IMP

Process View

Homo sapiens

17 genes annotated in human

negative regulation of mitotic metaphase anaphase transition

Any process that stops, prevents, or reduces the frequency, rate or extent of the mitotic metaphase to anaphase transition.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of mitotic metaphase anaphase transition"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of mitotic metaphase anaphase transition" (in gray)

Name	Description	Probability	Func Analog Organism
CDK2	cyclin-dependent kinase 2	0.995
CCNA2	cyclin A2	0.987
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.967	Fly
CCNB1	cyclin B1	0.940
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.926	Yeast
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.864
BRCA2	breast cancer 2, early onset	0.811
BUB1	budding uninhibited by benzimidazoles 1 homolog (yeast)	0.790	Fly
H2AFX	H2A histone family, member X	0.742
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.577
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.551
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.513
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.500
NDC80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.490
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.422
CDKN3	cyclin-dependent kinase inhibitor 3	0.402
SKP2	S-phase kinase-associated protein 2 (p45)	0.379
SKA1	spindle and kinetochore associated complex subunit 1	0.351
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.300
BRCA1	breast cancer 1, early onset	0.287
AURKB	aurora kinase B	0.271
CBX5	chromobox homolog 5	0.251
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.219
TTK	TTK protein kinase	0.204	Yeast
TPX2	TPX2, microtubule-associated, homolog (Xenopus laevis)	0.195
SKA2	spindle and kinetochore associated complex subunit 2	0.169
CDK1	cyclin-dependent kinase 1	0.141
CCNB2	cyclin B2	0.126
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.120
MAD2L1	MAD2 mitotic arrest deficient-like 1 (yeast)	0.116
NEK2	NIMA (never in mitosis gene a)-related kinase 2	0.114
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.110
CKS2	CDC28 protein kinase regulatory subunit 2	0.105
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.105
CCT4	chaperonin containing TCP1, subunit 4 (delta)	0.099
PRNP	prion protein	0.095
CDT1	chromatin licensing and DNA replication factor 1	0.093
CASC5	cancer susceptibility candidate 5	0.091
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.088
TINF2	TERF1 (TRF1)-interacting nuclear factor 2	0.088
SKA3	spindle and kinetochore associated complex subunit 3	0.086
ANAPC11	anaphase promoting complex subunit 11	0.084
CCNE2	cyclin E2	0.080	Fly
FBXO5	F-box protein 5	0.079
CCDC99	coiled-coil domain containing 99	0.077
PTTG1	pituitary tumor-transforming 1	0.076
KIF18A	kinesin family member 18A	0.073
NUF2	NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.072
SPC25	SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.070
FOXM1	forkhead box M1	0.070
CENPE	centromere protein E, 312kDa	0.069	Mouse
UHRF1	ubiquitin-like with PHD and ring finger domains 1	0.066
CEP55	centrosomal protein 55kDa	0.066
RAD51AP1	RAD51 associated protein 1	0.064
PRC1	protein regulator of cytokinesis 1	0.063
SMC4	structural maintenance of chromosomes 4	0.062
CCNE1	cyclin E1	0.060	Fly
DOT1L	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	0.060
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.059
CDC25A	cell division cycle 25 homolog A (S. pombe)	0.059
HMMR	hyaluronan-mediated motility receptor (RHAMM)	0.057
KIF11	kinesin family member 11	0.057
C19orf39	chromosome 19 open reading frame 39	0.056
UBE2C	ubiquitin-conjugating enzyme E2C	0.056
C13orf34	chromosome 13 open reading frame 34	0.054
TERF2IP	telomeric repeat binding factor 2, interacting protein	0.054
ASPM	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	0.051
CCND1	cyclin D1	0.049
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.049
SGOL1	shugoshin-like 1 (S. pombe)	0.047
ANAPC4	anaphase promoting complex subunit 4	0.047
CDC25C	cell division cycle 25 homolog C (S. pombe)	0.047
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.045
BLM	Bloom syndrome, RecQ helicase-like	0.043
PLK4	polo-like kinase 4	0.043
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.042
ANKRD52	ankyrin repeat domain 52	0.041
HERC2	hect domain and RLD 2	0.040
DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	0.039
DEPDC1	DEP domain containing 1	0.038
TOP2A	topoisomerase (DNA) II alpha 170kDa	0.038
CENPF	centromere protein F, 350/400kDa (mitosin)	0.038
KIF14	kinesin family member 14	0.037
TP53BP1	tumor protein p53 binding protein 1	0.034
SPC24	SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.034
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.034
C12orf48	chromosome 12 open reading frame 48	0.034
RB1	retinoblastoma 1	0.033
PPME1	protein phosphatase methylesterase 1	0.033
MAD2L1BP	MAD2L1 binding protein	0.032
SGOL2	shugoshin-like 2 (S. pombe)	0.032
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.032
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.032
RBL1	retinoblastoma-like 1 (p107)	0.031
MYST1	MYST histone acetyltransferase 1	0.031
ZWINT	ZW10 interactor	0.031
BIRC5	baculoviral IAP repeat containing 5	0.029
INCENP	inner centromere protein antigens 135/155kDa	0.029
PLK1	polo-like kinase 1	0.027
OTUB1	OTU domain, ubiquitin aldehyde binding 1	0.027
CDCA8	cell division cycle associated 8	0.026
DSN1	DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)	0.026
PARP3	poly (ADP-ribose) polymerase family, member 3	0.025
CHAF1B	chromatin assembly factor 1, subunit B (p60)	0.025
SMC3	structural maintenance of chromosomes 3	0.025
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.025
FXR2	fragile X mental retardation, autosomal homolog 2	0.024
ATMIN	ATM interactor	0.024
BRIP1	BRCA1 interacting protein C-terminal helicase 1	0.024
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.024
DLGAP5	discs, large (Drosophila) homolog-associated protein 5	0.024
CENPL	centromere protein L	0.023
ANLN	anillin, actin binding protein	0.023
BARD1	BRCA1 associated RING domain 1	0.023
NUSAP1	nucleolar and spindle associated protein 1	0.023
CDC6	cell division cycle 6 homolog (S. cerevisiae)	0.023
SERTAD4	SERTA domain containing 4	0.023
PPP4C	protein phosphatase 4, catalytic subunit	0.022
AXIN2	axin 2	0.021
HIST1H1B	histone cluster 1, H1b	0.020
RAD52	RAD52 homolog (S. cerevisiae)	0.020
SLC39A7	solute carrier family 39 (zinc transporter), member 7	0.020
SLX4	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)	0.020
USP44	ubiquitin specific peptidase 44	0.020
USP49	ubiquitin specific peptidase 49	0.020	Human
TP53	tumor protein p53	0.020
NASP	nuclear autoantigenic sperm protein (histone-binding)	0.019
MDC1	mediator of DNA-damage checkpoint 1	0.019
DMC1	DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)	0.019
AURKA	aurora kinase A	0.019
MAPRE1	microtubule-associated protein, RP/EB family, member 1	0.019
RFWD2	ring finger and WD repeat domain 2	0.019
HIST1H1E	histone cluster 1, H1e	0.018
HIST1H4A	histone cluster 1, H4a	0.018
ANAPC7	anaphase promoting complex subunit 7	0.018
PPP2R5D	protein phosphatase 2, regulatory subunit B', delta	0.018
TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	0.017
HUWE1	HECT, UBA and WWE domain containing 1	0.017
MIS18BP1	MIS18 binding protein 1	0.017
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.017
NRD1	nardilysin (N-arginine dibasic convertase)	0.017
NSL1	NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)	0.017
BRD7	bromodomain containing 7	0.016
RRM2	ribonucleotide reductase M2	0.016
EPM2A	epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)	0.016
LMNA	lamin A/C	0.016
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.016
PRRC2C	proline-rich coiled-coil 2C	0.015
CBX1	chromobox homolog 1	0.015
ZNF207	zinc finger protein 207	0.015
ATRX	alpha thalassemia/mental retardation syndrome X-linked	0.015
FZR1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.015
HNRNPM	heterogeneous nuclear ribonucleoprotein M	0.015
KPNA3	karyopherin alpha 3 (importin alpha 4)	0.014
MKRN1	makorin ring finger protein 1	0.014
TOP3A	topoisomerase (DNA) III alpha	0.014
MASTL	microtubule associated serine/threonine kinase-like	0.014
DCLRE1B	DNA cross-link repair 1B	0.014
PINX1	PIN2/TERF1 interacting, telomerase inhibitor 1	0.014
NSMCE1	non-SMC element 1 homolog (S. cerevisiae)	0.013
ZC3HAV1	zinc finger CCCH-type, antiviral 1	0.013
TFDP1	transcription factor Dp-1	0.013
GSK3B	glycogen synthase kinase 3 beta	0.013
KIF2C	kinesin family member 2C	0.013
ATAD2	ATPase family, AAA domain containing 2	0.013
DEPDC1B	DEP domain containing 1B	0.013
PPP6R2	protein phosphatase 6, regulatory subunit 2	0.013
FANCD2	Fanconi anemia, complementation group D2	0.013
C13orf27	chromosome 13 open reading frame 27	0.013
ERCC6L	excision repair cross-complementing rodent repair deficiency, complementation group 6-like	0.013
MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	0.013
PPP2R2C	protein phosphatase 2, regulatory subunit B, gamma	0.012	Yeast
TAF15	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa	0.012
LBR	lamin B receptor	0.012
ING1	inhibitor of growth family, member 1	0.012
STK24	serine/threonine kinase 24	0.012
PTK2	PTK2 protein tyrosine kinase 2	0.012
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	0.012
PPP2R2D	protein phosphatase 2, regulatory subunit B, delta	0.012	Yeast
GET4	golgi to ER traffic protein 4 homolog (S. cerevisiae)	0.012
EVI5	ecotropic viral integration site 5	0.012
KDM4A	lysine (K)-specific demethylase 4A	0.011
HMGB2	high mobility group box 2	0.011
BTRC	beta-transducin repeat containing	0.011
ORC1	origin recognition complex, subunit 1	0.011
RAD21	RAD21 homolog (S. pombe)	0.011
NUCKS1	nuclear casein kinase and cyclin-dependent kinase substrate 1	0.011
DYNC1I2	dynein, cytoplasmic 1, intermediate chain 2	0.011
PBK	PDZ binding kinase	0.011
RBL2	retinoblastoma-like 2 (p130)	0.011
ATM	ataxia telangiectasia mutated	0.011
NBN	nibrin	0.011
CCDC101	coiled-coil domain containing 101	0.011
ZNF828	zinc finger protein 828	0.011
MAPRE3	microtubule-associated protein, RP/EB family, member 3	0.011
MYST3	MYST histone acetyltransferase (monocytic leukemia) 3	0.011
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.011
KIF4A	kinesin family member 4A	0.010
VRK1	vaccinia related kinase 1	0.010
CLSPN	claspin	0.010