IMP

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Homo sapiens

31 genes annotated in human

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histone ubiquitination

GO:0016574

The modification of histones by addition of ubiquitin groups.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "histone ubiquitination"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "histone ubiquitination" (in gray)

Name	Description	Probability	Func Analog Organism
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	1.000
RING1	ring finger protein 1	1.000
RNF2	ring finger protein 2	1.000
RNF11	ring finger protein 11	1.000
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.999
UBE2D2	ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)	0.998
RNF5	ring finger protein 5	0.998
PCGF2	polycomb group ring finger 2	0.992	Human
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.990
RTF1	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.990
CBX8	chromobox homolog 8	0.987	Mouse
BMI1	BMI1 polycomb ring finger oncogene	0.985	Human Mouse
BCOR	BCL6 corepressor	0.983
CBX4	chromobox homolog 4	0.976
UBE2E1	ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)	0.972
UBE2B	ubiquitin-conjugating enzyme E2B (RAD6 homolog)	0.957
EED	embryonic ectoderm development	0.953
CDC73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.940
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.929
CTR9	Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.919
CBX7	chromobox homolog 7	0.895
ZNRF1	zinc and ring finger 1	0.876
USP11	ubiquitin specific peptidase 11	0.846
UBE2N	ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)	0.829
PCGF1	polycomb group ring finger 1	0.812
CUL1	cullin 1	0.795
MARCH7	membrane-associated ring finger (C3HC4) 7	0.766
CBX6	chromobox homolog 6	0.696
UBE2D4	ubiquitin-conjugating enzyme E2D 4 (putative)	0.674
MDC1	mediator of DNA-damage checkpoint 1	0.661
KPNA1	karyopherin alpha 1 (importin alpha 5)	0.607
RYBP	RING1 and YY1 binding protein	0.601
LEO1	Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.593
UBXN7	UBX domain protein 7	0.497
YY1	YY1 transcription factor	0.446
TRIM39	tripartite motif containing 39	0.441
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.421
CHFR	checkpoint with forkhead and ring finger domains	0.419	Human
UBE2E2	ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)	0.412	Human
XIAP	X-linked inhibitor of apoptosis	0.372
PARP9	poly (ADP-ribose) polymerase family, member 9	0.358
PAF1	Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)	0.350
VPRBP	Vpr (HIV-1) binding protein	0.325
PCGF3	polycomb group ring finger 3	0.296	Human Worm
UBA1	ubiquitin-like modifier activating enzyme 1	0.279
TCEA1	transcription elongation factor A (SII), 1	0.278
DAXX	death-domain associated protein	0.252
DZIP3	DAZ interacting protein 3, zinc finger	0.242
RNF14	ring finger protein 14	0.238
KDM2B	lysine (K)-specific demethylase 2B	0.230
RAD18	RAD18 homolog (S. cerevisiae)	0.222
UBE2W	ubiquitin-conjugating enzyme E2W (putative)	0.214
TLK1	tousled-like kinase 1	0.197
ARIH1	ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)	0.190
RSRC2	arginine/serine-rich coiled-coil 2	0.187
FBXW11	F-box and WD repeat domain containing 11	0.187
PCGF5	polycomb group ring finger 5	0.167	Human Worm
SIAH1	seven in absentia homolog 1 (Drosophila)	0.165
RNF20	ring finger protein 20	0.158
BAZ1A	bromodomain adjacent to zinc finger domain, 1A	0.157
RNF111	ring finger protein 111	0.149
INO80	INO80 homolog (S. cerevisiae)	0.148
UBE2A	ubiquitin-conjugating enzyme E2A (RAD6 homolog)	0.143
E2F1	E2F transcription factor 1	0.143
ZRANB1	zinc finger, RAN-binding domain containing 1	0.140
YAF2	YY1 associated factor 2	0.139	Human
CDAN1	congenital dyserythropoietic anemia, type I	0.139
RFWD2	ring finger and WD repeat domain 2	0.135
UBXN1	UBX domain protein 1	0.132
RLIM	ring finger protein, LIM domain interacting	0.127
TOPORS	topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase	0.120
SCMH1	sex comb on midleg homolog 1 (Drosophila)	0.118
TLK2	tousled-like kinase 2	0.111
TP53BP1	tumor protein p53 binding protein 1	0.110
RB1	retinoblastoma 1	0.108
FUBP1	far upstream element (FUSE) binding protein 1	0.106
ARIH2	ariadne homolog 2 (Drosophila)	0.105	Yeast
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.102
CDK2	cyclin-dependent kinase 2	0.093
RNF130	ring finger protein 130	0.090
RNF4	ring finger protein 4	0.088
CHAF1B	chromatin assembly factor 1, subunit B (p60)	0.086
CUL4B	cullin 4B	0.086
UBE2L3	ubiquitin-conjugating enzyme E2L 3	0.086
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.085
CUL2	cullin 2	0.085
UBR3	ubiquitin protein ligase E3 component n-recognin 3 (putative)	0.081
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.079
RNF114	ring finger protein 114	0.079
NBN	nibrin	0.077
UBE2E3	ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)	0.072	Human
TONSL	tonsoku-like, DNA repair protein	0.071
KIAA1712	KIAA1712	0.069
MARCH5	membrane-associated ring finger (C3HC4) 5	0.068
XPC	xeroderma pigmentosum, complementation group C	0.066
NCS1	neuronal calcium sensor 1	0.065
CCNE1	cyclin E1	0.060
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.059
FBXW7	F-box and WD repeat domain containing 7	0.057
HIST2H2AC	histone cluster 2, H2ac	0.056
RBX1	ring-box 1, E3 ubiquitin protein ligase	0.056
OPTN	optineurin	0.054
BFAR	bifunctional apoptosis regulator	0.053
CUL4A	cullin 4A	0.052	Human
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.051
PHC2	polyhomeotic homolog 2 (Drosophila)	0.050	Human
TRAF6	TNF receptor-associated factor 6	0.049
RNF38	ring finger protein 38	0.046
USP15	ubiquitin specific peptidase 15	0.043
USP4	ubiquitin specific peptidase 4 (proto-oncogene)	0.042
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.041
MED13L	mediator complex subunit 13-like	0.040
SETD2	SET domain containing 2	0.040
TRIM32	tripartite motif containing 32	0.040
MID1	midline 1 (Opitz/BBB syndrome)	0.040
BIRC2	baculoviral IAP repeat containing 2	0.039
RLF	rearranged L-myc fusion	0.038
BTRC	beta-transducin repeat containing	0.037
CDC40	cell division cycle 40 homolog (S. cerevisiae)	0.033
MYST1	MYST histone acetyltransferase 1	0.033
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.033
AMBRA1	autophagy/beclin-1 regulator 1	0.032
TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.032
FBXW2	F-box and WD repeat domain containing 2	0.032
E2F6	E2F transcription factor 6	0.031
GAPVD1	GTPase activating protein and VPS9 domains 1	0.031
AMFR	autocrine motility factor receptor	0.031
DCAF8	DDB1 and CUL4 associated factor 8	0.030
COPS5	COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)	0.030
EZH2	enhancer of zeste homolog 2 (Drosophila)	0.029
DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	0.028
DDB1	damage-specific DNA binding protein 1, 127kDa	0.028
RNF185	ring finger protein 185	0.028
SPRYD5	SPRY domain containing 5	0.027
HEXA	hexosaminidase A (alpha polypeptide)	0.027
RNF10	ring finger protein 10	0.026
KAT5	K(lysine) acetyltransferase 5	0.025
TRIM8	tripartite motif containing 8	0.025
MRPL10	mitochondrial ribosomal protein L10	0.025
NPLOC4	nuclear protein localization 4 homolog (S. cerevisiae)	0.024
UBE3A	ubiquitin protein ligase E3A	0.024
ADNP	activity-dependent neuroprotector homeobox	0.023
ANKRD28	ankyrin repeat domain 28	0.023
RNF26	ring finger protein 26	0.023
CNOT8	CCR4-NOT transcription complex, subunit 8	0.022
GSK3B	glycogen synthase kinase 3 beta	0.022
WDR61	WD repeat domain 61	0.022
CHD4	chromodomain helicase DNA binding protein 4	0.021
SNX9	sorting nexin 9	0.021
DDIT4	DNA-damage-inducible transcript 4	0.021
VCPIP1	valosin containing protein (p97)/p47 complex interacting protein 1	0.021
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.020
MIB1	mindbomb homolog 1 (Drosophila)	0.020
POLH	polymerase (DNA directed), eta	0.020
AARSD1	alanyl-tRNA synthetase domain containing 1	0.020
HUWE1	HECT, UBA and WWE domain containing 1	0.019
MEX3B	mex-3 homolog B (C. elegans)	0.019
ENSA	endosulfine alpha	0.019
WDR48	WD repeat domain 48	0.019
RNF115	ring finger protein 115	0.019
SIRT1	sirtuin 1	0.019
CCND1	cyclin D1	0.019
WDR26	WD repeat domain 26	0.018
HSPB1	heat shock 27kDa protein 1	0.018
CNOT4	CCR4-NOT transcription complex, subunit 4	0.018
ZCCHC8	zinc finger, CCHC domain containing 8	0.018
MED21	mediator complex subunit 21	0.018
TRIM27	tripartite motif containing 27	0.017
BRWD3	bromodomain and WD repeat domain containing 3	0.017
GABPB1	GA binding protein transcription factor, beta subunit 1	0.017
CUL3	cullin 3	0.017
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.017
PCGF6	polycomb group ring finger 6	0.017	Human
PXN	paxillin	0.016
SRPK2	SRSF protein kinase 2	0.016
FAF2	Fas associated factor family member 2	0.016
FHL3	four and a half LIM domains 3	0.016
USP42	ubiquitin specific peptidase 42	0.016
TRIM43	tripartite motif containing 43	0.016
ATXN7L3	ataxin 7-like 3	0.015
ERN1	endoplasmic reticulum to nucleus signaling 1	0.015
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.015
ZNF451	zinc finger protein 451	0.015
TRIM33	tripartite motif containing 33	0.015
MMS22L	MMS22-like, DNA repair protein	0.015
BIRC8	baculoviral IAP repeat containing 8	0.015
PARP14	poly (ADP-ribose) polymerase family, member 14	0.015
PSME4	proteasome (prosome, macropain) activator subunit 4	0.014
BRD1	bromodomain containing 1	0.014
MSL1	male-specific lethal 1 homolog (Drosophila)	0.014
FANCD2	Fanconi anemia, complementation group D2	0.014
OTUB1	OTU domain, ubiquitin aldehyde binding 1	0.014
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.013
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.013
PKMYT1	protein kinase, membrane associated tyrosine/threonine 1	0.013
RNF166	ring finger protein 166	0.013
RNF181	ring finger protein 181	0.013
DCAF11	DDB1 and CUL4 associated factor 11	0.013
CCND2	cyclin D2	0.013
RNF168	ring finger protein 168	0.013
TFDP1	transcription factor Dp-1	0.013
PHF3	PHD finger protein 3	0.013
E2F2	E2F transcription factor 2	0.013
UPF2	UPF2 regulator of nonsense transcripts homolog (yeast)	0.013
FDXR	ferredoxin reductase	0.013
CEP350	centrosomal protein 350kDa	0.012
SKP1	S-phase kinase-associated protein 1	0.012
MGEA5	meningioma expressed antigen 5 (hyaluronidase)	0.012
UBR5	ubiquitin protein ligase E3 component n-recognin 5	0.012
SMCHD1	structural maintenance of chromosomes flexible hinge domain containing 1	0.012
KATNA1	katanin p60 (ATPase containing) subunit A 1	0.012
HIPK1	homeodomain interacting protein kinase 1	0.012
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.012
UBE4B	ubiquitination factor E4B (UFD2 homolog, yeast)	0.012
RAP1B	RAP1B, member of RAS oncogene family	0.012
VSNL1	visinin-like 1	0.012
RNF25	ring finger protein 25	0.012
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.012
ZC3H7A	zinc finger CCCH-type containing 7A	0.011
BRD2	bromodomain containing 2	0.011
GPBP1	GC-rich promoter binding protein 1	0.011
CAND1	cullin-associated and neddylation-dissociated 1	0.011
AEBP2	AE binding protein 2	0.011
UBOX5	U-box domain containing 5	0.011
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.011
WAC	WW domain containing adaptor with coiled-coil	0.011
CDK6	cyclin-dependent kinase 6	0.011
NCALD	neurocalcin delta	0.011
KIF2A	kinesin heavy chain member 2A	0.011
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.011
PHIP	pleckstrin homology domain interacting protein	0.011
KBTBD2	kelch repeat and BTB (POZ) domain containing 2	0.011
TAF6L	TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	0.011
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.011	Human
PAIP2	poly(A) binding protein interacting protein 2	0.011
SUPT6H	suppressor of Ty 6 homolog (S. cerevisiae)	0.011
RBM11	RNA binding motif protein 11	0.011
PHC1	polyhomeotic homolog 1 (Drosophila)	0.011
UBE2R2	ubiquitin-conjugating enzyme E2R 2	0.011
ABHD16A	abhydrolase domain containing 16A	0.011
HAT1	histone acetyltransferase 1	0.010
AP1G1	adaptor-related protein complex 1, gamma 1 subunit	0.010
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.010
MUL1	mitochondrial E3 ubiquitin protein ligase 1	0.010