The network for 'regulation of binding' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of binding

Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.

Mus musculus
Name Description Probability Func Analog Organism
Pten phosphatase and tensin homolog 0.998
Trp53 transformation related protein 53 0.998
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.972
Otx2 orthodenticle homolog 2 (Drosophila) 0.966
Ctnnb1 catenin (cadherin associated protein), beta 1 0.965
Pax3 paired box gene 3 0.962
Gata4 GATA binding protein 4 0.962
Csf1 colony stimulating factor 1 (macrophage) 0.950
App amyloid beta (A4) precursor protein 0.939
Axin1 axin 1 0.938
Pax6 paired box gene 6 0.936
Fgfr1 fibroblast growth factor receptor 1 0.926
Notch1 Notch gene homolog 1 (Drosophila) 0.924
Pax2 paired box gene 2 0.924
Psen1 presenilin 1 0.920
Jag1 jagged 1 0.920
Ikzf1 IKAROS family zinc finger 1 0.918
En1 engrailed 1 0.918
Tgfbr2 transforming growth factor, beta receptor II 0.892
Gsk3b glycogen synthase kinase 3 beta 0.881
Tbx3 T-box 3 0.878
Tcf4 transcription factor 4 0.865
Smad4 MAD homolog 4 (Drosophila) 0.863
Arid1a AT rich interactive domain 1A (SWI-like) 0.862
Pitx2 paired-like homeodomain transcription factor 2 0.858
Rxra retinoid X receptor alpha 0.855
Mapk8 mitogen-activated protein kinase 8 0.850
Emx1 empty spiracles homolog 1 (Drosophila) 0.850
Tgfb2 transforming growth factor, beta 2 0.849
Smad3 MAD homolog 3 (Drosophila) 0.838
Fgf8 fibroblast growth factor 8 0.819
Rara retinoic acid receptor, alpha 0.795
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.786
Apc adenomatosis polyposis coli 0.786
Shh sonic hedgehog 0.779
Rarg retinoic acid receptor, gamma 0.769
Meox2 mesenchyme homeobox 2 0.763
Gli3 GLI-Kruppel family member GLI3 0.757
Foxc1 forkhead box C1 0.732
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.718
S100a8 S100 calcium binding protein A8 (calgranulin A) 0.716
Gbx2 gastrulation brain homeobox 2 0.716
Rb1 retinoblastoma 1 0.713
Fgfr2 fibroblast growth factor receptor 2 0.702
Lyz2 lysozyme 2 0.698
Ncoa3 nuclear receptor coactivator 3 0.696
Emx2 empty spiracles homolog 2 (Drosophila) 0.693
Bcl2 B-cell leukemia/lymphoma 2 0.686
Hes1 hairy and enhancer of split 1 (Drosophila) 0.684
Id1 inhibitor of DNA binding 1 0.675
Klc1 kinesin light chain 1 0.672
Foxg1 forkhead box G1 0.643
Sox11 SRY-box containing gene 11 0.638
Mstn myostatin 0.636
Tcf3 transcription factor 3 0.628
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.621
Lgals3 lectin, galactose binding, soluble 3 0.620
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.618
Hes5 hairy and enhancer of split 5 (Drosophila) 0.617
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.614
Lepr leptin receptor 0.614
S100a6 S100 calcium binding protein A6 (calcyclin) 0.614
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.612
Sox4 SRY-box containing gene 4 0.580
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.579
Foxf1a forkhead box F1a 0.557
Cd19 CD19 antigen 0.550
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.548
Pitx1 paired-like homeodomain transcription factor 1 0.540
Tbx1 T-box 1 0.532
Arrb1 arrestin, beta 1 0.531
Bmpr1a bone morphogenetic protein receptor, type 1A 0.522
Smad1 MAD homolog 1 (Drosophila) 0.521
Thra thyroid hormone receptor alpha 0.519
Lmx1a LIM homeobox transcription factor 1 alpha 0.518
Zeb1 zinc finger E-box binding homeobox 1 0.514
Myod1 myogenic differentiation 1 0.513
Agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 0.511
Tlr4 toll-like receptor 4 0.502
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.499
Nog noggin 0.495
Hand2 heart and neural crest derivatives expressed transcript 2 0.494
Mecom MDS1 and EVI1 complex locus 0.491
Neurod1 neurogenic differentiation 1 0.487
Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 0.486
Nrp1 neuropilin 1 0.481
Vegfa vascular endothelial growth factor A 0.463
Fst follistatin 0.462
Foxn1 forkhead box N1 0.461
Rac1 RAS-related C3 botulinum substrate 1 0.459
Ptf1a pancreas specific transcription factor, 1a 0.448
Lhx3 LIM homeobox protein 3 0.443
Lhx9 LIM homeobox protein 9 0.443
Ifnar1 interferon (alpha and beta) receptor 1 0.442
Csnk1e casein kinase 1, epsilon 0.442
Gpc3 glypican 3 0.438
Neurog3 neurogenin 3 0.430
Bmpr2 bone morphogenic protein receptor, type II (serine/threonine kinase) 0.429
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.426
Gata5 GATA binding protein 5 0.422
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
bambia BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a 0.616
robo3 roundabout homolog 3 0.598
hmgb1b high-mobility group box 1b 0.546
dla deltaA 0.494
cdh2 cadherin 2, neuronal 0.458
bmp4 bone morphogenetic protein 4 0.438
tal1 T-cell acute lymphocytic leukemia 1 0.419
mef2ca myocyte enhancer factor 2ca 0.364
smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) 0.347
alcama activated leukocyte cell adhesion molecule a 0.344
hsp90a.2 heat shock protein 90-alpha 2 0.339
hmgb1a high-mobility group box 1a 0.337
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.315
nkx2.5 NK2 transcription factor related 5 0.292
egr2b early growth response 2b 0.289
efnb2a ephrin B2a 0.283
klf4 Kruppel-like factor 4 0.278
ptmaa prothymosin, alpha a 0.270
bmp2b bone morphogenetic protein 2b 0.265
crabp2a cellular retinoic acid binding protein 2, a 0.264
lef1 lymphocyte enhancer binding factor 1 0.262
hmgb3a high-mobility group box 3a 0.260
ef1a elongation factor 1-alpha 0.259
hoxd4a homeo box D4a 0.258
plcg1 phospholipase C, gamma 1 0.227
mapk1 mitogen-activated protein kinase 1 0.226
slc4a1a solute carrier family 4, anion exchanger, member 1a 0.222
eif5a2 eukaryotic translation initiation factor 5A2 0.219
tnnt2a troponin T2a, cardiac 0.218
ccna2 cyclin A2 0.211
svil supervillin 0.208
wnt11r wingless-type MMTV integration site family, member 11, related 0.206
smyhc1 slow myosin heavy chain 1 0.205
tbx2b T-box 2b 0.203
gnat2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 0.196
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.192
extl3 exostoses (multiple)-like 3 0.192
foxd3 forkhead box D3 0.187
tbx5a T-box 5a 0.176
tlr3 toll-like receptor 3 0.173
crip2 cysteine-rich protein 2 0.173
notch3 notch homolog 3 0.166
flot1b flotillin 1b 0.163
sall1a sal-like 1a (Drosophila) 0.162
smad3b MAD, mothers against decapentaplegic homolog 3b (Drosophila) 0.162
icn ictacalcin 0.156
nrg2a neuregulin 2a 0.153
socs3a suppressor of cytokine signaling 3a 0.149
elmo1 engulfment and cell motility 1 (ced-12 homolog, C. elegans) 0.147
dlx5a distal-less homeobox gene 5a 0.147
hspb1 heat shock protein, alpha-crystallin-related, 1 0.145
gata2a GATA-binding protein 2a 0.145
lama5 laminin, alpha 5 0.145
zgc:92027 zgc:92027 0.143
sh3gl1b SH3-domain GRB2-like 1b 0.142
ndrg4 N-myc downstream regulated gene 4 0.142
actc1b actin, alpha, cardiac muscle 1b 0.140
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.139
tfe3a transcription factor binding to IGHM enhancer 3a 0.136
aplp2 amyloid beta (A4) precursor-like protein 2 0.136
cxcr4b chemokine (C-X-C motif), receptor 4b 0.134
appa amyloid beta (A4) precursor protein a 0.133
gadd45bb growth arrest and DNA-damage-inducible, beta b 0.133
kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 0.131
cx43 connexin 43 0.131
khdrbs1a KH domain containing, RNA binding, signal transduction associated 1a 0.131
hmx4 H6 family homeobox 4 0.130
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.127
angptl7 angiopoietin-like 7 0.127
ahctf1 AT hook containing transcription factor 1 0.126
rbpms2 RNA binding protein with multiple splicing 2 0.125
ptgs2a prostaglandin-endoperoxide synthase 2a 0.123
emx3 empty spiracles homeobox 3 0.121
phlda2 pleckstrin homology-like domain, family A, member 2 0.120
scg3 secretogranin III 0.118
gdf6a growth differentiation factor 6a 0.117
eng1a engrailed 1a 0.117
her6 hairy-related 6 0.115
brd4 bromodomain containing 4 0.114
gcga glucagon a and glucagon a-like 0.114
poll polymerase (DNA directed), lambda 0.113
pde6c phosphodiesterase 6C, cGMP-specific, cone, alpha prime 0.112
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.112
fabp7a fatty acid binding protein 7, brain, a 0.112
mapk4 mitogen-activated protein kinase 4 0.111
lft1 lefty1 0.109
hs3st3b1a heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1a 0.109
hdac4 histone deacetylase 4 0.109
mapk6 mitogen-activated protein kinase 6 0.107
tm4sf4 transmembrane 4 L six family member 4 0.105
wnt5b wingless-type MMTV integration site family, member 5b 0.105
rnf2 ring finger protein 2 0.104
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.103
bmpr1aa bone morphogenetic protein receptor, type 1aa 0.103
ntn1a netrin 1a 0.103
col1a1a collagen, type I, alpha 1a 0.103
hhex hematopoietically expressed homeobox 0.102
dlx2a distal-less homeobox gene 2a 0.102
mfn2 mitofusin 2 0.102
tcf12 transcription factor 12 0.101
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Dref DNA replication-related element factor 0.067
dap dacapo 0.057
nej nejire 0.044
ena enabled 0.043
Ptp69D Protein tyrosine phosphatase 69D 0.039
Mad Mothers against dpp 0.038
Nrg Neuroglian 0.033
Gug Grunge 0.022
dco discs overgrown 0.021
cora coracle 0.021
mei-41 meiotic 41 0.020
Su(H) Suppressor of Hairless 0.019
asp abnormal spindle 0.017
sax saxophone 0.016
ninaE neither inactivation nor afterpotential E 0.016
shn schnurri 0.016
phl pole hole 0.016
SoxN SoxNeuro 0.016
wupA wings up A 0.015
hth homothorax 0.015
CaMKII Calcium/calmodulin-dependent protein kinase II 0.014
arm armadillo 0.013
Adf1 Adh transcription factor 1 0.013
kay kayak 0.013
PICK1 CG6167 gene product from transcript CG6167-RA 0.013
opa odd paired 0.013
dpn deadpan 0.012
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.012
nuf nuclear fallout 0.012
Nrt Neurotactin 0.012
aop anterior open 0.012
tim timeless 0.012
mib1 mind bomb 1 0.011
hyd hyperplastic discs 0.011
prd paired 0.011
Uba1 Ubiquitin activating enzyme 1 0.011
fas faint sausage 0.011
disco disconnected 0.011
trx trithorax 0.011
tor torso 0.011
hrg hiiragi 0.010
crb crumbs 0.010
zpg zero population growth 0.010
Pka-C1 cAMP-dependent protein kinase 1 0.010
per period 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.984
FHL2 four and a half LIM domains 2 0.914
TGFB1 transforming growth factor, beta 1 0.899
ZNF43 zinc finger protein 43 0.877
SKIL SKI-like oncogene 0.830
NCOR2 nuclear receptor corepressor 2 0.753
SMAD3 SMAD family member 3 0.739
APP amyloid beta (A4) precursor protein 0.715
STAT1 signal transducer and activator of transcription 1, 91kDa 0.706
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.701
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.680
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.654
BCL2L1 BCL2-like 1 0.649
ZNF253 zinc finger protein 253 0.642
CREBBP CREB binding protein 0.596
CDK9 cyclin-dependent kinase 9 0.586
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.577
ENG endoglin 0.564
HDAC4 histone deacetylase 4 0.558
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.556
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.556
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.553
TGFBR1 transforming growth factor, beta receptor 1 0.537
JUN jun proto-oncogene 0.475
RB1 retinoblastoma 1 0.471
CSNK1E casein kinase 1, epsilon 0.456
ZMYND11 zinc finger, MYND-type containing 11 0.445
ZNF273 zinc finger protein 273 0.439
ZNF260 zinc finger protein 260 0.432
ZNF567 zinc finger protein 567 0.430
CDK2 cyclin-dependent kinase 2 0.426
SMAD4 SMAD family member 4 0.422
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.413
PSEN2 presenilin 2 (Alzheimer disease 4) 0.410
GSK3B glycogen synthase kinase 3 beta 0.410
RXRA retinoid X receptor, alpha 0.402
SPTB spectrin, beta, erythrocytic 0.381
ZNF512B zinc finger protein 512B 0.376
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.366
ANXA1 annexin A1 0.364
RBBP4 retinoblastoma binding protein 4 0.342
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.340
SMAD2 SMAD family member 2 0.339
ZNF675 zinc finger protein 675 0.339
ARRB1 arrestin, beta 1 0.339
HMGA1 high mobility group AT-hook 1 0.320
ZNF91 zinc finger protein 91 0.316
E2F1 E2F transcription factor 1 0.314
PTEN phosphatase and tensin homolog 0.312
IGF2R insulin-like growth factor 2 receptor 0.301
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 0.299
TP53 tumor protein p53 0.294
ZNF84 zinc finger protein 84 0.291
CDC20 cell division cycle 20 homolog (S. cerevisiae) 0.290
HEXIM1 hexamethylene bis-acetamide inducible 1 0.289
ATF3 activating transcription factor 3 0.281
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.277
PDIA3 protein disulfide isomerase family A, member 3 0.276
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.275
MYOD1 myogenic differentiation 1 0.274
EGFR epidermal growth factor receptor 0.268
C1QA complement component 1, q subcomponent, A chain 0.266
HSPA4 heat shock 70kDa protein 4 0.257
FN1 fibronectin 1 0.246
CSNK2B casein kinase 2, beta polypeptide 0.237
NCOR1 nuclear receptor corepressor 1 0.224
CCR5 chemokine (C-C motif) receptor 5 0.223
IFI44 interferon-induced protein 44 0.221
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.213
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.210
MEF2C myocyte enhancer factor 2C 0.210
TK1 thymidine kinase 1, soluble 0.209
PML promyelocytic leukemia 0.209
PINK1 PTEN induced putative kinase 1 0.205
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.199
FLNA filamin A, alpha 0.195
FOS FBJ murine osteosarcoma viral oncogene homolog 0.194
PRKD2 protein kinase D2 0.193
CAV1 caveolin 1, caveolae protein, 22kDa 0.192
LMO2 LIM domain only 2 (rhombotin-like 1) 0.190
FAF1 Fas (TNFRSF6) associated factor 1 0.190
ATF2 activating transcription factor 2 0.190
RCC1 regulator of chromosome condensation 1 0.189
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 0.189
ZNF430 zinc finger protein 430 0.188
SOCS3 suppressor of cytokine signaling 3 0.186
SUMO2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) 0.184
HTT huntingtin 0.183
ZNF85 zinc finger protein 85 0.177
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor 0.174
CXCL9 chemokine (C-X-C motif) ligand 9 0.165
CCL4 chemokine (C-C motif) ligand 4 0.164
PTPRC protein tyrosine phosphatase, receptor type, C 0.163
LRP6 low density lipoprotein receptor-related protein 6 0.162
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.162
AR androgen receptor 0.161
TPM1 tropomyosin 1 (alpha) 0.159
SETD7 SET domain containing (lysine methyltransferase) 7 0.159
ZNF93 zinc finger protein 93 0.159
ZNF680 zinc finger protein 680 0.157
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
CKS1 Cks1p 0.011
CLB2 Clb2p 0.010