IMP

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Mus musculus

26 genes annotated in mouse

t cell mediated cytotoxicity

GO:0001913

The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "t cell mediated cytotoxicity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "t cell mediated cytotoxicity" (in gray)

Name	Description	Probability	Func Analog Organism
B2m	beta-2 microglobulin	1.000
H2-K1	histocompatibility 2, K1, K region	0.999
Tapbp	TAP binding protein	0.987
H2-D1	histocompatibility 2, D region locus 1	0.966
H2-Q7	histocompatibility 2, Q region locus 7	0.929
Psmb8	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)	0.916
Fyn	Fyn proto-oncogene	0.891
Casp8	caspase 8	0.743
Lck	lymphocyte protein tyrosine kinase	0.729
Il2rg	interleukin 2 receptor, gamma chain	0.703
Pnp2	purine-nucleoside phosphorylase 2	0.649
Cd247	CD247 antigen	0.571
Rab27a	RAB27A, member RAS oncogene family	0.563
Lat	linker for activation of T cells	0.513
Gzmb	granzyme B	0.512
H2-Q6	histocompatibility 2, Q region locus 6	0.316	Mouse Rat
Klrk1	killer cell lectin-like receptor subfamily K, member 1	0.243
Psmb9	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)	0.206
Cd96	CD96 antigen	0.191
Tap1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.177	Mouse
Slc40a1	solute carrier family 40 (iron-regulated transporter), member 1	0.166
Gbp7	guanylate binding protein 7	0.165
Tcra	T-cell receptor alpha chain	0.136
Itk	IL2-inducible T-cell kinase	0.134
Stat1	signal transducer and activator of transcription 1	0.133
Il2rb	interleukin 2 receptor, beta chain	0.131
Mlph	melanophilin	0.130
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.130	Mouse
Chst14	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14	0.126
Litaf	LPS-induced TN factor	0.126
Klrg1	killer cell lectin-like receptor subfamily G, member 1	0.117
Klrc1	killer cell lectin-like receptor subfamily C, member 1	0.115
Anxa4	annexin A4	0.113
Prf1	perforin 1 (pore forming protein)	0.111
Gzmc	granzyme C	0.107	Mouse
Ctsw	cathepsin W	0.104
Gbp2	guanylate binding protein 2	0.102
Sh2d2a	SH2 domain protein 2A	0.097
Il10rb	interleukin 10 receptor, beta	0.092
Stx11	syntaxin 11	0.088
Mcpt8	mast cell protease 8	0.082	Mouse
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.081
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.080
Cst7	cystatin F (leukocystatin)	0.079
Gzmf	granzyme F	0.078	Mouse
Cma1	chymase 1, mast cell	0.073	Mouse
H2-Ab1	histocompatibility 2, class II antigen A, beta 1	0.073
Xcl1	chemokine (C motif) ligand 1	0.069
Glrp1	glutamine repeat protein 1	0.064
Ppp3r1	protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)	0.063
Ctsh	cathepsin H	0.062
Shisa5	shisa homolog 5 (Xenopus laevis)	0.061
Il23a	interleukin 23, alpha subunit p19	0.060
Gbp3	guanylate binding protein 3	0.060
Ccl22	chemokine (C-C motif) ligand 22	0.058
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.057
H2-Eb1	histocompatibility 2, class II antigen E beta	0.056
Nkg7	natural killer cell group 7 sequence	0.056
Sytl5	synaptotagmin-like 5	0.055
Tnfsf10	tumor necrosis factor (ligand) superfamily, member 10	0.054
Klf1	Kruppel-like factor 1 (erythroid)	0.052
Irgm1	immunity-related GTPase family M member 1	0.052
Cp	ceruloplasmin	0.050
Hexa	hexosaminidase A	0.049
Sdcbp	syndecan binding protein	0.048
Acot9	acyl-CoA thioesterase 9	0.047
Gzmd	granzyme D	0.046	Mouse
H2-Q8	histocompatibility 2, Q region locus 8	0.044
Lgmn	legumain	0.043
Gcet2	germinal center expressed transcript 2	0.042
Ciita	class II transactivator	0.042
Mcpt2	mast cell protease 2	0.042	Mouse
AW112010	expressed sequence AW112010	0.041
Srgn	serglycin	0.041
S100a6	S100 calcium binding protein A6 (calcyclin)	0.041
Mmp10	matrix metallopeptidase 10	0.039
Casp12	caspase 12	0.039
Egr2	early growth response 2	0.038
Trim21	tripartite motif-containing 21	0.038
Ccl5	chemokine (C-C motif) ligand 5	0.037
Cd38	CD38 antigen	0.037
Itgal	integrin alpha L	0.037
Cyp4v3	cytochrome P450, family 4, subfamily v, polypeptide 3	0.035
Gm2a	GM2 ganglioside activator protein	0.034
Upk3b	uroplakin 3B	0.033
Cd3g	CD3 antigen, gamma polypeptide	0.033
Cpa3	carboxypeptidase A3, mast cell	0.033
Fasl	Fas ligand (TNF superfamily, member 6)	0.031
Rnase4	ribonuclease, RNase A family 4	0.031
Klrb1b	killer cell lectin-like receptor subfamily B member 1B	0.031
Mdfic	MyoD family inhibitor domain containing	0.031
Itm2b	integral membrane protein 2B	0.030
Ctsb	cathepsin B	0.030
Tktl1	transketolase-like 1	0.030
Cd53	CD53 antigen	0.030
Fadd	Fas (TNFRSF6)-associated via death domain	0.029
Mlkl	mixed lineage kinase domain-like	0.029
Cd4	CD4 antigen	0.029
Il18rap	interleukin 18 receptor accessory protein	0.029
Grap2	GRB2-related adaptor protein 2	0.028
Skap2	src family associated phosphoprotein 2	0.028
P2rx3	purinergic receptor P2X, ligand-gated ion channel, 3	0.027	Mouse
C5ar1	complement component 5a receptor 1	0.027
Gzma	granzyme A	0.027	Mouse
Rfpl4	ret finger protein-like 4	0.027
Cytip	cytohesin 1 interacting protein	0.026
H2-Aa	histocompatibility 2, class II antigen A, alpha	0.026
F2rl2	coagulation factor II (thrombin) receptor-like 2	0.026
Hsd3b7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	0.026
Gfi1	growth factor independent 1	0.025
Sat1	spermidine/spermine N1-acetyl transferase 1	0.025
Ifi47	interferon gamma inducible protein 47	0.025
Il2	interleukin 2	0.025
Hexb	hexosaminidase B	0.025
Klra5	killer cell lectin-like receptor, subfamily A, member 5	0.024
Il15	interleukin 15	0.024
Il12rb1	interleukin 12 receptor, beta 1	0.023
Tnfrsf18	tumor necrosis factor receptor superfamily, member 18	0.023
Il1rl1	interleukin 1 receptor-like 1	0.023
Ccl8	chemokine (C-C motif) ligand 8	0.023
Ubd	ubiquitin D	0.023
Vamp3	vesicle-associated membrane protein 3	0.023
Capza2	capping protein (actin filament) muscle Z-line, alpha 2	0.023
Kcns2	K+ voltage-gated channel, subfamily S, 2	0.023
H2-M3	histocompatibility 2, M region locus 3	0.022
Pon3	paraoxonase 3	0.022
Serpinb6b	serine (or cysteine) peptidase inhibitor, clade B, member 6b	0.022
Mcpt4	mast cell protease 4	0.022	Mouse
Gimap4	GTPase, IMAP family member 4	0.022
Gp1ba	glycoprotein 1b, alpha polypeptide	0.022
Cflar	CASP8 and FADD-like apoptosis regulator	0.021
Zap70	zeta-chain (TCR) associated protein kinase	0.021
Map3k5	mitogen-activated protein kinase kinase kinase 5	0.021
Cd8a	CD8 antigen, alpha chain	0.021
Scpep1	serine carboxypeptidase 1	0.021
Tor3a	torsin family 3, member A	0.021
Lag3	lymphocyte-activation gene 3	0.020
Pag1	phosphoprotein associated with glycosphingolipid microdomains 1	0.020
Ly6e	lymphocyte antigen 6 complex, locus E	0.020
Cd302	CD302 antigen	0.020
Trim30a	tripartite motif-containing 30A	0.020
Uts2r	urotensin 2 receptor	0.020
Tm4sf1	transmembrane 4 superfamily member 1	0.020
Mfsd1	major facilitator superfamily domain containing 1	0.019
Wipf1	WAS/WASL interacting protein family, member 1	0.019
Iigp1	interferon inducible GTPase 1	0.019
Apbh	androgen-binding protein eta	0.019
Ncr1	natural cytotoxicity triggering receptor 1	0.018
Sva	seminal vesicle antigen	0.018
Ctsz	cathepsin Z	0.018	Mouse
Elane	elastase, neutrophil expressed	0.018
Sprr2h	small proline-rich protein 2H	0.018
Olr1	oxidized low density lipoprotein (lectin-like) receptor 1	0.018
P2rx4	purinergic receptor P2X, ligand-gated ion channel 4	0.018	Mouse
H2-T10	histocompatibility 2, T region locus 10	0.018	Mouse
Chl1	cell adhesion molecule with homology to L1CAM	0.018
Gp5	glycoprotein 5 (platelet)	0.018
Mmp3	matrix metallopeptidase 3	0.018
Cd47	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	0.018
Serpina12	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12	0.018
Ephx1	epoxide hydrolase 1, microsomal	0.018
C920025E04Rik	RIKEN cDNA C920025E04 gene	0.017
Il3	interleukin 3	0.017
Rap1b	RAS related protein 1b	0.017
Dntt	deoxynucleotidyltransferase, terminal	0.017
Ifnar2	interferon (alpha and beta) receptor 2	0.017
Ctsc	cathepsin C	0.017
Mpo	myeloperoxidase	0.017
Rab32	RAB32, member RAS oncogene family	0.017
Itgax	integrin alpha X	0.017
Rab27b	RAB27b, member RAS oncogene family	0.017	Mouse
Fcna	ficolin A	0.017
Ccr4	chemokine (C-C motif) receptor 4	0.017
Ostf1	osteoclast stimulating factor 1	0.017
Mef2a	myocyte enhancer factor 2A	0.017
Klrb1a	killer cell lectin-like receptor subfamily B member 1A	0.016
Pqlc3	PQ loop repeat containing	0.016
Klre1	killer cell lectin-like receptor family E member 1	0.016
Klra7	killer cell lectin-like receptor, subfamily A, member 7	0.016
Ccr8	chemokine (C-C motif) receptor 8	0.016
Adcy7	adenylate cyclase 7	0.016
C3	complement component 3	0.016
Spry4	sprouty homolog 4 (Drosophila)	0.015
Siglec1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.015
Gzme	granzyme E	0.015	Mouse
Gdf15	growth differentiation factor 15	0.015
Nab1	Ngfi-A binding protein 1	0.015
Dpp7	dipeptidylpeptidase 7	0.015
Itgb3	integrin beta 3	0.015
Plac8	placenta-specific 8	0.014
Enpp1	ectonucleotide pyrophosphatase/phosphodiesterase 1	0.014
Ripk3	receptor-interacting serine-threonine kinase 3	0.014
Tgtp2	T-cell specific GTPase 2	0.014
Cysltr2	cysteinyl leukotriene receptor 2	0.014
Ikbkg	inhibitor of kappaB kinase gamma	0.014
Cd74	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)	0.014
Tspan31	tetraspanin 31	0.014
Cxcl9	chemokine (C-X-C motif) ligand 9	0.014
Cyp2e1	cytochrome P450, family 2, subfamily e, polypeptide 1	0.014
Slc7a11	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	0.014
Ceacam12	carcinoembryonic antigen-related cell adhesion molecule 12	0.014
Timp2	tissue inhibitor of metalloproteinase 2	0.014
Slfn1	schlafen 1	0.014
Asah1	N-acylsphingosine amidohydrolase 1	0.014
Ctsl	cathepsin L	0.014
2210415F13Rik	RIKEN cDNA 2210415F13 gene	0.014
Csn3	casein kappa	0.014
Tnfsf4	tumor necrosis factor (ligand) superfamily, member 4	0.013
Dynlt1b	dynein light chain Tctex-type 1D	0.013
Ctss	cathepsin S	0.013
Dnase1l1	deoxyribonuclease 1-like 1	0.013
Klrb1c	killer cell lectin-like receptor subfamily B member 1C	0.013
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.013
Ftl1	ferritin light chain 1	0.013
Lamp2	lysosomal-associated membrane protein 2	0.013
Aqp7	aquaporin 7	0.013
Hps1	Hermansky-Pudlak syndrome 1 homolog (human)	0.013
Fuca1	fucosidase, alpha-L- 1, tissue	0.013
Elk4	ELK4, member of ETS oncogene family	0.013
Cxcl10	chemokine (C-X-C motif) ligand 10	0.013
Klra9	killer cell lectin-like receptor subfamily A, member 9	0.013
Mc5r	melanocortin 5 receptor	0.013
H2-Q2	histocompatibility 2, Q region locus 2	0.012
Dnase1l3	deoxyribonuclease 1-like 3	0.012
Gbp1	guanylate binding protein 1	0.012
Ms4a4b	membrane-spanning 4-domains, subfamily A, member 4B	0.012
Prg2	proteoglycan 2, bone marrow	0.012
C1s	complement component 1, s subcomponent	0.012
Cd80	CD80 antigen	0.012
Serpinb9	serine (or cysteine) peptidase inhibitor, clade B, member 9	0.012
Cxcr3	chemokine (C-X-C motif) receptor 3	0.012
Acot10	acyl-CoA thioesterase 10	0.012
Sp100	nuclear antigen Sp100	0.012
Lgals9	lectin, galactose binding, soluble 9	0.012
Ccrl2	chemokine (C-C motif) receptor-like 2	0.012
Foxn1	forkhead box N1	0.012
Blk	B lymphoid kinase	0.012
Ifngr1	interferon gamma receptor 1	0.012
Entpd2	ectonucleoside triphosphate diphosphohydrolase 2	0.012
Ern1	endoplasmic reticulum (ER) to nucleus signalling 1	0.012
Scin	scinderin	0.012
Cyp4a14	cytochrome P450, family 4, subfamily a, polypeptide 14	0.012
Tnfrsf11b	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	0.012
Camp	cathelicidin antimicrobial peptide	0.012
Pnp	purine-nucleoside phosphorylase	0.012
Vti1b	vesicle transport through interaction with t-SNAREs 1B homolog	0.012
Degs2	degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase	0.011
Erap1	endoplasmic reticulum aminopeptidase 1	0.011
Fam83f	family with sequence similarity 83, member F	0.011
Ptgir	prostaglandin I receptor (IP)	0.011
Cxcr6	chemokine (C-X-C motif) receptor 6	0.011
Nrgn	neurogranin	0.011
H2-Bl	histocompatibility 2, blastocyst	0.011
Naglu	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	0.011
Anxa5	annexin A5	0.011
Edem1	ER degradation enhancer, mannosidase alpha-like 1	0.011
Emr1	EGF-like module containing, mucin-like, hormone receptor-like sequence 1	0.011
Tap2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.011
Mup4	major urinary protein 4	0.011
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.011
S100a3	S100 calcium binding protein A3	0.011
F2rl3	coagulation factor II (thrombin) receptor-like 3	0.011
Adam8	a disintegrin and metallopeptidase domain 8	0.011
Try5	trypsin 5	0.011
Anxa1	annexin A1	0.011
Ms4a4c	membrane-spanning 4-domains, subfamily A, member 4C	0.011
Ly96	lymphocyte antigen 96	0.011
Xcr1	chemokine (C motif) receptor 1	0.011
Calcoco2	calcium binding and coiled-coil domain 2	0.011
Cd3e	CD3 antigen, epsilon polypeptide	0.011
Ptprn	protein tyrosine phosphatase, receptor type, N	0.011
Prkacb	protein kinase, cAMP dependent, catalytic, beta	0.011
Ctsg	cathepsin G	0.011	Mouse
Slamf8	SLAM family member 8	0.011
Sult1c1	sulfotransferase family, cytosolic, 1C, member 1	0.011
Ifi27l1	interferon, alpha-inducible protein 27 like 1	0.011
Dcn	decorin	0.011
Irgm2	immunity-related GTPase family M member 2	0.011
Tmem173	transmembrane protein 173	0.010
Baat	bile acid-Coenzyme A: amino acid N-acyltransferase	0.010
Hgf	hepatocyte growth factor	0.010
Igtp	interferon gamma induced GTPase	0.010
St8sia4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	0.010
Cd86	CD86 antigen	0.010
Cd160	CD160 antigen	0.010
Ocln	occludin	0.010
Hebp1	heme binding protein 1	0.010
Anxa3	annexin A3	0.010
Kdelr3	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3	0.010
Celf2	CUGBP, Elav-like family member 2	0.010
Rhoh	ras homolog gene family, member H	0.010
Gstt1	glutathione S-transferase, theta 1	0.010
Ap3b1	adaptor-related protein complex 3, beta 1 subunit	0.010
Renbp	renin binding protein	0.010