The network for 'negative regulation of peptidyl tyrosine phosphorylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of peptidyl tyrosine phosphorylation

Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.

Homo sapiens
Name Description Probability Func Analog Organism
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 1.000
PTPN1 protein tyrosine phosphatase, non-receptor type 1 1.000
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 1.000
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.999
GRB2 growth factor receptor-bound protein 2 0.999
LCK lymphocyte-specific protein tyrosine kinase 0.998
EGFR epidermal growth factor receptor 0.986
BTK Bruton agammaglobulinemia tyrosine kinase 0.983
GHR growth hormone receptor 0.933
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.922
FYN FYN oncogene related to SRC, FGR, YES 0.900
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.889
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.860
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.819
PLCG1 phospholipase C, gamma 1 0.730
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.708
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.582
SYK spleen tyrosine kinase 0.557
BCAR1 breast cancer anti-estrogen resistance 1 0.541
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.499
SFN stratifin 0.434
NCK1 NCK adaptor protein 1 0.421
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.387
VAV1 vav 1 guanine nucleotide exchange factor 0.350
PRKCZ protein kinase C, zeta 0.308
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.300
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 0.277
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.267
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.257
SH2D1A SH2 domain containing 1A 0.236
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.217
SPRR2A small proline-rich protein 2A 0.215
MUC1 mucin 1, cell surface associated 0.209
NCF1 neutrophil cytosolic factor 1 0.208
PSEN1 presenilin 1 0.202
EZR ezrin 0.202
ZNF496 zinc finger protein 496 0.192
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.188
SOCS1 suppressor of cytokine signaling 1 0.173
SLAMF1 signaling lymphocytic activation molecule family member 1 0.162
BLNK B-cell linker 0.160
PRKCB protein kinase C, beta 0.154
CD44 CD44 molecule (Indian blood group) 0.152
NOXA1 NADPH oxidase activator 1 0.151
ITK IL2-inducible T-cell kinase 0.147
IRS1 insulin receptor substrate 1 0.144
EPOR erythropoietin receptor 0.141
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.140
LAT linker for activation of T cells 0.137
PDCD6IP programmed cell death 6 interacting protein 0.137
GRB7 growth factor receptor-bound protein 7 0.130
TFF1 trefoil factor 1 0.128
SH2D3A SH2 domain containing 3A 0.117
JAK2 Janus kinase 2 0.115
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 0.115
MET met proto-oncogene (hepatocyte growth factor receptor) 0.096
SOCS2 suppressor of cytokine signaling 2 0.092
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.086
PROX1 prospero homeobox 1 0.080
SCHIP1 schwannomin interacting protein 1 0.078
MED28 mediator complex subunit 28 0.078
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.078
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.074
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.070
PTPRB protein tyrosine phosphatase, receptor type, B 0.069
PTEN phosphatase and tensin homolog 0.066
GAB1 GRB2-associated binding protein 1 0.064
PTK2B PTK2B protein tyrosine kinase 2 beta 0.063
PSEN2 presenilin 2 (Alzheimer disease 4) 0.062
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.060
UBASH3B ubiquitin associated and SH3 domain containing B 0.059
CUL2 cullin 2 0.059
PTK2 PTK2 protein tyrosine kinase 2 0.058
ADAM15 ADAM metallopeptidase domain 15 0.057
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.055
SH3KBP1 SH3-domain kinase binding protein 1 0.053
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.053
FLNA filamin A, alpha 0.051
CD84 CD84 molecule 0.046
NCF4 neutrophil cytosolic factor 4, 40kDa 0.045
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.042
TBC1D10A TBC1 domain family, member 10A 0.042
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.041
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.039
TNS4 tensin 4 0.037
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.037
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 0.037
VHL von Hippel-Lindau tumor suppressor 0.037
NCSTN nicastrin 0.036
NRG1 neuregulin 1 0.036
SORBS3 sorbin and SH3 domain containing 3 0.036
PRKCA protein kinase C, alpha 0.035
SH3BP2 SH3-domain binding protein 2 0.035
CD2AP CD2-associated protein 0.035
VAV2 vav 2 guanine nucleotide exchange factor 0.033
CDCP1 CUB domain containing protein 1 0.033
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.032
FLNB filamin B, beta 0.032
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.031
CAV2 caveolin 2 0.030
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
ash2 absent, small, or homeotic discs 2 0.706
krz kurtz 0.321
cv-2 crossveinless 2 0.206
CG32372 CG32372 gene product from transcript CG32372-RA 0.150
sima similar 0.148
defl deflated 0.143
aux auxillin 0.106
rl rolled 0.100
Pp2B-14D Protein phosphatase 2B at 14D 0.094
Exp6 Exportin 6 0.091
Shc SHC-adaptor protein 0.078
Dab Disabled 0.074
CSN4 COP9 complex homolog subunit 4 0.071
unk unkempt 0.061
drk downstream of receptor kinase 0.057
Sara Smad anchor for receptor activation 0.056
Zyx102EF CG32018 gene product from transcript CG32018-RA 0.051
sog short gastrulation 0.048
Bsg25D Blastoderm-specific gene 25D 0.043
Arr2 Arrestin 2 0.035
Hip14 Huntingtin-interacting protein 14 0.035
mth methuselah 0.034
Tm1 Tropomyosin 1 0.031
bmm brummer 0.028
CG12734 CG12734 gene product from transcript CG12734-RA 0.027
Snoo Sno oncogene 0.027
Mkp3 Mitogen-activated protein kinase phosphatase 3 0.026
smo smoothened 0.026
CG5794 CG5794 gene product from transcript CG5794-RB 0.026
Socs36E Suppressor of cytokine signaling at 36E 0.026
chp chaoptic 0.026
PTP-ER Protein tyrosine phosphatase-ERK/Enhancer of Ras1 0.025
trio CG18214 gene product from transcript CG18214-RA 0.024
Gga CG3002 gene product from transcript CG3002-RB 0.023
Mnn1 Menin 1 0.021
Ubqn Ubiquilin 0.020
mirr mirror 0.020
Sulf1 Sulfated 0.020
C3G CG42328 gene product from transcript CG42328-RC 0.020
A2bp1 Ataxin-2 binding protein 1 0.020
Upf2 CG2253 gene product from transcript CG2253-RA 0.019
boss bride of sevenless 0.019
nudE CG8104 gene product from transcript CG8104-RB 0.018
CG3194 CG3194 gene product from transcript CG3194-RB 0.018
RpL3 Ribosomal protein L3 0.018
ninaB neither inactivation nor afterpotential B 0.017
trpml transient receptor potential mucolipin 0.016
Ras64B Ras oncogene at 64B 0.016
CG17568 CG17568 gene product from transcript CG17568-RA 0.016
Top3alpha Topoisomerase 3alpha 0.016
hppy happyhour 0.016
Tao-1 CG14217 gene product from transcript CG14217-RF 0.015
l(2)35Bd lethal (2) 35Bd 0.015
L Lobe 0.015
ninaE neither inactivation nor afterpotential E 0.015
svr silver 0.015
Tip60 CG6121 gene product from transcript CG6121-RA 0.014
cln3 CG5582 gene product from transcript CG5582-RA 0.014
EDTP Egg-derived tyrosine phosphatase 0.014
CG1021 CG1021 gene product from transcript CG1021-RE 0.014
Rh6 Rhodopsin 6 0.013
rdgB retinal degeneration B 0.013
oys oysgedart 0.013
sop string of pearls 0.013
cdi center divider 0.012
l(3)L1231 lethal (3) L1231 0.012
CG13830 CG13830 gene product from transcript CG13830-RD 0.012
CG14614 CG14614 gene product from transcript CG14614-RA 0.012
26-29-p 26-29kD-proteinase 0.011
tsg twisted gastrulation 0.011
Pat1 Protein interacting with APP tail-1 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Grb2 growth factor receptor bound protein 2 0.999
Lepr leptin receptor 0.997
Fyn Fyn proto-oncogene 0.996
Egfr epidermal growth factor receptor 0.994
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.982
Slamf1 signaling lymphocytic activation molecule family member 1 0.978
Cd28 CD28 antigen 0.957
Jak2 Janus kinase 2 0.953
Cbl Casitas B-lineage lymphoma 0.936
Arrb2 arrestin, beta 2 0.924
Psen1 presenilin 1 0.923
Notch1 Notch gene homolog 1 (Drosophila) 0.906
Shc1 src homology 2 domain-containing transforming protein C1 0.892
Gab2 growth factor receptor bound protein 2-associated protein 2 0.761
Vhl von Hippel-Lindau tumor suppressor 0.759
Ctnnb1 catenin (cadherin associated protein), beta 1 0.739
Sfrp2 secreted frizzled-related protein 2 0.738
Stat3 signal transducer and activator of transcription 3 0.719
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.711
Arrb1 arrestin, beta 1 0.707
Sfrp1 secreted frizzled-related protein 1 0.608
Src Rous sarcoma oncogene 0.597
Cish cytokine inducible SH2-containing protein 0.590
Vav1 vav 1 oncogene 0.579
Notch2 Notch gene homolog 2 (Drosophila) 0.554
Ncstn nicastrin 0.444
Pparg peroxisome proliferator activated receptor gamma 0.433
Gsk3b glycogen synthase kinase 3 beta 0.417
Frs2 fibroblast growth factor receptor substrate 2 0.393
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.385
Dlg4 discs, large homolog 4 (Drosophila) 0.364
Bcl2 B-cell leukemia/lymphoma 2 0.363
Ncoa3 nuclear receptor coactivator 3 0.362
Plcg1 phospholipase C, gamma 1 0.360
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.349
Socs3 suppressor of cytokine signaling 3 0.349
Nf1 neurofibromatosis 1 0.340
Hif1a hypoxia inducible factor 1, alpha subunit 0.339
Ldb3 LIM domain binding 3 0.323
Sos1 son of sevenless homolog 1 (Drosophila) 0.280
Ptk2 PTK2 protein tyrosine kinase 2 0.246
Vangl2 vang-like 2 (van gogh, Drosophila) 0.238
Blnk B-cell linker 0.227
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.189
Nsf N-ethylmaleimide sensitive fusion protein 0.188
Fyb FYN binding protein 0.184
Vegfa vascular endothelial growth factor A 0.182
Vav2 vav 2 oncogene 0.182
Socs2 suppressor of cytokine signaling 2 0.171
Apc adenomatosis polyposis coli 0.162
Lck lymphocyte protein tyrosine kinase 0.153
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.152
Lmna lamin A 0.148
Cav1 caveolin 1, caveolae protein 0.139
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.135
Inpp5d inositol polyphosphate-5-phosphatase D 0.127
Insr insulin receptor 0.125
Foxo1 forkhead box O1 0.124
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.123
Ptrf polymerase I and transcript release factor 0.122
Ptpra protein tyrosine phosphatase, receptor type, A 0.120
Kit kit oncogene 0.117
Foxa2 forkhead box A2 0.115
Map4k1 mitogen-activated protein kinase kinase kinase kinase 1 0.111
Il1r1 interleukin 1 receptor, type I 0.110
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.102
Itk IL2-inducible T-cell kinase 0.098
Pxn paxillin 0.098
Sh3kbp1 SH3-domain kinase binding protein 1 0.096
Myd88 myeloid differentiation primary response gene 88 0.094
Cd84 CD84 antigen 0.094
Prkce protein kinase C, epsilon 0.091
Plxna4 plexin A4 0.089
Adam17 a disintegrin and metallopeptidase domain 17 0.088
Dnm1l dynamin 1-like 0.086
Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 0.084
Dll1 delta-like 1 (Drosophila) 0.082
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.080
Prkcd protein kinase C, delta 0.078
Arhgef7 Rho guanine nucleotide exchange factor (GEF7) 0.078
Flii flightless I homolog (Drosophila) 0.078
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.076
Mgat3 mannoside acetylglucosaminyltransferase 3 0.073
Jak1 Janus kinase 1 0.069
Bmpr2 bone morphogenic protein receptor, type II (serine/threonine kinase) 0.069
Ptpre protein tyrosine phosphatase, receptor type, E 0.068
Pten phosphatase and tensin homolog 0.067
Prkcb protein kinase C, beta 0.062
Ptpn1 protein tyrosine phosphatase, non-receptor type 1 0.062
Tnfrsf13b tumor necrosis factor receptor superfamily, member 13b 0.061
Stat5a signal transducer and activator of transcription 5A 0.059
Tnip1 TNFAIP3 interacting protein 1 0.058
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.058
Rps3 ribosomal protein S3 0.057
Ptk2b PTK2 protein tyrosine kinase 2 beta 0.057
Cul5 cullin 5 0.057
Gab1 growth factor receptor bound protein 2-associated protein 1 0.056
Vav3 vav 3 oncogene 0.056
Gna11 guanine nucleotide binding protein, alpha 11 0.054
4732456N10Rik RIKEN cDNA 4732456N10 gene 0.054
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism