IMP

Process View

Homo sapiens

33 genes annotated in human

antigen processing and presentation

GO:0019882

The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "antigen processing and presentation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "antigen processing and presentation" (in gray)

Name	Description	Probability	Func Analog Organism
HLA-DRA	major histocompatibility complex, class II, DR alpha	1.000
HLA-DRB1	major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1	0.999
HLA-DMA	major histocompatibility complex, class II, DM alpha	0.990
TAPBP	TAP binding protein (tapasin)	0.982
HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	0.977	Human Mouse
HLA-B	major histocompatibility complex, class I, B	0.977
CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.974	Mouse
HLA-C	major histocompatibility complex, class I, C	0.973
HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	0.972
HLA-G	major histocompatibility complex, class I, G	0.966	Human
HLA-DMB	major histocompatibility complex, class II, DM beta	0.961
PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)	0.958	Mouse
B2M	beta-2-microglobulin	0.893	Mouse
HLA-A	major histocompatibility complex, class I, A	0.889
HLA-F	major histocompatibility complex, class I, F	0.870	Human
PSMB9	proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)	0.850
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.807	Human
OCRL	oculocerebrorenal syndrome of Lowe	0.802
PSME1	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)	0.800	Mouse
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.749
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.734
PSMB10	proteasome (prosome, macropain) subunit, beta type, 10	0.717
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.643	Human
HLA-DRB5	major histocompatibility complex, class II, DR beta 5	0.621	Human
HLA-DPB1	major histocompatibility complex, class II, DP beta 1	0.604
GOLGA2	golgin A2	0.518
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.431
PILRA	paired immunoglobin-like type 2 receptor alpha	0.408
HLA-E	major histocompatibility complex, class I, E	0.393
PSME2	proteasome (prosome, macropain) activator subunit 2 (PA28 beta)	0.285	Mouse
PSAP	prosaposin	0.268
HLA-DRB4	major histocompatibility complex, class II, DR beta 4	0.214
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.211	Human
RAB1A	RAB1A, member RAS oncogene family	0.172	Human
GRN	granulin	0.145
CD86	CD86 molecule	0.140
CLEC10A	C-type lectin domain family 10, member A	0.139
SIGLEC7	sialic acid binding Ig-like lectin 7	0.123
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.123
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.122	Human
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.122	Mouse
PLEK	pleckstrin	0.121
NUCB1	nucleobindin 1	0.119
CCR1	chemokine (C-C motif) receptor 1	0.112
RIPK2	receptor-interacting serine-threonine kinase 2	0.109
CTSA	cathepsin A	0.102
ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	0.100
NPC2	Niemann-Pick disease, type C2	0.097
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.096
GDI2	GDP dissociation inhibitor 2	0.088
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.086
MAN2B1	mannosidase, alpha, class 2B, member 1	0.083
CD33	CD33 molecule	0.082
HK3	hexokinase 3 (white cell)	0.082
RAB2A	RAB2A, member RAS oncogene family	0.081	Human
TPP1	tripeptidyl peptidase I	0.076
ROD1	ROD1 regulator of differentiation 1 (S. pombe)	0.074
PLD3	phospholipase D family, member 3	0.074
MLPH	melanophilin	0.073
OS9	osteosarcoma amplified 9, endoplasmic reticulum lectin	0.072
PTAFR	platelet-activating factor receptor	0.071
C1orf38	chromosome 1 open reading frame 38	0.068
ATP6V0C	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c	0.064
TYMP	thymidine phosphorylase	0.063
CTSB	cathepsin B	0.063
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.063
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.063
FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)	0.060
BTN3A3	butyrophilin, subfamily 3, member A3	0.059
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.059
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.058
SLC15A3	solute carrier family 15, member 3	0.057
LY86	lymphocyte antigen 86	0.056
CST3	cystatin C	0.050
IFI30	interferon, gamma-inducible protein 30	0.050	Mouse
CD1A	CD1a molecule	0.050	Human
GAA	glucosidase, alpha; acid	0.048
MEFV	Mediterranean fever	0.045
HLA-DQA2	major histocompatibility complex, class II, DQ alpha 2	0.044
RARRES3	retinoic acid receptor responder (tazarotene induced) 3	0.041
NLRP3	NLR family, pyrin domain containing 3	0.041
RAB6A	RAB6A, member RAS oncogene family	0.040
TAPBPL	TAP binding protein-like	0.039
AIF1	allograft inflammatory factor 1	0.039
PDIA3	protein disulfide isomerase family A, member 3	0.038
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.038
IRF1	interferon regulatory factor 1	0.037
IGSF6	immunoglobulin superfamily, member 6	0.036
ARRB2	arrestin, beta 2	0.036
CCR2	chemokine (C-C motif) receptor 2	0.036
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.034
GM2A	GM2 ganglioside activator	0.034
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.034
SYK	spleen tyrosine kinase	0.034
PDIA4	protein disulfide isomerase family A, member 4	0.033
IRF8	interferon regulatory factor 8	0.033
HCK	hemopoietic cell kinase	0.033
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.033
NLRC4	NLR family, CARD domain containing 4	0.032
TYROBP	TYRO protein tyrosine kinase binding protein	0.032
CD1C	CD1c molecule	0.031	Human
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.031
CLEC7A	C-type lectin domain family 7, member A	0.030
ARL8B	ADP-ribosylation factor-like 8B	0.030
SIRPB1	signal-regulatory protein beta 1	0.029
AP1G1	adaptor-related protein complex 1, gamma 1 subunit	0.028
HLA-DQB2	major histocompatibility complex, class II, DQ beta 2	0.028
PDE6D	phosphodiesterase 6D, cGMP-specific, rod, delta	0.027
WARS	tryptophanyl-tRNA synthetase	0.027
GABARAP	GABA(A) receptor-associated protein	0.027
TREM1	triggering receptor expressed on myeloid cells 1	0.026
CD300C	CD300c molecule	0.026
RUSC2	RUN and SH3 domain containing 2	0.026
CAPG	capping protein (actin filament), gelsolin-like	0.026
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.026
RABAC1	Rab acceptor 1 (prenylated)	0.025
CD40	CD40 molecule, TNF receptor superfamily member 5	0.025
LRRK2	leucine-rich repeat kinase 2	0.025
IRAK2	interleukin-1 receptor-associated kinase 2	0.024
MS4A1	membrane-spanning 4-domains, subfamily A, member 1	0.024
RABIF	RAB interacting factor	0.024
IDO1	indoleamine 2,3-dioxygenase 1	0.023
CD1E	CD1e molecule	0.023	Human
VSIG4	V-set and immunoglobulin domain containing 4	0.023
CXCL9	chemokine (C-X-C motif) ligand 9	0.023
CALCOCO1	calcium binding and coiled-coil domain 1	0.023
SLAMF8	SLAM family member 8	0.022
C1QA	complement component 1, q subcomponent, A chain	0.022
CCL19	chemokine (C-C motif) ligand 19	0.022	Mouse
CD1D	CD1d molecule	0.022
SPHAR	S-phase response (cyclin related)	0.022
RAB1B	RAB1B, member RAS oncogene family	0.022	Human
BCL3	B-cell CLL/lymphoma 3	0.022
SYTL4	synaptotagmin-like 4	0.022
LILRB4	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	0.022	Human
MARCO	macrophage receptor with collagenous structure	0.022
MS4A6A	membrane-spanning 4-domains, subfamily A, member 6A	0.022
PPP1CB	protein phosphatase 1, catalytic subunit, beta isozyme	0.021
FPR3	formyl peptide receptor 3	0.021
CBR3	carbonyl reductase 3	0.021
CTSH	cathepsin H	0.021
HCP5	HLA complex P5	0.021
CLPTM1	cleft lip and palate associated transmembrane protein 1	0.021
GDI1	GDP dissociation inhibitor 1	0.021
EMR1	egf-like module containing, mucin-like, hormone receptor-like 1	0.021
PLEKHF2	pleckstrin homology domain containing, family F (with FYVE domain) member 2	0.021
CXCL16	chemokine (C-X-C motif) ligand 16	0.020
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.020
SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	0.020
BST2	bone marrow stromal cell antigen 2	0.019
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.019
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.019
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.019
CIITA	class II, major histocompatibility complex, transactivator	0.018
CD37	CD37 molecule	0.018
LILRA3	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	0.018	Human
GNA13	guanine nucleotide binding protein (G protein), alpha 13	0.018
PICALM	phosphatidylinositol binding clathrin assembly protein	0.018
CD68	CD68 molecule	0.018
SLC2A14	solute carrier family 2 (facilitated glucose transporter), member 14	0.018
CR1	complement component (3b/4b) receptor 1 (Knops blood group)	0.018
ENTPD1	ectonucleoside triphosphate diphosphohydrolase 1	0.017
FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	0.017
ISG20	interferon stimulated exonuclease gene 20kDa	0.017
WBP2	WW domain binding protein 2	0.017
EIF4G1	eukaryotic translation initiation factor 4 gamma, 1	0.017
NAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha	0.017
ATP6AP1	ATPase, H+ transporting, lysosomal accessory protein 1	0.017
TAP2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.017
SIGLEC9	sialic acid binding Ig-like lectin 9	0.016
CORO1B	coronin, actin binding protein, 1B	0.016
HLA-DOB	major histocompatibility complex, class II, DO beta	0.016
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.016
CLEC5A	C-type lectin domain family 5, member A	0.016
CD80	CD80 molecule	0.016
NINJ1	ninjurin 1	0.016
RNF11	ring finger protein 11	0.016
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.016
CD72	CD72 molecule	0.015
NOD2	nucleotide-binding oligomerization domain containing 2	0.015
CCR7	chemokine (C-C motif) receptor 7	0.015	Mouse
SIRPA	signal-regulatory protein alpha	0.015
SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	0.015
LAMP1	lysosomal-associated membrane protein 1	0.015
AOAH	acyloxyacyl hydrolase (neutrophil)	0.015
CTSS	cathepsin S	0.015
EEA1	early endosome antigen 1	0.015
MYO5A	myosin VA (heavy chain 12, myoxin)	0.014
GANAB	glucosidase, alpha; neutral AB	0.014
C3AR1	complement component 3a receptor 1	0.014
CD14	CD14 molecule	0.014
RAB5A	RAB5A, member RAS oncogene family	0.014	Human
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.014	Human
CCL22	chemokine (C-C motif) ligand 22	0.014
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.014
SS18	synovial sarcoma translocation, chromosome 18	0.014
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.014
LAPTM5	lysosomal protein transmembrane 5	0.014
IL2RA	interleukin 2 receptor, alpha	0.014
IL15RA	interleukin 15 receptor, alpha	0.014
RAB7A	RAB7A, member RAS oncogene family	0.014
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.014
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.014
NCKAP1L	NCK-associated protein 1-like	0.014
C1orf85	chromosome 1 open reading frame 85	0.014
CD1B	CD1b molecule	0.014	Human
UBXN6	UBX domain protein 6	0.014
SLMAP	sarcolemma associated protein	0.013
APPL1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	0.013
SLAMF1	signaling lymphocytic activation molecule family member 1	0.013
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.013
CTSD	cathepsin D	0.013	Human
CCL13	chemokine (C-C motif) ligand 13	0.013
IL10RA	interleukin 10 receptor, alpha	0.013
ACTR2	ARP2 actin-related protein 2 homolog (yeast)	0.013
CD180	CD180 molecule	0.013
CD52	CD52 molecule	0.013
LST1	leukocyte specific transcript 1	0.013
PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	0.013
TBC1D17	TBC1 domain family, member 17	0.012
COL1A1	collagen, type I, alpha 1	0.012
CD300A	CD300a molecule	0.012
MRC1	mannose receptor, C type 1	0.012
TCN2	transcobalamin II	0.012
UBASH3B	ubiquitin associated and SH3 domain containing B	0.012
RAB11FIP1	RAB11 family interacting protein 1 (class I)	0.012
SIGLEC10	sialic acid binding Ig-like lectin 10	0.012
CYBB	cytochrome b-245, beta polypeptide	0.012
ALOX5	arachidonate 5-lipoxygenase	0.012
FOLR3	folate receptor 3 (gamma)	0.012
TIMP2	TIMP metallopeptidase inhibitor 2	0.012
TBXAS1	thromboxane A synthase 1 (platelet)	0.012
PELI3	pellino homolog 3 (Drosophila)	0.011
CAPZA2	capping protein (actin filament) muscle Z-line, alpha 2	0.011
CXCL13	chemokine (C-X-C motif) ligand 13	0.011
APPL2	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	0.011
KDELR1	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1	0.011
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.011
CFP	complement factor properdin	0.011
MSR1	macrophage scavenger receptor 1	0.011
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.011	Mouse
CASP5	caspase 5, apoptosis-related cysteine peptidase	0.011
TGFB1	transforming growth factor, beta 1	0.011
FFAR2	free fatty acid receptor 2	0.011
CMTM3	CKLF-like MARVEL transmembrane domain containing 3	0.011
OSTF1	osteoclast stimulating factor 1	0.011
MARCH9	membrane-associated ring finger (C3HC4) 9	0.011	Human
HLA-DOA	major histocompatibility complex, class II, DO alpha	0.011
MMP19	matrix metallopeptidase 19	0.011
CHIT1	chitinase 1 (chitotriosidase)	0.011
VAMP8	vesicle-associated membrane protein 8 (endobrevin)	0.011
RNASE6	ribonuclease, RNase A family, k6	0.011
AIM2	absent in melanoma 2	0.011
SLC48A1	solute carrier family 48 (heme transporter), member 1	0.011
SOD2	superoxide dismutase 2, mitochondrial	0.011
HSD3B7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	0.011
IL21R	interleukin 21 receptor	0.011
CFL1	cofilin 1 (non-muscle)	0.011
C17orf60	chromosome 17 open reading frame 60	0.011
FPR1	formyl peptide receptor 1	0.011
LILRA5	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5	0.011	Human
TLR1	toll-like receptor 1	0.011
CMKLR1	chemokine-like receptor 1	0.011
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.011
GPR65	G protein-coupled receptor 65	0.011
BAG3	BCL2-associated athanogene 3	0.010
ACP5	acid phosphatase 5, tartrate resistant	0.010
NR1H2	nuclear receptor subfamily 1, group H, member 2	0.010
CXCL10	chemokine (C-X-C motif) ligand 10	0.010
PECAM1	platelet/endothelial cell adhesion molecule	0.010
SIGLEC5	sialic acid binding Ig-like lectin 5	0.010
MAST1	microtubule associated serine/threonine kinase 1	0.010
ATP6V0A1	ATPase, H+ transporting, lysosomal V0 subunit a1	0.010
RASSF4	Ras association (RalGDS/AF-6) domain family member 4	0.010
ZNF594	zinc finger protein 594	0.010
FCAR	Fc fragment of IgA, receptor for	0.010	Human
TM7SF4	transmembrane 7 superfamily member 4	0.010
RNASE2	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	0.010
IRF4	interferon regulatory factor 4	0.010
UBE2L6	ubiquitin-conjugating enzyme E2L 6	0.010
APBA1	amyloid beta (A4) precursor protein-binding, family A, member 1	0.010