The network for 'regulation of extrinsic apoptotic signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of extrinsic apoptotic signaling pathway

Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway.

Homo sapiens
Name Description Probability Func Analog Organism
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.000
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.000
BIRC3 baculoviral IAP repeat containing 3 1.000
BCL2 B-cell CLL/lymphoma 2 1.000
TRAF1 TNF receptor-associated factor 1 1.000
TRAF2 TNF receptor-associated factor 2 1.000
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.999
FHL2 four and a half LIM domains 2 0.998
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.995
BCL2L1 BCL2-like 1 0.993
FAS Fas (TNF receptor superfamily, member 6) 0.993
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.991
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.988
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.984
FADD Fas (TNFRSF6)-associated via death domain 0.980
CFLAR CASP8 and FADD-like apoptosis regulator 0.979
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.976
FN1 fibronectin 1 0.974
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.966
XIAP X-linked inhibitor of apoptosis 0.966
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.964
BAX BCL2-associated X protein 0.951
TRAF6 TNF receptor-associated factor 6 0.950
BIRC2 baculoviral IAP repeat containing 2 0.946
TRADD TNFRSF1A-associated via death domain 0.945
RIPK2 receptor-interacting serine-threonine kinase 2 0.940
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.928
SQSTM1 sequestosome 1 0.901
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.882
ENG endoglin 0.880
HSPA1B heat shock 70kDa protein 1B 0.877
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.876
TEK TEK tyrosine kinase, endothelial 0.858
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.856
PDPK1 3-phosphoinositide dependent protein kinase-1 0.852
CAV1 caveolin 1, caveolae protein, 22kDa 0.847
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.840
SMAD3 SMAD family member 3 0.840
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.822
BAD BCL2-associated agonist of cell death 0.818
TNF tumor necrosis factor 0.814
FGB fibrinogen beta chain 0.791
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.785
EGFR epidermal growth factor receptor 0.752
HCK hemopoietic cell kinase 0.745
TGIF1 TGFB-induced factor homeobox 1 0.743
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.738
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.734
FKBP1A FK506 binding protein 1A, 12kDa 0.730
TRAF3 TNF receptor-associated factor 3 0.717
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.695
TP53BP2 tumor protein p53 binding protein, 2 0.680
FLNA filamin A, alpha 0.658
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.657
PML promyelocytic leukemia 0.646
BID BH3 interacting domain death agonist 0.645
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.638
CASP8AP2 caspase 8 associated protein 2 0.638
FGA fibrinogen alpha chain 0.633
IL1R1 interleukin 1 receptor, type I 0.621
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.619
TGFB1 transforming growth factor, beta 1 0.609
TAL1 T-cell acute lymphocytic leukemia 1 0.591
CXCL2 chemokine (C-X-C motif) ligand 2 0.582
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.569
LCK lymphocyte-specific protein tyrosine kinase 0.556
BMP2 bone morphogenetic protein 2 0.532
IL8 interleukin 8 0.531
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.531
TRAF5 TNF receptor-associated factor 5 0.520
IRAK1 interleukin-1 receptor-associated kinase 1 0.514
LGALS1 lectin, galactoside-binding, soluble, 1 0.506
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.488
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.469
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.469
USP15 ubiquitin specific peptidase 15 0.465
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.454
CXCL11 chemokine (C-X-C motif) ligand 11 0.445
PXN paxillin 0.433
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.428
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.417
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.416
STK4 serine/threonine kinase 4 0.395
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.394
TIMP3 TIMP metallopeptidase inhibitor 3 0.390
MET met proto-oncogene (hepatocyte growth factor receptor) 0.382
STAT5A signal transducer and activator of transcription 5A 0.377
BCL3 B-cell CLL/lymphoma 3 0.374
HSPA1A heat shock 70kDa protein 1A 0.373
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.369
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.368
VCAM1 vascular cell adhesion molecule 1 0.368
CD63 CD63 molecule 0.362
VIM vimentin 0.360
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.360
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.356
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.355
STK3 serine/threonine kinase 3 0.350
FYN FYN oncogene related to SRC, FGR, YES 0.346
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.345
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
osr1 odd-skipped related 1 (Drosophila) 0.912
cmyb transcription factor cmyb 0.891
kdrl kinase insert domain receptor like 0.823
bcl2l1 bcl2-like 1 0.734
tnfrsfa tumor necrosis factor receptor superfamily, member a 0.730
mcl1a myeloid cell leukemia sequence 1a 0.683
cav1 caveolin 1 0.650
nrp1a neuropilin 1a 0.607
acvr2a activin receptor IIa 0.490
matn4 matrilin 4 0.462
nrg2a neuregulin 2a 0.454
fgfr1a fibroblast growth factor receptor 1a 0.443
cnn2 calponin 2 0.427
stc1l stanniocalcin 1, like 0.421
mpx myeloid-specific peroxidase 0.415
ntn2 netrin 2 0.413
ptgs1 prostaglandin-endoperoxide synthase 1 0.411
hoxa13a homeo box A13a 0.406
baxa bcl2-associated X protein, a 0.399
runx1 runt-related transcription factor 1 0.372
mapk6 mitogen-activated protein kinase 6 0.367
hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 0.348
frem3 Fras1 related extracellular matrix 3 0.343
pcsk5a proprotein convertase subtilisin/kexin type 5a 0.332
tbx22 T-box 22 0.327
efna5a ephrin A5a 0.318
zgc:101724 zgc:101724 0.314
mdm2 transformed 3T3 cell double minute 2 homolog (mouse) 0.305
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.298
rag1 recombination activating gene 1 0.298
igf1ra insulin-like growth factor 1a receptor 0.297
hmx2 H6 family homeobox 2 0.290
pitx3 paired-like homeodomain transcription factor 3 0.289
col4a2 collagen, type IV, alpha 2 0.283
ywhae1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 0.281
hbae1 hemoglobin alpha embryonic-1 0.281
nrp2a neuropilin 2a 0.281
wnt10a wingless-type MMTV integration site family, member 10a 0.281
ptgs2a prostaglandin-endoperoxide synthase 2a 0.272
fgg fibrinogen, gamma polypeptide 0.272
igf1 insulin-like growth factor 1 0.270
cntn2 contactin 2 0.267
aox3 aldehyde oxidase 3 0.262
met met proto-oncogene (hepatocyte growth factor receptor) 0.260
mapk14a mitogen-activated protein kinase 14a 0.256
tagln2 transgelin 2 0.250
fgfr1b fibroblast growth factor receptor 1b 0.245
fgfr3 fibroblast growth factor receptor 3 0.245
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.242
kita kit receptor a 0.241
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.238
ifnphi1 interferon phi 1 0.235
igfbp1b insulin-like growth factor binding protein 1b 0.232
sgk1 serum/glucocorticoid regulated kinase 1 0.230
ptprf protein tyrosine phosphatase, receptor type, F 0.229
coro1a coronin, actin binding protein, 1A 0.228
odc1 ornithine decarboxylase 1 0.225
pou1f1 POU domain, class 1, transcription factor 1 0.222
runx3 runt-related transcription factor 3 0.219
nos1 nitric oxide synthase 1 (neuronal) 0.218
notch2 notch homolog 2 0.218
cyp24a1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.217
col11a1a collagen, type XI, alpha 1a 0.211
gadd45aa growth arrest and DNA-damage-inducible, alpha, a 0.210
col7a1l collagen type VII alpha 1-like 0.209
csrnp1b cysteine-serine-rich nuclear protein 1b 0.209
stmn2b stathmin-like 2b 0.202
ywhai tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide 0.201
fn1 fibronectin 1 0.200
mcl1b myeloid cell leukemia sequence 1b 0.195
tgfb1a transforming growth factor, beta 1a 0.193
apom apolipoprotein M 0.193
myhz2 myosin, heavy polypeptide 2, fast muscle specific 0.190
mmp9 matrix metalloproteinase 9 0.186
zgc:110343 zgc:110343 0.185
mmp2 matrix metalloproteinase 2 0.185
sb:cb166 sb:cb166 0.183
six1b sine oculis homeobox homolog 1b 0.181
elmo1 engulfment and cell motility 1 (ced-12 homolog, C. elegans) 0.181
lcp1 lymphocyte cytosolic plastin 1 0.178
fzd7b frizzled homolog 7b 0.174
phox2b paired-like homeobox 2b 0.170
plxnb2a plexin b2a 0.169
hmgb2a high-mobility group box 2a 0.168
ptena phosphatase and tensin homolog A 0.166
igf1rb insulin-like growth factor 1b receptor 0.164
il1b interleukin 1, beta and interleukin 1, beta 0.163
atf3 activating transcription factor 3 0.163
ccz1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) 0.160
itgb3b integrin beta 3b 0.159
gdf9 growth differentiation factor 9 0.157
alas2 aminolevulinate, delta-, synthetase 2 0.156
si:ch211-14k19.8 si:ch211-14k19.8 0.156
inha inhibin, alpha 0.155
dct dopachrome tautomerase 0.154
hbbe1.1 hemoglobin beta embryonic-1.1 0.153
wnt3 wingless-type MMTV integration site family, member 3 0.152
crh corticotropin releasing hormone 0.151
chrna6 cholinergic receptor, nicotinic, alpha 6 0.149
abcf2 ATP-binding cassette, sub-family F (GCN20), member 2 0.148
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Col1a1 collagen, type I, alpha 1 1.000
Trp53 transformation related protein 53 1.000
Tnf tumor necrosis factor 0.998
Pten phosphatase and tensin homolog 0.998
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.993
Ctnnb1 catenin (cadherin associated protein), beta 1 0.993
Tgfb1 transforming growth factor, beta 1 0.992
Cd19 CD19 antigen 0.963
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.961
Lyz2 lysozyme 2 0.946
Csf1 colony stimulating factor 1 (macrophage) 0.943
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.922
Runx1 runt related transcription factor 1 0.917
Nos3 nitric oxide synthase 3, endothelial cell 0.916
Cd44 CD44 antigen 0.904
Bax BCL2-associated X protein 0.895
Ptgs2 prostaglandin-endoperoxide synthase 2 0.895
Tgfbr2 transforming growth factor, beta receptor II 0.882
Bcl2 B-cell leukemia/lymphoma 2 0.882
Casp8 caspase 8 0.882
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.871
Ikzf1 IKAROS family zinc finger 1 0.871
Notch2 Notch gene homolog 2 (Drosophila) 0.861
Esr1 estrogen receptor 1 (alpha) 0.856
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.844
Fbn1 fibrillin 1 0.826
Mmp9 matrix metallopeptidase 9 0.818
Tnip1 TNFAIP3 interacting protein 1 0.808
Il2rg interleukin 2 receptor, gamma chain 0.774
Bmpr1a bone morphogenetic protein receptor, type 1A 0.768
Egfr epidermal growth factor receptor 0.747
Foxp3 forkhead box P3 0.737
Igh immunoglobulin heavy chain complex 0.734
Sharpin SHANK-associated RH domain interacting protein 0.728
Nos1 nitric oxide synthase 1, neuronal 0.715
Apc adenomatosis polyposis coli 0.710
Notch1 Notch gene homolog 1 (Drosophila) 0.709
Il10 interleukin 10 0.707
Yap1 yes-associated protein 1 0.704
Fas Fas (TNF receptor superfamily member 6) 0.699
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.683
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.675
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.675
Nos2 nitric oxide synthase 2, inducible 0.665
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.664
Fst follistatin 0.655
Ccr2 chemokine (C-C motif) receptor 2 0.643
Itch itchy, E3 ubiquitin protein ligase 0.634
Nf1 neurofibromatosis 1 0.626
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.611
Il4ra interleukin 4 receptor, alpha 0.606
Col5a2 collagen, type V, alpha 2 0.603
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.596
Cbl Casitas B-lineage lymphoma 0.594
Pdcd1 programmed cell death 1 0.591
Hr hairless 0.584
App amyloid beta (A4) precursor protein 0.581
Nkx2-3 NK2 transcription factor related, locus 3 (Drosophila) 0.547
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.544
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.544
Ccr1 chemokine (C-C motif) receptor 1 0.540
Col3a1 collagen, type III, alpha 1 0.528
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.527
Cd40 CD40 antigen 0.511
Socs1 suppressor of cytokine signaling 1 0.509
Efnb2 ephrin B2 0.509
Ifng interferon gamma 0.503
Skil SKI-like 0.479
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.478
Thbs1 thrombospondin 1 0.477
Adam17 a disintegrin and metallopeptidase domain 17 0.476
Mdm2 transformed mouse 3T3 cell double minute 2 0.476
Lepr leptin receptor 0.475
Fshr follicle stimulating hormone receptor 0.474
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.455
Mcl1 myeloid cell leukemia sequence 1 0.449
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.437
Smad3 MAD homolog 3 (Drosophila) 0.418
Casp3 caspase 3 0.418
Rara retinoic acid receptor, alpha 0.412
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.407
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.406
Ret ret proto-oncogene 0.394
Runx2 runt related transcription factor 2 0.390
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.390
Fyn Fyn proto-oncogene 0.388
Tgfb2 transforming growth factor, beta 2 0.386
Rbl1 retinoblastoma-like 1 (p107) 0.381
Inpp5d inositol polyphosphate-5-phosphatase D 0.373
Fgfr1 fibroblast growth factor receptor 1 0.355
Vegfa vascular endothelial growth factor A 0.352
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.345
Bmpr2 bone morphogenic protein receptor, type II (serine/threonine kinase) 0.344
Snai1 snail homolog 1 (Drosophila) 0.336
Ltb lymphotoxin B 0.335
Wnt5a wingless-related MMTV integration site 5A 0.330
Cxcl12 chemokine (C-X-C motif) ligand 12 0.330
Psen1 presenilin 1 0.328
Bcl3 B-cell leukemia/lymphoma 3 0.328
Xiap X-linked inhibitor of apoptosis 0.324
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Rattus norvegicus
Name Description Probability Func Analog Organism
Hsp90b1 heat shock protein 90, beta, member 1 0.229
Sirpa signal-regulatory protein alpha 0.188
Igsf6 immunoglobulin superfamily, member 6 0.091
Cd86 CD86 molecule 0.059
Trim47 tripartite motif-containing 47 0.047
Csf1 colony stimulating factor 1 (macrophage) 0.047
Hpx hemopexin 0.038
Zyx zyxin 0.033
Glg1 golgi apparatus protein 1 0.033
Fgfr2 fibroblast growth factor receptor 2 0.032
Vat1 vesicle amine transport protein 1 homolog (T californica) 0.032
Mprip myosin phosphatase Rho interacting protein 0.032
Dock8 dedicator of cytokinesis 8 0.031
Il1a interleukin 1 alpha 0.031
Arpc1b actin related protein 2/3 complex, subunit 1B 0.029
Cd14 CD14 molecule 0.027
Il1b interleukin 1 beta 0.026
Ddr1 discoidin domain receptor tyrosine kinase 1 0.026
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.025
Ptprc protein tyrosine phosphatase, receptor type, C 0.025
Anxa5 annexin A5 0.025
Smad7 SMAD family member 7 0.024
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.023
Hck hemopoietic cell kinase 0.022
F2rl1 coagulation factor II (thrombin) receptor-like 1 0.022
Slc12a4 solute carrier family 12 (potassium/chloride transporters), member 4 0.021
Icam1 intercellular adhesion molecule 1 0.020
Magt1 magnesium transporter 1 0.020
Lrp10 low-density lipoprotein receptor-related protein 10 0.019
Lepr leptin receptor 0.019
Hp haptoglobin 0.018
Myh9 myosin, heavy chain 9, non-muscle 0.018
Inpp5d inositol polyphosphate-5-phosphatase D 0.017
Ptafr platelet-activating factor receptor 0.017
Nras neuroblastoma ras oncogene 0.017
Csnk1g1 casein kinase 1, gamma 1 0.016
Pdia4 protein disulfide isomerase family A, member 4 0.016
Lnpep leucyl/cystinyl aminopeptidase 0.016
Unc5b unc-5 homolog B (C. elegans) 0.016
Neurl3 neuralized homolog 3 (Drosophila) 0.016
Cd9 CD9 molecule 0.015
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.015
Cp ceruloplasmin 0.015
Ralgds ral guanine nucleotide dissociation stimulator 0.014
Gja5 gap junction protein, alpha 5 0.014
Fkbp2 FK506 binding protein 2 0.014
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.014
Tcof1 Treacher Collins-Franceschetti syndrome 1 homolog (human) 0.014
Il4ra interleukin 4 receptor, alpha 0.013
S100a11 S100 calcium binding protein A11 (calizzarin) 0.013
Prdm2 PR domain containing 2, with ZNF domain 0.013
Stat3 signal transducer and activator of transcription 3 0.013
Gpnmb glycoprotein (transmembrane) nmb 0.013
Flot2 flotillin 2 0.013
Ccl3 chemokine (C-C motif) ligand 3 0.012
Adora2a adenosine A2a receptor 0.012
Csnk1g3 casein kinase 1, gamma 3 0.012
Casp1 caspase 1 0.012
Notch2 Notch homolog 2 (Drosophila) 0.012
Nfib nuclear factor I/B 0.012
Ptch1 patched homolog 1 (Drosophila) 0.012
Orai1 ORAI calcium release-activated calcium modulator 1 0.012
Timp2 TIMP metallopeptidase inhibitor 2 0.011
Cdc37 cell division cycle 37 homolog (S. cerevisiae) 0.011
Arrdc1 arrestin domain containing 1 0.011
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.011
RGD1561143 similar to cell surface receptor FDFACT 0.011
Itgam integrin, alpha M 0.011
Cd4 Cd4 molecule 0.011
Marcks myristoylated alanine rich protein kinase C substrate 0.011
Cxcl10 chemokine (C-X-C motif) ligand 10 0.010
Ins1 insulin 1 0.010
Prkcd protein kinase C, delta 0.010
Cfp complement factor properdin 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism