IMP

Process View

Mus musculus

14 genes annotated in mouse

growth plate cartilage development

The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in mouse Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "growth plate cartilage development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "growth plate cartilage development" (in gray)

Name	Description	Probability	Func Analog Organism
Tgfbr2	transforming growth factor, beta receptor II	1.000
Rarg	retinoic acid receptor, gamma	0.996
Fgfr2	fibroblast growth factor receptor 2	0.993
Fgfr1	fibroblast growth factor receptor 1	0.992
Tgfb2	transforming growth factor, beta 2	0.987
Sox9	SRY-box containing gene 9	0.986
Fbn1	fibrillin 1	0.983
Bmp4	bone morphogenetic protein 4	0.982
Foxc1	forkhead box C1	0.976
Foxc2	forkhead box C2	0.970
Fgf8	fibroblast growth factor 8	0.967
Col1a1	collagen, type I, alpha 1	0.962
Ednra	endothelin receptor type A	0.949
Pax3	paired box gene 3	0.944
Tbx1	T-box 1	0.943
Acvr1	activin A receptor, type 1	0.932	Mouse
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.920
Prrx1	paired related homeobox 1	0.919
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.918
Shh	sonic hedgehog	0.918
Ece1	endothelin converting enzyme 1	0.917
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.916
Vegfa	vascular endothelial growth factor A	0.911
Chrd	chordin	0.905
Smo	smoothened homolog (Drosophila)	0.896
Eya1	eyes absent 1 homolog (Drosophila)	0.892
Tcfap2a	transcription factor AP-2, alpha	0.890
Lox	lysyl oxidase	0.857
Prrx2	paired related homeobox 2	0.848
Hoxa3	homeobox A3	0.821
Rara	retinoic acid receptor, alpha	0.799
Pitx2	paired-like homeodomain transcription factor 2	0.790
Rarb	retinoic acid receptor, beta	0.772
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.738
Rxra	retinoid X receptor alpha	0.731
Nos3	nitric oxide synthase 3, endothelial cell	0.702
Fgfr3	fibroblast growth factor receptor 3	0.686
Hand2	heart and neural crest derivatives expressed transcript 2	0.661
Hoxa1	homeobox A1	0.660
Apc	adenomatosis polyposis coli	0.647
Jag1	jagged 1	0.544
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.539
Gli2	GLI-Kruppel family member GLI2	0.526
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.526
Thra	thyroid hormone receptor alpha	0.493	Mouse
Gli3	GLI-Kruppel family member GLI3	0.478
Nodal	nodal	0.446
Pten	phosphatase and tensin homolog	0.417
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.394	Mouse
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.368
Csf1	colony stimulating factor 1 (macrophage)	0.362
Ctnnb1	catenin (cadherin associated protein), beta 1	0.336
Dlx5	distal-less homeobox 5	0.317
Meox2	mesenchyme homeobox 2	0.295
Isl1	ISL1 transcription factor, LIM/homeodomain	0.285
Twist2	twist homolog 2 (Drosophila)	0.280
Smad4	MAD homolog 4 (Drosophila)	0.273
Mmp2	matrix metallopeptidase 2	0.256	Mouse
Egfr	epidermal growth factor receptor	0.255
Msx1	homeobox, msh-like 1	0.253
Smad3	MAD homolog 3 (Drosophila)	0.252
Thbs2	thrombospondin 2	0.252	Mouse
Trp53	transformation related protein 53	0.251
Runx2	runt related transcription factor 2	0.250
Pkd1	polycystic kidney disease 1 homolog	0.221
Tgfbr1	transforming growth factor, beta receptor I	0.198	Mouse
Col6a2	collagen, type VI, alpha 2	0.190
Pax8	paired box gene 8	0.166
Gbx2	gastrulation brain homeobox 2	0.165
Pax2	paired box gene 2	0.163
Efemp2	epidermal growth factor-containing fibulin-like extracellular matrix protein 2	0.153
Hoxa2	homeobox A2	0.152
Fbln1	fibulin 1	0.146
Col16a1	collagen, type XVI, alpha 1	0.146
Msx2	homeobox, msh-like 2	0.142
Snai1	snail homolog 1 (Drosophila)	0.141
Nf1	neurofibromatosis 1	0.136
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.134
Gata4	GATA binding protein 4	0.130
Ltbp2	latent transforming growth factor beta binding protein 2	0.129
Fshr	follicle stimulating hormone receptor	0.121
Col1a2	collagen, type I, alpha 2	0.119
Col6a1	collagen, type VI, alpha 1	0.116
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.110
Hoxb3	homeobox B3	0.108
Leprel2	leprecan-like 2	0.102
Ltbp3	latent transforming growth factor beta binding protein 3	0.098
Apoe	apolipoprotein E	0.097
C1qtnf1	C1q and tumor necrosis factor related protein 1	0.096
Sox4	SRY-box containing gene 4	0.096
Esr1	estrogen receptor 1 (alpha)	0.094
Srpx	sushi-repeat-containing protein	0.092
Eln	elastin	0.081
Mesp1	mesoderm posterior 1	0.079
Mgp	matrix Gla protein	0.079
Bmp2	bone morphogenetic protein 2	0.075
Fgfrl1	fibroblast growth factor receptor-like 1	0.075
Twist1	twist homolog 1 (Drosophila)	0.074
Zic3	zinc finger protein of the cerebellum 3	0.074
Aebp1	AE binding protein 1	0.071
Alx3	aristaless-like homeobox 3	0.071
Col5a1	collagen, type V, alpha 1	0.069
Foxg1	forkhead box G1	0.069
Col11a1	collagen, type XI, alpha 1	0.065
Mfap5	microfibrillar associated protein 5	0.064
Col8a1	collagen, type VIII, alpha 1	0.062
Wisp1	WNT1 inducible signaling pathway protein 1	0.060
Cpxm1	carboxypeptidase X 1 (M14 family)	0.060
Loxl1	lysyl oxidase-like 1	0.060
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.058
Eng	endoglin	0.058
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.057
Gja1	gap junction protein, alpha 1	0.057
Il6st	interleukin 6 signal transducer	0.056
Thbs1	thrombospondin 1	0.055
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.055
Duox2	dual oxidase 2	0.054
Bmp7	bone morphogenetic protein 7	0.054
Gsc	goosecoid homeobox	0.053
Chd7	chromodomain helicase DNA binding protein 7	0.052
Dbp	D site albumin promoter binding protein	0.051
Inhba	inhibin beta-A	0.051
Clec4d	C-type lectin domain family 4, member d	0.050
Ctsk	cathepsin K	0.049
Emx2	empty spiracles homolog 2 (Drosophila)	0.049
Mkl2	MKL/myocardin-like 2	0.048
Ltbp1	latent transforming growth factor beta binding protein 1	0.048
Npr2	natriuretic peptide receptor 2	0.046
Idua	iduronidase, alpha-L-	0.046
Dlx2	distal-less homeobox 2	0.046
Hic1	hypermethylated in cancer 1	0.043
Ptch1	patched homolog 1	0.043
Fgf10	fibroblast growth factor 10	0.043
Col3a1	collagen, type III, alpha 1	0.043
Crlf1	cytokine receptor-like factor 1	0.042
Hoxd11	homeobox D11	0.042
Col2a1	collagen, type II, alpha 1	0.041
Fgf7	fibroblast growth factor 7	0.041
C5ar1	complement component 5a receptor 1	0.041
Tgfb3	transforming growth factor, beta 3	0.041
Hand1	heart and neural crest derivatives expressed transcript 1	0.041
Adam17	a disintegrin and metallopeptidase domain 17	0.039
Tgfbr3	transforming growth factor, beta receptor III	0.039
Agtr2	angiotensin II receptor, type 2	0.039
En1	engrailed 1	0.038
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.037
Htra3	HtrA serine peptidase 3	0.037
Pthlh	parathyroid hormone-like peptide	0.037
Tagln	transgelin	0.036
Fbln2	fibulin 2	0.036
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.036
Col11a2	collagen, type XI, alpha 2	0.035
Bmper	BMP-binding endothelial regulator	0.034
Col5a2	collagen, type V, alpha 2	0.034
Fmod	fibromodulin	0.034
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.033
Col6a3	collagen, type VI, alpha 3	0.033
Myf5	myogenic factor 5	0.033
Scara3	scavenger receptor class A, member 3	0.031
Grem1	gremlin 1	0.030	Mouse
Otx2	orthodenticle homolog 2 (Drosophila)	0.030
Foxd1	forkhead box D1	0.030
Prkg1	protein kinase, cGMP-dependent, type I	0.030
Fgf2	fibroblast growth factor 2	0.029
Bmp5	bone morphogenetic protein 5	0.029
Pcolce	procollagen C-endopeptidase enhancer protein	0.029
Islr	immunoglobulin superfamily containing leucine-rich repeat	0.028
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.028
Tll1	tolloid-like	0.027
Tef	thyrotroph embryonic factor	0.027
Mrc2	mannose receptor, C type 2	0.027
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.027
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.026
Npc1	Niemann Pick type C1	0.026
Pbx1	pre B-cell leukemia transcription factor 1	0.025
Mmp3	matrix metallopeptidase 3	0.025	Mouse
Vangl2	vang-like 2 (van gogh, Drosophila)	0.025
Hoxd3	homeobox D3	0.025
Cd248	CD248 antigen, endosialin	0.024
Dpt	dermatopontin	0.024
Fbn2	fibrillin 2	0.024
Matn4	matrilin 4	0.024	Mouse
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.024
Fgf9	fibroblast growth factor 9	0.023
Ret	ret proto-oncogene	0.023
Smoc2	SPARC related modular calcium binding 2	0.023
Il12b	interleukin 12b	0.023
Tbx15	T-box 15	0.023
Col12a1	collagen, type XII, alpha 1	0.023
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.023
Ptx3	pentraxin related gene	0.023
Atp7a	ATPase, Cu++ transporting, alpha polypeptide	0.023
Tshr	thyroid stimulating hormone receptor	0.023
Hoxa5	homeobox A5	0.023
Gdf3	growth differentiation factor 3	0.023
Foxi3	forkhead box I3	0.022
Inha	inhibin alpha	0.022
Nog	noggin	0.022
Tmem119	transmembrane protein 119	0.021
Il1rn	interleukin 1 receptor antagonist	0.021
Bgn	biglycan	0.021
Lmna	lamin A	0.021
Mmp10	matrix metallopeptidase 10	0.020	Mouse
Thbs3	thrombospondin 3	0.020
Mia1	melanoma inhibitory activity 1	0.020
Cyp1b1	cytochrome P450, family 1, subfamily b, polypeptide 1	0.020
Acvrl1	activin A receptor, type II-like 1	0.020	Mouse
Trim47	tripartite motif-containing 47	0.020
Adora2b	adenosine A2b receptor	0.019
Lama2	laminin, alpha 2	0.019
Zeb1	zinc finger E-box binding homeobox 1	0.019
Hr	hairless	0.019
Ddr2	discoidin domain receptor family, member 2	0.019
Fzd2	frizzled homolog 2 (Drosophila)	0.018
Lefty1	left right determination factor 1	0.018
C1qtnf3	C1q and tumor necrosis factor related protein 3	0.018
Lhx8	LIM homeobox protein 8	0.018
Mfap4	microfibrillar-associated protein 4	0.018
Ptgir	prostaglandin I receptor (IP)	0.018
Hoxd10	homeobox D10	0.018
St3gal2	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	0.018
Fmn1	formin 1	0.018
Lhx1	LIM homeobox protein 1	0.017
Tnfrsf11b	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	0.017
Vhl	von Hippel-Lindau tumor suppressor	0.017
1500015O10Rik	RIKEN cDNA 1500015O10 gene	0.017
Bmp1	bone morphogenetic protein 1	0.017
Shc1	src homology 2 domain-containing transforming protein C1	0.017
Col8a2	collagen, type VIII, alpha 2	0.017
Zfpm2	zinc finger protein, multitype 2	0.017
Figf	c-fos induced growth factor	0.017
Adamts2	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2	0.017
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.016
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.016
Plat	plasminogen activator, tissue	0.016
Ext1	exostoses (multiple) 1	0.016
Il11	interleukin 11	0.016
Fst	follistatin	0.016
Timp3	tissue inhibitor of metalloproteinase 3	0.016
Kcnj15	potassium inwardly-rectifying channel, subfamily J, member 15	0.016
Rdh10	retinol dehydrogenase 10 (all-trans)	0.016
Sftpd	surfactant associated protein D	0.016
Rcvrn	recoverin	0.016
Nkx3-2	NK3 homeobox 2	0.016
Lamb2	laminin, beta 2	0.016
Mdm2	transformed mouse 3T3 cell double minute 2	0.016
Psen1	presenilin 1	0.016
Il17a	interleukin 17A	0.016
Tg	thyroglobulin	0.016
Plcd1	phospholipase C, delta 1	0.016
Tnxb	tenascin XB	0.016
Nanog	Nanog homeobox	0.016
Hoxa11	homeobox A11	0.016
Ncoa2	nuclear receptor coactivator 2	0.015
Angptl2	angiopoietin-like 2	0.015
Lrp6	low density lipoprotein receptor-related protein 6	0.015
Fkbp10	FK506 binding protein 10	0.015
Ntf3	neurotrophin 3	0.015
Creb3l1	cAMP responsive element binding protein 3-like 1	0.015
Lum	lumican	0.015
Ncoa1	nuclear receptor coactivator 1	0.015
Ldlr	low density lipoprotein receptor	0.015
Wt1	Wilms tumor 1 homolog	0.015
Alx4	aristaless-like homeobox 4	0.015
Gfpt2	glutamine fructose-6-phosphate transaminase 2	0.015
Svep1	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	0.015
Slc16a2	solute carrier family 16 (monocarboxylic acid transporters), member 2	0.015
Arhgef25	Rho guanine nucleotide exchange factor (GEF) 25	0.015
Gata3	GATA binding protein 3	0.015
Slc12a4	solute carrier family 12, member 4	0.015
Dio2	deiodinase, iodothyronine, type II	0.015
Rtkn	rhotekin	0.014
Mmp16	matrix metallopeptidase 16	0.014
Tcf15	transcription factor 15	0.014
Nhedc2	Na+/H+ exchanger domain containing 2	0.014
Sfrp2	secreted frizzled-related protein 2	0.014
Shox2	short stature homeobox 2	0.014
Igf1	insulin-like growth factor 1	0.014
Rbl2	retinoblastoma-like 2	0.014
Ppfia4	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	0.014
Col9a2	collagen, type IX, alpha 2	0.014
C3ar1	complement component 3a receptor 1	0.014
Phldb1	pleckstrin homology-like domain, family B, member 1	0.014
Notch2	Notch gene homolog 2 (Drosophila)	0.014
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.014
Epas1	endothelial PAS domain protein 1	0.014
Acvr2b	activin receptor IIB	0.014
Ltbp4	latent transforming growth factor beta binding protein 4	0.014
Ptrf	polymerase I and transcript release factor	0.013
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.013
Nr1d1	nuclear receptor subfamily 1, group D, member 1	0.013	Mouse
Tnc	tenascin C	0.013
Plxnd1	plexin D1	0.013
Mecom	MDS1 and EVI1 complex locus	0.013
Gata6	GATA binding protein 6	0.013
Sall4	sal-like 4 (Drosophila)	0.013
Htr4	5 hydroxytryptamine (serotonin) receptor 4	0.013
Tenc1	tensin like C1 domain-containing phosphatase	0.013
Adamtsl4	ADAMTS-like 4	0.013
Homer3	homer homolog 3 (Drosophila)	0.013
Ptk7	PTK7 protein tyrosine kinase 7	0.013
Wnt4	wingless-related MMTV integration site 4	0.013
Fzd1	frizzled homolog 1 (Drosophila)	0.012
Col19a1	collagen, type XIX, alpha 1	0.012
Tsks	testis-specific serine kinase substrate	0.012
Nov	nephroblastoma overexpressed gene	0.012
Ghr	growth hormone receptor	0.012
Pitx1	paired-like homeodomain transcription factor 1	0.012
B3gnt9-ps	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9, pseudogene	0.012
Marveld1	MARVEL (membrane-associating) domain containing 1	0.012
Ccl11	chemokine (C-C motif) ligand 11	0.012
Dmrt1	doublesex and mab-3 related transcription factor 1	0.012
Smad6	MAD homolog 6 (Drosophila)	0.012
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.012
Sts	steroid sulfatase	0.012
Col4a5	collagen, type IV, alpha 5	0.012
Pax9	paired box gene 9	0.012
Slc12a1	solute carrier family 12, member 1	0.012
Timp2	tissue inhibitor of metalloproteinase 2	0.012
Ccl17	chemokine (C-C motif) ligand 17	0.012
Cpxm2	carboxypeptidase X 2 (M14 family)	0.011
Opn1sw	opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)	0.011
Tppp3	tubulin polymerization-promoting protein family member 3	0.011
Ppard	peroxisome proliferator activator receptor delta	0.011
Runx1	runt related transcription factor 1	0.011
Igfbp6	insulin-like growth factor binding protein 6	0.011
Ereg	epiregulin	0.011
Itgbl1	integrin, beta-like 1	0.011
Reg3a	regenerating islet-derived 3 alpha	0.011
Wnt3	wingless-related MMTV integration site 3	0.011
Ceacam12	carcinoembryonic antigen-related cell adhesion molecule 12	0.011
Cav1	caveolin 1, caveolae protein	0.011
Ch25h	cholesterol 25-hydroxylase	0.011
Pdgfb	platelet derived growth factor, B polypeptide	0.011
Apbb2	amyloid beta (A4) precursor protein-binding, family B, member 2	0.011
Zfp503	zinc finger protein 503	0.011
Gna11	guanine nucleotide binding protein, alpha 11	0.011
Mxra8	matrix-remodelling associated 8	0.011
Hes1	hairy and enhancer of split 1 (Drosophila)	0.011
Mfi2	antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5	0.011
Fzd8	frizzled homolog 8 (Drosophila)	0.011
Mrvi1	MRV integration site 1	0.011
Hsd17b1	hydroxysteroid (17-beta) dehydrogenase 1	0.011
Cilp	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	0.011
Cd276	CD276 antigen	0.011
Cdr2l	cerebellar degeneration-related protein 2-like	0.011
Sulf2	sulfatase 2	0.010
Pdgfa	platelet derived growth factor, alpha	0.010
Tcof1	Treacher Collins Franceschetti syndrome 1, homolog	0.010
Tlr4	toll-like receptor 4	0.010
Nfix	nuclear factor I/X	0.010
Nbl1	neuroblastoma, suppression of tumorigenicity 1	0.010	Mouse
Naip1	NLR family, apoptosis inhibitory protein 1	0.010
Odz1	odd Oz/ten-m homolog 1 (Drosophila)	0.010
Prx	periaxin	0.010
Htr2b	5-hydroxytryptamine (serotonin) receptor 2B	0.010
Ank	progressive ankylosis	0.010
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.010
Mst1r	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	0.010
C77068	expressed sequence C77068	0.010