IMP

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Homo sapiens

37 genes annotated in human

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microtubule polymerization or depolymerization

GO:0031109

Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "microtubule polymerization or depolymerization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "microtubule polymerization or depolymerization" (in gray)

Name	Description	Probability	Func Analog Organism
SKA1	spindle and kinetochore associated complex subunit 1	0.931
APC	adenomatous polyposis coli	0.905
CKS2	CDC28 protein kinase regulatory subunit 2	0.865
KIF23	kinesin family member 23	0.853
BIRC5	baculoviral IAP repeat containing 5	0.815
MAPT	microtubule-associated protein tau	0.799
CDKN3	cyclin-dependent kinase inhibitor 3	0.790
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.775
CDK2	cyclin-dependent kinase 2	0.735
KPNA2	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	0.703
KIF20A	kinesin family member 20A	0.692
MAPRE1	microtubule-associated protein, RP/EB family, member 1	0.673
PPP2R2B	protein phosphatase 2, regulatory subunit B, beta	0.642
CENPF	centromere protein F, 350/400kDa (mitosin)	0.616
TUBGCP3	tubulin, gamma complex associated protein 3	0.611	Fly
ITGB4	integrin, beta 4	0.594
CENPJ	centromere protein J	0.588
SKA2	spindle and kinetochore associated complex subunit 2	0.582
RACGAP1	Rac GTPase activating protein 1	0.573
CENPE	centromere protein E, 312kDa	0.550
KIF1B	kinesin family member 1B	0.543
CCNB1	cyclin B1	0.534
ZNF746	zinc finger protein 746	0.523
TBCD	tubulin folding cofactor D	0.441
MAPRE3	microtubule-associated protein, RP/EB family, member 3	0.440	Human
HSPB2	heat shock 27kDa protein 2	0.438
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.432
CKAP5	cytoskeleton associated protein 5	0.406	Worm Fly
TPX2	TPX2, microtubule-associated, homolog (Xenopus laevis)	0.404
GSK3B	glycogen synthase kinase 3 beta	0.384
NDC80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.374
TERF1	telomeric repeat binding factor (NIMA-interacting) 1	0.373
CCNB2	cyclin B2	0.355	Human
PRC1	protein regulator of cytokinesis 1	0.335	Worm Fly
SASS6	spindle assembly 6 homolog (C. elegans)	0.330
PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	0.321
COX17	COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)	0.320
ANLN	anillin, actin binding protein	0.315
CCT5	chaperonin containing TCP1, subunit 5 (epsilon)	0.285
CCT7	chaperonin containing TCP1, subunit 7 (eta)	0.261
CCT4	chaperonin containing TCP1, subunit 4 (delta)	0.254
MAPRE2	microtubule-associated protein, RP/EB family, member 2	0.254	Human
CDK1	cyclin-dependent kinase 1	0.253
TUBA1C	tubulin, alpha 1c	0.252
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.244
NEK6	NIMA (never in mitosis gene a)-related kinase 6	0.241
AURKA	aurora kinase A	0.240
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.236
DLGAP5	discs, large (Drosophila) homolog-associated protein 5	0.235
TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	0.216
GPSM2	G-protein signaling modulator 2	0.209
PLK4	polo-like kinase 4	0.202
INCENP	inner centromere protein antigens 135/155kDa	0.202
MZT1	mitotic spindle organizing protein 1	0.200
CCNA2	cyclin A2	0.192
NEK2	NIMA (never in mitosis gene a)-related kinase 2	0.189
SMAD9	SMAD family member 9	0.179
FOXM1	forkhead box M1	0.171
FASLG	Fas ligand (TNF superfamily, member 6)	0.170
CDCA8	cell division cycle associated 8	0.168
SPTBN1	spectrin, beta, non-erythrocytic 1	0.164
PPID	peptidylprolyl isomerase D	0.156
HMMR	hyaluronan-mediated motility receptor (RHAMM)	0.154
TOP2A	topoisomerase (DNA) II alpha 170kDa	0.151
DISC1	disrupted in schizophrenia 1	0.149
PSEN2	presenilin 2 (Alzheimer disease 4)	0.146
MZT2B	mitotic spindle organizing protein 2B	0.146
ARL2	ADP-ribosylation factor-like 2	0.127
EXOC1	exocyst complex component 1	0.125
DEPDC1	DEP domain containing 1	0.125
GLIS2	GLIS family zinc finger 2	0.124
TUBG1	tubulin, gamma 1	0.121	Worm
SKA3	spindle and kinetochore associated complex subunit 3	0.117
CRYGC	crystallin, gamma C	0.115
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.114
MARK2	MAP/microtubule affinity-regulating kinase 2	0.111
HSPB1	heat shock 27kDa protein 1	0.111
PTTG1	pituitary tumor-transforming 1	0.101
TTK	TTK protein kinase	0.100
STIL	SCL/TAL1 interrupting locus	0.100
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.098
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.094
PDE6D	phosphodiesterase 6D, cGMP-specific, rod, delta	0.090
EXOC2	exocyst complex component 2	0.089
C13orf34	chromosome 13 open reading frame 34	0.086
KIF2C	kinesin family member 2C	0.086
XPO1	exportin 1 (CRM1 homolog, yeast)	0.083
SPAG5	sperm associated antigen 5	0.082
TEX11	testis expressed 11	0.082
JUN	jun proto-oncogene	0.081
TACC3	transforming, acidic coiled-coil containing protein 3	0.081
KIF14	kinesin family member 14	0.081
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.079
TCP1	t-complex 1	0.077
FYN	FYN oncogene related to SRC, FGR, YES	0.075
FYB	FYN binding protein	0.074
ARL6IP1	ADP-ribosylation factor-like 6 interacting protein 1	0.074
DST	dystonin	0.072	Mouse Fly
CEP55	centrosomal protein 55kDa	0.071
TUBA4A	tubulin, alpha 4a	0.070
KIF5B	kinesin family member 5B	0.066	Fly
LMO2	LIM domain only 2 (rhombotin-like 1)	0.066
MKI67	antigen identified by monoclonal antibody Ki-67	0.063
SPRR2A	small proline-rich protein 2A	0.058
EXOC7	exocyst complex component 7	0.058
UBE2C	ubiquitin-conjugating enzyme E2C	0.054
BICD1	bicaudal D homolog 1 (Drosophila)	0.053
WASL	Wiskott-Aldrich syndrome-like	0.053
KIF15	kinesin family member 15	0.050
CYLD	cylindromatosis (turban tumor syndrome)	0.048
NUP133	nucleoporin 133kDa	0.047
AKAP9	A kinase (PRKA) anchor protein (yotiao) 9	0.047
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.046
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.046
NCAPG	non-SMC condensin I complex, subunit G	0.046
CACYBP	calcyclin binding protein	0.045
CDC25C	cell division cycle 25 homolog C (S. pombe)	0.042
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.042
SMC4	structural maintenance of chromosomes 4	0.042
FNBP1	formin binding protein 1	0.041
KIF11	kinesin family member 11	0.041	Fly
CP110	CP110 protein	0.041
LARP1	La ribonucleoprotein domain family, member 1	0.040
HSPB8	heat shock 22kDa protein 8	0.039
WHSC1	Wolf-Hirschhorn syndrome candidate 1	0.039
ARMC1	armadillo repeat containing 1	0.039
CRYAA	crystallin, alpha A	0.038
VPS29	vacuolar protein sorting 29 homolog (S. cerevisiae)	0.037
PPP5C	protein phosphatase 5, catalytic subunit	0.036
CCDC85A	coiled-coil domain containing 85A	0.036
ADRBK1	adrenergic, beta, receptor kinase 1	0.036
ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	0.036
TNIK	TRAF2 and NCK interacting kinase	0.036
EZR	ezrin	0.035
NUSAP1	nucleolar and spindle associated protein 1	0.035
AURKB	aurora kinase B	0.034
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.034
SNCAIP	synuclein, alpha interacting protein	0.034
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.034
BAG3	BCL2-associated athanogene 3	0.033
PDE4DIP	phosphodiesterase 4D interacting protein	0.032
MAP2K4	mitogen-activated protein kinase kinase 4	0.032
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.031
TACC1	transforming, acidic coiled-coil containing protein 1	0.031
ACD	adrenocortical dysplasia homolog (mouse)	0.030
RASA1	RAS p21 protein activator (GTPase activating protein) 1	0.030
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	0.030
SUFU	suppressor of fused homolog (Drosophila)	0.030
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.029
TUBB	tubulin, beta	0.029
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	0.028
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.028
CEP135	centrosomal protein 135kDa	0.028	Fly
ATF7IP	activating transcription factor 7 interacting protein	0.027
TROAP	trophinin associated protein (tastin)	0.027
DNM1L	dynamin 1-like	0.027
GNAI3	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	0.027
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.026
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.026
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.026
CCNF	cyclin F	0.026
ZFAND5	zinc finger, AN1-type domain 5	0.026
MED21	mediator complex subunit 21	0.026
GGH	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)	0.026
IMMT	inner membrane protein, mitochondrial	0.026
TOP3A	topoisomerase (DNA) III alpha	0.026
CDC25B	cell division cycle 25 homolog B (S. pombe)	0.025
XRCC4	X-ray repair complementing defective repair in Chinese hamster cells 4	0.025
SOS1	son of sevenless homolog 1 (Drosophila)	0.025
MAPK9	mitogen-activated protein kinase 9	0.025
NDEL1	nudE nuclear distribution gene E homolog (A. nidulans)-like 1	0.025
KIF4A	kinesin family member 4A	0.024
DYNC1H1	dynein, cytoplasmic 1, heavy chain 1	0.024
ZRANB1	zinc finger, RAN-binding domain containing 1	0.024
MIS18BP1	MIS18 binding protein 1	0.024
KCNE3	potassium voltage-gated channel, Isk-related family, member 3	0.024
NGFR	nerve growth factor receptor	0.024
PRKCA	protein kinase C, alpha	0.024
S100A2	S100 calcium binding protein A2	0.023
G2E3	G2/M-phase specific E3 ubiquitin protein ligase	0.023
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.023
LBR	lamin B receptor	0.023
CCDC99	coiled-coil domain containing 99	0.022
HJURP	Holliday junction recognition protein	0.022
CRYBB2	crystallin, beta B2	0.022
PBK	PDZ binding kinase	0.022
DEK	DEK oncogene	0.022
ROD1	ROD1 regulator of differentiation 1 (S. pombe)	0.022
CTTN	cortactin	0.021
ZNF775	zinc finger protein 775	0.021
GTSE1	G-2 and S-phase expressed 1	0.021
MACF1	microtubule-actin crosslinking factor 1	0.021	Fly
SRPK1	SRSF protein kinase 1	0.021
CLIP1	CAP-GLY domain containing linker protein 1	0.021
PRR11	proline rich 11	0.021
KIF20B	kinesin family member 20B	0.020
CSE1L	CSE1 chromosome segregation 1-like (yeast)	0.020
APLP1	amyloid beta (A4) precursor-like protein 1	0.020
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.020
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.020
PPP2R2C	protein phosphatase 2, regulatory subunit B, gamma	0.020
GTF2E1	general transcription factor IIE, polypeptide 1, alpha 56kDa	0.020
TINF2	TERF1 (TRF1)-interacting nuclear factor 2	0.019
LUC7L2	LUC7-like 2 (S. cerevisiae)	0.019
RANBP2	RAN binding protein 2	0.019
MAP2K7	mitogen-activated protein kinase kinase 7	0.019
ORC2	origin recognition complex, subunit 2	0.019
KLC2	kinesin light chain 2	0.019
EVI5	ecotropic viral integration site 5	0.019
IKBKAP	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	0.019
MTUS2	microtubule associated tumor suppressor candidate 2	0.019
CRYBA1	crystallin, beta A1	0.018
NUMA1	nuclear mitotic apparatus protein 1	0.018
YAP1	Yes-associated protein 1	0.018
ERC1	ELKS/RAB6-interacting/CAST family member 1	0.018
TRAF3IP1	TNF receptor-associated factor 3 interacting protein 1	0.018
SMC3	structural maintenance of chromosomes 3	0.018
SGOL2	shugoshin-like 2 (S. pombe)	0.018
HMGB2	high mobility group box 2	0.018
ANKRD28	ankyrin repeat domain 28	0.018
TUBGCP5	tubulin, gamma complex associated protein 5	0.018
CIT	citron (rho-interacting, serine/threonine kinase 21)	0.018
CDK5	cyclin-dependent kinase 5	0.018
ANAPC11	anaphase promoting complex subunit 11	0.017
AHSA1	AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)	0.017
RAD21	RAD21 homolog (S. pombe)	0.017
CDC5L	CDC5 cell division cycle 5-like (S. pombe)	0.017
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.017
CCNE1	cyclin E1	0.017
RNGTT	RNA guanylyltransferase and 5'-phosphatase	0.017
GIT1	G protein-coupled receptor kinase interacting ArfGAP 1	0.016
ANK2	ankyrin 2, neuronal	0.016
DCTN1	dynactin 1	0.016
VAV3	vav 3 guanine nucleotide exchange factor	0.016
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.016
KIAA1279	KIAA1279	0.016
KLHL7	kelch-like 7 (Drosophila)	0.016
WDR67	WD repeat domain 67	0.016
BBS10	Bardet-Biedl syndrome 10	0.016
USP24	ubiquitin specific peptidase 24	0.016
TUBB2C	tubulin, beta 2C	0.016
MPHOSPH9	M-phase phosphoprotein 9	0.015
ITSN1	intersectin 1 (SH3 domain protein)	0.015
SNX4	sorting nexin 4	0.015
ZFP106	zinc finger protein 106 homolog (mouse)	0.015
FBXO30	F-box protein 30	0.015
JUP	junction plakoglobin	0.015
WIPF1	WAS/WASL interacting protein family, member 1	0.015
LMO4	LIM domain only 4	0.015
PDPK1	3-phosphoinositide dependent protein kinase-1	0.015
GPN1	GPN-loop GTPase 1	0.015
C12orf48	chromosome 12 open reading frame 48	0.015
RASAL2	RAS protein activator like 2	0.015
CRIP2	cysteine-rich protein 2	0.015
SYNE1	spectrin repeat containing, nuclear envelope 1	0.015
CBX1	chromobox homolog 1	0.015
MYCBP2	MYC binding protein 2	0.015
BTRC	beta-transducin repeat containing	0.015
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.015
EEF2K	eukaryotic elongation factor-2 kinase	0.014
DLG4	discs, large homolog 4 (Drosophila)	0.014
SAE1	SUMO1 activating enzyme subunit 1	0.014
CCT2	chaperonin containing TCP1, subunit 2 (beta)	0.014
CDCA3	cell division cycle associated 3	0.014
FBXW11	F-box and WD repeat domain containing 11	0.014
BRAF	v-raf murine sarcoma viral oncogene homolog B1	0.014
THRAP3	thyroid hormone receptor associated protein 3	0.014
TUBGCP2	tubulin, gamma complex associated protein 2	0.014	Fly
INTS7	integrator complex subunit 7	0.014
GRAP2	GRB2-related adaptor protein 2	0.014
APP	amyloid beta (A4) precursor protein	0.014
GPRASP2	G protein-coupled receptor associated sorting protein 2	0.014
FBXW7	F-box and WD repeat domain containing 7	0.014
TLK1	tousled-like kinase 1	0.014
UNC119	unc-119 homolog (C. elegans)	0.013
APC2	adenomatosis polyposis coli 2	0.013	Human
MARK1	MAP/microtubule affinity-regulating kinase 1	0.013
EIF3F	eukaryotic translation initiation factor 3, subunit F	0.013
FHL1	four and a half LIM domains 1	0.013
SLBP	stem-loop binding protein	0.013
SRGAP2	SLIT-ROBO Rho GTPase activating protein 2	0.013
STAG1	stromal antigen 1	0.013
HDAC6	histone deacetylase 6	0.013	Mouse
HSF1	heat shock transcription factor 1	0.013
ECD	ecdysoneless homolog (Drosophila)	0.013
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.013
CDK11B	cyclin-dependent kinase 11B	0.013
ARL3	ADP-ribosylation factor-like 3	0.013
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.013
CDK8	cyclin-dependent kinase 8	0.013
MAP1B	microtubule-associated protein 1B	0.012
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.012
KPNB1	karyopherin (importin) beta 1	0.012
TRIO	triple functional domain (PTPRF interacting)	0.012
EPB41L3	erythrocyte membrane protein band 4.1-like 3	0.012
WWTR1	WW domain containing transcription regulator 1	0.012
EVC2	Ellis van Creveld syndrome 2	0.012
WNK1	WNK lysine deficient protein kinase 1	0.012
STK4	serine/threonine kinase 4	0.012
UBR5	ubiquitin protein ligase E3 component n-recognin 5	0.012
ACTR2	ARP2 actin-related protein 2 homolog (yeast)	0.012
MYO9B	myosin IXB	0.012
PHTF2	putative homeodomain transcription factor 2	0.012
POLH	polymerase (DNA directed), eta	0.012
PHLDB2	pleckstrin homology-like domain, family B, member 2	0.012
MAP4K3	mitogen-activated protein kinase kinase kinase kinase 3	0.012
TTYH1	tweety homolog 1 (Drosophila)	0.012
EXPH5	exophilin 5	0.012
UNC45A	unc-45 homolog A (C. elegans)	0.012
GIGYF2	GRB10 interacting GYF protein 2	0.011
EVL	Enah/Vasp-like	0.011
UBE2S	ubiquitin-conjugating enzyme E2S	0.011
CCDC88A	coiled-coil domain containing 88A	0.011
FANCC	Fanconi anemia, complementation group C	0.011
FEZ1	fasciculation and elongation protein zeta 1 (zygin I)	0.011
TBPL1	TBP-like 1	0.011
RABEP1	rabaptin, RAB GTPase binding effector protein 1	0.011
ERBB2IP	erbb2 interacting protein	0.011
ASF1A	ASF1 anti-silencing function 1 homolog A (S. cerevisiae)	0.011
FDPS	farnesyl diphosphate synthase	0.011
TJP2	tight junction protein 2 (zona occludens 2)	0.011
CEP97	centrosomal protein 97kDa	0.011
CENPL	centromere protein L	0.011
LRRK2	leucine-rich repeat kinase 2	0.011
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.011
NUP50	nucleoporin 50kDa	0.011
UBQLN1	ubiquilin 1	0.011
USP5	ubiquitin specific peptidase 5 (isopeptidase T)	0.011
LRP6	low density lipoprotein receptor-related protein 6	0.011
RFX7	regulatory factor X, 7	0.011
HIST1H4C	histone cluster 1, H4c	0.011
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.011
C18orf10	chromosome 18 open reading frame 10	0.011
PRR14	proline rich 14	0.011
CRLF3	cytokine receptor-like factor 3	0.011
GOLGA2	golgin A2	0.011
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.010
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.010
MARCH5	membrane-associated ring finger (C3HC4) 5	0.010
CITED1	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1	0.010
ANKS1A	ankyrin repeat and sterile alpha motif domain containing 1A	0.010
MARK4	MAP/microtubule affinity-regulating kinase 4	0.010
RDX	radixin	0.010
BUB1	budding uninhibited by benzimidazoles 1 homolog (yeast)	0.010
EIF2B2	eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa	0.010
DDX39A	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A	0.010
SKP1	S-phase kinase-associated protein 1	0.010