IMP
Process View
negative regulation of cell cycle g1 s phase transition
Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle G1/S phase transition.
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| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| RB1 | retinoblastoma 1 | 1.000 | Mouse | |
| RBL2 | retinoblastoma-like 2 (p130) | 0.982 | Fly | |
| TP53 | tumor protein p53 | 0.949 | ||
| CCND1 | cyclin D1 | 0.913 | ||
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.877 | ||
| CDK6 | cyclin-dependent kinase 6 | 0.864 | ||
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | 0.810 | Human | |
| MDM2 | Mdm2 p53 binding protein homolog (mouse) | 0.800 | ||
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 0.672 | ||
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 0.663 | Human | |
| CDK2 | cyclin-dependent kinase 2 | 0.618 | ||
| RBL1 | retinoblastoma-like 1 (p107) | 0.581 | Fly | |
| EGFR | epidermal growth factor receptor | 0.562 | Fly | |
| CCND3 | cyclin D3 | 0.506 | Human | |
| XIAP | X-linked inhibitor of apoptosis | 0.498 | ||
| SMAD1 | SMAD family member 1 | 0.449 | Fly | |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.422 | ||
| CDKN2A | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 0.411 | ||
| PPP2R1B | protein phosphatase 2, regulatory subunit A, beta | 0.389 | ||
| CHEK2 | CHK2 checkpoint homolog (S. pombe) | 0.349 | ||
| ABL1 | c-abl oncogene 1, non-receptor tyrosine kinase | 0.340 | ||
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.312 | ||
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.306 | ||
| APAF1 | apoptotic peptidase activating factor 1 | 0.293 | ||
| FAS | Fas (TNF receptor superfamily, member 6) | 0.275 | ||
| SMARCD1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 | 0.266 | ||
| NCOA1 | nuclear receptor coactivator 1 | 0.253 | ||
| ERBB3 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 0.243 | Fly | |
| SMAD7 | SMAD family member 7 | 0.242 | ||
| E2F8 | E2F transcription factor 8 | 0.240 | ||
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.239 | ||
| SMAD5 | SMAD family member 5 | 0.234 | Fly | |
| UHRF2 | ubiquitin-like with PHD and ring finger domains 2 | 0.233 | ||
| PAX3 | paired box 3 | 0.233 | ||
| RBBP8 | retinoblastoma binding protein 8 | 0.230 | ||
| HBP1 | HMG-box transcription factor 1 | 0.210 | ||
| CASP8 | caspase 8, apoptosis-related cysteine peptidase | 0.207 | Human | |
| SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | 0.205 | Fly | |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 0.195 | Fly | |
| E2F1 | E2F transcription factor 1 | 0.191 | ||
| BTRC | beta-transducin repeat containing | 0.189 | ||
| ERBB2 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 0.169 | Fly | |
| RTF1 | Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) | 0.154 | ||
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.151 | ||
| POU3F2 | POU class 3 homeobox 2 | 0.138 | ||
| CASP4 | caspase 4, apoptosis-related cysteine peptidase | 0.133 | Human | |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.132 | Fly | |
| WWOX | WW domain containing oxidoreductase | 0.131 | ||
| USP7 | ubiquitin specific peptidase 7 (herpes virus-associated) | 0.118 | ||
| SMARCB1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 | 0.117 | ||
| CBL | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 0.116 | ||
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.116 | ||
| E2F3 | E2F transcription factor 3 | 0.113 | ||
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.110 | ||
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | 0.110 | ||
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | 0.109 | ||
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | 0.108 | ||
| AR | androgen receptor | 0.100 | ||
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | 0.098 | Human | |
| POU5F1 | POU class 5 homeobox 1 | 0.095 | ||
| HNRNPUL1 | heterogeneous nuclear ribonucleoprotein U-like 1 | 0.095 | ||
| RBBP4 | retinoblastoma binding protein 4 | 0.093 | ||
| MDM4 | Mdm4 p53 binding protein homolog (mouse) | 0.084 | Human | |
| E2F2 | E2F transcription factor 2 | 0.082 | ||
| UBE3A | ubiquitin protein ligase E3A | 0.080 | ||
| NLRC4 | NLR family, CARD domain containing 4 | 0.078 | ||
| YAP1 | Yes-associated protein 1 | 0.076 | ||
| RAF1 | v-raf-1 murine leukemia viral oncogene homolog 1 | 0.076 | ||
| LIN54 | lin-54 homolog (C. elegans) | 0.070 | ||
| SPRR2A | small proline-rich protein 2A | 0.063 | ||
| DOT1L | DOT1-like, histone H3 methyltransferase (S. cerevisiae) | 0.060 | ||
| IFI16 | interferon, gamma-inducible protein 16 | 0.060 | ||
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.057 | ||
| BCL2 | B-cell CLL/lymphoma 2 | 0.056 | Mouse | |
| ABI1 | abl-interactor 1 | 0.056 | ||
| SMAD3 | SMAD family member 3 | 0.055 | ||
| PIK3R2 | phosphoinositide-3-kinase, regulatory subunit 2 (beta) | 0.054 | ||
| TFDP1 | transcription factor Dp-1 | 0.053 | ||
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.052 | ||
| BRD3 | bromodomain containing 3 | 0.052 | ||
| LRDD | leucine-rich repeats and death domain containing | 0.051 | ||
| NCOR1 | nuclear receptor corepressor 1 | 0.050 | ||
| PTCH1 | patched 1 | 0.050 | ||
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | 0.049 | ||
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 0.049 | Human | |
| LEO1 | Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) | 0.049 | ||
| E2F4 | E2F transcription factor 4, p107/p130-binding | 0.047 | Fly | |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.047 | ||
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.045 | ||
| RAD18 | RAD18 homolog (S. cerevisiae) | 0.044 | ||
| CTR9 | Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) | 0.044 | ||
| CUX1 | cut-like homeobox 1 | 0.044 | ||
| FASLG | Fas ligand (TNF superfamily, member 6) | 0.044 | ||
| GNL3L | guanine nucleotide binding protein-like 3 (nucleolar)-like | 0.044 | ||
| PLCG1 | phospholipase C, gamma 1 | 0.043 | ||
| TXNIP | thioredoxin interacting protein | 0.043 | ||
| PDE4DIP | phosphodiesterase 4D interacting protein | 0.041 | ||
| SATB2 | SATB homeobox 2 | 0.040 | ||
| PPP2R5A | protein phosphatase 2, regulatory subunit B', alpha | 0.039 | Human | |
| MLLT1 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 | 0.039 | ||
| CASP1 | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 0.038 | Human | |
| VAV1 | vav 1 guanine nucleotide exchange factor | 0.038 | ||
| MECP2 | methyl CpG binding protein 2 (Rett syndrome) | 0.038 | ||
| EP300 | E1A binding protein p300 | 0.037 | ||
| TCEA1 | transcription elongation factor A (SII), 1 | 0.036 | ||
| PURA | purine-rich element binding protein A | 0.034 | ||
| BTN3A3 | butyrophilin, subfamily 3, member A3 | 0.034 | ||
| TRRAP | transformation/transcription domain-associated protein | 0.033 | ||
| CCNE1 | cyclin E1 | 0.031 | ||
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | 0.031 | ||
| DBN1 | drebrin 1 | 0.031 | ||
| BTN3A1 | butyrophilin, subfamily 3, member A1 | 0.030 | ||
| FADD | Fas (TNFRSF6)-associated via death domain | 0.030 | ||
| LIN9 | lin-9 homolog (C. elegans) | 0.030 | ||
| ABL2 | v-abl Abelson murine leukemia viral oncogene homolog 2 | 0.030 | ||
| BTN3A2 | butyrophilin, subfamily 3, member A2 | 0.030 | ||
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma | 0.030 | ||
| KRT5 | keratin 5 | 0.030 | ||
| CDKN2C | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | 0.029 | ||
| CHEK1 | CHK1 checkpoint homolog (S. pombe) | 0.029 | ||
| IRAK1 | interleukin-1 receptor-associated kinase 1 | 0.029 | ||
| SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | 0.028 | Fly | |
| RPA1 | replication protein A1, 70kDa | 0.027 | ||
| AHR | aryl hydrocarbon receptor | 0.027 | ||
| MEOX2 | mesenchyme homeobox 2 | 0.025 | ||
| NRIP1 | nuclear receptor interacting protein 1 | 0.024 | ||
| ITCH | itchy E3 ubiquitin protein ligase homolog (mouse) | 0.024 | ||
| FOXD3 | forkhead box D3 | 0.024 | ||
| CARM1 | coactivator-associated arginine methyltransferase 1 | 0.023 | ||
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.022 | ||
| ARRB2 | arrestin, beta 2 | 0.022 | ||
| CDK4 | cyclin-dependent kinase 4 | 0.022 | ||
| CCND2 | cyclin D2 | 0.022 | Human | |
| RAD51 | RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) | 0.022 | ||
| ELF4 | E74-like factor 4 (ets domain transcription factor) | 0.022 | ||
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.021 | ||
| RPS27L | ribosomal protein S27-like | 0.021 | ||
| CBX5 | chromobox homolog 5 | 0.021 | ||
| RASSF1 | Ras association (RalGDS/AF-6) domain family member 1 | 0.021 | ||
| PCGF2 | polycomb group ring finger 2 | 0.020 | ||
| JAK2 | Janus kinase 2 | 0.020 | ||
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | 0.020 | ||
| NOTCH1 | notch 1 | 0.020 | ||
| TAF1 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | 0.020 | ||
| MCM7 | minichromosome maintenance complex component 7 | 0.020 | ||
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.020 | ||
| UBE2D1 | ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) | 0.020 | ||
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.019 | ||
| ZBTB16 | zinc finger and BTB domain containing 16 | 0.019 | ||
| PCNA | proliferating cell nuclear antigen | 0.019 | ||
| RNF20 | ring finger protein 20 | 0.019 | ||
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 | 0.019 | ||
| MARCKSL1 | MARCKS-like 1 | 0.019 | ||
| E2F5 | E2F transcription factor 5, p130-binding | 0.019 | Fly | |
| EID1 | EP300 interacting inhibitor of differentiation 1 | 0.019 | ||
| UBE2B | ubiquitin-conjugating enzyme E2B (RAD6 homolog) | 0.019 | Yeast | |
| CTDSP2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 | 0.018 | Mouse | |
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | 0.018 | ||
| TNIP1 | TNFAIP3 interacting protein 1 | 0.018 | ||
| YY1 | YY1 transcription factor | 0.018 | ||
| CASP9 | caspase 9, apoptosis-related cysteine peptidase | 0.018 | Human | |
| DLG2 | discs, large homolog 2 (Drosophila) | 0.018 | ||
| SKP2 | S-phase kinase-associated protein 2 (p45) | 0.017 | ||
| SGOL1 | shugoshin-like 1 (S. pombe) | 0.017 | ||
| CDKN2D | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) | 0.017 | ||
| FRK | fyn-related kinase | 0.017 | ||
| CDKN2B | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | 0.017 | Mouse | |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 0.017 | ||
| NRXN1 | neurexin 1 | 0.017 | ||
| FBXW11 | F-box and WD repeat domain containing 11 | 0.016 | ||
| RIOK3 | RIO kinase 3 (yeast) | 0.016 | ||
| BIRC2 | baculoviral IAP repeat containing 2 | 0.016 | ||
| GSK3B | glycogen synthase kinase 3 beta | 0.016 | ||
| SP100 | SP100 nuclear antigen | 0.016 | ||
| RNF40 | ring finger protein 40 | 0.016 | ||
| KDM5B | lysine (K)-specific demethylase 5B | 0.016 | ||
| GAB2 | GRB2-associated binding protein 2 | 0.016 | ||
| UNG | uracil-DNA glycosylase | 0.016 | ||
| SMPD1 | sphingomyelin phosphodiesterase 1, acid lysosomal | 0.016 | ||
| NR2E3 | nuclear receptor subfamily 2, group E, member 3 | 0.016 | ||
| SS18 | synovial sarcoma translocation, chromosome 18 | 0.016 | ||
| NCOA6 | nuclear receptor coactivator 6 | 0.016 | ||
| SUZ12 | suppressor of zeste 12 homolog (Drosophila) | 0.015 | ||
| SALL2 | sal-like 2 (Drosophila) | 0.015 | ||
| ING4 | inhibitor of growth family, member 4 | 0.015 | ||
| BRCA1 | breast cancer 1, early onset | 0.015 | ||
| NMI | N-myc (and STAT) interactor | 0.015 | ||
| HDAC4 | histone deacetylase 4 | 0.015 | ||
| NUCB2 | nucleobindin 2 | 0.015 | ||
| HIPK2 | homeodomain interacting protein kinase 2 | 0.015 | ||
| ANKLE2 | ankyrin repeat and LEM domain containing 2 | 0.015 | ||
| ELAVL1 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) | 0.015 | ||
| BCL2L1 | BCL2-like 1 | 0.015 | ||
| MYST2 | MYST histone acetyltransferase 2 | 0.015 | ||
| KAT2B | K(lysine) acetyltransferase 2B | 0.014 | ||
| PAF1 | Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) | 0.014 | ||
| ABI2 | abl-interactor 2 | 0.014 | ||
| PPP2R1A | protein phosphatase 2, regulatory subunit A, alpha | 0.014 | ||
| TRO | trophinin | 0.014 | ||
| DAXX | death-domain associated protein | 0.014 | ||
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | 0.014 | ||
| RAC1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 0.014 | ||
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | 0.014 | ||
| ING5 | inhibitor of growth family, member 5 | 0.013 | ||
| BAIAP2 | BAI1-associated protein 2 | 0.013 | ||
| MTUS2 | microtubule associated tumor suppressor candidate 2 | 0.013 | ||
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | 0.013 | ||
| CARD16 | caspase recruitment domain family, member 16 | 0.013 | ||
| WWP1 | WW domain containing E3 ubiquitin protein ligase 1 | 0.013 | ||
| DDAH2 | dimethylarginine dimethylaminohydrolase 2 | 0.013 | ||
| GAB1 | GRB2-associated binding protein 1 | 0.013 | ||
| CAP2 | CAP, adenylate cyclase-associated protein, 2 (yeast) | 0.013 | ||
| WASF2 | WAS protein family, member 2 | 0.013 | ||
| RYBP | RING1 and YY1 binding protein | 0.013 | ||
| AKAP8 | A kinase (PRKA) anchor protein 8 | 0.013 | ||
| BCL11A | B-cell CLL/lymphoma 11A (zinc finger protein) | 0.013 | ||
| MCM2 | minichromosome maintenance complex component 2 | 0.013 | ||
| TRIM11 | tripartite motif containing 11 | 0.013 | ||
| ATF2 | activating transcription factor 2 | 0.013 | ||
| HIST2H3C | histone cluster 2, H3c | 0.013 | ||
| ESR1 | estrogen receptor 1 | 0.013 | ||
| DUSP23 | dual specificity phosphatase 23 | 0.013 | ||
| MED31 | mediator complex subunit 31 | 0.012 | ||
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | 0.012 | ||
| MSH5 | mutS homolog 5 (E. coli) | 0.012 | ||
| POLE | polymerase (DNA directed), epsilon | 0.012 | ||
| BANP | BTG3 associated nuclear protein | 0.012 | ||
| SESN1 | sestrin 1 | 0.012 | ||
| TRPC1 | transient receptor potential cation channel, subfamily C, member 1 | 0.012 | ||
| DZIP1 | DAZ interacting protein 1 | 0.012 | ||
| TRIM38 | tripartite motif containing 38 | 0.012 | ||
| SKI | v-ski sarcoma viral oncogene homolog (avian) | 0.012 | ||
| PPP5C | protein phosphatase 5, catalytic subunit | 0.012 | ||
| WHSC1 | Wolf-Hirschhorn syndrome candidate 1 | 0.012 | ||
| MYD88 | myeloid differentiation primary response gene (88) | 0.012 | ||
| MED15 | mediator complex subunit 15 | 0.012 | ||
| ASXL1 | additional sex combs like 1 (Drosophila) | 0.012 | ||
| PBRM1 | polybromo 1 | 0.012 | ||
| PAPD7 | PAP associated domain containing 7 | 0.012 | ||
| SEPT8 | septin 8 | 0.012 | ||
| AXIN1 | axin 1 | 0.012 | ||
| POLH | polymerase (DNA directed), eta | 0.012 | ||
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.012 | ||
| MAGED1 | melanoma antigen family D, 1 | 0.011 | ||
| KRT6C | keratin 6C | 0.011 | ||
| NTRK1 | neurotrophic tyrosine kinase, receptor, type 1 | 0.011 | ||
| RNF11 | ring finger protein 11 | 0.011 | ||
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | 0.011 | ||
| WWP2 | WW domain containing E3 ubiquitin protein ligase 2 | 0.011 | ||
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | 0.011 | ||
| SOX5 | SRY (sex determining region Y)-box 5 | 0.011 | ||
| ANKS1A | ankyrin repeat and sterile alpha motif domain containing 1A | 0.011 | ||
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.011 | ||
| ATM | ataxia telangiectasia mutated | 0.011 | ||
| GBP1 | guanylate binding protein 1, interferon-inducible | 0.011 | ||
| DEAF1 | deformed epidermal autoregulatory factor 1 (Drosophila) | 0.011 | ||
| IL15 | interleukin 15 | 0.011 | ||
| CBX6 | chromobox homolog 6 | 0.011 | ||
| CDC25A | cell division cycle 25 homolog A (S. pombe) | 0.011 | ||
| GORAB | golgin, RAB6-interacting | 0.011 | ||
| PAFAH1B3 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) | 0.011 | ||
| SKP1 | S-phase kinase-associated protein 1 | 0.011 | ||
| WDR61 | WD repeat domain 61 | 0.011 | ||
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4 | 0.011 | ||
| XPC | xeroderma pigmentosum, complementation group C | 0.011 | ||
| GLRX | glutaredoxin (thioltransferase) | 0.011 | ||
| PSMD10 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | 0.011 | ||
| SAFB2 | scaffold attachment factor B2 | 0.010 | ||
| FZD7 | frizzled homolog 7 (Drosophila) | 0.010 | ||
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.010 | ||
| CTBP1 | C-terminal binding protein 1 | 0.010 | ||
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) | 0.010 | ||
| CSK | c-src tyrosine kinase | 0.010 | ||
| TAP1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 0.010 | ||
| SMAD4 | SMAD family member 4 | 0.010 | ||
| AMOTL1 | angiomotin like 1 | 0.010 | ||
| FGFR1 | fibroblast growth factor receptor 1 | 0.010 | ||
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.010 | ||
| HDAC1 | histone deacetylase 1 | 0.010 | ||
| WASF1 | WAS protein family, member 1 | 0.010 | ||
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.010 |