTR2	cysteinyl leukotriene receptor 2	0.017	Human
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.017
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.017
SIRT1	sirtuin 1	0.017
ARID1A	AT rich interactive domain 1A (SWI-like)	0.016
FRA10AC1	fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1	0.016
TMEM173	transmembrane protein 173	0.016
WRN	Werner syndrome, RecQ helicase-like	0.016
FOXO1	forkhead box O1	0.016
PTEN	phosphatase and tensin homolog	0.016
TCF4	transcription factor 4	0.016	Human
SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	0.016	Mouse
ZNF282	zinc finger protein 282	0.015
FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)	0.015
SELPLG	selectin P ligand	0.015
AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	0.015
IL1B	interleukin 1, beta	0.015
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.015
DAXX	death-domain associated protein	0.015
TRIM22	tripartite motif containing 22	0.015
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.015
PYDC2	pyrin domain containing 2	0.015
ARID2	AT rich interactive domain 2 (ARID, RFX-like)	0.015
HIPK2	homeodomain interacting protein kinase 2	0.015
BTG1	B-cell translocation gene 1, anti-proliferative	0.014
CAV1	caveolin 1, caveolae protein, 22kDa	0.014
NCOA6	nuclear receptor coactivator 6	0.014
PTPRC	protein tyrosine phosphatase, receptor type, C	0.014
PYCARD	PYD and CARD domain containing	0.014
TCF12	transcription factor 12	0.014	Human
CD48	CD48 molecule	0.014
DBNL	drebrin-like	0.014
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.014
EVI2A	ecotropic viral integration site 2A	0.014
CNR2	cannabinoid receptor 2 (macrophage)	0.013
E2F3	E2F transcription factor 3	0.013
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.013
DDX17	DEAD (Asp-Glu-Ala-Asp) box polypeptide 17	0.013
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.013
BAZ1B	bromodomain adjacent to zinc finger domain, 1B	0.013
GRB7	growth factor receptor-bound protein 7	0.013
POLR2A	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	0.013
BAX	BCL2-associated X protein	0.013	Human
IKZF1	IKAROS family zinc finger 1 (Ikaros)	0.013	Mouse
CD69	CD69 molecule	0.013
HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	0.013
KAT5	K(lysine) acetyltransferase 5	0.013
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.013
IL2RA	interleukin 2 receptor, alpha	0.013
TRAF3IP3	TRAF3 interacting protein 3	0.013
PELI3	pellino homolog 3 (Drosophila)	0.013
SASH3	SAM and SH3 domain containing 3	0.013	Mouse
RB1	retinoblastoma 1	0.013
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.012
PTPRCAP	protein tyrosine phosphatase, receptor type, C-associated protein	0.012
NCOA2	nuclear receptor coactivator 2	0.012
MYST1	MYST histone acetyltransferase 1	0.012
ASCL1	achaete-scute complex homolog 1 (Drosophila)	0.012
BRCA1	breast cancer 1, early onset	0.012
MAPK12	mitogen-activated protein kinase 12	0.012
IRF5	interferon regulatory factor 5	0.012
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.012
RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	0.012
STK17B	serine/threonine kinase 17b	0.012
STAP2	signal transducing adaptor family member 2	0.012
IRAK3	interleukin-1 receptor-associated kinase 3	0.012
STK11	serine/threonine kinase 11	0.012
LRMP	lymphoid-restricted membrane protein	0.011
CD300C	CD300c molecule	0.011	Human
GPI	glucose-6-phosphate isomerase	0.011
UVRAG	UV radiation resistance associated gene	0.011
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.011
RUNX2	runt-related transcription factor 2	0.011
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.011
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.011
TLR2	toll-like receptor 2	0.011
RIPK2	receptor-interacting serine-threonine kinase 2	0.011
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.011
GPR65	G protein-coupled receptor 65	0.011
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.011
XAB2	XPA binding protein 2	0.011
CARD11	caspase recruitment domain family, member 11	0.011	Mouse
UBASH3B	ubiquitin associated and SH3 domain containing B	0.011
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.011
NCKAP1L	NCK-associated protein 1-like	0.010
LRP6	low density lipoprotein receptor-related protein 6	0.010
CD37	CD37 molecule	0.010
BTN3A1	butyrophilin, subfamily 3, member A1	0.010
PILRA	paired immunoglobin-like type 2 receptor alpha	0.010
MLL3	myeloid/lymphoid or mixed-lineage leukemia 3	0.010
RNR2	l-rRNA	0.010
ARNTL	aryl hydrocarbon receptor nuclear translocator-like	0.010
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.010