The network for 'positive regulation of lymphocyte activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of lymphocyte activation

Any process that activates or increases the frequency, rate or extent of lymphocyte activation.

Mus musculus
Name Description Probability Func Analog Organism
Cd40 CD40 antigen 0.999
Tnf tumor necrosis factor 0.999
Lepr leptin receptor 0.996
Ikzf1 IKAROS family zinc finger 1 0.993
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.988
Pdcd1 programmed cell death 1 0.969
Lck lymphocyte protein tyrosine kinase 0.956
Ptprc protein tyrosine phosphatase, receptor type, C 0.953
Fyn Fyn proto-oncogene 0.946
Pax2 paired box gene 2 0.929
Jak2 Janus kinase 2 0.913
Fas Fas (TNF receptor superfamily member 6) 0.905
Rybp RING1 and YY1 binding protein 0.896
Lta lymphotoxin A 0.894
Il2rb interleukin 2 receptor, beta chain 0.875
Myd88 myeloid differentiation primary response gene 88 0.872
Efnb2 ephrin B2 0.866
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.865
Socs1 suppressor of cytokine signaling 1 0.864
Cd247 CD247 antigen 0.858
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.849
Cd28 CD28 antigen 0.847
Ccr2 chemokine (C-C motif) receptor 2 0.840
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.837
Cd5 CD5 antigen 0.817
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.813
Cd6 CD6 antigen 0.774
Icos inducible T-cell co-stimulator 0.770
Lat linker for activation of T cells 0.757
Gli2 GLI-Kruppel family member GLI2 0.756
Tgfbr1 transforming growth factor, beta receptor I 0.742
Fasl Fas ligand (TNF superfamily, member 6) 0.741
Fos FBJ osteosarcoma oncogene 0.732
Itgal integrin alpha L 0.717
Ifng interferon gamma 0.707
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.707
Stat5b signal transducer and activator of transcription 5B 0.706
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.705
Zap70 zeta-chain (TCR) associated protein kinase 0.704
Il2rg interleukin 2 receptor, gamma chain 0.703
Ptgs2 prostaglandin-endoperoxide synthase 2 0.702
Cd80 CD80 antigen 0.697
Stat3 signal transducer and activator of transcription 3 0.693
Ar androgen receptor 0.692
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.690
Cd44 CD44 antigen 0.676
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.671
Snai1 snail homolog 1 (Drosophila) 0.661
Il2 interleukin 2 0.658
Cd86 CD86 antigen 0.657
Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) 0.656
Il4 interleukin 4 0.651
Tbx21 T-box 21 0.647
Trp63 transformation related protein 63 0.644
Sh2d2a SH2 domain protein 2A 0.635
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.634
Csf1 colony stimulating factor 1 (macrophage) 0.632
Runx1 runt related transcription factor 1 0.628
Casp1 caspase 1 0.623
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.621
Batf basic leucine zipper transcription factor, ATF-like 0.620
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.620
Gli3 GLI-Kruppel family member GLI3 0.617
Tbx3 T-box 3 0.610
Itk IL2-inducible T-cell kinase 0.609
Rarg retinoic acid receptor, gamma 0.607
Gpr132 G protein-coupled receptor 132 0.605
Pparg peroxisome proliferator activated receptor gamma 0.603
Il6 interleukin 6 0.599
Ccl4 chemokine (C-C motif) ligand 4 0.596
Lag3 lymphocyte-activation gene 3 0.595
Traf1 TNF receptor-associated factor 1 0.595
Ccl2 chemokine (C-C motif) ligand 2 0.593
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.592
Dok2 docking protein 2 0.591
Cd96 CD96 antigen 0.590
Foxn1 forkhead box N1 0.584
Psap prosaposin 0.574
Cd14 CD14 antigen 0.574
Gata6 GATA binding protein 6 0.561
Lyz2 lysozyme 2 0.556
Ccr6 chemokine (C-C motif) receptor 6 0.532
Prdm1 PR domain containing 1, with ZNF domain 0.528
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.528
Ccr9 chemokine (C-C motif) receptor 9 0.528
Gdf3 growth differentiation factor 3 0.527
Pitx3 paired-like homeodomain transcription factor 3 0.526
Fcer2a Fc receptor, IgE, low affinity II, alpha polypeptide 0.522
Rhoh ras homolog gene family, member H 0.516
Gzmk granzyme K 0.513
Tlr4 toll-like receptor 4 0.511
Ccr7 chemokine (C-C motif) receptor 7 0.511
Traf2 TNF receptor-associated factor 2 0.507
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.504
Irf8 interferon regulatory factor 8 0.503
Ltb lymphotoxin B 0.485
Il12b interleukin 12b 0.480
a nonagouti 0.480
Ccr5 chemokine (C-C motif) receptor 5 0.479
Ifnar1 interferon (alpha and beta) receptor 1 0.473
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 1.000
LCK lymphocyte-specific protein tyrosine kinase 0.997
IL4R interleukin 4 receptor 0.958
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.957
FGFR2 fibroblast growth factor receptor 2 0.907
SYK spleen tyrosine kinase 0.896
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.885
CD80 CD80 molecule 0.880
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.878
GRB2 growth factor receptor-bound protein 2 0.854
HLA-DRA major histocompatibility complex, class II, DR alpha 0.831
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.807
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.791
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.789
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.771
BCL2 B-cell CLL/lymphoma 2 0.770
SH3KBP1 SH3-domain kinase binding protein 1 0.730
CD86 CD86 molecule 0.687
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.666
CXCL9 chemokine (C-X-C motif) ligand 9 0.662
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.653
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.642
SOCS3 suppressor of cytokine signaling 3 0.629
HLA-DMA major histocompatibility complex, class II, DM alpha 0.626
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.622
CCR7 chemokine (C-C motif) receptor 7 0.621
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.621
B2M beta-2-microglobulin 0.618
CCL5 chemokine (C-C motif) ligand 5 0.618
HLA-B major histocompatibility complex, class I, B 0.616
HLA-F major histocompatibility complex, class I, F 0.612
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.610
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.605
TICAM2 toll-like receptor adaptor molecule 2 0.602
CAV1 caveolin 1, caveolae protein, 22kDa 0.599
IL1B interleukin 1, beta 0.592
BTN3A3 butyrophilin, subfamily 3, member A3 0.581
ICAM1 intercellular adhesion molecule 1 0.576
IL2RG interleukin 2 receptor, gamma 0.575
BTN3A1 butyrophilin, subfamily 3, member A1 0.556
BTN3A2 butyrophilin, subfamily 3, member A2 0.533
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.516
SLAMF1 signaling lymphocytic activation molecule family member 1 0.501
SH2D1A SH2 domain containing 1A 0.480
CCL22 chemokine (C-C motif) ligand 22 0.467
CCR5 chemokine (C-C motif) receptor 5 0.437
LAT linker for activation of T cells 0.435
IL1R1 interleukin 1 receptor, type I 0.424
IL2RB interleukin 2 receptor, beta 0.410
CCL4 chemokine (C-C motif) ligand 4 0.398
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.388
ITK IL2-inducible T-cell kinase 0.384
HLA-DMB major histocompatibility complex, class II, DM beta 0.375
IRAK1 interleukin-1 receptor-associated kinase 1 0.363
NCOR2 nuclear receptor corepressor 2 0.359
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.359
SIGLEC7 sialic acid binding Ig-like lectin 7 0.351
IL10RA interleukin 10 receptor, alpha 0.343
TLR2 toll-like receptor 2 0.340
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.335
CD247 CD247 molecule 0.329
IRF4 interferon regulatory factor 4 0.328
INSR insulin receptor 0.315
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.304
CXCL10 chemokine (C-X-C motif) ligand 10 0.284
STAT4 signal transducer and activator of transcription 4 0.276
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.272
NLRC4 NLR family, CARD domain containing 4 0.259
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.255
JAK1 Janus kinase 1 0.251
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.236
TGIF1 TGFB-induced factor homeobox 1 0.233
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.231
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.231
AXL AXL receptor tyrosine kinase 0.229
BCL2L1 BCL2-like 1 0.229
TRAF1 TNF receptor-associated factor 1 0.223
CCL8 chemokine (C-C motif) ligand 8 0.223
CD40 CD40 molecule, TNF receptor superfamily member 5 0.222
CD6 CD6 molecule 0.221
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.220
IL6R interleukin 6 receptor 0.210
IRAK2 interleukin-1 receptor-associated kinase 2 0.197
HLA-E major histocompatibility complex, class I, E 0.197
GAS6 growth arrest-specific 6 0.195
BIRC3 baculoviral IAP repeat containing 3 0.187
CD28 CD28 molecule 0.183
TRAF6 TNF receptor-associated factor 6 0.175
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.174
IFNG interferon, gamma 0.170
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.169
IL2RA interleukin 2 receptor, alpha 0.169
EPOR erythropoietin receptor 0.167
LIN9 lin-9 homolog (C. elegans) 0.165
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.160
TNF tumor necrosis factor 0.158
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.157
FAS Fas (TNF receptor superfamily, member 6) 0.155
GAS7 growth arrest-specific 7 0.154
PILRA paired immunoglobin-like type 2 receptor alpha 0.153
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Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-Da RT1 class II, locus Da 0.658
RT1-Ba RT1 class II, locus Ba 0.436
Cd37 CD37 molecule 0.416
Cd247 Cd247 molecule 0.311
RT1-Bb RT1 class II, locus Bb 0.302
RT1-Db1 RT1 class II, locus Db1 0.270
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.248
Itgb7 integrin, beta 7 0.189
Cd5 Cd5 molecule 0.140
Ptprc protein tyrosine phosphatase, receptor type, C 0.102
Cd2 Cd2 molecule 0.086
Il2rb interleukin 2 receptor, beta 0.081
Calcr calcitonin receptor 0.075
Il2rg interleukin 2 receptor, gamma 0.070
RT1-DMb RT1 class II, locus DMb 0.061
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.057
Ciita class II, major histocompatibility complex, transactivator 0.057
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.055
Reg3g regenerating islet-derived 3 gamma 0.055
Il10 interleukin 10 0.055
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.049
Calcrl calcitonin receptor-like 0.045
Kcnv1 potassium channel, subfamily V, member 1 0.045
Ccr5 chemokine (C-C motif) receptor 5 0.045
Htr1b 5-hydroxytryptamine (serotonin) receptor 1B 0.043
Map4k1 mitogen activated protein kinase kinase kinase kinase 1 0.043
Zbp1 Z-DNA binding protein 1 0.043
Cxcr3 chemokine (C-X-C motif) receptor 3 0.041
Scn11a sodium channel, voltage-gated, type XI, alpha 0.039
Tcrb T-cell receptor beta chain 0.039
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.039
Fmnl1 formin-like 1 0.038
Il1b interleukin 1 beta 0.038
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.037
Ptafr platelet-activating factor receptor 0.036
Cd38 CD38 molecule 0.036
Nkg7 natural killer cell group 7 sequence 0.035
Gzmk granzyme K 0.035
Cd53 Cd53 molecule 0.034
Alox5 arachidonate 5-lipoxygenase 0.034
Napsa napsin A aspartic peptidase 0.033
Vip vasoactive intestinal peptide 0.032
Socs3 suppressor of cytokine signaling 3 0.030
Add2 adducin 2 (beta) 0.030
Casp1 caspase 1 0.030
Icos inducible T-cell co-stimulator 0.029
Cd3g CD3 molecule, gamma 0.029
Arhgap4 Rho GTPase activating protein 4 0.029
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.029
Prl8a9 prolactin family 8, subfamily a, member 9 0.029
Cd22 CD22 molecule 0.029
Flt1 FMS-related tyrosine kinase 1 0.028
Dnase1l3 deoxyribonuclease 1-like 3 0.028
Il6 interleukin 6 0.028
Arrb2 arrestin, beta 2 0.027
Mmp10 matrix metallopeptidase 10 0.027
Kcnh7 potassium voltage-gated channel, subfamily H (eag-related), member 7 0.027
Gja4 gap junction protein, alpha 4 0.027
Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 0.026
Csn1s1 casein alpha s1 0.026
Il17ra interleukin 17 receptor A 0.025
Met met proto-oncogene 0.025
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.025
Itgad integrin, alpha D 0.024
Il9r interleukin 9 receptor 0.024
Cd4 Cd4 molecule 0.024
Cfp complement factor properdin 0.024
Csf1 colony stimulating factor 1 (macrophage) 0.024
Il6st interleukin 6 signal transducer 0.023
Kl Klotho 0.023
Spn sialophorin 0.023
Gdnf glial cell derived neurotrophic factor 0.022
Il1r1 interleukin 1 receptor, type I 0.022
Rin1 Ras and Rab interactor 1 0.022
Aif1 allograft inflammatory factor 1 0.022
Dock8 dedicator of cytokinesis 8 0.021
Npy5r neuropeptide Y receptor Y5 0.021
Psp parotid secretory protein 0.020
Syt8 synaptotagmin VIII 0.020
Ccl5 chemokine (C-C motif) ligand 5 0.020
Prkcq protein kinase C, theta 0.020
Slfn2 schlafen 2 0.020
Olr1500 olfactory receptor 1500 0.020
Inpp5d inositol polyphosphate-5-phosphatase D 0.020
Il2ra interleukin 2 receptor, alpha 0.019
Hmha1 histocompatibility (minor) HA-1 0.019
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.019
Psd4 pleckstrin and Sec7 domain containing 4 0.019
Apol3 apolipoprotein L, 3 0.019
Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 0.019
Sell selectin L 0.019
Hcst hematopoietic cell signal transducer 0.019
Ereg epiregulin 0.019
Ido1 indoleamine 2,3-dioxygenase 1 0.019
Ly6g6c lymphocyte antigen 6 complex, locus G6C 0.018
Srd5a2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 0.018
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.018
Faslg Fas ligand (TNF superfamily, member 6) 0.018
Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain 0.018
Il7r interleukin 7 receptor 0.018
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism