The network for 'cell cycle arrest' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cell cycle arrest

A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).

Homo sapiens
Name Description Probability Func Analog Organism
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.999
RB1 retinoblastoma 1 0.997
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.997
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.996
SMAD7 SMAD family member 7 0.994
SMAD1 SMAD family member 1 0.992
CCND1 cyclin D1 0.992
FGFR2 fibroblast growth factor receptor 2 0.991
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.982
MAPK1 mitogen-activated protein kinase 1 0.978
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.971
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.965
SMAD3 SMAD family member 3 0.965
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.958
BRCA1 breast cancer 1, early onset 0.948
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.931
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.919
CCND3 cyclin D3 0.918
SMAD2 SMAD family member 2 0.914
CDK6 cyclin-dependent kinase 6 0.908
STK3 serine/threonine kinase 3 0.872
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.854
IRF1 interferon regulatory factor 1 0.834
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.828
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.813
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.806
H2AFX H2A histone family, member X 0.787
AR androgen receptor 0.769
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.756
EP300 E1A binding protein p300 0.734
FGF1 fibroblast growth factor 1 (acidic) 0.713
SIRT1 sirtuin 1 0.710
APAF1 apoptotic peptidase activating factor 1 0.705
XIAP X-linked inhibitor of apoptosis 0.703
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.700
CXCL2 chemokine (C-X-C motif) ligand 2 0.694
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.690
CXCL3 chemokine (C-X-C motif) ligand 3 0.671
STK4 serine/threonine kinase 4 0.668
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.659
CCNE1 cyclin E1 0.658
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.650
MOBKL1B MOB1, Mps One Binder kinase activator-like 1B (yeast) 0.650
SMAD5 SMAD family member 5 0.637
CDK2 cyclin-dependent kinase 2 0.578
RBL1 retinoblastoma-like 1 (p107) 0.572
CREBBP CREB binding protein 0.565
PML promyelocytic leukemia 0.527
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.520
RIN3 Ras and Rab interactor 3 0.514
STAT1 signal transducer and activator of transcription 1, 91kDa 0.490
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.486
APP amyloid beta (A4) precursor protein 0.484
ADRB1 adrenergic, beta-1-, receptor 0.475
IER3 immediate early response 3 0.464
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.444
CFLAR CASP8 and FADD-like apoptosis regulator 0.432
CKS2 CDC28 protein kinase regulatory subunit 2 0.408
FAS Fas (TNF receptor superfamily, member 6) 0.391
CDK4 cyclin-dependent kinase 4 0.379
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.377
PSEN1 presenilin 1 0.376
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.368
SNX9 sorting nexin 9 0.367
IL8 interleukin 8 0.366
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.339
POU3F2 POU class 3 homeobox 2 0.314
POU5F1 POU class 5 homeobox 1 0.300
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.288
SCHIP1 schwannomin interacting protein 1 0.287
CXCL10 chemokine (C-X-C motif) ligand 10 0.284
TADA3 transcriptional adaptor 3 0.283
RXRA retinoid X receptor, alpha 0.282
CDC25B cell division cycle 25 homolog B (S. pombe) 0.280
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.278
FGFR1 fibroblast growth factor receptor 1 0.273
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.273
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 0.271
PKM2 pyruvate kinase, muscle 0.268
CDC6 cell division cycle 6 homolog (S. cerevisiae) 0.259
KAT2B K(lysine) acetyltransferase 2B 0.258
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.251
NBN nibrin 0.246
LRDD leucine-rich repeats and death domain containing 0.240
STAT2 signal transducer and activator of transcription 2, 113kDa 0.240
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.238
FGF10 fibroblast growth factor 10 0.232
RARA retinoic acid receptor, alpha 0.215
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.214
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 0.207
LRP1 low density lipoprotein receptor-related protein 1 0.202
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.201
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 0.201
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 0.198
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 125kDa 0.196
SMAD4 SMAD family member 4 0.195
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.194
PIAS4 protein inhibitor of activated STAT, 4 0.189
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.189
DAXX death-domain associated protein 0.188
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
mpk-1 Protein MPK-1 0.026
cam-1 Protein CAM-1 0.015
pha-4 Protein PHA-4 0.015
zfp-3 Protein ZFP-3 0.012
elt-6 Protein ELT-6 0.011
ttm-4 Protein TTM-4 0.010
spdl-1 Protein SPDL-1 0.010
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Danio rerio
Name Description Probability Func Analog Organism
zgc:55813 zgc:55813 0.165
myca myelocytomatosis oncogene a 0.154
sox11a SRY-box containing gene 11a 0.127
ddx46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.119
inhbaa inhibin, beta Aa 0.117
sgcd sarcoglycan, delta (dystrophin-associated glycoprotein) 0.100
mapk1 mitogen-activated protein kinase 1 0.095
crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.095
sox11b SRY-box containing gene 11b 0.089
igf1rb insulin-like growth factor 1b receptor 0.088
mef2ca myocyte enhancer factor 2ca 0.086
lpp LIM domain containing preferred translocation partner in lipoma 0.084
bmp4 bone morphogenetic protein 4 0.082
dtng dystrobrevin, gamma and dystrobrevin, gamma-like 0.082
ascl1a achaete-scute complex-like 1a (Drosophila) 0.080
tgfb1a transforming growth factor, beta 1a 0.078
rxrga retinoid x receptor, gamma a 0.077
rtkn2 rhotekin 2 0.073
frzb frizzled-related protein 0.066
ldlrap1a low density lipoprotein receptor adaptor protein 1a 0.063
btg1 B-cell translocation gene 1 0.060
ntrk1 neurotrophic tyrosine kinase, receptor, type 1 0.060
jhdm1da jumonji C domain containing histone demethylase 1 homolog Da (S. cerevisiae) 0.059
lamc1 laminin, gamma 1 0.059
rrad Ras-related associated with diabetes 0.058
smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) 0.058
alcama activated leukocyte cell adhesion molecule a 0.058
acvr1b activin A receptor, type IB 0.057
rac3a ras-related C3 botulinum toxin substrate 3a (rho family, small GTP binding protein Rac3) 0.054
dmd dystrophin 0.053
wnt10a wingless-type MMTV integration site family, member 10a 0.050
inha inhibin, alpha 0.050
sox3 SRY-box containing gene 3 0.048
wnt11r wingless-type MMTV integration site family, member 11, related 0.048
myf6 myogenic factor 6 0.047
bon bonnie and clyde 0.045
akt2 v-akt murine thymoma viral oncogene homolog 2 0.045
sulf2l sulfatase 2, like 0.045
lrrn1 leucine rich repeat neuronal 1 0.045
bbc3 BCL2 binding component 3 0.045
nr2f1b nuclear receptor subfamily 2, group F, member 1b 0.044
lhcgr luteinizing hormone/choriogonadotropin receptor 0.044
tfap2b transcription factor AP-2 beta 0.043
islr2 immunoglobulin superfamily containing leucine-rich repeat 2 0.043
hoxd4a homeo box D4a 0.043
hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 0.043
hsp90a.1 heat shock protein 90-alpha 1 0.043
stac3 SH3 and cysteine rich domain 3 0.042
brd2a bromodomain-containing 2a 0.042
aldh18a1 aldehyde dehydrogenase 18 family, member A1 0.042
fbxl14a F-box and leucine-rich repeat protein 14a 0.042
tbx1 T-box 1 0.041
zc4h2 zinc finger, C4H2 domain containing 0.041
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.041
marcksa myristoylated alanine rich protein kinase C substrate a 0.041
enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.040
paqr7b progestin and adipoQ receptor family member VII, b 0.040
stap2a signal transducing adaptor family member 2a 0.040
vsx1 visual system homeobox 1 homolog, chx10-like 0.040
tpm4 tropomyosin 4 0.040
mef2d myocyte enhancer factor 2d 0.040
plagl2 pleiomorphic adenoma gene-like 2 0.039
tgfbi transforming growth factor, beta-induced 0.039
jun jun proto-oncogene 0.039
irf2bp2a interferon regulatory factor 2 binding protein 2a 0.038
slc7a6os solute carrier family 7, member 6 opposite strand 0.038
det1 de-etiolated homolog 1 (Arabidopsis) 0.038
pole polymerase (DNA directed), epsilon 0.038
mych myelocytomatosis oncogene homolog 0.037
neurod neurogenic differentiation 0.037
acss2 acyl-CoA synthetase short-chain family member 2 0.037
tcf12 transcription factor 12 0.036
sdprb serum deprivation response b 0.036
mybl2 myeloblastosis oncogene-like 2 0.036
fcho2 FCH domain only 2 0.036
rrp1 ribosomal RNA processing 1 homolog (S. cerevisiae) 0.036
junbl jun B proto-oncogene, like 0.036
g2e3 G2/M-phase specific E3 ubiquitin ligase 0.035
stmn4l stathmin-like 4, like 0.035
tppp3 tubulin polymerization-promoting protein family member 3 0.034
igf2r insulin-like growth factor 2 receptor 0.034
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.034
zgc:110434 zgc:110434 0.034
polr1a polymerase (RNA) I polypeptide A 0.034
runx1 runt-related transcription factor 1 0.033
celsr1b cadherin EGF LAG seven-pass G-type receptor 1b 0.033
chrna1 cholinergic receptor, nicotinic, alpha polypeptide 1 0.033
dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) 0.033
chrnd cholinergic receptor, nicotinic, delta polypeptide 0.033
igf1 insulin-like growth factor 1 0.033
mettl3 methyltransferase like 3 0.033
gapdh glyceraldehyde-3-phosphate dehydrogenase 0.033
LOC100151531 zinc finger protein Gfi-1b-like 0.032
ccng1 cyclin G1 0.032
tmsb thymosin, beta 0.032
zgc:65861 zgc:65861 0.032
acvr2a activin receptor IIa 0.032
esco2 establishment of cohesion 1 homolog 2 0.032
fgf20a fibroblast growth factor 20a 0.032
spc24 SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae) 0.031
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Drosophila melanogaster
Name Description Probability Func Analog Organism
p53 CG33336 gene product from transcript CG33336-RB 0.368
rl rolled 0.163
debcl death executioner Bcl-2 homologue 0.108
SAK Sak kinase 0.105
Dcp-1 Death caspase-1 0.093
Actn alpha actinin 0.086
how held out wings 0.085
tan tantalus 0.082
dap dacapo 0.081
brat brain tumor 0.078
hpo hippo 0.077
Dsor1 Downstream of raf1 0.072
rin rasputin 0.067
Ras85D Ras oncogene at 85D 0.061
nej nejire 0.059
Akt1 CG4006 gene product from transcript CG4006-RA 0.058
CycD Cyclin D 0.057
Fs Follistatin 0.056
Abl Abl tyrosine kinase 0.055
Rel Relish 0.054
AP-1sigma CG5864 gene product from transcript CG5864-RA 0.054
EndoGI Endonuclease G inhibitor 0.053
arm armadillo 0.049
CadN Cadherin-N 0.049
stck steamer duck 0.048
coro CG9446 gene product from transcript CG9446-RC 0.046
cher cheerio 0.044
aop anterior open 0.043
Ssdp Sequence-specific single-stranded DNA-binding protein 0.043
imd immune deficiency 0.041
rols rolling pebbles 0.040
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.039
dm diminutive 0.039
14-3-3epsilon CG31196 gene product from transcript CG31196-RA 0.039
Cg25C Collagen type IV 0.038
eya eyes absent 0.038
park parkin 0.037
ttm50 tiny tim 50 0.036
pie pineapple eye 0.036
Egfr Epidermal growth factor receptor 0.035
Rac1 CG2248 gene product from transcript CG2248-RA 0.035
Ice CG7788 gene product from transcript CG7788-RA 0.035
Oli Olig family 0.034
nbs CG6754 gene product from transcript CG6754-RC 0.034
Csp Cysteine string protein 0.034
Msp-300 Muscle-specific protein 300 0.033
CG10267 CG10267 gene product from transcript CG10267-RB 0.033
betaTub60D beta-Tubulin at 60D 0.033
CycE Cyclin E 0.033
Jra Jun-related antigen 0.033
Rab11 Rab-protein 11 0.032
dnc dunce 0.032
stj straightjacket 0.032
hts hu li tai shao 0.031
sr stripe 0.031
amon amontillado 0.031
neb nebbish 0.031
loqs loquacious 0.031
Su(H) Suppressor of Hairless 0.031
CG5933 CG5933 gene product from transcript CG5933-RA 0.030
dally division abnormally delayed 0.030
RagA CG11968 gene product from transcript CG11968-RA 0.030
pnut peanut 0.030
gbb glass bottom boat 0.030
alpha-Cat alpha Catenin 0.029
Vrp1 Verprolin 1 0.029
phl pole hole 0.029
Lasp CG3849 gene product from transcript CG3849-RB 0.029
spn-A spindle A 0.029
G-oalpha47A G protein oalpha 47A 0.029
Max CG9648 gene product from transcript CG9648-RA 0.028
Mad Mothers against dpp 0.028
rhea CG6831 gene product from transcript CG6831-RA 0.027
Mtor Megator 0.027
Dok Downstream of kinase 0.027
CycJ Cyclin J 0.027
spi spitz 0.027
eff effete 0.027
klg klingon 0.027
E(z) Enhancer of zeste 0.026
Sdc Syndecan 0.026
mael maelstrom 0.026
bdg bedraggled 0.026
da daughterless 0.026
Ppcs Phosphopantothenoylcysteine synthetase 0.025
cln3 CG5582 gene product from transcript CG5582-RA 0.025
CkIalpha Casein kinase Ialpha 0.025
so sine oculis 0.025
sls sallimus 0.025
Dip3 Dorsal interacting protein 3 0.025
plu plutonium 0.025
bib big brain 0.025
CycA Cyclin A 0.025
pAbp polyA-binding protein 0.025
PPP4R2r Protein phosphatase 4 regulatory subunit 2-related protein 0.025
S6k RPS6-p70-protein kinase 0.024
kek5 kekkon5 0.024
CtBP C-terminal Binding Protein 0.024
kuk kugelkern 0.024
gcm glial cells missing 0.024
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 1.000
Rb1 retinoblastoma 1 0.999
Mdm2 transformed mouse 3T3 cell double minute 2 0.999
Apc adenomatosis polyposis coli 0.995
Neurod1 neurogenic differentiation 1 0.983
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.973
Brca1 breast cancer 1 0.927
Pten phosphatase and tensin homolog 0.888
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.882
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.870
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.843
Ctnnb1 catenin (cadherin associated protein), beta 1 0.734
Gata4 GATA binding protein 4 0.730
Rxra retinoid X receptor alpha 0.691
Msh2 mutS homolog 2 (E. coli) 0.655
Id3 inhibitor of DNA binding 3 0.621
Id1 inhibitor of DNA binding 1 0.594
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.552
Rara retinoic acid receptor, alpha 0.543
Mdm4 transformed mouse 3T3 cell double minute 4 0.494
Braf Braf transforming gene 0.490
Daxx Fas death domain-associated protein 0.455
Fst follistatin 0.430
Trp63 transformation related protein 63 0.420
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.404
Gata5 GATA binding protein 5 0.402
Pitx2 paired-like homeodomain transcription factor 2 0.396
Vhl von Hippel-Lindau tumor suppressor 0.385
Stk11 serine/threonine kinase 11 0.384
Hdac1 histone deacetylase 1 0.382
Ptf1a pancreas specific transcription factor, 1a 0.381
Tcf3 transcription factor 3 0.362
Meox2 mesenchyme homeobox 2 0.359
Pax3 paired box gene 3 0.359
Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 0.347
Trp73 transformation related protein 73 0.339
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.330
Thbs1 thrombospondin 1 0.328
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.321
Neurog2 neurogenin 2 0.317
Gli2 GLI-Kruppel family member GLI2 0.316
E2f1 E2F transcription factor 1 0.314
Tcf4 transcription factor 4 0.314
Nf1 neurofibromatosis 1 0.312
Neurod4 neurogenic differentiation 4 0.287
Cdk2 cyclin-dependent kinase 2 0.285
Amhr2 anti-Mullerian hormone type 2 receptor 0.279
Ccnd1 cyclin D1 0.273
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.264
Isl1 ISL1 transcription factor, LIM/homeodomain 0.253
Foxo3 forkhead box O3 0.251
Onecut1 one cut domain, family member 1 0.243
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.241
Cdk4 cyclin-dependent kinase 4 0.240
Nbn nibrin 0.238
Sox9 SRY-box containing gene 9 0.237
App amyloid beta (A4) precursor protein 0.222
Bmpr1a bone morphogenetic protein receptor, type 1A 0.219
T brachyury 0.218
Pthlh parathyroid hormone-like peptide 0.217
Pax8 paired box gene 8 0.199
Hif1a hypoxia inducible factor 1, alpha subunit 0.198
Hprt hypoxanthine guanine phosphoribosyl transferase 0.197
Sox11 SRY-box containing gene 11 0.197
Mecom MDS1 and EVI1 complex locus 0.195
Gdnf glial cell line derived neurotrophic factor 0.188
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.185
Prkar1a protein kinase, cAMP dependent regulatory, type I, alpha 0.183
Pdx1 pancreatic and duodenal homeobox 1 0.172
Esr1 estrogen receptor 1 (alpha) 0.171
Wnt3a wingless-related MMTV integration site 3A 0.165
Twist1 twist homolog 1 (Drosophila) 0.165
Gja1 gap junction protein, alpha 1 0.164
En1 engrailed 1 0.162
Myc myelocytomatosis oncogene 0.158
Brca2 breast cancer 2 0.152
Pax6 paired box gene 6 0.151
Cdx2 caudal type homeobox 2 0.150
Pax7 paired box gene 7 0.147
Psen1 presenilin 1 0.143
Six6 sine oculis-related homeobox 6 homolog (Drosophila) 0.139
Rbl1 retinoblastoma-like 1 (p107) 0.135
Hoxa13 homeobox A13 0.132
Shh sonic hedgehog 0.130
Wnt10b wingless related MMTV integration site 10b 0.129
Runx1t1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.127
Nf2 neurofibromatosis 2 0.124
Xpa xeroderma pigmentosum, complementation group A 0.122
Hes1 hairy and enhancer of split 1 (Drosophila) 0.121
Gli3 GLI-Kruppel family member GLI3 0.121
Neurog3 neurogenin 3 0.119
Ar androgen receptor 0.117
Wfikkn2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.117
Cdx1 caudal type homeobox 1 0.115
Kl klotho 0.114
Axin1 axin 1 0.113
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.112
Insm1 insulinoma-associated 1 0.111
Ptch1 patched homolog 1 0.109
Rarb retinoic acid receptor, beta 0.108
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism