IMP

Process View

Homo sapiens

30 genes annotated in human

lamellipodium organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lamellipodium. A lamellipodium is a thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "lamellipodium organization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "lamellipodium organization" (in gray)

Name	Description	Probability	Func Analog Organism
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.999
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.988	Human Fly
ILK	integrin-linked kinase	0.842
GRB7	growth factor receptor-bound protein 7	0.829
ZNF746	zinc finger protein 746	0.807
ACTR3	ARP3 actin-related protein 3 homolog (yeast)	0.726	Rat Fly
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.706
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.678
GRB2	growth factor receptor-bound protein 2	0.656
VAV1	vav 1 guanine nucleotide exchange factor	0.652
BAIAP2	BAI1-associated protein 2	0.610
GAS7	growth arrest-specific 7	0.596
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.586
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.462
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.392
PRKCZ	protein kinase C, zeta	0.387
NCK1	NCK adaptor protein 1	0.365	Mouse
TWF2	twinfilin, actin-binding protein, homolog 2 (Drosophila)	0.343
ARPC1B	actin related protein 2/3 complex, subunit 1B, 41kDa	0.334
ARPC3	actin related protein 2/3 complex, subunit 3, 21kDa	0.326
EPS8	epidermal growth factor receptor pathway substrate 8	0.318
SPTAN1	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	0.308
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.282
ARPC5	actin related protein 2/3 complex, subunit 5, 16kDa	0.259
LIMS1	LIM and senescent cell antigen-like domains 1	0.231
SORBS3	sorbin and SH3 domain containing 3	0.224
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.222
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.218
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.212
CSNK1E	casein kinase 1, epsilon	0.187
PLCG1	phospholipase C, gamma 1	0.184
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.178	Fly
TRIP6	thyroid hormone receptor interactor 6	0.176
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.175
ACTR2	ARP2 actin-related protein 2 homolog (yeast)	0.164
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.155
ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa	0.152
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.152
CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.150
DSG2	desmoglein 2	0.148
NCOA1	nuclear receptor coactivator 1	0.140
VHL	von Hippel-Lindau tumor suppressor	0.138
JUP	junction plakoglobin	0.128
INSR	insulin receptor	0.125
CTNND1	catenin (cadherin-associated protein), delta 1	0.122
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.119
EFNA5	ephrin-A5	0.115
CD2AP	CD2-associated protein	0.113
ATN1	atrophin 1	0.108
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.106
LDOC1	leucine zipper, down-regulated in cancer 1	0.104
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.100
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.095
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.093
GIT1	G protein-coupled receptor kinase interacting ArfGAP 1	0.092
WASF1	WAS protein family, member 1	0.091	Human Mouse Fly
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.091
GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	0.090
ABI1	abl-interactor 1	0.088	Mouse Fly
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.086
ADAM19	ADAM metallopeptidase domain 19	0.085
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.083
MAPK8	mitogen-activated protein kinase 8	0.079
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.076
SPTBN1	spectrin, beta, non-erythrocytic 1	0.074
CYFIP2	cytoplasmic FMR1 interacting protein 2	0.072
FYN	FYN oncogene related to SRC, FGR, YES	0.071
KIF5B	kinesin family member 5B	0.071
EFNA1	ephrin-A1	0.070
SNAI1	snail homolog 1 (Drosophila)	0.069
EGFR	epidermal growth factor receptor	0.068
PFDN1	prefoldin subunit 1	0.067
CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	0.066
FN1	fibronectin 1	0.063
MOBKL1B	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.061
PAK2	p21 protein (Cdc42/Rac)-activated kinase 2	0.061
NCKAP1	NCK-associated protein 1	0.060
CAPZB	capping protein (actin filament) muscle Z-line, beta	0.057	Fly
FMNL1	formin-like 1	0.057
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.056
SH3BGRL3	SH3 domain binding glutamic acid-rich protein like 3	0.056
LRRK2	leucine-rich repeat kinase 2	0.055
LLGL1	lethal giant larvae homolog 1 (Drosophila)	0.055
ABI2	abl-interactor 2	0.055	Fly
COTL1	coactosin-like 1 (Dictyostelium)	0.054
CHRD	chordin	0.052
MEF2C	myocyte enhancer factor 2C	0.051
PVRL2	poliovirus receptor-related 2 (herpesvirus entry mediator B)	0.050
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.049	Human
CDC42EP3	CDC42 effector protein (Rho GTPase binding) 3	0.046
PXN	paxillin	0.046	Mouse
SH3KBP1	SH3-domain kinase binding protein 1	0.046
ZYX	zyxin	0.044
NCKIPSD	NCK interacting protein with SH3 domain	0.044
PACSIN1	protein kinase C and casein kinase substrate in neurons 1	0.043
ARHGEF1	Rho guanine nucleotide exchange factor (GEF) 1	0.043
LRP6	low density lipoprotein receptor-related protein 6	0.042
TLN1	talin 1	0.041
MSN	moesin	0.041
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.041	Fly
SH3BP2	SH3-domain binding protein 2	0.040
RHOG	ras homolog gene family, member G (rho G)	0.039	Human
PVRL1	poliovirus receptor-related 1 (herpesvirus entry mediator C)	0.037
SH2D1A	SH2 domain containing 1A	0.035
NUMB	numb homolog (Drosophila)	0.035
RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	0.034
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.033
DOK1	docking protein 1, 62kDa (downstream of tyrosine kinase 1)	0.033
KITLG	KIT ligand	0.033
MAP3K11	mitogen-activated protein kinase kinase kinase 11	0.032
DOCK1	dedicator of cytokinesis 1	0.032
LLGL2	lethal giant larvae homolog 2 (Drosophila)	0.032
FZD1	frizzled homolog 1 (Drosophila)	0.030
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.030
SPRR2A	small proline-rich protein 2A	0.030
SORBS2	sorbin and SH3 domain containing 2	0.029
ARPC4	actin related protein 2/3 complex, subunit 4, 20kDa	0.028
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.028
RHOU	ras homolog gene family, member U	0.028
AXIN1	axin 1	0.027
DEF6	differentially expressed in FDCP 6 homolog (mouse)	0.027
PFN1	profilin 1	0.026
RPTOR	regulatory associated protein of MTOR, complex 1	0.026
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.026
IRS1	insulin receptor substrate 1	0.025
EPHA8	EPH receptor A8	0.025	Human
BCR	breakpoint cluster region	0.025
LRRC41	leucine rich repeat containing 41	0.024
PVRL3	poliovirus receptor-related 3	0.024
PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	0.024
SORBS1	sorbin and SH3 domain containing 1	0.023
DBNL	drebrin-like	0.023
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.023
MYL12B	myosin, light chain 12B, regulatory	0.022
CAPZA1	capping protein (actin filament) muscle Z-line, alpha 1	0.022	Fly
GNAI3	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	0.022
SNIP1	Smad nuclear interacting protein 1	0.022
FES	feline sarcoma oncogene	0.021	Human
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.021	Human
EFNB2	ephrin-B2	0.021
LMO2	LIM domain only 2 (rhombotin-like 1)	0.021
WASL	Wiskott-Aldrich syndrome-like	0.020
FYB	FYN binding protein	0.020
HCK	hemopoietic cell kinase	0.020
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.020
PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	0.020
GPRASP2	G protein-coupled receptor associated sorting protein 2	0.020
SFRP1	secreted frizzled-related protein 1	0.020
RHOA	ras homolog gene family, member A	0.020
FGF18	fibroblast growth factor 18	0.020
RSU1	Ras suppressor protein 1	0.020
KIAA1217	KIAA1217	0.019
NPTN	neuroplastin	0.019
NRAS	neuroblastoma RAS viral (v-ras) oncogene homolog	0.019
PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	0.019
ZNF775	zinc finger protein 775	0.019
TCF4	transcription factor 4	0.019
PPP1CB	protein phosphatase 1, catalytic subunit, beta isozyme	0.018
WNT1	wingless-type MMTV integration site family, member 1	0.018
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.018
UBE2R2	ubiquitin-conjugating enzyme E2R 2	0.018
EPHB6	EPH receptor B6	0.018	Human
MCC	mutated in colorectal cancers	0.018
CD164	CD164 molecule, sialomucin	0.017
HOOK2	hook homolog 2 (Drosophila)	0.017
TNK2	tyrosine kinase, non-receptor, 2	0.017
BZW1	basic leucine zipper and W2 domains 1	0.017
ABL2	v-abl Abelson murine leukemia viral oncogene homolog 2	0.017
AHNAK	AHNAK nucleoprotein	0.016
PTK6	PTK6 protein tyrosine kinase 6	0.016
EML3	echinoderm microtubule associated protein like 3	0.016
TAOK1	TAO kinase 1	0.016
CEP164	centrosomal protein 164kDa	0.016
GLIS2	GLIS family zinc finger 2	0.016
IRS2	insulin receptor substrate 2	0.016
APC	adenomatous polyposis coli	0.016
RARG	retinoic acid receptor, gamma	0.016
MPRIP	myosin phosphatase Rho interacting protein	0.016
RHOC	ras homolog gene family, member C	0.016
EZR	ezrin	0.016
JAK2	Janus kinase 2	0.016
PARVA	parvin, alpha	0.015	Human
CMPK1	cytidine monophosphate (UMP-CMP) kinase 1, cytosolic	0.015
MYH10	myosin, heavy chain 10, non-muscle	0.015
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.015
WT1	Wilms tumor 1	0.015
RNPEPL1	arginyl aminopeptidase (aminopeptidase B)-like 1	0.015
FASLG	Fas ligand (TNF superfamily, member 6)	0.015
PTOV1	prostate tumor overexpressed 1	0.015
DPYSL4	dihydropyrimidinase-like 4	0.015
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.015
WIPF1	WAS/WASL interacting protein family, member 1	0.014
ABR	active BCR-related gene	0.014
MAPK8IP3	mitogen-activated protein kinase 8 interacting protein 3	0.014
PKP1	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	0.014
KIAA1539	KIAA1539	0.014
DSP	desmoplakin	0.014
TGFB1I1	transforming growth factor beta 1 induced transcript 1	0.014
VAV2	vav 2 guanine nucleotide exchange factor	0.014	Mouse
WASF2	WAS protein family, member 2	0.014
WIF1	WNT inhibitory factor 1	0.014
DDR1	discoidin domain receptor tyrosine kinase 1	0.014
UCP2	uncoupling protein 2 (mitochondrial, proton carrier)	0.014
FZD8	frizzled homolog 8 (Drosophila)	0.013
KIF1C	kinesin family member 1C	0.013
BMP7	bone morphogenetic protein 7	0.013
RGS19	regulator of G-protein signaling 19	0.013
CFL1	cofilin 1 (non-muscle)	0.013
ELF4	E74-like factor 4 (ets domain transcription factor)	0.013
BRAF	v-raf murine sarcoma viral oncogene homolog B1	0.013
LIMD2	LIM domain containing 2	0.013
PKP3	plakophilin 3	0.013
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.013
CORO1C	coronin, actin binding protein, 1C	0.013	Human
FLII	flightless I homolog (Drosophila)	0.013
GPSM3	G-protein signaling modulator 3	0.013
CNKSR1	connector enhancer of kinase suppressor of Ras 1	0.013
DOK4	docking protein 4	0.013
PARVB	parvin, beta	0.013
SEMA3F	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.013
DDX24	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	0.013
PAK4	p21 protein (Cdc42/Rac)-activated kinase 4	0.013
TCIRG1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3	0.013
PIK3CB	phosphoinositide-3-kinase, catalytic, beta polypeptide	0.013
EPHA7	EPH receptor A7	0.012	Human
MAP1B	microtubule-associated protein 1B	0.012
CORO1A	coronin, actin binding protein, 1A	0.012	Human
ARHGAP4	Rho GTPase activating protein 4	0.012	Human
WNT10A	wingless-type MMTV integration site family, member 10A	0.012	Human
ARVCF	armadillo repeat gene deleted in velocardiofacial syndrome	0.012
FERMT2	fermitin family member 2	0.012
CCDC115	coiled-coil domain containing 115	0.012
SIPA1	signal-induced proliferation-associated 1	0.012
FKBP1A	FK506 binding protein 1A, 12kDa	0.012
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.012
SLC12A9	solute carrier family 12 (potassium/chloride transporters), member 9	0.012
FLNA	filamin A, alpha	0.012
CDK11B	cyclin-dependent kinase 11B	0.012
RIPK3	receptor-interacting serine-threonine kinase 3	0.012
LIMK1	LIM domain kinase 1	0.012
APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	0.012
FLNB	filamin B, beta	0.012
WDR1	WD repeat domain 1	0.011
VASP	vasodilator-stimulated phosphoprotein	0.011
TMC6	transmembrane channel-like 6	0.011
C19orf50	chromosome 19 open reading frame 50	0.011
PLEKHM2	pleckstrin homology domain containing, family M (with RUN domain) member 2	0.011
TMEM108	transmembrane protein 108	0.011
WNT7A	wingless-type MMTV integration site family, member 7A	0.011	Human
TGFB2	transforming growth factor, beta 2	0.011
PER1	period homolog 1 (Drosophila)	0.011
HSPG2	heparan sulfate proteoglycan 2	0.011
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.011
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.011
TNS4	tensin 4	0.011
EPHB4	EPH receptor B4	0.011	Human
TIAM1	T-cell lymphoma invasion and metastasis 1	0.011
FAM110A	family with sequence similarity 110, member A	0.011
SCRIB	scribbled homolog (Drosophila)	0.011
ACTN1	actinin, alpha 1	0.011
NADK	NAD kinase	0.011
ELMO1	engulfment and cell motility 1	0.011
FNBP1	formin binding protein 1	0.011
RAP1B	RAP1B, member of RAS oncogene family	0.011
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.011
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.011
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.011
SH3RF3	SH3 domain containing ring finger 3	0.011
STK10	serine/threonine kinase 10	0.010
RICTOR	RPTOR independent companion of MTOR, complex 2	0.010
SEMA5A	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	0.010
TOM1L1	target of myb1 (chicken)-like 1	0.010
ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	0.010
AP1M1	adaptor-related protein complex 1, mu 1 subunit	0.010
TSC22D4	TSC22 domain family, member 4	0.010
HES1	hairy and enhancer of split 1, (Drosophila)	0.010
SOCS6	suppressor of cytokine signaling 6	0.010
SOS1	son of sevenless homolog 1 (Drosophila)	0.010
PAX8	paired box 8	0.010
DOCK2	dedicator of cytokinesis 2	0.010
GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1	0.010
RAP2C	RAP2C, member of RAS oncogene family	0.010
ZNF71	zinc finger protein 71	0.010
MSH5	mutS homolog 5 (E. coli)	0.010
BTK	Bruton agammaglobulinemia tyrosine kinase	0.010
CADM4	cell adhesion molecule 4	0.010
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.010
MMP11	matrix metallopeptidase 11 (stromelysin 3)	0.010
MFNG	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.010
GRAP2	GRB2-related adaptor protein 2	0.010
GNG10	guanine nucleotide binding protein (G protein), gamma 10	0.010
MAVS	mitochondrial antiviral signaling protein	0.010
CTNNBIP1	catenin, beta interacting protein 1	0.010
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.010	Fly