The network for 'regulation of transforming growth factor beta receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of transforming growth factor beta receptor signaling pathway

Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway.

Mus musculus
Name Description Probability Func Analog Organism
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.948
Tgfb2 transforming growth factor, beta 2 0.919
Smad3 MAD homolog 3 (Drosophila) 0.913
Apc adenomatosis polyposis coli 0.901
Pten phosphatase and tensin homolog 0.897
Smad4 MAD homolog 4 (Drosophila) 0.881
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.880
Smad7 MAD homolog 7 (Drosophila) 0.850
Nodal nodal 0.826
Fgfr2 fibroblast growth factor receptor 2 0.806
Tgfbr2 transforming growth factor, beta receptor II 0.781
Bgn biglycan 0.760
Smad6 MAD homolog 6 (Drosophila) 0.721
Ctnnb1 catenin (cadherin associated protein), beta 1 0.720
Thbs1 thrombospondin 1 0.706
Lum lumican 0.683
Mdm2 transformed mouse 3T3 cell double minute 2 0.661
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.661
Tgfbr1 transforming growth factor, beta receptor I 0.641
Axin1 axin 1 0.586
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.585
Bmp4 bone morphogenetic protein 4 0.548
Fgf10 fibroblast growth factor 10 0.542
Chrd chordin 0.511
Rb1 retinoblastoma 1 0.497
Gpc3 glypican 3 0.480
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.475
Braf Braf transforming gene 0.462
Onecut1 one cut domain, family member 1 0.442
Fmod fibromodulin 0.414
Acvrl1 activin A receptor, type II-like 1 0.393
Nf1 neurofibromatosis 1 0.386
Cdx2 caudal type homeobox 2 0.375
Acvr1 activin A receptor, type 1 0.375
Amhr2 anti-Mullerian hormone type 2 receptor 0.370
Trp63 transformation related protein 63 0.367
Smad1 MAD homolog 1 (Drosophila) 0.358
Ptrf polymerase I and transcript release factor 0.348
Itgb3 integrin beta 3 0.336
Axin2 axin2 0.331
Gata6 GATA binding protein 6 0.330
Pkd2 polycystic kidney disease 2 0.316
Gdnf glial cell line derived neurotrophic factor 0.306
Smad2 MAD homolog 2 (Drosophila) 0.287
Wnt4 wingless-related MMTV integration site 4 0.275
Trp53 transformation related protein 53 0.263
Msh2 mutS homolog 2 (E. coli) 0.258
Fgf8 fibroblast growth factor 8 0.252
Nos1 nitric oxide synthase 1, neuronal 0.251
Meox2 mesenchyme homeobox 2 0.232
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.223
Adam12 a disintegrin and metallopeptidase domain 12 (meltrin alpha) 0.220
Lhx1 LIM homeobox protein 1 0.207
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.205
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.202
Pgr progesterone receptor 0.202
Bmpr2 bone morphogenic protein receptor, type II (serine/threonine kinase) 0.200
Adam15 a disintegrin and metallopeptidase domain 15 (metargidin) 0.198
Fgfr1 fibroblast growth factor receptor 1 0.197
Rarg retinoic acid receptor, gamma 0.196
Lef1 lymphoid enhancer binding factor 1 0.192
Col1a1 collagen, type I, alpha 1 0.188
Nos3 nitric oxide synthase 3, endothelial cell 0.184
Rarb retinoic acid receptor, beta 0.181
Pitx2 paired-like homeodomain transcription factor 2 0.181
Vhl von Hippel-Lindau tumor suppressor 0.179
Itga3 integrin alpha 3 0.179
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.178
Ar androgen receptor 0.174
Pax8 paired box gene 8 0.173
Ret ret proto-oncogene 0.171
Prlr prolactin receptor 0.169
Vegfa vascular endothelial growth factor A 0.167
Fgf5 fibroblast growth factor 5 0.165
Igf2 insulin-like growth factor 2 0.165
Wls wntless homolog (Drosophila) 0.164
Fzd1 frizzled homolog 1 (Drosophila) 0.162
Nog noggin 0.160
Foxf1a forkhead box F1a 0.159
Bmpr1a bone morphogenetic protein receptor, type 1A 0.158
Lep leptin 0.154
Trp73 transformation related protein 73 0.151
Tcf21 transcription factor 21 0.151
Gab2 growth factor receptor bound protein 2-associated protein 2 0.149
Plin1 perilipin 1 0.147
Fgf15 fibroblast growth factor 15 0.144
Ece1 endothelin converting enzyme 1 0.142
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.140
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.137
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.137
Rara retinoic acid receptor, alpha 0.136
Twist2 twist homolog 2 (Drosophila) 0.136
Chuk conserved helix-loop-helix ubiquitous kinase 0.136
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.133
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.132
Lox lysyl oxidase 0.130
Tgfbr3 transforming growth factor, beta receptor III 0.129
Ptk7 PTK7 protein tyrosine kinase 7 0.127
Sox4 SRY-box containing gene 4 0.126
Fgf2 fibroblast growth factor 2 0.124
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
daf-11 Protein DAF-11 0.636
cat-1 Protein CAT-1 0.408
tax-4 Protein TAX-4 0.285
unc-9 Protein UNC-9 0.169
osm-3 Protein OSM-3 0.166
daf-1 Protein DAF-1 0.159
che-2 Protein CHE-2 0.147
osm-6 Protein OSM-6 0.124
che-1 Protein CHE-1 0.120
osm-5 Protein OSM-5 0.089
gcy-22 Protein GCY-22 0.079
egl-18 Protein EGL-18 0.072
R05G6.10 Protein R05G6.10 0.055
che-13 Protein CHE-13 0.042
che-3 Protein CHE-3 0.040
eat-4 Protein EAT-4 0.039
vab-3 Protein VAB-3 0.038
unc-36 Protein UNC-36 0.035
faah-1 Protein FAAH-1 0.028
tax-2 Protein TAX-2 0.027
unc-7 Protein UNC-7 0.027
daf-7 Protein DAF-7 0.022
daf-4 Protein DAF-4 0.022
che-11 Protein CHE-11 0.022
haly-1 Protein HALY-1 0.022
osm-1 Protein OSM-1 0.019
mboa-3 Protein MBOA-3 0.019
math-26 Protein MATH-26 0.018
inx-2 Protein INX-2 0.018
syx-3 Protein SYX-3 0.017
egl-8 Protein EGL-8 0.017
CELE_C08F11.13 Protein C08F11.13 0.017
itr-1 Protein ITR-1 0.016
hsp-4 Protein HSP-4 0.016
daf-10 Protein DAF-10 0.016
daf-12 Protein DAF-12 0.016
odr-3 Protein ODR-3 0.014
tag-320 Protein TAG-320 0.014
sma-6 Protein SMA-6 0.014
aak-2 Protein AAK-2 0.014
lin-25 Protein LIN-25 0.013
bar-1 Protein BAR-1 0.012
vab-8 Protein VAB-8 0.012
svh-2 Protein SVH-2 0.012
cat-4 Protein CAT-4 0.011
gsp-4 Protein GSP-4 0.011
pqn-62 Protein PQN-62 0.010
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Mad Mothers against dpp 0.996
babo baboon 0.973
Dad Daughters against dpp 0.941
tkv thickveins 0.774
Akt1 CG4006 gene product from transcript CG4006-RA 0.635
ci cubitus interruptus 0.527
mew multiple edematous wings 0.464
CG11347 CG11347 gene product from transcript CG11347-RE 0.370
shn schnurri 0.357
sog short gastrulation 0.296
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.262
gbb glass bottom boat 0.165
mib1 mind bomb 1 0.135
Egfr Epidermal growth factor receptor 0.135
Cdc42 CG12530 gene product from transcript CG12530-RA 0.124
fng fringe 0.117
gro groucho 0.104
Pk61C Protein kinase 61C 0.101
sty sprouty 0.100
pan pangolin 0.092
arr arrow 0.080
kn knot 0.071
foxo forkhead box, sub-group O 0.067
Nrt Neurotactin 0.062
if inflated 0.061
tefu telomere fusion 0.056
svr silver 0.055
unc-104 CG8566 gene product from transcript CG8566-RB 0.052
sax saxophone 0.049
Rpn6 Proteasome p44.5 subunit 0.047
net CG11450 gene product from transcript CG11450-RB 0.044
ash2 absent, small, or homeotic discs 2 0.044
kek5 kekkon5 0.043
ab abrupt 0.043
mys myospheroid 0.040
eya eyes absent 0.040
Ubqn Ubiquilin 0.040
htl heartless 0.036
Sir2 CG5216 gene product from transcript CG5216-RA 0.034
wee CG4488 gene product from transcript CG4488-RA 0.031
neur neuralized 0.029
Smox Smad on X 0.028
trbl tribbles 0.028
twi twist 0.028
Mical Molecule interacting with CasL 0.027
wit wishful thinking 0.027
CtBP C-terminal Binding Protein 0.026
neuroligin CG13772 gene product from transcript CG13772-RA 0.025
A2bp1 Ataxin-2 binding protein 1 0.025
CG31122 CG31122 gene product from transcript CG31122-RA 0.024
ex expanded 0.024
kay kayak 0.023
fwd four wheel drive 0.022
mask multiple ankyrin repeats single KH domain 0.022
Lasp CG3849 gene product from transcript CG3849-RB 0.021
sbb scribbler 0.021
NetB Netrin-B 0.021
Irk2 Inwardly rectifying potassium channel 2 0.020
put punt 0.019
Ras85D Ras oncogene at 85D 0.019
par-6 CG5884 gene product from transcript CG5884-RA 0.019
brk brinker 0.019
VAChT CG32848 gene product from transcript CG32848-RA 0.019
zfh1 Zn finger homeodomain 1 0.019
Socs36E Suppressor of cytokine signaling at 36E 0.019
Atg1 Autophagy-specific gene 1 0.018
Csp Cysteine string protein 0.017
cv-2 crossveinless 2 0.017
tld tolloid 0.016
pr-set7 CG3307 gene product from transcript CG3307-RC 0.016
tara taranis 0.016
dlg1 discs large 1 0.015
tok tolkin 0.015
myoglianin CG1838 gene product from transcript CG1838-RD 0.015
wun wunen 0.015
daw dawdle 0.015
scb scab 0.015
hth homothorax 0.014
h hairy 0.014
Kr-h1 Kruppel homolog 1 0.014
LamC Lamin C 0.014
bel belle 0.014
CG14614 CG14614 gene product from transcript CG14614-RA 0.014
Adar Adenosine deaminase acting on RNA 0.013
Plc21C Phospholipase C at 21C 0.013
ct cut 0.013
para paralytic 0.012
Eip74EF Ecdysone-induced protein 74EF 0.012
dpp decapentaplegic 0.012
Gyc76C Guanylyl cyclase at 76C 0.012
Eip93F CG18389 gene product from transcript CG18389-RB 0.012
Sdc Syndecan 0.012
CG6701 CG6701 gene product from transcript CG6701-RD 0.012
tws twins 0.012
CG6051 CG6051 gene product from transcript CG6051-RB 0.011
argos CG4531 gene product from transcript CG4531-RA 0.011
RhoGAP100F CG1976 gene product from transcript CG1976-RB 0.011
so sine oculis 0.011
emc extra macrochaetae 0.011
Stat92E Signal-transducer and activator of transcription protein at 92E 0.011
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Homo sapiens
Name Description Probability Func Analog Organism
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.000
SMAD7 SMAD family member 7 1.000
SMAD4 SMAD family member 4 1.000
FHL2 four and a half LIM domains 2 1.000
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 1.000
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 1.000
SMAD1 SMAD family member 1 1.000
SKIL SKI-like oncogene 1.000
SMAD3 SMAD family member 3 0.999
SMAD2 SMAD family member 2 0.999
FN1 fibronectin 1 0.998
ENG endoglin 0.998
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.989
TP53 tumor protein p53 0.973
CREBBP CREB binding protein 0.972
PTK2 PTK2 protein tyrosine kinase 2 0.968
TGFB1 transforming growth factor, beta 1 0.967
ABI2 abl-interactor 2 0.966
TGFBR1 transforming growth factor, beta receptor 1 0.961
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.948
EP300 E1A binding protein p300 0.946
PXN paxillin 0.939
COL1A1 collagen, type I, alpha 1 0.922
CXXC5 CXXC finger protein 5 0.892
PIAS4 protein inhibitor of activated STAT, 4 0.879
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.876
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.873
TBX5 T-box 5 0.864
PAX3 paired box 3 0.836
SMAD5 SMAD family member 5 0.831
TPBG trophoblast glycoprotein 0.816
PDIA3 protein disulfide isomerase family A, member 3 0.797
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.771
POU3F2 POU class 3 homeobox 2 0.770
COL4A1 collagen, type IV, alpha 1 0.757
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.730
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.725
SKI v-ski sarcoma viral oncogene homolog (avian) 0.698
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.672
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.670
CTBP1 C-terminal binding protein 1 0.653
TLN1 talin 1 0.606
MAGEF1 melanoma antigen family F, 1 0.602
AR androgen receptor 0.581
COL3A1 collagen, type III, alpha 1 0.577
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.572
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.572
ZFYVE9 zinc finger, FYVE domain containing 9 0.568
PTPRC protein tyrosine phosphatase, receptor type, C 0.550
FBXL12 F-box and leucine-rich repeat protein 12 0.542
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.519
CAV1 caveolin 1, caveolae protein, 22kDa 0.502
PML promyelocytic leukemia 0.497
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.462
COL1A2 collagen, type I, alpha 2 0.433
BCAR1 breast cancer anti-estrogen resistance 1 0.417
HIPK2 homeodomain interacting protein kinase 2 0.410
TGFB3 transforming growth factor, beta 3 0.405
MTMR4 myotubularin related protein 4 0.403
VCL vinculin 0.396
DLG1 discs, large homolog 1 (Drosophila) 0.395
FLNA filamin A, alpha 0.352
COL4A2 collagen, type IV, alpha 2 0.349
POU5F1 POU class 5 homeobox 1 0.334
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.329
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.318
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae) 0.310
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.296
SNX33 sorting nexin 33 0.295
IGFBP3 insulin-like growth factor binding protein 3 0.288
SNX6 sorting nexin 6 0.288
ITGB5 integrin, beta 5 0.285
AEBP1 AE binding protein 1 0.284
NRP1 neuropilin 1 0.280
TRIM33 tripartite motif containing 33 0.271
SIRT1 sirtuin 1 0.269
NCK2 NCK adaptor protein 2 0.264
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.263
COL5A1 collagen, type V, alpha 1 0.259
SNX2 sorting nexin 2 0.252
TGFB1I1 transforming growth factor beta 1 induced transcript 1 0.250
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.248
STRADA STE20-related kinase adaptor alpha 0.247
CALD1 caldesmon 1 0.246
TIMP3 TIMP metallopeptidase inhibitor 3 0.241
FSTL1 follistatin-like 1 0.238
THBS1 thrombospondin 1 0.234
ILK integrin-linked kinase 0.213
IGFBP5 insulin-like growth factor binding protein 5 0.208
FBXL15 F-box and leucine-rich repeat protein 15 0.203
LUM lumican 0.200
PIAS1 protein inhibitor of activated STAT, 1 0.199
SH3D19 SH3 domain containing 19 0.194
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.194
TGIF1 TGFB-induced factor homeobox 1 0.193
ERBB2IP erbb2 interacting protein 0.192
COL6A1 collagen, type VI, alpha 1 0.168
COL6A3 collagen, type VI, alpha 3 0.157
MXRA5 matrix-remodelling associated 5 0.155
FOXD3 forkhead box D3 0.155
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Rattus norvegicus
Name Description Probability Func Analog Organism
Lamc1 laminin, gamma 1 0.240
Bgn biglycan 0.128
Pecam1 platelet/endothelial cell adhesion molecule 1 0.116
Loxl1 lysyl oxidase-like 1 0.102
Col1a1 collagen, type I, alpha 1 0.080
Pmepa1 prostate transmembrane protein, androgen induced 1 0.076
Stat6 signal transducer and activator of transcription 6 0.063
Slco2a1 solute carrier organic anion transporter family, member 2a1 0.060
Crtap cartilage associated protein 0.052
Copb1 coatomer protein complex, subunit beta 1 0.051
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.050
Col3a1 collagen, type III, alpha 1 0.050
Lum lumican 0.047
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.045
Ggt5 gamma-glutamyltransferase 5 0.043
Ece1 endothelin converting enzyme 1 0.043
Eln elastin 0.041
Nos3 nitric oxide synthase 3, endothelial cell 0.038
Rara retinoic acid receptor, alpha 0.037
Pdia4 protein disulfide isomerase family A, member 4 0.036
Atp1b3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.034
Tgfbr2 transforming growth factor, beta receptor II 0.034
Cish cytokine inducible SH2-containing protein 0.030
Aoc3 amine oxidase, copper containing 3 (vascular adhesion protein 1) 0.028
Cpsf2 cleavage and polyadenylation specific factor 2 0.027
Met met proto-oncogene 0.026
Elk3 ELK3, ETS-domain protein 0.025
Jak2 Janus kinase 2 0.023
Mafb v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) 0.023
Fstl1 follistatin-like 1 0.022
Ncan neurocan 0.021
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.020
Fbln5 fibulin 5 0.019
Plod1 procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 0.018
Socs2 suppressor of cytokine signaling 2 0.018
Il1rap interleukin 1 receptor accessory protein 0.018
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.017
Gsk3b glycogen synthase kinase 3 beta 0.017
Setd8-ps1 SET domain containing (lysine methyltransferase) 8, pseudogene 1 0.017
Smad7 SMAD family member 7 0.016
Dpt dermatopontin 0.016
Hsp90b1 heat shock protein 90, beta, member 1 0.016
Ecm1 extracellular matrix protein 1 0.016
Uso1 USO1 homolog, vesicle docking protein (yeast) 0.016
Lyve1 lymphatic vessel endothelial hyaluronan receptor 1 0.016
Lox lysyl oxidase 0.016
Synpo synaptopodin 0.015
Col12a1 collagen, type XII, alpha 1 0.015
Tgm2 transglutaminase 2, C polypeptide 0.014
Gja4 gap junction protein, alpha 4 0.014
Cald1 caldesmon 1 0.014
Tspan18 tetraspanin 18 0.014
Col5a2 collagen, type V, alpha 2 0.014
Sox17 SRY (sex determining region Y)-box 17 0.013
Lama5 laminin, alpha 5 0.013
Agtr1a angiotensin II receptor, type 1a 0.013
Adra2b adrenergic, alpha-2B-, receptor 0.013
Mmp23 matrix metallopeptidase 23 0.013
Lrp1 low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) 0.013
Flt1 FMS-related tyrosine kinase 1 0.012
Lmcd1 LIM and cysteine-rich domains 1 0.012
Mfap5 microfibrillar associated protein 5 0.012
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.012
Ctrb1 chymotrypsinogen B1 0.012
Acta2 smooth muscle alpha-actin 0.012
Akt1s1 AKT1 substrate 1 (proline-rich) 0.012
Col5a1 collagen, type V, alpha 1 0.011
Sf1 splicing factor 1 0.011
Cdc42ep1 CDC42 effector protein (Rho GTPase binding) 1 0.011
Ptprk protein tyrosine phosphatase, receptor type, K, extracellular region 0.010
Dusp6 dual specificity phosphatase 6 0.010
Tp53 tumor protein p53 0.010
Prkch protein kinase C, eta 0.010
Bmp1 bone morphogenetic protein 1 0.010
Col1a2 collagen, type I, alpha 2 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism