IMP

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Homo sapiens

27 genes annotated in human

transcription initiation from rna polymerase ii promoter

Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "transcription initiation from rna polymerase ii promoter"

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Name	Description	Probability	Func Analog Organism
TBP	TATA box binding protein	1.000	Yeast Fly
MED1	mediator complex subunit 1	1.000
MED29	mediator complex subunit 29	0.998
TAF4	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa	0.998
CDK19	cyclin-dependent kinase 19	0.995
MED10	mediator complex subunit 10	0.992
MED26	mediator complex subunit 26	0.989
TRRAP	transformation/transcription domain-associated protein	0.987
CDK8	cyclin-dependent kinase 8	0.984
LEO1	Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.983
SMAD4	SMAD family member 4	0.979
TAF5	TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa	0.953
MED21	mediator complex subunit 21	0.936
PSMD10	proteasome (prosome, macropain) 26S subunit, non-ATPase, 10	0.902
MED13	mediator complex subunit 13	0.892
PSMD4	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	0.875
PSMC1	proteasome (prosome, macropain) 26S subunit, ATPase, 1	0.870
MED12	mediator complex subunit 12	0.866
PSMC5	proteasome (prosome, macropain) 26S subunit, ATPase, 5	0.861	Yeast
MED6	mediator complex subunit 6	0.859
PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	0.853
PSMC6	proteasome (prosome, macropain) 26S subunit, ATPase, 6	0.836	Yeast
TAF9	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa	0.831	Yeast Fly
MED4	mediator complex subunit 4	0.807
TAF1	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	0.785	Fly
PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	0.780
PSMD7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	0.744
DCP1A	DCP1 decapping enzyme homolog A (S. cerevisiae)	0.744
PSMD13	proteasome (prosome, macropain) 26S subunit, non-ATPase, 13	0.742
PSMC2	proteasome (prosome, macropain) 26S subunit, ATPase, 2	0.692	Yeast
TRIM33	tripartite motif containing 33	0.677
SP1	Sp1 transcription factor	0.675
GTF2B	general transcription factor IIB	0.630	Yeast Fly
PSMC3	proteasome (prosome, macropain) 26S subunit, ATPase, 3	0.622	Yeast
TAF1C	TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa	0.604
GTF2H1	general transcription factor IIH, polypeptide 1, 62kDa	0.593
CREBBP	CREB binding protein	0.592
KAT2B	K(lysine) acetyltransferase 2B	0.582
KAT2A	K(lysine) acetyltransferase 2A	0.564
MED24	mediator complex subunit 24	0.545
PSMD6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.524
TBX5	T-box 5	0.505
MED17	mediator complex subunit 17	0.460
TAF11	TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa	0.452	Fly
MED28	mediator complex subunit 28	0.433
NCOA6	nuclear receptor coactivator 6	0.432
MED25	mediator complex subunit 25	0.401
TBPL1	TBP-like 1	0.371	Yeast
SMAD2	SMAD family member 2	0.337
SMAD9	SMAD family member 9	0.323
NCOR1	nuclear receptor corepressor 1	0.322
TAF2	TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa	0.320
FERMT2	fermitin family member 2	0.305
SKIL	SKI-like oncogene	0.300
RARA	retinoic acid receptor, alpha	0.300	Human
PSMC4	proteasome (prosome, macropain) 26S subunit, ATPase, 4	0.295	Yeast
EP300	E1A binding protein p300	0.272
MED23	mediator complex subunit 23	0.253
CDK7	cyclin-dependent kinase 7	0.248
AR	androgen receptor	0.241
MED19	mediator complex subunit 19	0.239
PSMD8	proteasome (prosome, macropain) 26S subunit, non-ATPase, 8	0.198
WAPAL	wings apart-like homolog (Drosophila)	0.185
MED20	mediator complex subunit 20	0.185
RXRA	retinoid X receptor, alpha	0.184
ATXN7	ataxin 7	0.174
POLE3	polymerase (DNA directed), epsilon 3 (p17 subunit)	0.164
CCNC	cyclin C	0.163
NBN	nibrin	0.159
NCOR2	nuclear receptor corepressor 2	0.158
RTF1	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.155
BAZ1A	bromodomain adjacent to zinc finger domain, 1A	0.154
ESR1	estrogen receptor 1	0.148
RNF138	ring finger protein 138	0.143
ARNT	aryl hydrocarbon receptor nuclear translocator	0.128
GTF2A2	general transcription factor IIA, 2, 12kDa	0.125
TP53BP1	tumor protein p53 binding protein 1	0.120
DCP1B	DCP1 decapping enzyme homolog B (S. cerevisiae)	0.116
PRMT6	protein arginine methyltransferase 6	0.116
HTT	huntingtin	0.107
SSRP1	structure specific recognition protein 1	0.101	Yeast
ZMYM2	zinc finger, MYM-type 2	0.099
E2F1	E2F transcription factor 1	0.098
SIRT1	sirtuin 1	0.098
PPARA	peroxisome proliferator-activated receptor alpha	0.092
TAF6L	TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	0.086
NCOA1	nuclear receptor coactivator 1	0.084
MED14	mediator complex subunit 14	0.082
GTF2E1	general transcription factor IIE, polypeptide 1, alpha 56kDa	0.080	Worm
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.074
HMGN2	high mobility group nucleosomal binding domain 2	0.073
KLHL24	kelch-like 24 (Drosophila)	0.071
MED30	mediator complex subunit 30	0.066
MED13L	mediator complex subunit 13-like	0.065	Human
UPF2	UPF2 regulator of nonsense transcripts homolog (yeast)	0.063
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.060
SUZ12	suppressor of zeste 12 homolog (Drosophila)	0.059
PSMD3	proteasome (prosome, macropain) 26S subunit, non-ATPase, 3	0.056
MED8	mediator complex subunit 8	0.054
GTF2A1	general transcription factor IIA, 1, 19/37kDa	0.054	Yeast
TAF10	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa	0.054
SCAF8	SR-related CTD-associated factor 8	0.053
TAF12	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa	0.053
MED16	mediator complex subunit 16	0.052
SMNDC1	survival motor neuron domain containing 1	0.051
NCOA3	nuclear receptor coactivator 3	0.051
CDC73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.051
HMGA1	high mobility group AT-hook 1	0.050
BAZ1B	bromodomain adjacent to zinc finger domain, 1B	0.048
TP53	tumor protein p53	0.047
HMGB2	high mobility group box 2	0.047	Human
LSM2	LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)	0.045
HNF4A	hepatocyte nuclear factor 4, alpha	0.043
DEK	DEK oncogene	0.043
RXRB	retinoid X receptor, beta	0.042
ERCC3	excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)	0.042	Yeast
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.040
NFYA	nuclear transcription factor Y, alpha	0.040
PAXIP1	PAX interacting (with transcription-activation domain) protein 1	0.038
SETD7	SET domain containing (lysine methyltransferase) 7	0.037
MED18	mediator complex subunit 18	0.037
LBR	lamin B receptor	0.036
MACF1	microtubule-actin crosslinking factor 1	0.033
TAF6	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa	0.032
MDC1	mediator of DNA-damage checkpoint 1	0.032	Human
NFYB	nuclear transcription factor Y, beta	0.032
PSMD9	proteasome (prosome, macropain) 26S subunit, non-ATPase, 9	0.032
POLR2J	polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa	0.030
BRF1	BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)	0.030
NRIP1	nuclear receptor interacting protein 1	0.030
NFYC	nuclear transcription factor Y, gamma	0.029
TAF1A	TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa	0.029
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.029
NCOA7	nuclear receptor coactivator 7	0.028
SNW1	SNW domain containing 1	0.028
CUX1	cut-like homeobox 1	0.028
RAD23A	RAD23 homolog A (S. cerevisiae)	0.027
EPG5	ectopic P-granules autophagy protein 5 homolog (C. elegans)	0.027
MED9	mediator complex subunit 9	0.026
PAAF1	proteasomal ATPase-associated factor 1	0.026
SUPT16H	suppressor of Ty 16 homolog (S. cerevisiae)	0.025	Yeast
PPP1R14A	protein phosphatase 1, regulatory (inhibitor) subunit 14A	0.025
C5orf41	chromosome 5 open reading frame 41	0.025
RPA1	replication protein A1, 70kDa	0.025
TAF13	TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa	0.025	Yeast
MAGED2	melanoma antigen family D, 2	0.024
PAF1	Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)	0.024
CXXC5	CXXC finger protein 5	0.024
MORC3	MORC family CW-type zinc finger 3	0.024
E2F3	E2F transcription factor 3	0.024
THRA	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)	0.024
HMGN1	high mobility group nucleosome binding domain 1	0.024
MYOCD	myocardin	0.024
GABPA	GA binding protein transcription factor, alpha subunit 60kDa	0.023
EDC4	enhancer of mRNA decapping 4	0.023
HIPK3	homeodomain interacting protein kinase 3	0.023
TCF12	transcription factor 12	0.023
DGUOK	deoxyguanosine kinase	0.023
GATA4	GATA binding protein 4	0.023
NFAT5	nuclear factor of activated T-cells 5, tonicity-responsive	0.023
LAPTM5	lysosomal protein transmembrane 5	0.022
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.022
SMC1A	structural maintenance of chromosomes 1A	0.022
USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	0.022
SMAD3	SMAD family member 3	0.022
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.021
WHSC1	Wolf-Hirschhorn syndrome candidate 1	0.021
SHFM1	split hand/foot malformation (ectrodactyly) type 1	0.021
POGZ	pogo transposable element with ZNF domain	0.021
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.020
MTF2	metal response element binding transcription factor 2	0.020
FBXW7	F-box and WD repeat domain containing 7	0.020
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.019
CDK2	cyclin-dependent kinase 2	0.019
PPM1D	protein phosphatase, Mg2+/Mn2+ dependent, 1D	0.018
MYOD1	myogenic differentiation 1	0.018
MAGOH	mago-nashi homolog, proliferation-associated (Drosophila)	0.018
TAF1B	TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa	0.018
GPBP1	GC-rich promoter binding protein 1	0.018
DUSP11	dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)	0.018
CTCF	CCCTC-binding factor (zinc finger protein)	0.017
POU2F1	POU class 2 homeobox 1	0.017
RSBN1	round spermatid basic protein 1	0.017
PIAS1	protein inhibitor of activated STAT, 1	0.017
BPTF	bromodomain PHD finger transcription factor	0.017
SORBS3	sorbin and SH3 domain containing 3	0.016
USP22	ubiquitin specific peptidase 22	0.016
MED7	mediator complex subunit 7	0.016
PSMD14	proteasome (prosome, macropain) 26S subunit, non-ATPase, 14	0.016
NCOA2	nuclear receptor coactivator 2	0.016
TAF3	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa	0.016
TADA2A	transcriptional adaptor 2A	0.016
ESR2	estrogen receptor 2 (ER beta)	0.016
RSF1	remodeling and spacing factor 1	0.016
CRLF3	cytokine receptor-like factor 3	0.016
NUP153	nucleoporin 153kDa	0.016
PTGES3	prostaglandin E synthase 3 (cytosolic)	0.015
WRN	Werner syndrome, RecQ helicase-like	0.015
HNF1A	HNF1 homeobox A	0.015
H2AFX	H2A histone family, member X	0.015
PRRC2C	proline-rich coiled-coil 2C	0.015
HIPK1	homeodomain interacting protein kinase 1	0.015
MYOG	myogenin (myogenic factor 4)	0.015
DCC	deleted in colorectal carcinoma	0.015
MAGEA11	melanoma antigen family A, 11	0.014
SMAD1	SMAD family member 1	0.014
DYRK1B	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	0.014
ZNF518A	zinc finger protein 518A	0.014
PKP2	plakophilin 2	0.014
MLL3	myeloid/lymphoid or mixed-lineage leukemia 3	0.014
PAPPA	pregnancy-associated plasma protein A, pappalysin 1	0.014
PRPF4B	PRP4 pre-mRNA processing factor 4 homolog B (yeast)	0.014
HNF1B	HNF1 homeobox B	0.014
FAM190B	family with sequence similarity 190, member B	0.013
TGS1	trimethylguanosine synthase 1	0.013
RDBP	RD RNA binding protein	0.013
LEMD3	LEM domain containing 3	0.013
LSM6	LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)	0.013
RB1	retinoblastoma 1	0.013
CHRAC1	chromatin accessibility complex 1	0.013
BANF1	barrier to autointegration factor 1	0.013
POLR2B	polymerase (RNA) II (DNA directed) polypeptide B, 140kDa	0.013
CSNK1A1	casein kinase 1, alpha 1	0.013
ORC6	origin recognition complex, subunit 6	0.013
MYST3	MYST histone acetyltransferase (monocytic leukemia) 3	0.013
MSL2	male-specific lethal 2 homolog (Drosophila)	0.012
CIZ1	CDKN1A interacting zinc finger protein 1	0.012
JMY	junction mediating and regulatory protein, p53 cofactor	0.012
PAN3	PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	0.012
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.012
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.012
EDF1	endothelial differentiation-related factor 1	0.012
SETD2	SET domain containing 2	0.012
SREBF2	sterol regulatory element binding transcription factor 2	0.012
POLR2F	polymerase (RNA) II (DNA directed) polypeptide F	0.012
PGR	progesterone receptor	0.012
E2F2	E2F transcription factor 2	0.012
PAPD7	PAP associated domain containing 7	0.011
MARK3	MAP/microtubule affinity-regulating kinase 3	0.011
PROX1	prospero homeobox 1	0.011
PCBD2	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2	0.011
TFDP1	transcription factor Dp-1	0.011
MAPK14	mitogen-activated protein kinase 14	0.011
POLR2C	polymerase (RNA) II (DNA directed) polypeptide C, 33kDa	0.011
LSM1	LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)	0.011
BCL6	B-cell CLL/lymphoma 6	0.011
AP2S1	adaptor-related protein complex 2, sigma 1 subunit	0.011
GTF2F1	general transcription factor IIF, polypeptide 1, 74kDa	0.011
ARL6IP1	ADP-ribosylation factor-like 6 interacting protein 1	0.010
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.010
MEA1	male-enhanced antigen 1	0.010
PURA	purine-rich element binding protein A	0.010
DRAP1	DR1-associated protein 1 (negative cofactor 2 alpha)	0.010	Fly
MYSM1	Myb-like, SWIRM and MPN domains 1	0.010
H3F3B	H3 histone, family 3B (H3.3B)	0.010
GTF2H4	general transcription factor IIH, polypeptide 4, 52kDa	0.010