IMP

Process View

Mus musculus

3 genes annotated in mouse

cell migration involved in endocardial cushion formation

The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cell migration involved in endocardial cushion formation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cell migration involved in endocardial cushion formation" (in gray)

Name	Description	Probability	Func Analog Organism
Notch1	Notch gene homolog 1 (Drosophila)	1.000
Psen1	presenilin 1	0.999
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.998
Dll1	delta-like 1 (Drosophila)	0.998
Jag1	jagged 1	0.996
Dll4	delta-like 4 (Drosophila)	0.989
Notch2	Notch gene homolog 2 (Drosophila)	0.983	Mouse
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.959
Fgfr1	fibroblast growth factor receptor 1	0.950
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.948
Ctnnb1	catenin (cadherin associated protein), beta 1	0.909
Efnb2	ephrin B2	0.874
Nos3	nitric oxide synthase 3, endothelial cell	0.870
Acvrl1	activin A receptor, type II-like 1	0.848
Tgfbr2	transforming growth factor, beta receptor II	0.776
Rxra	retinoid X receptor alpha	0.743
Hes1	hairy and enhancer of split 1 (Drosophila)	0.708
Vegfa	vascular endothelial growth factor A	0.700
Fgfr2	fibroblast growth factor receptor 2	0.641
Psen2	presenilin 2	0.634
Sox18	SRY-box containing gene 18	0.620
Tbx1	T-box 1	0.613
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.602
Pten	phosphatase and tensin homolog	0.576
Chd7	chromodomain helicase DNA binding protein 7	0.564
Foxc1	forkhead box C1	0.545
Pkd1	polycystic kidney disease 1 homolog	0.538
Cdh5	cadherin 5	0.512
Ptf1a	pancreas specific transcription factor, 1a	0.491
Efnb1	ephrin B1	0.437
Lama5	laminin, alpha 5	0.434
Hdac7	histone deacetylase 7	0.425
Rarg	retinoic acid receptor, gamma	0.400
Tead3	TEA domain family member 3	0.350
Pitx2	paired-like homeodomain transcription factor 2	0.343
Jag2	jagged 2	0.329
Shh	sonic hedgehog	0.316
She	src homology 2 domain-containing transforming protein E	0.311
Itga5	integrin alpha 5 (fibronectin receptor alpha)	0.307
Col4a2	collagen, type IV, alpha 2	0.268
Kdr	kinase insert domain protein receptor	0.251
Gli3	GLI-Kruppel family member GLI3	0.231
Vangl2	vang-like 2 (van gogh, Drosophila)	0.219
Egfl7	EGF-like domain 7	0.215
Rb1	retinoblastoma 1	0.214
Bmp4	bone morphogenetic protein 4	0.211
Adcy4	adenylate cyclase 4	0.206
Tbx2	T-box 2	0.204
Pdgfb	platelet derived growth factor, B polypeptide	0.195
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.183
Hic1	hypermethylated in cancer 1	0.182
BC020535	cDNA sequence BC020535	0.174
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.173
Pax3	paired box gene 3	0.170
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.169
Trp53	transformation related protein 53	0.161
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.155
Gata4	GATA binding protein 4	0.150
Notch3	Notch gene homolog 3 (Drosophila)	0.145	Mouse
Gata2	GATA binding protein 2	0.133
Sox17	SRY-box containing gene 17	0.128
Bcl2	B-cell leukemia/lymphoma 2	0.127
Ece1	endothelin converting enzyme 1	0.122
Sema3f	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.120
Cntn2	contactin 2	0.117
Flt4	FMS-like tyrosine kinase 4	0.108
Col4a1	collagen, type IV, alpha 1	0.104
Ephb4	Eph receptor B4	0.102
Snai1	snail homolog 1 (Drosophila)	0.094	Mouse
Eng	endoglin	0.093
Foxc2	forkhead box C2	0.091
Robo4	roundabout homolog 4 (Drosophila)	0.090
Smad6	MAD homolog 6 (Drosophila)	0.089
Sox7	SRY-box containing gene 7	0.086
Ddr2	discoidin domain receptor family, member 2	0.078
Six5	sine oculis-related homeobox 5 homolog (Drosophila)	0.078
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.077
Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.076
Tbx3	T-box 3	0.075
Ptprb	protein tyrosine phosphatase, receptor type, B	0.075
Tgfb2	transforming growth factor, beta 2	0.072
Smo	smoothened homolog (Drosophila)	0.069
Foxf1a	forkhead box F1a	0.067
Gata3	GATA binding protein 3	0.066
Hand2	heart and neural crest derivatives expressed transcript 2	0.066
Ptk7	PTK7 protein tyrosine kinase 7	0.062
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.062
Foxo1	forkhead box O1	0.061
Meox2	mesenchyme homeobox 2	0.061
Tnks1bp1	tankyrase 1 binding protein 1	0.059
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.057
Ier5l	immediate early response 5-like	0.057
Tenc1	tensin like C1 domain-containing phosphatase	0.054
Shank3	SH3/ankyrin domain gene 3	0.053
Trp73	transformation related protein 73	0.052
Gata6	GATA binding protein 6	0.051
Sorbs3	sorbin and SH3 domain containing 3	0.050
Egfr	epidermal growth factor receptor	0.050
Flt1	FMS-like tyrosine kinase 1	0.049
Braf	Braf transforming gene	0.048
Ubtd1	ubiquitin domain containing 1	0.047
Esam	endothelial cell-specific adhesion molecule	0.046
Vhl	von Hippel-Lindau tumor suppressor	0.044
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.043
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.043
Cldn5	claudin 5	0.042
Aph1a	anterior pharynx defective 1a homolog (C. elegans)	0.042
Nes	nestin	0.041
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.041
Hoxa1	homeobox A1	0.041
Lrp5	low density lipoprotein receptor-related protein 5	0.040
Nynrin	NYN domain and retroviral integrase containing	0.040
Igf1r	insulin-like growth factor I receptor	0.040
Mll1	myeloid/lymphoid or mixed-lineage leukemia 1	0.039
Scn5a	sodium channel, voltage-gated, type V, alpha	0.039
Runx1	runt related transcription factor 1	0.038
Smad3	MAD homolog 3 (Drosophila)	0.037
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.036
Tgfb1i1	transforming growth factor beta 1 induced transcript 1	0.036
Ptch1	patched homolog 1	0.036
Gdnf	glial cell line derived neurotrophic factor	0.035
Zfp362	zinc finger protein 362	0.035
Klf3	Kruppel-like factor 3 (basic)	0.035
Cox4i2	cytochrome c oxidase subunit IV isoform 2	0.035
Hif1a	hypoxia inducible factor 1, alpha subunit	0.034
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.034
Twist2	twist homolog 2 (Drosophila)	0.034
Amotl2	angiomotin-like 2	0.033
Fzd1	frizzled homolog 1 (Drosophila)	0.033
Bcl6b	B-cell CLL/lymphoma 6, member B	0.033
Phldb1	pleckstrin homology-like domain, family B, member 1	0.033
Acvr1	activin A receptor, type 1	0.031
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.031
Epas1	endothelial PAS domain protein 1	0.030
Rasip1	Ras interacting protein 1	0.030
Emx1	empty spiracles homolog 1 (Drosophila)	0.030
Fas	Fas (TNF receptor superfamily member 6)	0.029
Lef1	lymphoid enhancer binding factor 1	0.029
Tgfb1	transforming growth factor, beta 1	0.029
Dscaml1	Down syndrome cell adhesion molecule-like 1	0.029
Itga3	integrin alpha 3	0.029
Fgf8	fibroblast growth factor 8	0.028
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.028
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.028
Mrc2	mannose receptor, C type 2	0.027
Hspa12b	heat shock protein 12B	0.027
Zfhx3	zinc finger homeobox 3	0.027
Ramp2	receptor (calcitonin) activity modifying protein 2	0.027
Tgfbr1	transforming growth factor, beta receptor I	0.026
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.026
Lamc1	laminin, gamma 1	0.026
Slc25a29	solute carrier family 25 (mitochondrial carrier, palmitoylcarnitine transporter), member 29	0.025
Foxe3	forkhead box E3	0.025
Tead2	TEA domain family member 2	0.024
Rara	retinoic acid receptor, alpha	0.024
Meox1	mesenchyme homeobox 1	0.024
Pitx3	paired-like homeodomain transcription factor 3	0.024
Gja4	gap junction protein, alpha 4	0.024
Caskin2	CASK-interacting protein 2	0.023
Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.023
Neurl1a	neuralized homolog 1A (Drosophila)	0.023
Jup	junction plakoglobin	0.022
Apoe	apolipoprotein E	0.022
Itpkb	inositol 1,4,5-trisphosphate 3-kinase B	0.022
Heyl	hairy/enhancer-of-split related with YRPW motif-like	0.022
Zfpm2	zinc finger protein, multitype 2	0.021
Mfng	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.021
Mark4	MAP/microtubule affinity-regulating kinase 4	0.021
Zfp651	zinc finger protein 651	0.021
Ednra	endothelin receptor type A	0.021
Hlx	H2.0-like homeobox	0.021
Zfp503	zinc finger protein 503	0.021
Prrx2	paired related homeobox 2	0.020
Col1a1	collagen, type I, alpha 1	0.020
Fgd5	FYVE, RhoGEF and PH domain containing 5	0.020
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.020
Fev	FEV (ETS oncogene family)	0.020
Sh2b3	SH2B adaptor protein 3	0.020
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.020
Trim62	tripartite motif-containing 62	0.019
Wnt3a	wingless-related MMTV integration site 3A	0.019
Wiz	widely-interspaced zinc finger motifs	0.019
Plxna1	plexin A1	0.019
Lmx1a	LIM homeobox transcription factor 1 alpha	0.019
Nxph4	neurexophilin 4	0.019
Prkd2	protein kinase D2	0.019
Ncstn	nicastrin	0.019
Kcnh3	potassium voltage-gated channel, subfamily H (eag-related), member 3	0.019
Dmbx1	diencephalon/mesencephalon homeobox 1	0.019
Pofut1	protein O-fucosyltransferase 1	0.018
Ets1	E26 avian leukemia oncogene 1, 5' domain	0.018
Smad7	MAD homolog 7 (Drosophila)	0.018
Kremen1	kringle containing transmembrane protein 1	0.018
Ncor2	nuclear receptor co-repressor 2	0.018
Aplnr	apelin receptor	0.018
Tcf15	transcription factor 15	0.018
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.018
Mdm2	transformed mouse 3T3 cell double minute 2	0.018
Ski	ski sarcoma viral oncogene homolog (avian)	0.017
Nckap5l	NCK-associated protein 5-like	0.017
Foxl2	forkhead box L2	0.017
Nkx2-4	NK2 transcription factor related, locus 4 (Drosophila)	0.017
Atoh8	atonal homolog 8 (Drosophila)	0.017
Dysf	dysferlin	0.017
Irx1	Iroquois related homeobox 1 (Drosophila)	0.017
Sox13	SRY-box containing gene 13	0.017
Gli2	GLI-Kruppel family member GLI2	0.017
Fzd2	frizzled homolog 2 (Drosophila)	0.017
Isl2	insulin related protein 2 (islet 2)	0.017
Gpr132	G protein-coupled receptor 132	0.017
Cic	capicua homolog (Drosophila)	0.016
Pou4f3	POU domain, class 4, transcription factor 3	0.016
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.016
Plxnd1	plexin D1	0.016
Iglon5	IgLON family member 5	0.016
Hoxb4	homeobox B4	0.016
Ushbp1	Usher syndrome 1C binding protein 1	0.016
Srrm4	serine/arginine repetitive matrix 4	0.016
Ehd2	EH-domain containing 2	0.015
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.015
Madcam1	mucosal vascular addressin cell adhesion molecule 1	0.015
Bhlha15	basic helix-loop-helix family, member a15	0.015
Tinagl1	tubulointerstitial nephritis antigen-like 1	0.015
Gas1	growth arrest specific 1	0.015
Mark1	MAP/microtubule affinity-regulating kinase 1	0.015
Hip1	huntingtin interacting protein 1	0.015
Ltbp4	latent transforming growth factor beta binding protein 4	0.015
Angptl2	angiopoietin-like 2	0.015
Yap1	yes-associated protein 1	0.015
Fzd4	frizzled homolog 4 (Drosophila)	0.015
Obsl1	obscurin-like 1	0.015
Foxg1	forkhead box G1	0.015
Lrp6	low density lipoprotein receptor-related protein 6	0.015
Pecam1	platelet/endothelial cell adhesion molecule 1	0.014
Cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	0.014
Tcf21	transcription factor 21	0.014
Cdr2l	cerebellar degeneration-related protein 2-like	0.014
Bcl9l	B-cell CLL/lymphoma 9-like	0.014
Scarf2	scavenger receptor class F, member 2	0.014
St8sia2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.014
Bnc1	basonuclin 1	0.014
Nfatc4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.014
Map3k3	mitogen-activated protein kinase kinase kinase 3	0.014
Sp6	trans-acting transcription factor 6	0.013
Cxcl12	chemokine (C-X-C motif) ligand 12	0.013
Pear1	platelet endothelial aggregation receptor 1	0.013
Des	desmin	0.013
Eltd1	EGF, latrophilin seven transmembrane domain containing 1	0.013
Podxl	podocalyxin-like	0.013
Wnt11	wingless-related MMTV integration site 11	0.013
Zbtb7c	zinc finger and BTB domain containing 7C	0.013
Hoxa13	homeobox A13	0.013
Diras1	DIRAS family, GTP-binding RAS-like 1	0.013
Arhgef10	Rho guanine nucleotide exchange factor (GEF) 10	0.013
Dll3	delta-like 3 (Drosophila)	0.013
Col5a1	collagen, type V, alpha 1	0.013
Msx1	homeobox, msh-like 1	0.013
Marveld1	MARVEL (membrane-associating) domain containing 1	0.013
Fscn1	fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus)	0.013
Irx4	Iroquois related homeobox 4 (Drosophila)	0.013
Mmp15	matrix metallopeptidase 15	0.013
Itgb3	integrin beta 3	0.013
Mnx1	motor neuron and pancreas homeobox 1	0.013
Grm2	glutamate receptor, metabotropic 2	0.013
Tspan9	tetraspanin 9	0.013
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.013
Plekhg2	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	0.013
Thbd	thrombomodulin	0.012
Mcam	melanoma cell adhesion molecule	0.012
Fzd8	frizzled homolog 8 (Drosophila)	0.012
Smad4	MAD homolog 4 (Drosophila)	0.012
Lrfn1	leucine rich repeat and fibronectin type III domain containing 1	0.012
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.012
Wwtr1	WW domain containing transcription regulator 1	0.012
Prr12	proline rich 12	0.012
Sox14	SRY-box containing gene 14	0.012
Efna2	ephrin A2	0.012
Mmrn2	multimerin 2	0.012
Sox9	SRY-box containing gene 9	0.012
Gja1	gap junction protein, alpha 1	0.012
Igf2bp2	insulin-like growth factor 2 mRNA binding protein 2	0.012
Ahdc1	AT hook, DNA binding motif, containing 1	0.012
BC018465	cDNA sequence BC018465	0.012
Emid2	EMI domain containing 2	0.012
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.012
Kit	kit oncogene	0.011
Smtn	smoothelin	0.011
Ephb2	Eph receptor B2	0.011
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.011
Lrp1	low density lipoprotein receptor-related protein 1	0.011
Samd4b	sterile alpha motif domain containing 4B	0.011
Pitx1	paired-like homeodomain transcription factor 1	0.011
Tek	endothelial-specific receptor tyrosine kinase	0.011
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.011
S1pr3	sphingosine-1-phosphate receptor 3	0.011
Foxd3	forkhead box D3	0.011
Nrp1	neuropilin 1	0.011
Spsb1	splA/ryanodine receptor domain and SOCS box containing 1	0.011
Ltbr	lymphotoxin B receptor	0.011
Npr1	natriuretic peptide receptor 1	0.011
B3gat1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	0.011
Cacng7	calcium channel, voltage-dependent, gamma subunit 7	0.011
Foxo3	forkhead box O3	0.011
Cd93	CD93 antigen	0.011
Rasl12	RAS-like, family 12	0.010
Ntn3	netrin 3	0.010
Tbx4	T-box 4	0.010
Foxn4	forkhead box N4	0.010
Plekha4	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	0.010
Zfp703	zinc finger protein 703	0.010
Nid1	nidogen 1	0.010
Csf1	colony stimulating factor 1 (macrophage)	0.010
Lhx4	LIM homeobox protein 4	0.010
Fmnl3	formin-like 3	0.010