The network for 'lymphocyte activation involved in immune response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

lymphocyte activation involved in immune response

A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.

Mus musculus
Name Description Probability Func Analog Organism
Tnf tumor necrosis factor 1.000
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.994
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.991
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.967
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.955
Stat3 signal transducer and activator of transcription 3 0.954
Il10 interleukin 10 0.948
Ifng interferon gamma 0.946
Ccl2 chemokine (C-C motif) ligand 2 0.943
Socs1 suppressor of cytokine signaling 1 0.919
Lepr leptin receptor 0.900
Tlr2 toll-like receptor 2 0.895
Bcl3 B-cell leukemia/lymphoma 3 0.894
Il1r1 interleukin 1 receptor, type I 0.888
Il2rg interleukin 2 receptor, gamma chain 0.878
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.871
Fas Fas (TNF receptor superfamily member 6) 0.871
Cd40 CD40 antigen 0.844
Il4 interleukin 4 0.828
Foxp3 forkhead box P3 0.821
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.806
Stat6 signal transducer and activator of transcription 6 0.790
Stat1 signal transducer and activator of transcription 1 0.785
Lyz2 lysozyme 2 0.770
Fyn Fyn proto-oncogene 0.766
Pitx1 paired-like homeodomain transcription factor 1 0.747
Tbx3 T-box 3 0.693
Cd28 CD28 antigen 0.686
H2-K1 histocompatibility 2, K1, K region 0.683
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.667
Runx1 runt related transcription factor 1 0.664
Irf9 interferon regulatory factor 9 0.662
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.660
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.654
B2m beta-2 microglobulin 0.653
Il1b interleukin 1 beta 0.620
Il4ra interleukin 4 receptor, alpha 0.613
Prf1 perforin 1 (pore forming protein) 0.612
Ccr1 chemokine (C-C motif) receptor 1 0.601
Rag1 recombination activating gene 1 0.590
Myd88 myeloid differentiation primary response gene 88 0.581
Cd44 CD44 antigen 0.581
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.579
Jak2 Janus kinase 2 0.570
Irf4 interferon regulatory factor 4 0.558
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.553
Ltb lymphotoxin B 0.553
Creb1 cAMP responsive element binding protein 1 0.552
Ccr2 chemokine (C-C motif) receptor 2 0.544
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.539
H2-D1 histocompatibility 2, D region locus 1 0.534
Ikzf1 IKAROS family zinc finger 1 0.526
Socs3 suppressor of cytokine signaling 3 0.526
Il10ra interleukin 10 receptor, alpha 0.522
Rc3h1 RING CCCH (C3H) domains 1 0.514
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.508
Stat2 signal transducer and activator of transcription 2 0.496
Rab27a RAB27A, member RAS oncogene family 0.481
Pten phosphatase and tensin homolog 0.459
Csf1 colony stimulating factor 1 (macrophage) 0.434
Prdm1 PR domain containing 1, with ZNF domain 0.429
Irf1 interferon regulatory factor 1 0.421
Bcl6 B-cell leukemia/lymphoma 6 0.414
Msr1 macrophage scavenger receptor 1 0.406
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.401
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.394
Lef1 lymphoid enhancer binding factor 1 0.383
Ikbkb inhibitor of kappaB kinase beta 0.382
Lta lymphotoxin A 0.381
Gdf3 growth differentiation factor 3 0.380
Traf6 TNF receptor-associated factor 6 0.367
Il6st interleukin 6 signal transducer 0.367
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.356
Chd7 chromodomain helicase DNA binding protein 7 0.356
Cish cytokine inducible SH2-containing protein 0.349
Ccr7 chemokine (C-C motif) receptor 7 0.342
Cdx2 caudal type homeobox 2 0.338
Atxn1 ataxin 1 0.333
Tlr4 toll-like receptor 4 0.330
Atm ataxia telangiectasia mutated homolog (human) 0.326
Ccl3 chemokine (C-C motif) ligand 3 0.324
Irf5 interferon regulatory factor 5 0.320
Foxp1 forkhead box P1 0.313
Gli2 GLI-Kruppel family member GLI2 0.308
Cyld cylindromatosis (turban tumor syndrome) 0.305
Nlrp3 NLR family, pyrin domain containing 3 0.301
Ikbkg inhibitor of kappaB kinase gamma 0.293
Il2rb interleukin 2 receptor, beta chain 0.292
Ncoa3 nuclear receptor coactivator 3 0.290
Sema6d sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.289
Fgf10 fibroblast growth factor 10 0.281
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.274
Unc93b1 unc-93 homolog B1 (C. elegans) 0.268
Tapbp TAP binding protein 0.267
Birc3 baculoviral IAP repeat-containing 3 0.266
Cd14 CD14 antigen 0.262
Nos2 nitric oxide synthase 2, inducible 0.261
Il18rap interleukin 18 receptor accessory protein 0.258
a nonagouti 0.258
Gm12185 predicted gene 12185 0.243
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.950
FHL2 four and a half LIM domains 2 0.854
IL4R interleukin 4 receptor 0.424
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.330
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.232
PILRA paired immunoglobin-like type 2 receptor alpha 0.228
GRAP2 GRB2-related adaptor protein 2 0.166
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.151
HLA-DMA major histocompatibility complex, class II, DM alpha 0.150
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.149
MDC1 mediator of DNA-damage checkpoint 1 0.137
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.132
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.127
APLF aprataxin and PNKP like factor 0.123
ENG endoglin 0.112
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.107
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.097
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.095
RXRA retinoid X receptor, alpha 0.088
BRCA1 breast cancer 1, early onset 0.085
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.085
LIN9 lin-9 homolog (C. elegans) 0.081
TGIF1 TGFB-induced factor homeobox 1 0.076
H2AFX H2A histone family, member X 0.076
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.069
BIRC3 baculoviral IAP repeat containing 3 0.066
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.064
FLNA filamin A, alpha 0.060
CALCOCO2 calcium binding and coiled-coil domain 2 0.058
MSH6 mutS homolog 6 (E. coli) 0.057
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.056
THOC5 THO complex 5 0.055
SIGLEC7 sialic acid binding Ig-like lectin 7 0.050
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.048
CD22 CD22 molecule 0.048
PTPRC protein tyrosine phosphatase, receptor type, C 0.047
PECAM1 platelet/endothelial cell adhesion molecule 0.047
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.046
THOC4 THO complex 4 0.045
IL23A interleukin 23, alpha subunit p19 0.043
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.043
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.040
ESR1 estrogen receptor 1 0.039
LIG4 ligase IV, DNA, ATP-dependent 0.039
CD86 CD86 molecule 0.038
NCSTN nicastrin 0.037
PLEK pleckstrin 0.037
IL2RG interleukin 2 receptor, gamma 0.036
NOD2 nucleotide-binding oligomerization domain containing 2 0.036
GBA glucosidase, beta, acid 0.035
RUNX1 runt-related transcription factor 1 0.033
BCL3 B-cell CLL/lymphoma 3 0.033
MSH3 mutS homolog 3 (E. coli) 0.030
ICAM1 intercellular adhesion molecule 1 0.029
NCOR2 nuclear receptor corepressor 2 0.028
PML promyelocytic leukemia 0.028
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 0.028
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.028
CD1C CD1c molecule 0.026
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.026
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.026
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.026
HDAC9 histone deacetylase 9 0.026
SOCS3 suppressor of cytokine signaling 3 0.025
RAB14 RAB14, member RAS oncogene family 0.025
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.024
PDZD11 PDZ domain containing 11 0.024
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.023
RAD50 RAD50 homolog (S. cerevisiae) 0.022
TLN1 talin 1 0.022
CD33 CD33 molecule 0.022
IL4 interleukin 4 0.021
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.021
TGFB1 transforming growth factor, beta 1 0.021
TYMP thymidine phosphorylase 0.021
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.021
IL6R interleukin 6 receptor 0.021
LAPTM5 lysosomal protein transmembrane 5 0.020
MICA MHC class I polypeptide-related sequence A 0.020
PPARA peroxisome proliferator-activated receptor alpha 0.020
EMP3 epithelial membrane protein 3 0.018
HCK hemopoietic cell kinase 0.018
TRAF3 TNF receptor-associated factor 3 0.018
CCR2 chemokine (C-C motif) receptor 2 0.017
CD40 CD40 molecule, TNF receptor superfamily member 5 0.017
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 0.017
PTAFR platelet-activating factor receptor 0.017
FLNB filamin B, beta 0.017
HK3 hexokinase 3 (white cell) 0.017
SPI1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.017
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.016
FRA10AC1 fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 0.016
CD1B CD1b molecule 0.016
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 0.016
TICAM2 toll-like receptor adaptor molecule 2 0.015
LY96 lymphocyte antigen 96 0.015
TMSB10 thymosin beta 10 0.015
CCL22 chemokine (C-C motif) ligand 22 0.015
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.015
LIN54 lin-54 homolog (C. elegans) 0.014
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Rattus norvegicus
Name Description Probability Func Analog Organism
Bin2 bridging integrator 2 0.065
Anpep alanyl (membrane) aminopeptidase 0.058
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.053
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.050
Ptafr platelet-activating factor receptor 0.049
Hck hemopoietic cell kinase 0.039
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.036
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.035
Tgfbr2 transforming growth factor, beta receptor II 0.034
Cd4 Cd4 molecule 0.032
Ctse cathepsin E 0.032
Arhgap4 Rho GTPase activating protein 4 0.031
Lcp2 lymphocyte cytosolic protein 2 0.031
Dock8 dedicator of cytokinesis 8 0.028
Nckap1l NCK associated protein 1 like 0.028
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.028
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.027
Il2rb interleukin 2 receptor, beta 0.027
Ptprc protein tyrosine phosphatase, receptor type, C 0.026
Laptm5 lysosomal protein transmembrane 5 0.025
Epn1 Epsin 1 0.025
Hmha1 histocompatibility (minor) HA-1 0.024
Il7r interleukin 7 receptor 0.024
Socs3 suppressor of cytokine signaling 3 0.024
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.024
Il1r1 interleukin 1 receptor, type I 0.022
Kcnj13 potassium inwardly-rectifying channel, subfamily J, member 13 0.021
Vav1 vav 1 guanine nucleotide exchange factor 0.021
Cand1 cullin-associated and neddylation-dissociated 1 0.021
Cd38 CD38 molecule 0.020
Abcb4 ATP-binding cassette, subfamily B (MDR/TAP), member 4 0.020
Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.020
Rhoh ras homolog gene family, member H 0.020
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.020
Pyy peptide YY (mapped) 0.019
Lrg1 leucine-rich alpha-2-glycoprotein 1 0.019
Reg1a regenerating islet-derived 1 alpha 0.019
Il1a interleukin 1 alpha 0.019
Lta lymphotoxin alpha (TNF superfamily, member 1) 0.019
Cmklr1 chemokine-like receptor 1 0.018
LOC100360406 rCG34104-like 0.018
Tgfbr3 transforming growth factor, beta receptor III 0.018
Mmp12 matrix metallopeptidase 12 0.018
Adrb2 adrenergic, beta-2-, receptor, surface 0.018
Arfgap1 ADP-ribosylation factor GTPase activating protein 1 0.018
Lilrb3l leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like 0.018
Ly6b lymphocyte antigen 6 complex, locus B 0.018
Fancc Fanconi anemia, complementation group C 0.018
Scn11a sodium channel, voltage-gated, type XI, alpha 0.018
Zcwpw1 zinc finger, CW-type with PWWP domain 1 0.018
Nr5a2 nuclear receptor subfamily 5, group A, member 2 0.017
Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) 0.017
Chordc1 cysteine and histidine-rich domain (CHORD)-containing 1 0.017
Arl5c ADP-ribosylation factor-like 5C 0.017
Il1b interleukin 1 beta 0.017
Cldn7 claudin 7 0.017
Prss8 protease, serine, 8 0.017
Cd86 CD86 molecule 0.017
Dctn4 dynactin 4 0.017
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.017
Cd247 Cd247 molecule 0.017
Il8rb interleukin 8 receptor, beta 0.017
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.017
Hsph1 heat shock 105/110 protein 1 0.017
Sstr3 somatostatin receptor 3 0.016
Myh9 myosin, heavy chain 9, non-muscle 0.016
Psd4 pleckstrin and Sec7 domain containing 4 0.016
Cd37 CD37 molecule 0.016
B4galt1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.016
Evi2a ecotropic viral integration site 2A 0.016
Stat6 signal transducer and activator of transcription 6 0.016
Myo1e myosin IE 0.016
Ptpn1 protein tyrosine phosphatase, non-receptor type 1 0.016
Htr1b 5-hydroxytryptamine (serotonin) receptor 1B 0.016
Rab10 RAB10, member RAS oncogene family 0.016
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.016
Ripk3 receptor-interacting serine-threonine kinase 3 0.016
Pik3cd phosphoinositide-3-kinase, catalytic, delta polypeptide 0.016
Gna15 guanine nucleotide binding protein, alpha 15 0.015
Arhgap9 Rho GTPase activating protein 9 0.015
Vom1r90 vomeronasal 1 receptor 90 0.015
Il17ra interleukin 17 receptor A 0.015
Ppard peroxisome proliferator-activated receptor delta 0.015
Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 0.015
Rab6a RAB6A, member RAS oncogene family 0.015
Cd40 CD40 molecule, TNF receptor superfamily member 5 0.015
Wipf1 WAS/WASL interacting protein family, member 1 0.015
Rara retinoic acid receptor, alpha 0.015
Hspa8 heat shock protein 8 0.015
Bcl3 B-cell CLL/lymphoma 3 0.015
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.015
Ceacam1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.015
Slco2a1 solute carrier organic anion transporter family, member 2a1 0.015
Scamp2 secretory carrier membrane protein 2 0.015
RGD1306474 similar to RIKEN cDNA 9530003J23 0.015
Il4ra interleukin 4 receptor, alpha 0.015
Htr2b 5-hydroxytryptamine (serotonin) receptor 2B 0.015
Dlst dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 0.014
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.014
Pparg peroxisome proliferator-activated receptor gamma 0.014
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism