IMP
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signal transduction involved in dna damage checkpoint
A signal transduction process that contributes to a DNA damage checkpoint.
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Click on a gene's description to view its network relationships with genes known to be involved in "signal transduction involved in dna damage checkpoint"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Trp53 | transformation related protein 53 | 1.000 | ||
| Mdm4 | transformed mouse 3T3 cell double minute 4 | 0.896 | ||
| Rb1 | retinoblastoma 1 | 0.887 | ||
| Brca1 | breast cancer 1 | 0.883 | ||
| Brca2 | breast cancer 2 | 0.845 | ||
| Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 0.803 | Human | |
| Kit | kit oncogene | 0.693 | ||
| Skil | SKI-like | 0.643 | ||
| Cdkn1b | cyclin-dependent kinase inhibitor 1B | 0.629 | ||
| Daxx | Fas death domain-associated protein | 0.612 | ||
| Trp73 | transformation related protein 73 | 0.559 | Mouse | |
| Rxra | retinoid X receptor alpha | 0.556 | ||
| Rara | retinoic acid receptor, alpha | 0.504 | ||
| Apc | adenomatosis polyposis coli | 0.486 | ||
| Sfn | stratifin | 0.404 | ||
| Mdm2 | transformed mouse 3T3 cell double minute 2 | 0.385 | Human | |
| Thbs1 | thrombospondin 1 | 0.345 | ||
| Cdkn2a | cyclin-dependent kinase inhibitor 2A | 0.299 | ||
| Msh2 | mutS homolog 2 (E. coli) | 0.295 | ||
| Meox2 | mesenchyme homeobox 2 | 0.262 | ||
| Trp63 | transformation related protein 63 | 0.258 | Mouse | |
| Sin3a | transcriptional regulator, SIN3A (yeast) | 0.160 | ||
| Itgb1 | integrin beta 1 (fibronectin receptor beta) | 0.150 | ||
| Runx1 | runt related transcription factor 1 | 0.141 | ||
| Cdkn2c | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | 0.135 | ||
| E2f1 | E2F transcription factor 1 | 0.131 | ||
| Huwe1 | HECT, UBA and WWE domain containing 1 | 0.119 | ||
| Col1a1 | collagen, type I, alpha 1 | 0.117 | ||
| Atm | ataxia telangiectasia mutated homolog (human) | 0.110 | Human | |
| Itga3 | integrin alpha 3 | 0.110 | ||
| Nap1l4 | nucleosome assembly protein 1-like 4 | 0.102 | ||
| Pten | phosphatase and tensin homolog | 0.102 | ||
| Irf9 | interferon regulatory factor 9 | 0.096 | ||
| Rbl1 | retinoblastoma-like 1 (p107) | 0.096 | ||
| Mybl2 | myeloblastosis oncogene-like 2 | 0.090 | ||
| Mlh1 | mutL homolog 1 (E. coli) | 0.089 | ||
| Psen1 | presenilin 1 | 0.087 | ||
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.086 | ||
| Vhl | von Hippel-Lindau tumor suppressor | 0.083 | ||
| Braf | Braf transforming gene | 0.080 | ||
| Aldh1a2 | aldehyde dehydrogenase family 1, subfamily A2 | 0.078 | ||
| Wrn | Werner syndrome homolog (human) | 0.076 | ||
| Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.071 | ||
| Nbn | nibrin | 0.068 | ||
| Casp2 | caspase 2 | 0.067 | Human | |
| Gata3 | GATA binding protein 3 | 0.065 | ||
| Ptch1 | patched homolog 1 | 0.063 | ||
| Notch1 | Notch gene homolog 1 (Drosophila) | 0.063 | ||
| Ccnd1 | cyclin D1 | 0.062 | ||
| Lef1 | lymphoid enhancer binding factor 1 | 0.061 | ||
| Fadd | Fas (TNFRSF6)-associated via death domain | 0.061 | ||
| Stk11 | serine/threonine kinase 11 | 0.060 | ||
| Pms2 | postmeiotic segregation increased 2 (S. cerevisiae) | 0.057 | ||
| Armc10 | armadillo repeat containing 10 | 0.057 | ||
| Rnf8 | ring finger protein 8 | 0.054 | ||
| Llgl1 | lethal giant larvae homolog 1 (Drosophila) | 0.053 | ||
| Tcf3 | transcription factor 3 | 0.049 | ||
| Gadd45a | growth arrest and DNA-damage-inducible 45 alpha | 0.047 | ||
| Ahr | aryl-hydrocarbon receptor | 0.047 | ||
| Krt19 | keratin 19 | 0.046 | ||
| Nf2 | neurofibromatosis 2 | 0.045 | ||
| Mbd4 | methyl-CpG binding domain protein 4 | 0.045 | ||
| Whsc2 | Wolf-Hirschhorn syndrome candidate 2 (human) | 0.045 | ||
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.044 | ||
| Xpa | xeroderma pigmentosum, complementation group A | 0.042 | ||
| Prps2 | phosphoribosyl pyrophosphate synthetase 2 | 0.041 | ||
| Smarcc1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 0.041 | ||
| Sox9 | SRY-box containing gene 9 | 0.041 | ||
| Nf1 | neurofibromatosis 1 | 0.040 | ||
| Fancc | Fanconi anemia, complementation group C | 0.038 | ||
| Terf1 | telomeric repeat binding factor 1 | 0.037 | ||
| Nfe2l2 | nuclear factor, erythroid derived 2, like 2 | 0.037 | ||
| Hhat | hedgehog acyltransferase | 0.036 | ||
| Ncoa3 | nuclear receptor coactivator 3 | 0.036 | ||
| Pold1 | polymerase (DNA directed), delta 1, catalytic subunit | 0.036 | ||
| Tsc1 | tuberous sclerosis 1 | 0.036 | ||
| Nfya | nuclear transcription factor-Y alpha | 0.034 | ||
| Cables1 | CDK5 and Abl enzyme substrate 1 | 0.034 | ||
| Hif1a | hypoxia inducible factor 1, alpha subunit | 0.034 | ||
| Yap1 | yes-associated protein 1 | 0.033 | ||
| Abl1 | c-abl oncogene 1, non-receptor tyrosine kinase | 0.033 | ||
| Asxl1 | additional sex combs like 1 (Drosophila) | 0.032 | ||
| Esr1 | estrogen receptor 1 (alpha) | 0.032 | ||
| Mfng | MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 0.032 | ||
| a | nonagouti | 0.031 | ||
| Vegfa | vascular endothelial growth factor A | 0.031 | ||
| Men1 | multiple endocrine neoplasia 1 | 0.031 | ||
| Sox11 | SRY-box containing gene 11 | 0.030 | ||
| Smad5 | MAD homolog 5 (Drosophila) | 0.030 | ||
| Trpc2 | transient receptor potential cation channel, subfamily C, member 2 | 0.029 | ||
| Tcf19 | transcription factor 19 | 0.028 | ||
| Irf6 | interferon regulatory factor 6 | 0.028 | ||
| Ints7 | integrator complex subunit 7 | 0.028 | ||
| Dok1 | docking protein 1 | 0.028 | ||
| Telo2 | TEL2, telomere maintenance 2, homolog (S. cerevisiae) | 0.027 | ||
| Cxcr4 | chemokine (C-X-C motif) receptor 4 | 0.027 | ||
| Zbtb45 | zinc finger and BTB domain containing 45 | 0.027 | ||
| Map4k1 | mitogen-activated protein kinase kinase kinase kinase 1 | 0.027 | ||
| Smyd2 | SET and MYND domain containing 2 | 0.027 | ||
| Ikbkb | inhibitor of kappaB kinase beta | 0.026 | ||
| Foxp1 | forkhead box P1 | 0.025 | ||
| Pds5b | PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) | 0.025 | ||
| Slc27a3 | solute carrier family 27 (fatty acid transporter), member 3 | 0.025 | ||
| Lrrc23 | leucine rich repeat containing 23 | 0.024 | ||
| Gtpbp1 | GTP binding protein 1 | 0.024 | ||
| Cdt1 | chromatin licensing and DNA replication factor 1 | 0.024 | ||
| Sp1 | trans-acting transcription factor 1 | 0.023 | ||
| Fam83f | family with sequence similarity 83, member F | 0.023 | ||
| Cdca7l | cell division cycle associated 7 like | 0.023 | ||
| AW146020 | expressed sequence AW146020 | 0.022 | ||
| Lamb3 | laminin, beta 3 | 0.022 | ||
| Suv420h2 | suppressor of variegation 4-20 homolog 2 (Drosophila) | 0.022 | ||
| Helb | helicase (DNA) B | 0.022 | ||
| Emx1 | empty spiracles homolog 1 (Drosophila) | 0.022 | ||
| Rnf135 | ring finger protein 135 | 0.022 | ||
| Ar | androgen receptor | 0.022 | ||
| Polm | polymerase (DNA directed), mu | 0.021 | ||
| Rttn | rotatin | 0.021 | ||
| Frmd8 | FERM domain containing 8 | 0.021 | ||
| Hjurp | Holliday junction recognition protein | 0.020 | ||
| Eri2 | exoribonuclease 2 | 0.020 | ||
| Cbl | Casitas B-lineage lymphoma | 0.020 | ||
| Tcfap4 | transcription factor AP4 | 0.020 | ||
| Numa1 | nuclear mitotic apparatus protein 1 | 0.020 | ||
| Fam60a | family with sequence similarity 60, member A | 0.019 | ||
| Cdrt4 | CMT1A duplicated region transcript 4 | 0.019 | ||
| Bcl2l11 | BCL2-like 11 (apoptosis facilitator) | 0.019 | ||
| Aarsd1 | alanyl-tRNA synthetase domain containing 1 | 0.019 | ||
| Stat5a | signal transducer and activator of transcription 5A | 0.019 | ||
| Bcl2 | B-cell leukemia/lymphoma 2 | 0.019 | ||
| Mycn | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) | 0.019 | ||
| Spice1 | spindle and centriole associated protein 1 | 0.018 | ||
| Lamc2 | laminin, gamma 2 | 0.018 | ||
| Bckdk | branched chain ketoacid dehydrogenase kinase | 0.018 | ||
| Tti1 | Tel2 interacting protein 1 homolog (S. pombe) | 0.018 | ||
| Axin1 | axin 1 | 0.018 | ||
| Stag3 | stromal antigen 3 | 0.018 | ||
| Zfp296 | zinc finger protein 296 | 0.018 | ||
| Polr1a | polymerase (RNA) I polypeptide A | 0.018 | ||
| Zbtb12 | zinc finger and BTB domain containing 12 | 0.018 | ||
| Hmgxb4 | HMG box domain containing 4 | 0.017 | ||
| Zbed3 | zinc finger, BED domain containing 3 | 0.017 | ||
| Lpcat1 | lysophosphatidylcholine acyltransferase 1 | 0.017 | ||
| Stk4 | serine/threonine kinase 4 | 0.017 | ||
| Samd9l | sterile alpha motif domain containing 9-like | 0.017 | ||
| Mutyh | mutY homolog (E. coli) | 0.017 | ||
| Anapc1 | anaphase promoting complex subunit 1 | 0.017 | ||
| Irf7 | interferon regulatory factor 7 | 0.017 | ||
| Cdk2 | cyclin-dependent kinase 2 | 0.017 | ||
| Pkp3 | plakophilin 3 | 0.017 | ||
| Myh3 | myosin, heavy polypeptide 3, skeletal muscle, embryonic | 0.017 | ||
| Htatip2 | HIV-1 tat interactive protein 2, homolog (human) | 0.017 | ||
| Elp3 | elongation protein 3 homolog (S. cerevisiae) | 0.017 | ||
| Itgb4 | integrin beta 4 | 0.016 | ||
| Ehf | ets homologous factor | 0.016 | ||
| Adig | adipogenin | 0.016 | ||
| Notch2 | Notch gene homolog 2 (Drosophila) | 0.016 | ||
| Rpia | ribose 5-phosphate isomerase A | 0.016 | ||
| Raf1 | v-raf-leukemia viral oncogene 1 | 0.016 | ||
| Hr | hairless | 0.016 | ||
| Rad51l3 | RAD51-like 3 (S. cerevisiae) | 0.016 | ||
| Sct | secretin | 0.016 | ||
| Fcho1 | FCH domain only 1 | 0.016 | ||
| Acd | adrenocortical dysplasia | 0.016 | ||
| Ap1m2 | adaptor protein complex AP-1, mu 2 subunit | 0.016 | ||
| Rint1 | RAD50 interactor 1 | 0.015 | ||
| Vangl2 | vang-like 2 (van gogh, Drosophila) | 0.015 | ||
| Patz1 | POZ (BTB) and AT hook containing zinc finger 1 | 0.015 | ||
| Cdk6 | cyclin-dependent kinase 6 | 0.015 | ||
| St14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.015 | ||
| Wwox | WW domain-containing oxidoreductase | 0.015 | ||
| Casp3 | caspase 3 | 0.015 | ||
| Ankle1 | ankyrin repeat and LEM domain containing 1 | 0.015 | ||
| Fam122b | family with sequence similarity 122, member B | 0.015 | ||
| Ikbkap | inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein | 0.015 | ||
| Lig4 | ligase IV, DNA, ATP-dependent | 0.015 | ||
| Bcl2l1 | BCL2-like 1 | 0.015 | ||
| Smarcd1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 | 0.015 | ||
| Fancg | Fanconi anemia, complementation group G | 0.015 | ||
| Tcfcp2l1 | transcription factor CP2-like 1 | 0.015 | ||
| Rarb | retinoic acid receptor, beta | 0.015 | ||
| Foxo1 | forkhead box O1 | 0.014 | ||
| Slc25a13 | solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13 | 0.014 | ||
| Dclre1a | DNA cross-link repair 1A, PSO2 homolog (S. cerevisiae) | 0.014 | ||
| Fmnl3 | formin-like 3 | 0.014 | ||
| Zfp26 | zinc finger protein 26 | 0.014 | ||
| Obfc2b | oligonucleotide/oligosaccharide-binding fold containing 2B | 0.014 | ||
| Klf5 | Kruppel-like factor 5 | 0.014 | ||
| Kcnn4 | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 | 0.014 | ||
| Igbp1 | immunoglobulin (CD79A) binding protein 1 | 0.014 | ||
| Adam17 | a disintegrin and metallopeptidase domain 17 | 0.014 | ||
| Pinx1 | PIN2/TERF1 interacting, telomerase inhibitor 1 | 0.014 | ||
| Tgfb1 | transforming growth factor, beta 1 | 0.014 | ||
| Prcc | papillary renal cell carcinoma (translocation-associated) | 0.014 | ||
| Hltf | helicase-like transcription factor | 0.014 | ||
| Orc1 | origin recognition complex, subunit 1 | 0.014 | ||
| Tead2 | TEA domain family member 2 | 0.014 | ||
| Polr2a | polymerase (RNA) II (DNA directed) polypeptide A | 0.013 | ||
| Hipk1 | homeodomain interacting protein kinase 1 | 0.013 | ||
| Parn | poly(A)-specific ribonuclease (deadenylation nuclease) | 0.013 | ||
| Krt4 | keratin 4 | 0.013 | ||
| 2310067B10Rik | RIKEN cDNA 2310067B10 gene | 0.013 | ||
| BC021614 | cDNA sequence BC021614 | 0.013 | ||
| Hdac7 | histone deacetylase 7 | 0.013 | ||
| Slc39a4 | solute carrier family 39 (zinc transporter), member 4 | 0.013 | ||
| Gtf2h3 | general transcription factor IIH, polypeptide 3 | 0.013 | ||
| Zfp866 | zinc finger protein 866 | 0.013 | ||
| Zfp422 | zinc finger protein 422 | 0.013 | ||
| Tacstd2 | tumor-associated calcium signal transducer 2 | 0.013 | ||
| Rfx1 | regulatory factor X, 1 (influences HLA class II expression) | 0.013 | ||
| Eif4b | eukaryotic translation initiation factor 4B | 0.013 | ||
| Swap70 | SWA-70 protein | 0.013 | ||
| Retn | resistin | 0.013 | ||
| Cdk5rap1 | CDK5 regulatory subunit associated protein 1 | 0.013 | ||
| 1500010J02Rik | RIKEN cDNA 1500010J02 gene | 0.012 | ||
| Bcat2 | branched chain aminotransferase 2, mitochondrial | 0.012 | ||
| Rab25 | RAB25, member RAS oncogene family | 0.012 | ||
| Ldb1 | LIM domain binding 1 | 0.012 | ||
| Ckap5 | cytoskeleton associated protein 5 | 0.012 | ||
| Ccnd3 | cyclin D3 | 0.012 | ||
| Cdx2 | caudal type homeobox 2 | 0.012 | ||
| Setd8 | SET domain containing (lysine methyltransferase) 8 | 0.012 | ||
| Tmem194b | transmembrane protein 194B | 0.012 | ||
| Rhox9 | reproductive homeobox 9 | 0.012 | ||
| Pou2f1 | POU domain, class 2, transcription factor 1 | 0.012 | ||
| Fam53a | family with sequence similarity 53, member A | 0.012 | ||
| Myb | myeloblastosis oncogene | 0.012 | ||
| Timeless | timeless homolog (Drosophila) | 0.012 | ||
| Fgfr1 | fibroblast growth factor receptor 1 | 0.012 | ||
| Naa40 | N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae) | 0.012 | ||
| Mmp11 | matrix metallopeptidase 11 | 0.012 | ||
| Gtf3c5 | general transcription factor IIIC, polypeptide 5 | 0.012 | ||
| Nudt1 | nudix (nucleoside diphosphate linked moiety X)-type motif 1 | 0.012 | ||
| Pmf1 | polyamine-modulated factor 1 | 0.012 | ||
| E2f4 | E2F transcription factor 4 | 0.012 | ||
| Pola2 | polymerase (DNA directed), alpha 2 | 0.012 | ||
| Ilf3 | interleukin enhancer binding factor 3 | 0.012 | ||
| H2-Ob | histocompatibility 2, O region beta locus | 0.012 | ||
| Tex19.2 | testis expressed gene 19.2 | 0.011 | ||
| Nfe2l3 | nuclear factor, erythroid derived 2, like 3 | 0.011 | ||
| Xrn1 | 5'-3' exoribonuclease 1 | 0.011 | ||
| Ddah2 | dimethylarginine dimethylaminohydrolase 2 | 0.011 | ||
| Vpreb2 | pre-B lymphocyte gene 2 | 0.011 | ||
| Ctnnd1 | catenin (cadherin associated protein), delta 1 | 0.011 | ||
| Homer3 | homer homolog 3 (Drosophila) | 0.011 | ||
| Pml | promyelocytic leukemia | 0.011 | ||
| Eif2ak2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.011 | ||
| Haus5 | HAUS augmin-like complex, subunit 5 | 0.011 | ||
| Pou5f1 | POU domain, class 5, transcription factor 1 | 0.011 | ||
| Wdr90 | WD repeat domain 90 | 0.011 | ||
| Nqo2 | NAD(P)H dehydrogenase, quinone 2 | 0.011 | ||
| Zfp689 | zinc finger protein 689 | 0.011 | ||
| Trim27 | tripartite motif-containing 27 | 0.011 | ||
| Rarg | retinoic acid receptor, gamma | 0.011 | ||
| Sars2 | seryl-aminoacyl-tRNA synthetase 2 | 0.011 | ||
| Cep68 | centrosomal protein 68 | 0.011 | ||
| Top3a | topoisomerase (DNA) III alpha | 0.011 | ||
| Il2rb | interleukin 2 receptor, beta chain | 0.011 | ||
| Rnls | renalase, FAD-dependent amine oxidase | 0.011 | ||
| Atad5 | ATPase family, AAA domain containing 5 | 0.011 | ||
| Mylpf | myosin light chain, phosphorylatable, fast skeletal muscle | 0.011 | ||
| Ccdc69 | coiled-coil domain containing 69 | 0.011 | ||
| Lipe | lipase, hormone sensitive | 0.011 | ||
| 4930444A02Rik | RIKEN cDNA 4930444A02 gene | 0.011 | ||
| BC100451 | cDNA sequence BC100451 | 0.011 | ||
| Cenpf | centromere protein F | 0.011 | ||
| Bglap2 | bone gamma-carboxyglutamate protein 2 | 0.011 | ||
| Mtor | mechanistic target of rapamycin (serine/threonine kinase) | 0.011 | ||
| Papss1 | 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | 0.011 | ||
| Ildr1 | immunoglobulin-like domain containing receptor 1 | 0.010 | ||
| Id1 | inhibitor of DNA binding 1 | 0.010 | ||
| Tmpo | thymopoietin | 0.010 | ||
| Parp1 | poly (ADP-ribose) polymerase family, member 1 | 0.010 | ||
| Apobec3 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3 | 0.010 | ||
| Tnfrsf18 | tumor necrosis factor receptor superfamily, member 18 | 0.010 | ||
| Bard1 | BRCA1 associated RING domain 1 | 0.010 | ||
| Map3k4 | mitogen-activated protein kinase kinase kinase 4 | 0.010 | ||
| Rfx5 | regulatory factor X, 5 (influences HLA class II expression) | 0.010 | ||
| Gpr56 | G protein-coupled receptor 56 | 0.010 | ||
| Spint1 | serine protease inhibitor, Kunitz type 1 | 0.010 | ||
| Elf3 | E74-like factor 3 | 0.010 | ||
| Cdkal1 | CDK5 regulatory subunit associated protein 1-like 1 | 0.010 | ||
| Cdc25b | cell division cycle 25 homolog B (S. pombe) | 0.010 | ||
| Zfp414 | zinc finger protein 414 | 0.010 | ||
| Tcof1 | Treacher Collins Franceschetti syndrome 1, homolog | 0.010 | ||
| Ltf | lactotransferrin | 0.010 |