IMP
Process View
The network for 'negative regulation of inflammatory response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
negative regulation of inflammatory response
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Lyz2 | lysozyme 2 | 0.994 | |
| Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a | 0.963 | |
| Tnf | tumor necrosis factor | 0.952 | |
| Cd44 | CD44 antigen | 0.938 | |
| Apoe | apolipoprotein E | 0.935 | |
| Relb | avian reticuloendotheliosis viral (v-rel) oncogene related B | 0.915 | |
| Stat3 | signal transducer and activator of transcription 3 | 0.904 | |
| Il10 | interleukin 10 | 0.903 | |
| Lepr | leptin receptor | 0.836 | |
| Fcer1g | Fc receptor, IgE, high affinity I, gamma polypeptide | 0.834 | |
| Axl | AXL receptor tyrosine kinase | 0.833 | |
| Pax2 | paired box gene 2 | 0.758 | |
| Nfkbia | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.754 | |
| Chrna3 | cholinergic receptor, nicotinic, alpha polypeptide 3 | 0.735 | |
| Nfkb1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 | 0.717 | |
| Fas | Fas (TNF receptor superfamily member 6) | 0.701 | |
| Prf1 | perforin 1 (pore forming protein) | 0.671 | |
| Smad3 | MAD homolog 3 (Drosophila) | 0.658 | |
| Nlrp3 | NLR family, pyrin domain containing 3 | 0.608 | |
| Cd80 | CD80 antigen | 0.608 | |
| Il6 | interleukin 6 | 0.599 | |
| Chrnb4 | cholinergic receptor, nicotinic, beta polypeptide 4 | 0.590 | |
| Pdcd1 | programmed cell death 1 | 0.587 | |
| Ccr1 | chemokine (C-C motif) receptor 1 | 0.571 | |
| Ctla2b | cytotoxic T lymphocyte-associated protein 2 beta | 0.558 | |
| Ctla2a | cytotoxic T lymphocyte-associated protein 2 alpha | 0.551 | |
| Otx2 | orthodenticle homolog 2 (Drosophila) | 0.546 | |
| Junb | Jun-B oncogene | 0.541 | |
| Lyn | Yamaguchi sarcoma viral (v-yes-1) oncogene homolog | 0.537 | |
| Tnfaip3 | tumor necrosis factor, alpha-induced protein 3 | 0.532 | |
| Krt6a | keratin 6A | 0.530 | |
| Sprr1a | small proline-rich protein 1A | 0.508 | |
| Foxn1 | forkhead box N1 | 0.497 | |
| Socs1 | suppressor of cytokine signaling 1 | 0.480 | |
| Chrnb2 | cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) | 0.480 | |
| Emx2 | empty spiracles homolog 2 (Drosophila) | 0.473 | |
| Ccl2 | chemokine (C-C motif) ligand 2 | 0.469 | |
| C1qb | complement component 1, q subcomponent, beta polypeptide | 0.465 | |
| Ptgir | prostaglandin I receptor (IP) | 0.459 | |
| C1qa | complement component 1, q subcomponent, alpha polypeptide | 0.436 | |
| Nos2 | nitric oxide synthase 2, inducible | 0.431 | |
| Arrb2 | arrestin, beta 2 | 0.414 | |
| Ifngr1 | interferon gamma receptor 1 | 0.407 | |
| Il4ra | interleukin 4 receptor, alpha | 0.400 | |
| Il1r1 | interleukin 1 receptor, type I | 0.392 | |
| Pax6 | paired box gene 6 | 0.382 | |
| C3ar1 | complement component 3a receptor 1 | 0.380 | |
| Robo1 | roundabout homolog 1 (Drosophila) | 0.369 | |
| Axin1 | axin 1 | 0.346 | |
| Stat6 | signal transducer and activator of transcription 6 | 0.339 | |
| Map3k14 | mitogen-activated protein kinase kinase kinase 14 | 0.325 | |
| Smad7 | MAD homolog 7 (Drosophila) | 0.322 | |
| Slc6a3 | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | 0.316 | |
| Cd19 | CD19 antigen | 0.311 | |
| Ifng | interferon gamma | 0.310 | |
| Tnfrsf1b | tumor necrosis factor receptor superfamily, member 1b | 0.305 | |
| Smad1 | MAD homolog 1 (Drosophila) | 0.304 | |
| Tff1 | trefoil factor 1 | 0.301 | |
| Tlr4 | toll-like receptor 4 | 0.297 | |
| Spp1 | secreted phosphoprotein 1 | 0.293 | |
| Il4 | interleukin 4 | 0.290 | |
| Rho | rhodopsin | 0.286 | |
| Ptgs2 | prostaglandin-endoperoxide synthase 2 | 0.278 | |
| Traf2 | TNF receptor-associated factor 2 | 0.277 | |
| Gfra1 | glial cell line derived neurotrophic factor family receptor alpha 1 | 0.274 | |
| Traf6 | TNF receptor-associated factor 6 | 0.265 | |
| Tyrobp | TYRO protein tyrosine kinase binding protein | 0.255 | |
| Irf1 | interferon regulatory factor 1 | 0.255 | |
| Casp4 | caspase 4, apoptosis-related cysteine peptidase | 0.252 | |
| Il10ra | interleukin 10 receptor, alpha | 0.251 | |
| Arrb1 | arrestin, beta 1 | 0.251 | |
| Ccr2 | chemokine (C-C motif) receptor 2 | 0.247 | |
| Cebpb | CCAAT/enhancer binding protein (C/EBP), beta | 0.244 | |
| Folr2 | folate receptor 2 (fetal) | 0.244 | |
| Krt18 | keratin 18 | 0.233 | |
| Fgr | Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog | 0.233 | |
| C1qc | complement component 1, q subcomponent, C chain | 0.232 | |
| Gpr132 | G protein-coupled receptor 132 | 0.232 | |
| Il6st | interleukin 6 signal transducer | 0.229 | |
| Foxp3 | forkhead box P3 | 0.225 | |
| Tyro3 | TYRO3 protein tyrosine kinase 3 | 0.219 | |
| Mrc1 | mannose receptor, C type 1 | 0.219 | |
| Mefv | Mediterranean fever | 0.213 | |
| Krt1 | keratin 1 | 0.209 | |
| Matn1 | matrilin 1, cartilage matrix protein | 0.208 | |
| Pitx2 | paired-like homeodomain transcription factor 2 | 0.205 | |
| Selp | selectin, platelet | 0.203 | |
| Rnf111 | ring finger 111 | 0.202 | |
| Rela | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.199 | |
| Fos | FBJ osteosarcoma oncogene | 0.196 | |
| Mab21l2 | mab-21-like 2 (C. elegans) | 0.195 | |
| Syt8 | synaptotagmin VIII | 0.183 | |
| Socs2 | suppressor of cytokine signaling 2 | 0.176 | |
| Klf6 | Kruppel-like factor 6 | 0.175 | |
| Pkp1 | plakophilin 1 | 0.173 | |
| Wt1 | Wilms tumor 1 homolog | 0.173 | |
| Ccl4 | chemokine (C-C motif) ligand 4 | 0.173 | |
| Cd28 | CD28 antigen | 0.168 | |
| C3 | complement component 3 | 0.164 | |
| Krt17 | keratin 17 | 0.159 |
Loading network...
Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| FADD | Fas (TNFRSF6)-associated via death domain | 0.409 | |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 0.293 | |
| CASP8 | caspase 8, apoptosis-related cysteine peptidase | 0.264 | |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.262 | |
| TAL1 | T-cell acute lymphocytic leukemia 1 | 0.155 | |
| PSMB2 | proteasome (prosome, macropain) subunit, beta type, 2 | 0.122 | |
| IL10RA | interleukin 10 receptor, alpha | 0.115 | |
| TNF | tumor necrosis factor | 0.112 | |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 0.095 | |
| NR0B1 | nuclear receptor subfamily 0, group B, member 1 | 0.093 | |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.089 | |
| HLA-DRB5 | major histocompatibility complex, class II, DR beta 5 | 0.088 | |
| TBXA2R | thromboxane A2 receptor | 0.086 | |
| PYCARD | PYD and CARD domain containing | 0.075 | |
| RUNX1 | runt-related transcription factor 1 | 0.075 | |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 0.064 | |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.055 | |
| PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | 0.055 | |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.053 | |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.053 | |
| INPP5D | inositol polyphosphate-5-phosphatase, 145kDa | 0.049 | |
| TRADD | TNFRSF1A-associated via death domain | 0.049 | |
| APOC1 | apolipoprotein C-I | 0.047 | |
| TNFRSF10A | tumor necrosis factor receptor superfamily, member 10a | 0.046 | |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.046 | |
| PTGIR | prostaglandin I2 (prostacyclin) receptor (IP) | 0.044 | |
| ZNF496 | zinc finger protein 496 | 0.043 | |
| UBE2I | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) | 0.042 | |
| SMAD2 | SMAD family member 2 | 0.041 | |
| HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 | 0.041 | |
| JUNB | jun B proto-oncogene | 0.040 | |
| EPOR | erythropoietin receptor | 0.038 | |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.037 | |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | 0.036 | |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 0.036 | |
| HP | haptoglobin | 0.036 | |
| HLA-DMB | major histocompatibility complex, class II, DM beta | 0.036 | |
| PELP1 | proline, glutamate and leucine rich protein 1 | 0.032 | |
| ITGB1BP3 | integrin beta 1 binding protein 3 | 0.031 | |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.031 | |
| DRD2 | dopamine receptor D2 | 0.031 | |
| DERL1 | Der1-like domain family, member 1 | 0.030 | |
| EDF1 | endothelial differentiation-related factor 1 | 0.029 | |
| PPP2R5B | protein phosphatase 2, regulatory subunit B', beta | 0.029 | |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 0.027 | |
| APBA3 | amyloid beta (A4) precursor protein-binding, family A, member 3 | 0.027 | |
| SUMO3 | SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae) | 0.025 | |
| LCAT | lecithin-cholesterol acyltransferase | 0.025 | |
| A2M | alpha-2-macroglobulin | 0.024 | |
| TRAF1 | TNF receptor-associated factor 1 | 0.024 | |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.022 | |
| C19orf50 | chromosome 19 open reading frame 50 | 0.022 | |
| GHR | growth hormone receptor | 0.022 | |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 0.021 | |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.021 | |
| PPM1F | protein phosphatase, Mg2+/Mn2+ dependent, 1F | 0.021 | |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 0.020 | |
| IL22 | interleukin 22 | 0.019 | |
| PSMD4 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 | 0.019 | |
| SLC9A3R1 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 | 0.018 | |
| PSMA5 | proteasome (prosome, macropain) subunit, alpha type, 5 | 0.018 | |
| IL8 | interleukin 8 | 0.017 | |
| HLA-DRB4 | major histocompatibility complex, class II, DR beta 4 | 0.017 | |
| NCOA1 | nuclear receptor coactivator 1 | 0.017 | |
| RNF31 | ring finger protein 31 | 0.016 | |
| POMP | proteasome maturation protein | 0.016 | |
| ICAM1 | intercellular adhesion molecule 1 | 0.016 | |
| TNFRSF9 | tumor necrosis factor receptor superfamily, member 9 | 0.015 | |
| SMAD7 | SMAD family member 7 | 0.015 | |
| MAP3K8 | mitogen-activated protein kinase kinase kinase 8 | 0.015 | |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | 0.014 | |
| TBX5 | T-box 5 | 0.014 | |
| MLLT4 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 | 0.014 | |
| REL | v-rel reticuloendotheliosis viral oncogene homolog (avian) | 0.014 | |
| IL4R | interleukin 4 receptor | 0.013 | |
| TEX10 | testis expressed 10 | 0.013 | |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | 0.013 | |
| HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 | 0.013 | |
| TNIP2 | TNFAIP3 interacting protein 2 | 0.013 | |
| EGR2 | early growth response 2 | 0.012 | |
| CFTR | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) | 0.012 | |
| TNFRSF10C | tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain | 0.012 | |
| NECAB2 | N-terminal EF-hand calcium binding protein 2 | 0.012 | |
| BCL3 | B-cell CLL/lymphoma 3 | 0.012 | |
| HNF4A | hepatocyte nuclear factor 4, alpha | 0.012 | |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.012 | |
| TRAF2 | TNF receptor-associated factor 2 | 0.012 | |
| LYN | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 0.012 | |
| IKBKB | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 0.011 | |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.011 | |
| GHRL | ghrelin/obestatin prepropeptide | 0.011 | |
| SYK | spleen tyrosine kinase | 0.011 | |
| IL12RB2 | interleukin 12 receptor, beta 2 | 0.011 | |
| ADORA2A | adenosine A2a receptor | 0.011 | |
| SMAD1 | SMAD family member 1 | 0.011 | |
| JAK3 | Janus kinase 3 | 0.010 | |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.010 | |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 0.010 | |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | 0.010 | |
| PSMB7 | proteasome (prosome, macropain) subunit, beta type, 7 | 0.010 |