The network for 'dna damage response signal transduction by p53 class mediator' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

dna damage response signal transduction by p53 class mediator

A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.

Homo sapiens
Name Description Probability Func Analog Organism
BRCA1 breast cancer 1, early onset 1.000
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.983
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.977
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.977
ATM ataxia telangiectasia mutated 0.976
TP53 tumor protein p53 0.951
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.940
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.923
CREBBP CREB binding protein 0.910
NBN nibrin 0.904
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.900
XIAP X-linked inhibitor of apoptosis 0.899
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.838
BCL2 B-cell CLL/lymphoma 2 0.780
MAPK1 mitogen-activated protein kinase 1 0.774
E2F7 E2F transcription factor 7 0.766
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.738
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.727
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.712
E2F8 E2F transcription factor 8 0.689
PML promyelocytic leukemia 0.683
CDK2 cyclin-dependent kinase 2 0.671
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.666
FAS Fas (TNF receptor superfamily, member 6) 0.585
H2AFX H2A histone family, member X 0.581
MAPK8 mitogen-activated protein kinase 8 0.572
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.552
EP300 E1A binding protein p300 0.549
MDC1 mediator of DNA-damage checkpoint 1 0.535
BCAS2 breast carcinoma amplified sequence 2 0.522
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.494
MAPK14 mitogen-activated protein kinase 14 0.471
FANCD2 Fanconi anemia, complementation group D2 0.463
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.458
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.407
TWIST1 twist homolog 1 (Drosophila) 0.393
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.387
IER3 immediate early response 3 0.384
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 0.382
GSK3B glycogen synthase kinase 3 beta 0.378
OTUB1 OTU domain, ubiquitin aldehyde binding 1 0.358
CCNE1 cyclin E1 0.354
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.344
HIPK2 homeodomain interacting protein kinase 2 0.341
APAF1 apoptotic peptidase activating factor 1 0.339
DAXX death-domain associated protein 0.320
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.313
CCND3 cyclin D3 0.311
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.282
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.280
NCOA3 nuclear receptor coactivator 3 0.271
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.270
SETD8 SET domain containing (lysine methyltransferase) 8 0.262
CDC5L CDC5 cell division cycle 5-like (S. pombe) 0.258
TP53BP1 tumor protein p53 binding protein 1 0.252
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 0.249
RAD50 RAD50 homolog (S. cerevisiae) 0.248
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.242
TNIP2 TNFAIP3 interacting protein 2 0.240
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.239
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.238
DDAH2 dimethylarginine dimethylaminohydrolase 2 0.234
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.212
RAD18 RAD18 homolog (S. cerevisiae) 0.211
PARP1 poly (ADP-ribose) polymerase 1 0.208
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.207
SP110 SP110 nuclear body protein 0.205
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.198
MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.188
IFI16 interferon, gamma-inducible protein 16 0.185
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.181
HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog 0.173
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 0.172
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.172
HDAC1 histone deacetylase 1 0.167
SETD7 SET domain containing (lysine methyltransferase) 7 0.165
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.163
MAPK3 mitogen-activated protein kinase 3 0.159
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.158
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.154
LRDD leucine-rich repeats and death domain containing 0.146
CFLAR CASP8 and FADD-like apoptosis regulator 0.144
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.143
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.132
PLK1 polo-like kinase 1 0.132
HIC2 hypermethylated in cancer 2 0.131
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.125
CDC25A cell division cycle 25 homolog A (S. pombe) 0.121
EGFR epidermal growth factor receptor 0.119
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.118
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.115
RB1 retinoblastoma 1 0.114
SP100 SP100 nuclear antigen 0.114
RUNX1 runt-related transcription factor 1 0.113
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.107
RIPK2 receptor-interacting serine-threonine kinase 2 0.105
TP53BP2 tumor protein p53 binding protein, 2 0.103
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 0.099
PRKCA protein kinase C, alpha 0.097
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.097
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
gsc goosecoid 0.027
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Drosophila melanogaster
Name Description Probability Func Analog Organism
p53 CG33336 gene product from transcript CG33336-RB 0.013
CtBP C-terminal Binding Protein 0.012
Gap1 GTPase-activating protein 1 0.011
imd immune deficiency 0.011
pan pangolin 0.011
Sir2 CG5216 gene product from transcript CG5216-RA 0.011
Liprin-alpha CG11199 gene product from transcript CG11199-RB 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 1.000
Mdm2 transformed mouse 3T3 cell double minute 2 0.996
Pten phosphatase and tensin homolog 0.976
Rb1 retinoblastoma 1 0.955
Brca1 breast cancer 1 0.896
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.883
Apc adenomatosis polyposis coli 0.698
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.688
Kit kit oncogene 0.525
Tgfb1 transforming growth factor, beta 1 0.523
Mdm4 transformed mouse 3T3 cell double minute 4 0.456
Skil SKI-like 0.401
Ctnnb1 catenin (cadherin associated protein), beta 1 0.329
Atm ataxia telangiectasia mutated homolog (human) 0.251
Nbn nibrin 0.246
Thbs1 thrombospondin 1 0.209
Hprt hypoxanthine guanine phosphoribosyl transferase 0.192
Brca2 breast cancer 2 0.167
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.162
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.156
Kitl kit ligand 0.150
Braf Braf transforming gene 0.141
Smc1a structural maintenance of chromosomes 1A 0.135
Arid1b AT rich interactive domain 1B (SWI-like) 0.133
Ep300 E1A binding protein p300 0.120
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.111
H2-Aa histocompatibility 2, class II antigen A, alpha 0.092
Smad3 MAD homolog 3 (Drosophila) 0.088
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.088
2500003M10Rik RIKEN cDNA 2500003M10 gene 0.083
Cyld cylindromatosis (turban tumor syndrome) 0.082
Hif1a hypoxia inducible factor 1, alpha subunit 0.080
H2-Eb1 histocompatibility 2, class II antigen E beta 0.080
Daxx Fas death domain-associated protein 0.080
Mecp2 methyl CpG binding protein 2 0.078
Ccnd1 cyclin D1 0.076
E2f1 E2F transcription factor 1 0.071
En1 engrailed 1 0.069
Snai1 snail homolog 1 (Drosophila) 0.069
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.067
Stat3 signal transducer and activator of transcription 3 0.066
Meox2 mesenchyme homeobox 2 0.063
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.063
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.062
Mcl1 myeloid cell leukemia sequence 1 0.061
Evl Ena-vasodilator stimulated phosphoprotein 0.061
Enah enabled homolog (Drosophila) 0.060
Icam1 intercellular adhesion molecule 1 0.060
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.059
Smad4 MAD homolog 4 (Drosophila) 0.058
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.055
Socs1 suppressor of cytokine signaling 1 0.053
Cdk4 cyclin-dependent kinase 4 0.051
Msh2 mutS homolog 2 (E. coli) 0.051
Ar androgen receptor 0.051
Ets1 E26 avian leukemia oncogene 1, 5' domain 0.050
Myc myelocytomatosis oncogene 0.049
Irf4 interferon regulatory factor 4 0.047
Gtse1 G two S phase expressed protein 1 0.047
Gli3 GLI-Kruppel family member GLI3 0.047
Kdm2b lysine (K)-specific demethylase 2B 0.046
Ptch1 patched homolog 1 0.046
Mybl2 myeloblastosis oncogene-like 2 0.045
Notch1 Notch gene homolog 1 (Drosophila) 0.045
Rbl1 retinoblastoma-like 1 (p107) 0.044
Jak3 Janus kinase 3 0.044
Prkar1a protein kinase, cAMP dependent regulatory, type I, alpha 0.043
H2-DMa histocompatibility 2, class II, locus DMa 0.043
Foxo3 forkhead box O3 0.041
Runx1 runt related transcription factor 1 0.041
Mmp9 matrix metallopeptidase 9 0.040
Dok1 docking protein 1 0.038
Ccl2 chemokine (C-C motif) ligand 2 0.038
Kif19a kinesin family member 19A 0.037
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.036
Rnf38 ring finger protein 38 0.035
Polr2a polymerase (RNA) II (DNA directed) polypeptide A 0.035
Smad2 MAD homolog 2 (Drosophila) 0.035
Tnf tumor necrosis factor 0.035
Nf1 neurofibromatosis 1 0.034
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.033
Tsc1 tuberous sclerosis 1 0.033
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.033
Ep400 E1A binding protein p400 0.032
S1pr2 sphingosine-1-phosphate receptor 2 0.032
Tcf7l2 transcription factor 7-like 2, T-cell specific, HMG-box 0.031
Chst8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 0.030
Smn1 survival motor neuron 1 0.030
Wdr77 WD repeat domain 77 0.030
Smc3 structural maintenace of chromosomes 3 0.030
Smarcd1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.030
Arid1a AT rich interactive domain 1A (SWI-like) 0.030
Abl2 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) 0.030
Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.030
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.030
Ythdf1 YTH domain family 1 0.029
Irf1 interferon regulatory factor 1 0.029
Vhl von Hippel-Lindau tumor suppressor 0.029
Stk11 serine/threonine kinase 11 0.029
Mapk8 mitogen-activated protein kinase 8 0.028
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism