The network for 'positive regulation of t cell activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of t cell activation

Any process that activates or increases the frequency, rate or extent of T cell activation.

Mus musculus
Name Description Probability Func Analog Organism
Ikzf1 IKAROS family zinc finger 1 0.999
Tnf tumor necrosis factor 0.995
Cd40 CD40 antigen 0.994
Icos inducible T-cell co-stimulator 0.994
Lyz2 lysozyme 2 0.992
Lck lymphocyte protein tyrosine kinase 0.990
Cd19 CD19 antigen 0.988
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.978
Lepr leptin receptor 0.972
Igh immunoglobulin heavy chain complex 0.968
Efnb2 ephrin B2 0.957
Fas Fas (TNF receptor superfamily member 6) 0.952
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.951
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.951
Il2rb interleukin 2 receptor, beta chain 0.936
Btk Bruton agammaglobulinemia tyrosine kinase 0.928
Itk IL2-inducible T-cell kinase 0.917
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.915
Cd5 CD5 antigen 0.905
Pdcd1 programmed cell death 1 0.902
Cd28 CD28 antigen 0.895
Rnf2 ring finger protein 2 0.890
Ar androgen receptor 0.887
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.881
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.879
Ccr1 chemokine (C-C motif) receptor 1 0.873
Lta lymphotoxin A 0.870
Fasl Fas ligand (TNF superfamily, member 6) 0.868
Jak2 Janus kinase 2 0.860
Il1r1 interleukin 1 receptor, type I 0.857
Stat3 signal transducer and activator of transcription 3 0.849
Fyn Fyn proto-oncogene 0.846
Ptprc protein tyrosine phosphatase, receptor type, C 0.843
Csf1 colony stimulating factor 1 (macrophage) 0.833
Gli3 GLI-Kruppel family member GLI3 0.818
Batf basic leucine zipper transcription factor, ATF-like 0.812
Cd247 CD247 antigen 0.784
Stat5b signal transducer and activator of transcription 5B 0.782
Cd7 CD7 antigen 0.780
H2-Eb1 histocompatibility 2, class II antigen E beta 0.779
Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) 0.779
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.778
Cd44 CD44 antigen 0.770
Rybp RING1 and YY1 binding protein 0.758
Ccr7 chemokine (C-C motif) receptor 7 0.757
Cd86 CD86 antigen 0.756
Ltb lymphotoxin B 0.745
Cd6 CD6 antigen 0.744
Foxp3 forkhead box P3 0.719
Cd96 CD96 antigen 0.715
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.702
Sh2d2a SH2 domain protein 2A 0.698
Cd3e CD3 antigen, epsilon polypeptide 0.697
Il4 interleukin 4 0.696
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.679
S1pr4 sphingosine-1-phosphate receptor 4 0.675
H2-Aa histocompatibility 2, class II antigen A, alpha 0.666
Itgal integrin alpha L 0.666
Ciita class II transactivator 0.658
Traf1 TNF receptor-associated factor 1 0.657
Cd80 CD80 antigen 0.652
Il2rg interleukin 2 receptor, gamma chain 0.641
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.631
Cd3g CD3 antigen, gamma polypeptide 0.630
Ccr9 chemokine (C-C motif) receptor 9 0.627
Tgfbr2 transforming growth factor, beta receptor II 0.622
Tgfb2 transforming growth factor, beta 2 0.621
Rarg retinoic acid receptor, gamma 0.614
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.607
Kiss1 KiSS-1 metastasis-suppressor 0.596
Cd4 CD4 antigen 0.595
H2-DMb2 histocompatibility 2, class II, locus Mb2 0.593
Cxcr5 chemokine (C-X-C motif) receptor 5 0.588
Ifng interferon gamma 0.578
Il4ra interleukin 4 receptor, alpha 0.564
Il2 interleukin 2 0.561
Ncr1 natural cytotoxicity triggering receptor 1 0.561
Clec4n C-type lectin domain family 4, member n 0.560
Casp8 caspase 8 0.560
Il18rap interleukin 18 receptor accessory protein 0.547
Ccl4 chemokine (C-C motif) ligand 4 0.545
Stat5a signal transducer and activator of transcription 5A 0.536
Ccr6 chemokine (C-C motif) receptor 6 0.529
Runx1 runt related transcription factor 1 0.523
Fcer2a Fc receptor, IgE, low affinity II, alpha polypeptide 0.519
Ccr2 chemokine (C-C motif) receptor 2 0.505
Ubd ubiquitin D 0.503
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.502
Nck2 non-catalytic region of tyrosine kinase adaptor protein 2 0.489
Cd8a CD8 antigen, alpha chain 0.476
Smad4 MAD homolog 4 (Drosophila) 0.475
Spib Spi-B transcription factor (Spi-1/PU.1 related) 0.470
Fgfr2 fibroblast growth factor receptor 2 0.470
Irf4 interferon regulatory factor 4 0.462
Il1b interleukin 1 beta 0.460
Ctsw cathepsin W 0.452
Socs1 suppressor of cytokine signaling 1 0.449
Cd22 CD22 antigen 0.448
Ntf3 neurotrophin 3 0.444
Smad3 MAD homolog 3 (Drosophila) 0.443
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
LCK lymphocyte-specific protein tyrosine kinase 0.999
ICAM1 intercellular adhesion molecule 1 0.881
B2M beta-2-microglobulin 0.872
HLA-G major histocompatibility complex, class I, G 0.864
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.836
HLA-F major histocompatibility complex, class I, F 0.833
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.830
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.825
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.812
CD86 CD86 molecule 0.807
CXCL9 chemokine (C-X-C motif) ligand 9 0.806
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.799
HCK hemopoietic cell kinase 0.723
HLA-DMB major histocompatibility complex, class II, DM beta 0.700
HLA-B major histocompatibility complex, class I, B 0.660
GRB2 growth factor receptor-bound protein 2 0.656
IL1R1 interleukin 1 receptor, type I 0.635
SH2D1A SH2 domain containing 1A 0.635
SYK spleen tyrosine kinase 0.634
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.622
CCR5 chemokine (C-C motif) receptor 5 0.607
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.581
CCL5 chemokine (C-C motif) ligand 5 0.576
CCL4 chemokine (C-C motif) ligand 4 0.565
CCL22 chemokine (C-C motif) ligand 22 0.562
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.558
HLA-E major histocompatibility complex, class I, E 0.553
SOCS3 suppressor of cytokine signaling 3 0.542
PTPRC protein tyrosine phosphatase, receptor type, C 0.538
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.534
CXCL10 chemokine (C-X-C motif) ligand 10 0.522
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.514
ITK IL2-inducible T-cell kinase 0.508
IL1B interleukin 1, beta 0.496
HLA-DRA major histocompatibility complex, class II, DR alpha 0.493
IL2RG interleukin 2 receptor, gamma 0.488
CD247 CD247 molecule 0.473
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.472
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.431
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.421
STAT4 signal transducer and activator of transcription 4 0.416
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.402
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.397
CD80 CD80 molecule 0.387
IL2RB interleukin 2 receptor, beta 0.344
HLA-DMA major histocompatibility complex, class II, DM alpha 0.330
CD3G CD3g molecule, gamma (CD3-TCR complex) 0.320
HLA-C major histocompatibility complex, class I, C 0.305
CARD11 caspase recruitment domain family, member 11 0.295
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.292
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.291
FAS Fas (TNF receptor superfamily, member 6) 0.285
IL4R interleukin 4 receptor 0.284
JAK2 Janus kinase 2 0.272
BCL10 B-cell CLL/lymphoma 10 0.271
CXCL11 chemokine (C-X-C motif) ligand 11 0.269
CD2 CD2 molecule 0.261
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.260
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.255
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.250
PILRA paired immunoglobin-like type 2 receptor alpha 0.250
IL6R interleukin 6 receptor 0.236
IL16 interleukin 16 (lymphocyte chemoattractant factor) 0.231
IL7R interleukin 7 receptor 0.223
LIN9 lin-9 homolog (C. elegans) 0.223
GRAP2 GRB2-related adaptor protein 2 0.222
BLNK B-cell linker 0.217
HLA-A major histocompatibility complex, class I, A 0.212
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.208
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.207
CCL13 chemokine (C-C motif) ligand 13 0.204
CD1C CD1c molecule 0.203
CD28 CD28 molecule 0.202
CD52 CD52 molecule 0.197
SPTB spectrin, beta, erythrocytic 0.196
BIRC3 baculoviral IAP repeat containing 3 0.192
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.191
SLA Src-like-adaptor 0.189
CCL2 chemokine (C-C motif) ligand 2 0.184
IL4 interleukin 4 0.184
PLCG1 phospholipase C, gamma 1 0.183
NCK1 NCK adaptor protein 1 0.181
BTK Bruton agammaglobulinemia tyrosine kinase 0.178
JAK1 Janus kinase 1 0.177
IFNG interferon, gamma 0.176
IL10 interleukin 10 0.175
EGFR epidermal growth factor receptor 0.172
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.166
CCR7 chemokine (C-C motif) receptor 7 0.165
CCL8 chemokine (C-C motif) ligand 8 0.163
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 0.152
NLRC4 NLR family, CARD domain containing 4 0.150
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.145
BTN3A1 butyrophilin, subfamily 3, member A1 0.142
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.135
CXCL13 chemokine (C-X-C motif) ligand 13 0.131
LY86 lymphocyte antigen 86 0.126
CD40 CD40 molecule, TNF receptor superfamily member 5 0.125
RXRA retinoid X receptor, alpha 0.124
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.123
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Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-Da RT1 class II, locus Da 0.446
Tcrb T-cell receptor beta chain 0.226
RT1-Ba RT1 class II, locus Ba 0.165
Cd247 Cd247 molecule 0.126
RT1-Db1 RT1 class II, locus Db1 0.063
Cd37 CD37 molecule 0.062
Cd5 Cd5 molecule 0.030
Gimap4 GTPase, IMAP family member 4 0.022
Gzmk granzyme K 0.019
Calcrl calcitonin receptor-like 0.017
Il2rb interleukin 2 receptor, beta 0.017
Itgb7 integrin, beta 7 0.016
LOC100364854 similar to RIKEN cDNA A430107P09 gene-like 0.015
RT1-Bb RT1 class II, locus Bb 0.015
Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.015
Casp1 caspase 1 0.014
Cd3g CD3 molecule, gamma 0.014
RT1-DMa RT1 class II, locus DMa 0.013
Cd2 Cd2 molecule 0.013
Cd53 Cd53 molecule 0.012
Itgad integrin, alpha D 0.012
Spn sialophorin 0.012
Nkg7 natural killer cell group 7 sequence 0.012
Lat linker for activation of T cells 0.012
Dnase1l3 deoxyribonuclease 1-like 3 0.012
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.011
Cd4 Cd4 molecule 0.011
Cd3d CD3 molecule, delta 0.010
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism