The network for 'antigen receptor mediated signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

antigen receptor mediated signaling pathway

A series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell.

Homo sapiens
Name Description Probability Func Analog Organism
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 1.000
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.999
LCK lymphocyte-specific protein tyrosine kinase 0.998
LAT linker for activation of T cells 0.998
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.997
GRB2 growth factor receptor-bound protein 2 0.996
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 0.995
EGFR epidermal growth factor receptor 0.993
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.991
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.990
FYN FYN oncogene related to SRC, FGR, YES 0.984
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.973
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.972
PTK2 PTK2 protein tyrosine kinase 2 0.964
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.962
SYK spleen tyrosine kinase 0.948
VAV1 vav 1 guanine nucleotide exchange factor 0.933
BCL2L1 BCL2-like 1 0.911
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.881
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.880
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.850
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.831
PLCG1 phospholipase C, gamma 1 0.805
BTN3A2 butyrophilin, subfamily 3, member A2 0.783
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.763
GRAP2 GRB2-related adaptor protein 2 0.751
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.747
PTPRC protein tyrosine phosphatase, receptor type, C 0.743
WIPF1 WAS/WASL interacting protein family, member 1 0.724
SH2D1A SH2 domain containing 1A 0.722
FYB FYN binding protein 0.709
TRAF3 TNF receptor-associated factor 3 0.689
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.676
BIRC3 baculoviral IAP repeat containing 3 0.608
BCL2 B-cell CLL/lymphoma 2 0.591
CD80 CD80 molecule 0.580
BLNK B-cell linker 0.577
CD247 CD247 molecule 0.529
CD79A CD79a molecule, immunoglobulin-associated alpha 0.522
PSEN1 presenilin 1 0.520
BTN3A3 butyrophilin, subfamily 3, member A3 0.520
ABI1 abl-interactor 1 0.511
BAX BCL2-associated X protein 0.509
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.504
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.486
SPRR2A small proline-rich protein 2A 0.451
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.434
MPDZ multiple PDZ domain protein 0.421
PRKCQ protein kinase C, theta 0.418
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.416
CARD11 caspase recruitment domain family, member 11 0.380
SOS1 son of sevenless homolog 1 (Drosophila) 0.371
GHR growth hormone receptor 0.368
TRAF1 TNF receptor-associated factor 1 0.349
SQSTM1 sequestosome 1 0.345
TRAF6 TNF receptor-associated factor 6 0.336
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.329
TFF1 trefoil factor 1 0.323
CD40 CD40 molecule, TNF receptor superfamily member 5 0.281
NCK1 NCK adaptor protein 1 0.281
BTN3A1 butyrophilin, subfamily 3, member A1 0.280
RNF31 ring finger protein 31 0.278
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.263
BCAR1 breast cancer anti-estrogen resistance 1 0.259
SH3KBP1 SH3-domain kinase binding protein 1 0.252
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.243
GAB1 GRB2-associated binding protein 1 0.216
HDAC7 histone deacetylase 7 0.189
SH3BP2 SH3-domain binding protein 2 0.169
ADAM15 ADAM metallopeptidase domain 15 0.168
MAPK1 mitogen-activated protein kinase 1 0.167
PTK2B PTK2B protein tyrosine kinase 2 beta 0.166
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.161
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.152
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.142
VAV2 vav 2 guanine nucleotide exchange factor 0.141
HDAC9 histone deacetylase 9 0.131
TRIP6 thyroid hormone receptor interactor 6 0.127
SLA Src-like-adaptor 0.126
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.123
STRADA STE20-related kinase adaptor alpha 0.121
GAS7 growth arrest-specific 7 0.120
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 0.119
GRB10 growth factor receptor-bound protein 10 0.116
CD79B CD79b molecule, immunoglobulin-associated beta 0.113
TRIM32 tripartite motif containing 32 0.110
SH2D2A SH2 domain containing 2A 0.106
BID BH3 interacting domain death agonist 0.104
BCL10 B-cell CLL/lymphoma 10 0.104
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.101
NCK2 NCK adaptor protein 2 0.100
MAPK3 mitogen-activated protein kinase 3 0.098
NCF1 neutrophil cytosolic factor 1 0.097
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.096
CTNND1 catenin (cadherin-associated protein), delta 1 0.092
CD22 CD22 molecule 0.090
SFN stratifin 0.090
TRAF5 TNF receptor-associated factor 5 0.089
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.088
FHL2 four and a half LIM domains 2 0.085
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Lat linker for activation of T cells 0.999
Fyn Fyn proto-oncogene 0.998
Ikzf1 IKAROS family zinc finger 1 0.994
Inpp5d inositol polyphosphate-5-phosphatase D 0.991
Ptprc protein tyrosine phosphatase, receptor type, C 0.984
Lck lymphocyte protein tyrosine kinase 0.983
Traf6 TNF receptor-associated factor 6 0.980
Cd19 CD19 antigen 0.974
Itk IL2-inducible T-cell kinase 0.973
Igh immunoglobulin heavy chain complex 0.962
Cd247 CD247 antigen 0.961
Gata4 GATA binding protein 4 0.955
Cd6 CD6 antigen 0.942
Icos inducible T-cell co-stimulator 0.942
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.940
Ptk2 PTK2 protein tyrosine kinase 2 0.931
Cbl Casitas B-lineage lymphoma 0.929
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.929
Ltb lymphotoxin B 0.928
Il2rg interleukin 2 receptor, gamma chain 0.927
Cd28 CD28 antigen 0.919
Il2rb interleukin 2 receptor, beta chain 0.918
Zap70 zeta-chain (TCR) associated protein kinase 0.915
Vav1 vav 1 oncogene 0.889
Cd5 CD5 antigen 0.880
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.863
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.860
Slamf1 signaling lymphocytic activation molecule family member 1 0.854
Grb2 growth factor receptor bound protein 2 0.853
Foxp3 forkhead box P3 0.840
Was Wiskott-Aldrich syndrome homolog (human) 0.811
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.800
Il27ra interleukin 27 receptor, alpha 0.796
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.784
Fas Fas (TNF receptor superfamily member 6) 0.780
Socs1 suppressor of cytokine signaling 1 0.765
Cd3e CD3 antigen, epsilon polypeptide 0.763
Bcl2 B-cell leukemia/lymphoma 2 0.745
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.736
Fasl Fas ligand (TNF superfamily, member 6) 0.732
Cd40 CD40 antigen 0.729
Itgal integrin alpha L 0.723
Tcra T-cell receptor alpha chain 0.713
Gimap7 GTPase, IMAP family member 7 0.712
Cd7 CD7 antigen 0.694
Prdm1 PR domain containing 1, with ZNF domain 0.688
Runx1 runt related transcription factor 1 0.682
Slamf6 SLAM family member 6 0.675
Fcrla Fc receptor-like A 0.655
Cd4 CD4 antigen 0.651
Ikzf3 IKAROS family zinc finger 3 0.649
Stat3 signal transducer and activator of transcription 3 0.626
Rhoh ras homolog gene family, member H 0.626
Sell selectin, lymphocyte 0.623
Grap2 GRB2-related adaptor protein 2 0.621
Rxra retinoid X receptor alpha 0.621
Dok1 docking protein 1 0.612
Src Rous sarcoma oncogene 0.607
Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 0.605
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.604
Cd3g CD3 antigen, gamma polypeptide 0.596
Cd22 CD22 antigen 0.594
Btk Bruton agammaglobulinemia tyrosine kinase 0.593
Il10ra interleukin 10 receptor, alpha 0.582
Card11 caspase recruitment domain family, member 11 0.570
Cd27 CD27 antigen 0.562
Cd3d CD3 antigen, delta polypeptide 0.554
Cd2 CD2 antigen 0.540
Nfatc1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.537
Fcgr2b Fc receptor, IgG, low affinity IIb 0.532
Cd44 CD44 antigen 0.531
Tnfrsf13c tumor necrosis factor receptor superfamily, member 13c 0.522
Tnfrsf13b tumor necrosis factor receptor superfamily, member 13b 0.521
Cd96 CD96 antigen 0.519
Tnf tumor necrosis factor 0.506
Casp8 caspase 8 0.489
Il7r interleukin 7 receptor 0.477
Il21r interleukin 21 receptor 0.476
Rc3h1 RING CCCH (C3H) domains 1 0.474
Sit1 suppression inducing transmembrane adaptor 1 0.472
Ccr6 chemokine (C-C motif) receptor 6 0.472
Prkce protein kinase C, epsilon 0.471
Batf basic leucine zipper transcription factor, ATF-like 0.470
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.466
Lyl1 lymphoblastomic leukemia 1 0.462
Cd8a CD8 antigen, alpha chain 0.460
S1pr4 sphingosine-1-phosphate receptor 4 0.453
Sh2d2a SH2 domain protein 2A 0.451
Jak2 Janus kinase 2 0.447
Tgfb1 transforming growth factor, beta 1 0.442
Ccr1 chemokine (C-C motif) receptor 1 0.438
Sh2d1a SH2 domain protein 1A 0.432
Pou2af1 POU domain, class 2, associating factor 1 0.429
Cd80 CD80 antigen 0.423
Pten phosphatase and tensin homolog 0.408
Cd180 CD180 antigen 0.404
Ccl2 chemokine (C-C motif) ligand 2 0.401
Cd8b1 CD8 antigen, beta chain 1 0.394
Flt1 FMS-like tyrosine kinase 1 0.381
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.378
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ptpn18 protein tyrosine phosphatase, non-receptor type 18 0.463
Lcp2 lymphocyte cytosolic protein 2 0.363
Klhl6 kelch-like 6 (Drosophila) 0.310
Stk10 serine/threonine kinase 10 0.138
Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.133
Cd247 Cd247 molecule 0.132
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.127
Cd3g CD3 molecule, gamma 0.109
Vav1 vav 1 guanine nucleotide exchange factor 0.098
Il2rg interleukin 2 receptor, gamma 0.098
Cd37 CD37 molecule 0.097
Stap1 signal transducing adaptor family member 1 0.093
Icos inducible T-cell co-stimulator 0.092
Arhgap25 Rho GTPase activating protein 25 0.084
Sash3 SAM and SH3 domain containing 3 0.083
Arhgap4 Rho GTPase activating protein 4 0.070
Limd2 LIM domain containing 2 0.060
Inpp5d inositol polyphosphate-5-phosphatase D 0.058
Cd83 CD83 molecule 0.057
Sept6 septin 6 0.054
LOC100364854 similar to RIKEN cDNA A430107P09 gene-like 0.053
Ctse cathepsin E 0.052
Ncf4 neutrophil cytosolic factor 4 0.050
Bin2 bridging integrator 2 0.050
Casp1 caspase 1 0.049
Sirpa signal-regulatory protein alpha 0.049
Lck lymphocyte-specific protein tyrosine kinase 0.048
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.048
Map3k3 mitogen activated protein kinase kinase kinase 3 0.046
Elk3 ELK3, ETS-domain protein 0.046
Cd86 CD86 molecule 0.045
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.042
Coro1b coronin, actin-binding protein, 1B 0.042
Csk c-src tyrosine kinase 0.042
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.041
Fam26f family with sequence similarity 26, member F 0.041
Cd8a CD8a molecule 0.041
Rac1 ras-related C3 botulinum toxin substrate 1 0.041
Btk Bruton agammaglobulinemia tyrosine kinase 0.041
Gimap4 GTPase, IMAP family member 4 0.040
Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.040
Cybb cytochrome b-245, beta polypeptide 0.040
Gata2 GATA binding protein 2 0.038
Igh-6 immunoglobulin heavy chain 6 0.038
Ptafr platelet-activating factor receptor 0.038
Cybasc3 cytochrome b, ascorbate dependent 3 0.036
Gmfg glia maturation factor, gamma 0.036
Dock8 dedicator of cytokinesis 8 0.035
Tcrb T-cell receptor beta chain 0.035
Cd2 Cd2 molecule 0.034
Mov10 Moloney leukemia virus 10 0.034
Fyn FYN oncogene related to SRC, FGR, YES 0.034
Cfp complement factor properdin 0.034
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.033
Gpsm3 G-protein signaling modulator 3 (AGS3-like, C. elegans) 0.032
Tle4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) 0.032
Il16 interleukin 16 0.032
Cr2 complement receptor 2 0.032
Vegfa vascular endothelial growth factor A 0.032
Pctp phosphatidylcholine transfer protein 0.032
RGD1560108 similar to RIKEN cDNA 2700081O15 0.032
Cxcr3 chemokine (C-X-C motif) receptor 3 0.032
Nrg2 neuregulin 2 0.031
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 0.031
Ptpn7 protein tyrosine phosphatase, non-receptor type 7 0.031
Aif1 allograft inflammatory factor 1 0.030
Arrb2 arrestin, beta 2 0.030
Stk4 serine/threonine kinase 4 0.029
Plcg2 phospholipase C, gamma 2 0.029
Dgka diacylglycerol kinase, alpha 0.029
Evi2a ecotropic viral integration site 2A 0.028
Tpm3 tropomyosin 3, gamma 0.028
Traf3ip3 TRAF3 interacting protein 3 0.028
Cdc2l6 cell division cycle 2-like 6 (CDK8-like) 0.027
Sdc3 syndecan 3 0.027
Cxcr4 chemokine (C-X-C motif) receptor 4 0.027
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.027
Prkcd protein kinase C, delta 0.027
LOC308990 hypothetical protein LOC308990 0.027
Trafd1 TRAF type zinc finger domain containing 1 0.027
Myo1b myosin Ib 0.027
Rnasel ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 0.027
Il2rb interleukin 2 receptor, beta 0.026
Il18r1 interleukin 18 receptor 1 0.026
Elf1 E74-like factor 1 0.026
Stat4 signal transducer and activator of transcription 4 0.026
Tor1aip1 torsin A interacting protein 1 0.026
Fam113b family with sequence similarity 113, member B 0.025
Ly86 lymphocyte antigen 86 0.025
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.025
Psd4 pleckstrin and Sec7 domain containing 4 0.025
Cd8b CD8b molecule 0.025
Smad7 SMAD family member 7 0.025
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.025
Figf c-fos induced growth factor 0.024
Dusp2 dual specificity phosphatase 2 0.024
Otud5 OTU domain containing 5 0.024
RT1-M3-1 RT1 class Ib, locus M3, gene 1 0.024
Cyb5r1 cytochrome b5 reductase 1 0.024
Zbp1 Z-DNA binding protein 1 0.023
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism