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Homo sapiens

38 genes annotated in human

protein deacetylation

The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "protein deacetylation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "protein deacetylation" (in gray)

Name	Description	Probability	Func Analog Organism
HDAC1	histone deacetylase 1	1.000
HDAC2	histone deacetylase 2	0.998
NCOR2	nuclear receptor corepressor 2	0.996
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.996
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.992
HDAC7	histone deacetylase 7	0.955	Human Fly
HDAC3	histone deacetylase 3	0.946
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.876
BCL6	B-cell CLL/lymphoma 6	0.852	Mouse
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.843
EP300	E1A binding protein p300	0.799
MAPK14	mitogen-activated protein kinase 14	0.780	Human
RB1	retinoblastoma 1	0.764
TGIF1	TGFB-induced factor homeobox 1	0.651
NRP1	neuropilin 1	0.625
PPARA	peroxisome proliferator-activated receptor alpha	0.579
JUN	jun proto-oncogene	0.499
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.480
NCOR1	nuclear receptor corepressor 1	0.465	Mouse
IRF2BP1	interferon regulatory factor 2 binding protein 1	0.442
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.437
HDAC4	histone deacetylase 4	0.426
MRFAP1	Morf4 family associated protein 1	0.396
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.360
MAP2K4	mitogen-activated protein kinase kinase 4	0.324
CREBBP	CREB binding protein	0.314	Human
KDM1A	lysine (K)-specific demethylase 1A	0.306
SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.275
ATF2	activating transcription factor 2	0.245
ZMYM2	zinc finger, MYM-type 2	0.234
MEF2C	myocyte enhancer factor 2C	0.230
SUDS3	suppressor of defective silencing 3 homolog (S. cerevisiae)	0.228
BRMS1	breast cancer metastasis suppressor 1	0.221
SMAD2	SMAD family member 2	0.211
SMAD4	SMAD family member 4	0.199
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.184
PGR	progesterone receptor	0.175
CEP70	centrosomal protein 70kDa	0.172
CDC14B	CDC14 cell division cycle 14 homolog B (S. cerevisiae)	0.172
HDAC5	histone deacetylase 5	0.170
CTBP1	C-terminal binding protein 1	0.167
RUNX1	runt-related transcription factor 1	0.158
MED15	mediator complex subunit 15	0.157
TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	0.152	Fly
MAPK8	mitogen-activated protein kinase 8	0.149
HIPK2	homeodomain interacting protein kinase 2	0.145
MORF4L1	mortality factor 4 like 1	0.130
FZR1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.127
SMAD3	SMAD family member 3	0.119
HDAC9	histone deacetylase 9	0.118
SP1	Sp1 transcription factor	0.118
DNAJB2	DnaJ (Hsp40) homolog, subfamily B, member 2	0.118
SIRT3	sirtuin 3	0.116
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.116
KDM2A	lysine (K)-specific demethylase 2A	0.113
ESR1	estrogen receptor 1	0.110
PML	promyelocytic leukemia	0.109
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.109
ARRB1	arrestin, beta 1	0.107
BCL3	B-cell CLL/lymphoma 3	0.102
SUMO1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	0.102
CDC5L	CDC5 cell division cycle 5-like (S. pombe)	0.099
KAT2B	K(lysine) acetyltransferase 2B	0.085
PRKD2	protein kinase D2	0.085
MTA3	metastasis associated 1 family, member 3	0.078
SKIL	SKI-like oncogene	0.077
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.070
TBL1X	transducin (beta)-like 1X-linked	0.070	Fly
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.067
C16orf70	chromosome 16 open reading frame 70	0.064
HGS	hepatocyte growth factor-regulated tyrosine kinase substrate	0.063
SIRT1	sirtuin 1	0.061
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.060
MORF4L2	mortality factor 4 like 2	0.057	Human Yeast
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.055	Human
RARA	retinoic acid receptor, alpha	0.055
MAPK3	mitogen-activated protein kinase 3	0.055
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.054	Mouse
NCOA2	nuclear receptor coactivator 2	0.054
PDGFC	platelet derived growth factor C	0.053
CUX1	cut-like homeobox 1	0.052
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.052
BAZ2B	bromodomain adjacent to zinc finger domain, 2B	0.051
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.051
KIAA0182	KIAA0182	0.050
PDGFA	platelet-derived growth factor alpha polypeptide	0.050	Human
SETD7	SET domain containing (lysine methyltransferase) 7	0.049
TP53	tumor protein p53	0.049	Mouse
ZBTB16	zinc finger and BTB domain containing 16	0.048
HSPA1L	heat shock 70kDa protein 1-like	0.048
RBBP4	retinoblastoma binding protein 4	0.047
STAG1	stromal antigen 1	0.046
ADRBK1	adrenergic, beta, receptor kinase 1	0.046
YY1	YY1 transcription factor	0.045
ATF3	activating transcription factor 3	0.043
MTA1	metastasis associated 1	0.042
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.042
MECP2	methyl CpG binding protein 2 (Rett syndrome)	0.042
CDR2	cerebellar degeneration-related protein 2, 62kDa	0.042
COL5A1	collagen, type V, alpha 1	0.042
SAP30	Sin3A-associated protein, 30kDa	0.042
HCFC1	host cell factor C1 (VP16-accessory protein)	0.041
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.039
RCOR1	REST corepressor 1	0.038
UBR5	ubiquitin protein ligase E3 component n-recognin 5	0.038
HNRNPM	heterogeneous nuclear ribonucleoprotein M	0.038
MAPK9	mitogen-activated protein kinase 9	0.038	Human
ZNF217	zinc finger protein 217	0.037
RBBP7	retinoblastoma binding protein 7	0.036
OGT	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	0.035
NCOA6	nuclear receptor coactivator 6	0.035
PKN2	protein kinase N2	0.035
FOXO3	forkhead box O3	0.035
RSF1	remodeling and spacing factor 1	0.034
SIRT5	sirtuin 5	0.034
TAOK1	TAO kinase 1	0.033
KDM5B	lysine (K)-specific demethylase 5B	0.033
FOXP3	forkhead box P3	0.032
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.032	Mouse
NONO	non-POU domain containing, octamer-binding	0.032
FOXO1	forkhead box O1	0.032
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.032
HIC1	hypermethylated in cancer 1	0.032
MBD2	methyl-CpG binding domain protein 2	0.031
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.030
HDAC6	histone deacetylase 6	0.030
PHF21A	PHD finger protein 21A	0.030
DUSP1	dual specificity phosphatase 1	0.029
RICTOR	RPTOR independent companion of MTOR, complex 2	0.029
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.029
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.029
ARFGEF1	ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)	0.029
XPO7	exportin 7	0.029
THAP11	THAP domain containing 11	0.028
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.028
ETV6	ets variant 6	0.027
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.027
TARBP2	TAR (HIV-1) RNA binding protein 2	0.027
GATAD2B	GATA zinc finger domain containing 2B	0.027
TOP1	topoisomerase (DNA) I	0.027
LDLR	low density lipoprotein receptor	0.026
MUL1	mitochondrial E3 ubiquitin protein ligase 1	0.026
MAPK10	mitogen-activated protein kinase 10	0.026	Human
HES1	hairy and enhancer of split 1, (Drosophila)	0.026
ARRB2	arrestin, beta 2	0.025
TRIM11	tripartite motif containing 11	0.025
MAGEA2	melanoma antigen family A, 2	0.025
DYRK1B	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	0.025
TSC22D1	TSC22 domain family, member 1	0.025
PHF12	PHD finger protein 12	0.025
GORASP1	golgi reassembly stacking protein 1, 65kDa	0.024
PKN1	protein kinase N1	0.024
CSNK1E	casein kinase 1, epsilon	0.024
NCOA3	nuclear receptor coactivator 3	0.024
SUMO2	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)	0.023
MBD3	methyl-CpG binding domain protein 3	0.023
MPRIP	myosin phosphatase Rho interacting protein	0.023
PLCG1	phospholipase C, gamma 1	0.023
SAP30L	SAP30-like	0.022
CDK6	cyclin-dependent kinase 6	0.022
RUNX2	runt-related transcription factor 2	0.022
ADNP	activity-dependent neuroprotector homeobox	0.022
USP17	ubiquitin specific peptidase 17	0.022
OSGEP	O-sialoglycoprotein endopeptidase	0.022
CUL7	cullin 7	0.022
CTBP2	C-terminal binding protein 2	0.021	Human
SNW1	SNW domain containing 1	0.021
HMG20A	high mobility group 20A	0.021
CYLD	cylindromatosis (turban tumor syndrome)	0.021
SNAI1	snail homolog 1 (Drosophila)	0.020	Fly
USF2	upstream transcription factor 2, c-fos interacting	0.020
SP3	Sp3 transcription factor	0.020
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.020
PUM2	pumilio homolog 2 (Drosophila)	0.019
KIAA1712	KIAA1712	0.019
THBS1	thrombospondin 1	0.019
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.019
SREBF2	sterol regulatory element binding transcription factor 2	0.019
COL6A1	collagen, type VI, alpha 1	0.019
IKZF4	IKAROS family zinc finger 4 (Eos)	0.019
AKAP8L	A kinase (PRKA) anchor protein 8-like	0.018
COL4A1	collagen, type IV, alpha 1	0.018
PIAS2	protein inhibitor of activated STAT, 2	0.018
MEF2A	myocyte enhancer factor 2A	0.018
MLL5	myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)	0.018
SAP25	sin3A-binding protein 25	0.018
SIRT4	sirtuin 4	0.018	Mouse
SOX13	SRY (sex determining region Y)-box 13	0.018
CTTN	cortactin	0.018
ULK1	unc-51-like kinase 1 (C. elegans)	0.018
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.018
MRFAP1L1	Morf4 family associated protein 1-like 1	0.018
ARID2	AT rich interactive domain 2 (ARID, RFX-like)	0.018
MYST1	MYST histone acetyltransferase 1	0.017
MT2A	metallothionein 2A	0.017
ZMYM3	zinc finger, MYM-type 3	0.017
TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.017
HSF1	heat shock transcription factor 1	0.017
TP53BP2	tumor protein p53 binding protein, 2	0.017
IRS2	insulin receptor substrate 2	0.017
ZBTB4	zinc finger and BTB domain containing 4	0.016
DNAJB6	DnaJ (Hsp40) homolog, subfamily B, member 6	0.016
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.016
AHR	aryl hydrocarbon receptor	0.016
SIRT2	sirtuin 2	0.016
DUSP4	dual specificity phosphatase 4	0.016
MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	0.016
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.016
RAB3GAP2	RAB3 GTPase activating protein subunit 2 (non-catalytic)	0.016
ZNF148	zinc finger protein 148	0.016
THRAP3	thyroid hormone receptor associated protein 3	0.016
RREB1	ras responsive element binding protein 1	0.016
NCF1	neutrophil cytosolic factor 1	0.015
NUFIP2	nuclear fragile X mental retardation protein interacting protein 2	0.015
MSL2	male-specific lethal 2 homolog (Drosophila)	0.015
FBXO11	F-box protein 11	0.015
AXIN1	axin 1	0.015
E2F2	E2F transcription factor 2	0.015
SNRNP70	small nuclear ribonucleoprotein 70kDa (U1)	0.015
DAXX	death-domain associated protein	0.015
TGFBR1	transforming growth factor, beta receptor 1	0.015
PRKCA	protein kinase C, alpha	0.015
TTC19	tetratricopeptide repeat domain 19	0.015
STAG2	stromal antigen 2	0.015
ZNF219	zinc finger protein 219	0.015
GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	0.014
BHLHE40	basic helix-loop-helix family, member e40	0.014
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.014
ZNF227	zinc finger protein 227	0.014
SRF	serum response factor (c-fos serum response element-binding transcription factor)	0.014
RPS6KB1	ribosomal protein S6 kinase, 70kDa, polypeptide 1	0.014
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.014
ELF2	E74-like factor 2 (ets domain transcription factor)	0.014
BRWD1	bromodomain and WD repeat domain containing 1	0.014
MCPH1	microcephalin 1	0.014
KAT5	K(lysine) acetyltransferase 5	0.014
XPNPEP1	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	0.014
CMYA5	cardiomyopathy associated 5	0.014
PCDH9	protocadherin 9	0.014
MAPK15	mitogen-activated protein kinase 15	0.014
FLNB	filamin B, beta	0.014
MAPK8IP3	mitogen-activated protein kinase 8 interacting protein 3	0.013
C10orf46	chromosome 10 open reading frame 46	0.013
VIM	vimentin	0.013
SOCS3	suppressor of cytokine signaling 3	0.013
ELF4	E74-like factor 4 (ets domain transcription factor)	0.013
DDIT4	DNA-damage-inducible transcript 4	0.013
MAPK1	mitogen-activated protein kinase 1	0.013
KAT2A	K(lysine) acetyltransferase 2A	0.013
SGSM2	small G protein signaling modulator 2	0.013
ZEB1	zinc finger E-box binding homeobox 1	0.013
FAM118B	family with sequence similarity 118, member B	0.013
NINL	ninein-like	0.013
BBS10	Bardet-Biedl syndrome 10	0.013
MT1X	metallothionein 1X	0.013
MAML1	mastermind-like 1 (Drosophila)	0.013
BANP	BTG3 associated nuclear protein	0.013
PHLDA1	pleckstrin homology-like domain, family A, member 1	0.013
KDM6B	lysine (K)-specific demethylase 6B	0.013
CDK17	cyclin-dependent kinase 17	0.013
HNRNPA0	heterogeneous nuclear ribonucleoprotein A0	0.013
COL1A2	collagen, type I, alpha 2	0.013
EGR1	early growth response 1	0.013
STC1	stanniocalcin 1	0.013
FAM117B	family with sequence similarity 117, member B	0.013
ZBTB7A	zinc finger and BTB domain containing 7A	0.013
SNF8	SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)	0.013
RYK	RYK receptor-like tyrosine kinase	0.013
CCND1	cyclin D1	0.013
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.012
SPSB3	splA/ryanodine receptor domain and SOCS box containing 3	0.012
ELK1	ELK1, member of ETS oncogene family	0.012	Human
EPC2	enhancer of polycomb homolog 2 (Drosophila)	0.012
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.012
ALDH2	aldehyde dehydrogenase 2 family (mitochondrial)	0.012
TPM3	tropomyosin 3	0.012
PPP1R12C	protein phosphatase 1, regulatory (inhibitor) subunit 12C	0.012
SCD	stearoyl-CoA desaturase (delta-9-desaturase)	0.012
GPS2	G protein pathway suppressor 2	0.012
NFATC1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.012
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.012
ZNF207	zinc finger protein 207	0.012
PA2G4	proliferation-associated 2G4, 38kDa	0.012
AR	androgen receptor	0.012
TRAF3	TNF receptor-associated factor 3	0.012
GTF3C3	general transcription factor IIIC, polypeptide 3, 102kDa	0.012
WRN	Werner syndrome, RecQ helicase-like	0.012
PLA2G6	phospholipase A2, group VI (cytosolic, calcium-independent)	0.012
BCL11B	B-cell CLL/lymphoma 11B (zinc finger protein)	0.012
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.012
BIRC6	baculoviral IAP repeat containing 6	0.011
REST	RE1-silencing transcription factor	0.011
HDAC10	histone deacetylase 10	0.011
GPBP1L1	GC-rich promoter binding protein 1-like 1	0.011
CRY2	cryptochrome 2 (photolyase-like)	0.011
GOLGA7	golgin A7	0.011
NR2C2	nuclear receptor subfamily 2, group C, member 2	0.011
SAMD3	sterile alpha motif domain containing 3	0.011
ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	0.011
IKZF1	IKAROS family zinc finger 1 (Ikaros)	0.011
RIPK2	receptor-interacting serine-threonine kinase 2	0.011
LMNA	lamin A/C	0.011
CDYL	chromodomain protein, Y-like	0.011
HNRNPK	heterogeneous nuclear ribonucleoprotein K	0.011
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.011
DICER1	dicer 1, ribonuclease type III	0.011
LCORL	ligand dependent nuclear receptor corepressor-like	0.011
KIAA0240	KIAA0240	0.011
BOD1L	biorientation of chromosomes in cell division 1-like	0.010
RFX7	regulatory factor X, 7	0.010
EHMT1	euchromatic histone-lysine N-methyltransferase 1	0.010
PER2	period homolog 2 (Drosophila)	0.010	Mouse
ELOF1	elongation factor 1 homolog (S. cerevisiae)	0.010
ZBTB7B	zinc finger and BTB domain containing 7B	0.010
CUEDC2	CUE domain containing 2	0.010
HOXD8	homeobox D8	0.010
NFYA	nuclear transcription factor Y, alpha	0.010
CCND2	cyclin D2	0.010
CREB1	cAMP responsive element binding protein 1	0.010
LGALS8	lectin, galactoside-binding, soluble, 8	0.010
L3MBTL2	l(3)mbt-like 2 (Drosophila)	0.010
FTSJ3	FtsJ homolog 3 (E. coli)	0.010
TUBA1A	tubulin, alpha 1a	0.010
ATXN1L	ataxin 1-like	0.010
BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2	0.010
DUSP9	dual specificity phosphatase 9	0.010