IMP

Process View

Danio rerio

15 genes annotated in zebrafish

Multi-species View

regulation of endodermal cell fate specification

GO:0042663

Any process that mediates the specification of a cell into an endoderm cell.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in zebrafish Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of endodermal cell fate specification"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of endodermal cell fate specification" (in gray)

Name	Description	Probability	Func Analog Organism
chd	chordin	0.999
bmp2b	bone morphogenetic protein 2b	0.994
fgf3	fibroblast growth factor 3	0.984
pax2a	paired box gene 2a	0.975
flh	floating head	0.964
cdh2	cadherin 2, neuronal	0.882
ndr2	nodal-related 2	0.850
tbx16	T-box gene 16	0.806
vent	ventral expressed homeobox	0.791
gbx2	gastrulation brain homeo box 2	0.784
foxi1	forkhead box I1	0.744
pcdh8	protocadherin 8	0.744
gli1	GLI-Kruppel family member 1	0.692
tll1	tolloid-like 1	0.614
dharma	dharma	0.602
emx3	empty spiracles homeobox 3	0.587
wif1	wnt inhibitory factor 1	0.574
fgfr1a	fibroblast growth factor receptor 1a	0.571
fgfr4	fibroblast growth factor receptor 4	0.560	Zebrafish
her7	hairy and enhancer of split related-7	0.554
lhx1b	LIM homeobox 1b	0.540
shha	sonic hedgehog a	0.528
her1	hairy-related 1	0.489
bmp4	bone morphogenetic protein 4	0.482
ved	ventrally expressed dharma/bozozok antagonist	0.465
tbx6	T-box gene 6	0.448
lhx1a	LIM homeobox 1a	0.437
eya1	eyes absent homolog 1	0.437
her5	hairy-related 5	0.432
wnt5b	wingless-type MMTV integration site family, member 5b	0.424
sox3	SRY-box containing gene 3	0.407	Zebrafish
nkx2.2a	NK2 transcription factor related 2a	0.392
atoh1a	atonal homolog 1a	0.386
foxg1a	forkhead box G1a	0.383
ndr1	nodal-related 1	0.378
fgf8a	fibroblast growth factor 8 a	0.374
sox1a	SRY-box containing gene 1a	0.370	Zebrafish
ascl1a	achaete-scute complex-like 1a (Drosophila)	0.356
bmp7a	bone morphogenetic protein 7a	0.349
meis3	myeloid ecotropic viral integration site 3	0.340
dkk1b	dickkopf 1b	0.339
cdx4	caudal type homeo box transcription factor 4	0.338
sox32	SRY-box containing gene 32	0.335
irx1b	iroquois homeobox protein 1, b	0.329
dbx1b	developing brain homeobox 1b	0.326
mecom	MDS1 and EVI1 complex locus	0.323
jag2	jagged 2	0.320
hmx4	H6 family homeobox 4	0.308
sox19a	SRY-box containing gene 19a	0.304	Zebrafish
ephb4b	eph receptor B4b	0.292
notch1a	notch homolog 1a	0.286
msxc	muscle segment homeobox C	0.284
fzd8b	frizzled homolog 8b	0.259
wnt8b	wingless-type MMTV integration site family, member 8b	0.255
dusp6	dual specificity phosphatase 6	0.255
sall4	sal-like 4 (Drosophila)	0.253
osr2	odd-skipped related 2 (Drosophila)	0.251
eve1	even-skipped-like1	0.241
mab21l2	mab-21-like 2	0.224
her12	hairy-related 12	0.220
six4b	sine oculis homeobox homolog 4b	0.217
foxh1	forkhead box H1	0.213
jag1b	jagged 1b	0.211
otx1a	orthodenticle homolog 1a	0.209
lft1	lefty1	0.209
dlc	deltaC	0.204
hoxa2b	homeo box A2b	0.203
snai1b	snail homolog 1b (Drosophila)	0.201
runx2b	runt-related transcription factor 2b	0.199
bmp2a	bone morphogenetic protein 2a	0.196	Zebrafish
gdf6a	growth differentiation factor 6a	0.189	Zebrafish
runx2a	runt-related transcription factor 2a	0.178
spry1	sprouty homolog 1 (Drosophila)	0.167
fzd5	frizzled homolog 5	0.166
hoxb2a	homeo box B2a	0.165
fgfr2	fibroblast growth factor receptor 2	0.161	Zebrafish
pou2f1a	POU class 2 homeobox 1a	0.157	Zebrafish
nanos3	nanos homolog 3	0.155
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.154
boc	brother of CDO	0.151
msxb	muscle segment homeobox B	0.150
pdgfaa	platelet-derived growth factor alpha a	0.147
dla	deltaA	0.145
foxd5	forkhead box D5	0.143
dlx2a	distal-less homeobox gene 2a	0.143
gli2a	GLI-Kruppel family member GLI2a	0.143
otpb	orthopedia homolog b	0.142
oep	one-eyed pinhead	0.140
sp5l	Sp5 transcription factor-like	0.134
her8a	hairy-related 8a	0.133
hey1	hairy/enhancer-of-split related with YRPW motif 1	0.132
foxd3	forkhead box D3	0.129
spry4	sprouty (Drosophila) homolog 4	0.126
tbx1	T-box 1	0.126
irx3b	iroquois homeobox protein 3b	0.122
etv2	ets variant gene 2	0.121
pitx2	paired-like homeodomain transcription factor 2	0.121
twist3	twist3	0.120
six4a	sine oculis homeobox homolog 4a	0.115
hoxb5a	homeo box B5a	0.115
sox19b	SRY-box containing gene 19b	0.114	Zebrafish
pax7a	paired box gene 7a	0.111
admp	anti-dorsalizing morphogenic protein	0.111	Zebrafish
dld	deltaD	0.109
hsd3b1	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	0.109
zic1	zic family member 1 (odd-paired homolog, Drosophila)	0.109
tbx20	T-box 20	0.108
mespa	mesoderm posterior a	0.107	Mouse
chrna2a	cholinergic receptor, nicotinic, alpha polypeptide 2a (neuronal)	0.107
ptch1	patched 1	0.105
hnf1ba	HNF1 homeobox Ba	0.099	Mouse
pou3f3b	POU class 3 homeobox 3b	0.099
si:ch211-235f6.2	si:ch211-235f6.2	0.094
nr2f2	nuclear receptor subfamily 2, group F, member 2	0.093
prdm1a	PR domain containing 1a, with ZNF domain	0.092
pax8	paired box gene 8	0.091
zic2a	zic family member 2 (odd-paired homolog, Drosophila), a	0.091
ascl1b	achaete-scute complex-like 1b (Drosophila)	0.091
pou3f2	POU class 3 homeobox 2	0.090
mespb	mesoderm posterior b	0.086	Mouse
pax6b	paired box gene 6b	0.085
junbl	jun B proto-oncogene, like	0.083
mib	mind bomb	0.083
aplnra	apelin receptor a	0.083
hhip	hedgehog interacting protein	0.081
lfng	lunatic fringe homolog	0.080
tbpl2	TATA box binding protein like 2	0.080
atoh1b	atonal homolog 1b	0.077
dbx1a	developing brain homeobox 1a	0.076
pax2b	paired box gene 2b	0.074
srf	serum response factor	0.074
osr1	odd-skipped related 1 (Drosophila)	0.074
pcdh10b	protocadherin 10b	0.073
nr2e1	nuclear receptor subfamily 2, group E, member 1	0.073
gbx1	gastrulation brain homeobox 1	0.072
sox17	SRY-box containing gene 17	0.071	Zebrafish
pou5f1	POU domain, class 5, transcription factor 1	0.070
twist2	twist2	0.068
lmx1b.2	LIM homeobox transcription factor 1, beta 2	0.068
notch3	notch homolog 3	0.068	Zebrafish
tbx24	T-box 24	0.068
epha4a	eph receptor A4a	0.067
vax2	ventral anterior homeobox 2	0.064
notch2	notch homolog 2	0.063	Zebrafish
cdc25	cell division cycle 25 homolog	0.063
pitx3	paired-like homeodomain transcription factor 3	0.063
lmx1b.1	LIM homeobox transcription factor 1, beta 1	0.062
lhx3	LIM homeobox 3	0.061
trpm7	transient receptor potential cation channel, subfamily M, member 7	0.061
zic3	zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)	0.061
zic4	zic family member 4	0.061
alcamb	activated leukocyte cell adhesion molecule b	0.060
dact2	dapper homolog 2, antagonist of beta-catenin (xenopus)	0.060
hoxa9a	homeo box A9a	0.059
sfrp1a	secreted frizzled-related protein 1a	0.058
btg2	B-cell translocation gene 2	0.057
gro1	groucho 1	0.057
evx1	even-skipped homeobox 1	0.057
zgc:112180	zgc:112180	0.056
mxtx2	mix-type homeobox gene 2	0.055
prl	prolactin	0.055
nr2f1a	nuclear receptor subfamily 2, group F, member 1a	0.054
irx4b	iroquois homeobox protein 4b	0.053
efnb2a	ephrin B2a	0.053
gdf6b	growth differentiation factor 6b	0.052	Zebrafish
lhx2b	LIM homeobox 2b	0.052
gpr126	G protein-coupled receptor 126	0.050
hoxd11a	homeo box D11a	0.050
nkx2.1a	NK2 homeobox 1a	0.049
tshb	thyroid stimulating hormone, beta subunit	0.048
dlb	deltaB	0.047
hey2	hairy/enhancer-of-split related with YRPW motif 2	0.046
rerea	arginine-glutamic acid dipeptide (RE) repeats a	0.046
insm1b	insulinoma-associated 1b	0.046
gpc4	glypican 4	0.045
wnt4a	wingless-type MMTV integration site family, member 4a	0.045
fzd10	frizzled homolog 10	0.044
sox2	SRY-box containing gene 2	0.044	Zebrafish
slc6a6	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	0.044
efnb1	ephrin B1	0.043
rarab	retinoic acid receptor, alpha b	0.043
fezf2	FEZ family zinc finger 2	0.043
msgn1	mesogenin 1	0.043
rx2	retinal homeobox gene 2	0.042
og9x	OG9 homeobox gene	0.042
ctnnd2b	catenin (cadherin-associated protein), delta 2b	0.042
eng2b	engrailed 2b	0.042
sox11a	SRY-box containing gene 11a	0.041
neurod4	neurogenic differentiation 4	0.041
hoxa3a	homeo box A3a	0.041
gata3	GATA-binding protein 3	0.040
sall1a	sal-like 1a (Drosophila)	0.040
hoxb1b	homeo box B1b	0.039
vox	ventral homeobox	0.038
msxe	muscle segment homeobox E	0.036
gata4	GATA-binding protein 4	0.035
coro1b	coronin, actin binding protein, 1B	0.035
dvr1	decapentaplegic and Vg-related 1	0.035	Zebrafish
tbx18	T-box 18	0.035
nkx2.1b	NK2 homeobox 1b	0.034
mafba	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	0.034
hoxa11a	homeo box A11a	0.033
fstl1b	follistatin-like 1b	0.033
atp1b2b	ATPase, Na+/K+ transporting, beta 2b polypeptide	0.032
frem2a	Fras1 related extracellular matrix protein 2a	0.032
fli1a	friend leukemia integration 1a	0.032
vangl2	vang-like 2 (van gogh, Drosophila)	0.032
ppp1r14ab	protein phosphatase 1, regulatory (inhibitor) subunit 14Ab	0.031
hoxb3a	homeo box B3a	0.030
nxn	nucleoredoxin	0.029
foxb1.2	forkhead box B1.2	0.029
nrg2a	neuregulin 2a	0.029
fibin	fin bud initiation factor	0.029
rasl11b	RAS-like, family 11, member B	0.029
per3	period homolog 3 (Drosophila)	0.029
slc12a2	solute carrier family 12 (potassium/chloride transporters), member 2	0.028
aldh1a3	aldehyde dehydrogenase 1 family, member A3	0.028
vsx2	visual system homeobox 2	0.028
gata2a	GATA-binding protein 2a	0.028
egr2a	early growth response 2a	0.028
flt4	fms-related tyrosine kinase 4	0.028
sgk1	serum/glucocorticoid regulated kinase 1	0.028
gro2	groucho 2	0.028
asph	aspartate beta-hydroxylase	0.028
zfand5a	zinc finger, AN1-type domain 5a	0.028
vax1	ventral anterior homeobox 1	0.027
wnt1	wingless-type MMTV integration site family, member 1	0.027
arx	aristaless related homeobox	0.027
runx3	runt-related transcription factor 3	0.027
ntla	no tail a	0.026
si:ch211-1n9.7	si:ch211-1n9.7	0.026
npas2	neuronal PAS domain protein 2	0.026
id2a	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a	0.026
rfng	radical fringe homolog (Drosophila)	0.026
nkx1.2la	NK1 transcription factor related 2-like,a	0.026
rx3	retinal homeobox gene 3	0.026
wt1a	wilms tumor 1a	0.026
epha4b	eph receptor A4b	0.026
foxc1a	forkhead box C1a	0.026
six3a	sine oculis homeobox homolog 3a	0.026
evx2	even-skipped homeobox 2	0.026
nkx2.3	NK2 transcription factor related 3	0.025
siah2l	seven in absentia homolog 2 (Drosophila)-like	0.025
gadd45ab	growth arrest and DNA-damage-inducible, alpha, b	0.024
irx7	iroquois homeobox protein 7	0.024
wnt10a	wingless-type MMTV integration site family, member 10a	0.024
wu:fv91b12	wu:fv91b12	0.024
wnt2ba	wingless-type MMTV integration site family, member 2Ba	0.024
twsg1b	twisted gastrulation homolog 1b (Drosophila)	0.024
grhl2a	grainyhead-like 2a (Drosophila)	0.024
lhx5	LIM homeobox 5	0.024
slc38a2	solute carrier family 38, member 2	0.023
wu:fc18d04	wu:fc18d04	0.023
junb	jun B proto-oncogene	0.023
dlx4b	distal-less homeobox gene 4b	0.023
irx3a	iroquois homeobox protein 3a	0.023
nfkbiab	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b	0.023
twist1b	twist1b	0.022
cga	glycoprotein hormones, alpha polypeptide	0.022
fsta	follistatin a	0.022
gli2b	GLI-Kruppel family member GLI2b	0.022
bmp3	bone morphogenetic protein 3	0.022	Zebrafish
gyltl1b	glycosyltransferase-like 1b	0.022
cdx1a	caudal type homeo box transcription factor 1 a	0.022
slc25a25a	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a	0.022
ier2	immediate early response 2	0.022
tph1a	tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a	0.022
bmp7b	bone morphogenetic protein 7b	0.022	Zebrafish
aplnrb	apelin receptor b	0.021
fgfrl1b	fibroblast growth factor receptor-like 1b	0.021
vasa	vasa homolog	0.021
sim2	single-minded homolog 2 (Drosophila)	0.021
piwil1	piwi-like 1 (Drosophila)	0.021
dusp5	dual specificity phosphatase 5	0.021	Zebrafish
fos	v-fos FBJ murine osteosarcoma viral oncogene homolog	0.021
gsc	goosecoid	0.020
fgf4	fibroblast growth factor 4	0.020
bmp15	bone morphogenetic protein 15	0.020	Zebrafish
zgc:193933	zgc:193933	0.020
hhex	hematopoietically expressed homeobox	0.020
foxe3	forkhead box E3	0.020
nkx2.2b	NK2 transcription factor related 2b	0.020
tfe3b	transcription factor binding to IGHM enhancer 3b	0.020
zgc:66326	zgc:66326	0.019
krml2.2	Kreisler (mouse) maf-related leucine zipper homolog 2.2	0.019
cyp26c1	cytochrome P450, family 26, subfamily C, polypeptide 1	0.019
pth2r	parathyroid hormone 2 receptor	0.019
raraa	retinoic acid receptor, alpha a	0.018
otx2	orthodenticle homolog 2	0.018
cyp26b1	cytochrome P450, family 26, subfamily b, polypeptide 1	0.018
hlxb9la	homeo box HB9 like a	0.018
cyp11a1	cytochrome P450, subfamily XIA, polypeptide 1	0.018
foxn4	forkhead box N4	0.018
ihhb	Indian hedgehog homolog b	0.018
ihha	Indian hedgehog homolog a	0.017
acvr1b	activin A receptor, type IB	0.017
etv5a	ets variant 5a	0.017
twist1a	twist1a	0.017
dmrta2	doublesex and mab-3 related transcription factor like family A2	0.017
tp63	tumor protein p63	0.017
csrnp1b	cysteine-serine-rich nuclear protein 1b	0.017
atf3	activating transcription factor 3	0.017
zgc:64051	zgc:64051	0.017
hmx3	homeo box (H6 family) 3	0.017
olig3	oligodendrocyte transcription factor 3	0.017
rims2a	regulating synaptic membrane exocytosis 2a	0.017
hoxa10b	homeo box A10b	0.017
irx5a	iroquois homeobox protein 5a	0.017
six3b	sine oculis homeobox homolog 3b	0.017
jag1a	jagged 1a	0.016
eng2a	engrailed 2a	0.016
spns2	spinster homolog 2 (Drosophila)	0.016
scd	stearoyl-CoA desaturase (delta-9-desaturase)	0.016
crestin	crestin	0.016
ripply2	ripply2	0.016
tfap2a	transcription factor AP-2 alpha	0.016
zbtb16a	zinc finger and BTB domain containing 16a	0.016
efnb3b	ephrin B3b	0.016
fshb	follicle stimulating hormone, beta polypeptide	0.016
sc:d411	sc:d411	0.016
sim1a	single-minded homolog 1a (Drosophila)	0.016
plagl2	pleiomorphic adenoma gene-like 2	0.016
kitb	kit receptor b	0.016
smo	smoothened homolog (Drosophila)	0.016
gh1	growth hormone 1	0.016
ephb3a	eph receptor B3a	0.016
LOC567678	avidin-like	0.015
im:7138239	im:7138239	0.015
wnt3a	wingless-type MMTV integration site family, member 3A	0.015
zic6	zic family member 6	0.015
ephb4a	eph receptor B4a	0.015
dhrs3a	dehydrogenase/reductase (SDR family) member 3a	0.015
gsdf	gonadal somatic cell derived factor	0.015
shmt2	serine hydroxymethyltransferase 2 (mitochondrial)	0.015
elavl3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	0.015
spry2	sprouty homolog 2	0.015
retsatl	retinol saturase (all-trans-retinol 13,14-reductase) like	0.015
foxa2	forkhead box A2	0.015
igf1rb	insulin-like growth factor 1b receptor	0.015
col7a1l	collagen type VII alpha 1-like	0.015
ets2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.015
si:dkey-8l13.4	si:dkey-8l13.4	0.015
LOC555739	serine/threonine-protein kinase LMTK1-like	0.015
pdzrn3	PDZ domain containing RING finger 3 and PDZ domain containing ring finger 3	0.014
igf1ra	insulin-like growth factor 1a receptor	0.014
piwil2	piwi-like 2 (Drosophila)	0.014
eng1a	engrailed 1a	0.014
ptgs1	prostaglandin-endoperoxide synthase 1	0.014
klf4a	Kruppel-like transcription factor 4a	0.014
neo1	neogenin 1	0.014
hapln3	hyaluronan and proteoglycan link protein 3	0.014
axin2	axin 2 (conductin, axil)	0.014
fn1	fibronectin 1	0.014
col8a1a	collagen, type VIII, alpha 1a	0.014
cltca	clathrin, heavy polypeptide a (Hc)	0.014
hgfa	hepatocyte growth factor a	0.013
cdh17	cadherin 17, LI cadherin (liver-intestine)	0.013
gata5	GATA-binding protein 5	0.013
sox21a	SRY-box containing gene 21a	0.013
scinla	scinderin like a	0.013
hesx1	homeo box (expressed in ES cells) 1	0.013
fzd8a	frizzled homolog 8a	0.013
kirrela	kin of IRRE like a	0.013
cdx1b	caudal type homeobox 1 b	0.013
cyp26a1	cytochrome P450, subfamily XXVIA, polypeptide 1	0.013
cryaba	crystallin, alpha B, a	0.013
zgc:153997	zgc:153997	0.013
sfrp2	secreted frizzled-related protein 2	0.013
mesp2	mesoderm posterior 2 homolog (mouse)	0.012
zgc:77051	zgc:77051	0.012
pnx	posterior neuron-specific homeobox	0.012
clec14a	C-type lectin domain family 14, member A	0.012
sema3fb	semaphorin 3fb	0.012
pax6a	paired box gene 6a	0.012
hfe2	hemochromatosis type 2	0.012
tsc22d3	TSC22 domain family, member 3	0.012
hoxd10a	homeo box D10a	0.012
rspo3	R-spondin 3 homolog (Xenopus laevis)	0.012
msxa	muscle segment homeobox A	0.012
bmp6	bone morphogenetic protein 6	0.012	Zebrafish
nkx2.5	NK2 transcription factor related 5	0.012
pid1	phosphotyrosine interaction domain containing 1	0.012
bokb	BCL2-related ovarian killer b	0.012
sox10	SRY-box containing gene 10	0.012
hoxb5b	homeo box B5b	0.012
cdh23	cadherin-like 23	0.012
cyp51	cytochrome P450, family 51	0.011
mos	v-mos Moloney murine sarcoma viral oncogene homolog	0.011
fgfr3	fibroblast growth factor receptor 3	0.011	Zebrafish
egr1	early growth response 1	0.011
lhx8a	LIM homeobox 8a	0.011
emx2	empty spiracles homeobox 2	0.011
hspa12b	heat shock protein 12B	0.011
epb4.1l4	erythrocyte protein band 4.1-like 4	0.011
hoxd13a	homeo box D13a	0.011
her15.1	hairy and enhancer of split-related 15.1	0.011
pitx1	paired-like homeodomain transcription factor 1	0.011
tuba1l	tubulin, alpha 1, like	0.011
emx1	empty spiracles homeobox 1	0.011
notch1b	notch homolog 1b	0.011	Zebrafish
uts2a	urotensin 2, alpha	0.011
lft2	lefty2	0.011
neurog3	neurogenin 3	0.011
acvr2a	activin receptor IIa	0.011
msxd	muscle segment homeobox D	0.011
her4.2	hairy-related 4.2	0.011
chrna7	cholinergic receptor, nicotinic, alpha polypeptide 7	0.010
pcdh18a	protocadherin 18a	0.010
zgc:153154	zgc:153154	0.010
traf4a	tnf receptor-associated factor 4a	0.010
otul	OTU like protein	0.010
igf3	insulin-like growth factor 3	0.010
sox9a	SRY-box containing gene 9a	0.010	Zebrafish
birc5b	baculoviral IAP repeat-containing 5B	0.010
nkx2.7	NK2 transcription factor related 7	0.010
runx1	runt-related transcription factor 1	0.010
neurog1	neurogenin 1	0.010
her3	hairy-related 3	0.010