The network for 'cytokine metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cytokine metabolic process

The chemical reactions and pathways involving cytokines, any of a group of proteins or glycoproteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.

Mus musculus
Name Description Probability Func Analog Organism
Myd88 myeloid differentiation primary response gene 88 0.981
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.980
Tlr4 toll-like receptor 4 0.972
Il10 interleukin 10 0.966
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.961
Tnf tumor necrosis factor 0.960
Il4 interleukin 4 0.957
Ccr2 chemokine (C-C motif) receptor 2 0.953
Il1r1 interleukin 1 receptor, type I 0.952
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.945
Cd40 CD40 antigen 0.933
Sfpi1 SFFV proviral integration 1 0.932
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.912
Cd19 CD19 antigen 0.907
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.796
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.789
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.786
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.778
Stat5b signal transducer and activator of transcription 5B 0.739
Birc3 baculoviral IAP repeat-containing 3 0.724
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.717
Ccr7 chemokine (C-C motif) receptor 7 0.703
Foxp3 forkhead box P3 0.640
Ikbkg inhibitor of kappaB kinase gamma 0.638
Cd7 CD7 antigen 0.625
Clec4d C-type lectin domain family 4, member d 0.620
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.609
Cd80 CD80 antigen 0.607
Icos inducible T-cell co-stimulator 0.588
Stat6 signal transducer and activator of transcription 6 0.583
Lyz2 lysozyme 2 0.582
Irf4 interferon regulatory factor 4 0.573
Ccl2 chemokine (C-C motif) ligand 2 0.560
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.548
Il4ra interleukin 4 receptor, alpha 0.537
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.532
Ifnar2 interferon (alpha and beta) receptor 2 0.525
Ccr6 chemokine (C-C motif) receptor 6 0.524
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.488
Stat3 signal transducer and activator of transcription 3 0.472
Fcgr2b Fc receptor, IgG, low affinity IIb 0.453
Cxcr2 chemokine (C-X-C motif) receptor 2 0.442
Sell selectin, lymphocyte 0.410
Il2ra interleukin 2 receptor, alpha chain 0.409
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.405
Fasl Fas ligand (TNF superfamily, member 6) 0.399
Il27ra interleukin 27 receptor, alpha 0.377
Il1b interleukin 1 beta 0.366
Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.364
Cd5 CD5 antigen 0.361
Lta lymphotoxin A 0.357
Pdcd1 programmed cell death 1 0.349
Traf1 TNF receptor-associated factor 1 0.345
Ikzf1 IKAROS family zinc finger 1 0.336
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.332
Casp1 caspase 1 0.324
Socs1 suppressor of cytokine signaling 1 0.303
Il1rl1 interleukin 1 receptor-like 1 0.300
Clec4e C-type lectin domain family 4, member e 0.295
Cxcl13 chemokine (C-X-C motif) ligand 13 0.294
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.293
Tnip1 TNFAIP3 interacting protein 1 0.281
Fcrla Fc receptor-like A 0.269
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.267
Tnfrsf13b tumor necrosis factor receptor superfamily, member 13b 0.267
C3ar1 complement component 3a receptor 1 0.267
Irf1 interferon regulatory factor 1 0.256
Traf3ip2 TRAF3 interacting protein 2 0.254
Il10ra interleukin 10 receptor, alpha 0.247
Bcl3 B-cell leukemia/lymphoma 3 0.246
Fgd3 FYVE, RhoGEF and PH domain containing 3 0.239
Cd28 CD28 antigen 0.237
Il1a interleukin 1 alpha 0.235
Clec4n C-type lectin domain family 4, member n 0.222
Ccr3 chemokine (C-C motif) receptor 3 0.216
Csf1 colony stimulating factor 1 (macrophage) 0.210
Ccr1 chemokine (C-C motif) receptor 1 0.209
Tlr7 toll-like receptor 7 0.209
Ifng interferon gamma 0.207
Itgal integrin alpha L 0.207
Ccr5 chemokine (C-C motif) receptor 5 0.197
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.196
Cd44 CD44 antigen 0.195
Cd4 CD4 antigen 0.193
Mmp8 matrix metallopeptidase 8 0.188
Lair1 leukocyte-associated Ig-like receptor 1 0.182
Il1f9 interleukin 1 family, member 9 0.181
Cybb cytochrome b-245, beta polypeptide 0.179
Cd14 CD14 antigen 0.177
Asprv1 aspartic peptidase, retroviral-like 1 0.176
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.176
Inhba inhibin beta-A 0.172
Irg1 immunoresponsive gene 1 0.170
Rel reticuloendotheliosis oncogene 0.170
Ccl3 chemokine (C-C motif) ligand 3 0.168
Il18r1 interleukin 18 receptor 1 0.165
Flt3 FMS-like tyrosine kinase 3 0.160
Il2 interleukin 2 0.159
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.154
Il1rn interleukin 1 receptor antagonist 0.154
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
epor erythropoietin receptor 0.040
mmp9 matrix metalloproteinase 9 0.035
LOC100332193 growth hormone secretagogue receptor type 1-like 0.033
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.029
irak4 interleukin-1 receptor-associated kinase 4 0.029
optc opticin 0.028
tnfa tumor necrosis factor a (TNF superfamily, member 2) 0.026
cpox coproporphyrinogen oxidase 0.024
tlr18 toll-like receptor 18 0.023
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.022
bmp2b bone morphogenetic protein 2b 0.022
cdkn1a cyclin-dependent kinase inhibitor 1A 0.021
fn1 fibronectin 1 0.021
LOC100003514 protein kinase C alpha type-like 0.021
sp2 sp2 transcription factor 0.021
nod1 nucleotide-binding oligomerization domain containing 1 0.020
nod2 nucleotide-binding oligomerization domain containing 2 0.019
stc1l stanniocalcin 1, like 0.019
stat1b signal transducer and activator of transcription 1b 0.019
il8 interleukin 8 0.018
hcrt hypocretin (orexin) neuropeptide precursor 0.018
ppardb peroxisome proliferator-activated receptor delta b 0.018
mtp microsomal triglyceride transfer protein 0.018
tlr2 toll-like receptor 2 0.018
fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.018
nfyc nuclear transcription factor Y, gamma 0.018
isg15 ISG15 ubiquitin-like modifier 0.018
ctsl1a cathepsin L, 1 a 0.018
tlr3 toll-like receptor 3 0.017
dag1 dystroglycan 1 0.017
csf3r colony stimulating factor 3 receptor (granulocyte) 0.017
igfbp1a insulin-like growth factor binding protein 1a 0.017
vcanb versican b 0.017
smyd3 SET and MYND domain containing 3 0.017
traf6 TNF receptor-associated factor 6 0.016
tph2 tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) 0.016
foxd3 forkhead box D3 0.016
ryr1b ryanodine receptor 1b (skeletal) 0.016
igf2a insulin-like growth factor 2a 0.016
matn4 matrilin 4 0.016
tirap toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.016
btk Bruton agammaglobulinemia tyrosine kinase 0.016
atf3 activating transcription factor 3 0.015
ghrl ghrelin/obestatin preprohormone 0.015
fxyd1 FXYD domain containing ion transport regulator 1 (phospholemman) 0.015
LOC557072 caspase recruitment domain-containing protein 11-like 0.015
wu:fc23b05 wu:fc23b05 0.015
il6r interleukin 6 receptor 0.015
gadd45ba growth arrest and DNA-damage-inducible, beta a 0.015
chrna4 cholinergic receptor, nicotinic, alpha 4 0.015
amotl2a angiomotin like 2a 0.015
csad cysteine sulfinic acid decarboxylase 0.014
dnm2 dynamin 2 0.014
c1qc complement component 1, q subcomponent, C chain 0.014
hbae1 hemoglobin alpha embryonic-1 0.014
dkk1b dickkopf 1b 0.014
fcho2 FCH domain only 2 0.014
fbxl14b F-box and leucine-rich repeat protein 14b 0.014
wnt4a wingless-type MMTV integration site family, member 4a 0.014
dusp1 dual specificity phosphatase 1 0.014
mobkl1b MOB1, Mps One Binder kinase activator-like 1B (yeast) 0.013
smarcal1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 0.013
LOC100534776 toll-like receptor 7-like 0.013
pdcd2 programmed cell death 2 0.013
kctd12.1 potassium channel tetramerisation domain containing 12.1 0.013
tlr20a toll-like receptor 20a 0.013
comta catechol-O-methyltransferase a 0.013
wnt4b wingless-type MMTV integration site family, member 4b 0.013
maff v-maf musculoaponeurotic fibrosarcoma oncogene homolog f (avian) 0.013
mmp13a matrix metalloproteinase 13a 0.013
pxn paxillin 0.013
spry2 sprouty homolog 2 0.013
tal2 T-cell acute lymphocytic leukemia 2 0.013
ptprsa protein tyrosine phosphatase, receptor type, s, a 0.013
drl draculin 0.013
smc1al structural maintenance of chromosomes 1A, like 0.013
gatsl2 GATS protein-like 2 0.013
fzd9b frizzled homolog 9b 0.013
lgi1b leucine-rich, glioma inactivated 1b 0.012
elovl1a elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1a 0.012
inhbaa inhibin, beta Aa 0.012
ifng1-2 interferon, gamma 1-2 0.012
hoxc8a homeo box C8a 0.012
vtg1 vitellogenin 1 0.012
sass6 spindle assembly 6 homolog (C. elegans) 0.012
erbb3a v-erb-b2 erythroblastic leukemia viral oncogene homolog 3a 0.012
prok2 prokineticin 2 0.012
ptk2.1 protein tyrosine kinase 2a 0.012
zgc:153148 zgc:153148 0.012
slc17a7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 0.012
tdh L-threonine dehydrogenase 0.012
alk anaplastic lymphoma kinase (Ki-1) 0.012
glula glutamate-ammonia ligase (glutamine synthase) a 0.011
abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.011
ntrk3b neurotrophic tyrosine kinase, receptor, type 3b 0.011
rasgef1bb RasGEF domain family, member 1Bb 0.011
hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 0.011
smox spermine oxidase 0.011
prkcbb protein kinase C, beta b 0.011
sb:cb930 sb:cb930 0.011
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.948
TICAM2 toll-like receptor adaptor molecule 2 0.794
RIPK2 receptor-interacting serine-threonine kinase 2 0.775
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.704
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.694
BIRC3 baculoviral IAP repeat containing 3 0.656
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.651
CD80 CD80 molecule 0.613
SYK spleen tyrosine kinase 0.496
IL4R interleukin 4 receptor 0.456
BTN3A3 butyrophilin, subfamily 3, member A3 0.450
STAT2 signal transducer and activator of transcription 2, 113kDa 0.441
BTN3A1 butyrophilin, subfamily 3, member A1 0.423
IL1R1 interleukin 1 receptor, type I 0.391
BTN3A2 butyrophilin, subfamily 3, member A2 0.388
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.381
CD2 CD2 molecule 0.275
TRAF5 TNF receptor-associated factor 5 0.273
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.234
IL1B interleukin 1, beta 0.226
MYD88 myeloid differentiation primary response gene (88) 0.219
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.216
LAT linker for activation of T cells 0.212
IRF7 interferon regulatory factor 7 0.206
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.175
IL2RB interleukin 2 receptor, beta 0.170
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.168
DDIT3 DNA-damage-inducible transcript 3 0.153
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.139
LCK lymphocyte-specific protein tyrosine kinase 0.131
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.129
IL8 interleukin 8 0.126
TRAF1 TNF receptor-associated factor 1 0.126
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.122
CD247 CD247 molecule 0.107
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.105
PIAS4 protein inhibitor of activated STAT, 4 0.105
SH2D1A SH2 domain containing 1A 0.104
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.095
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.094
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.090
KLF6 Kruppel-like factor 6 0.085
PRF1 perforin 1 (pore forming protein) 0.078
ZFP36 zinc finger protein 36, C3H type, homolog (mouse) 0.076
IL10RA interleukin 10 receptor, alpha 0.075
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.074
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.073
IRAK2 interleukin-1 receptor-associated kinase 2 0.070
BCL3 B-cell CLL/lymphoma 3 0.069
KLF4 Kruppel-like factor 4 (gut) 0.068
CFLAR CASP8 and FADD-like apoptosis regulator 0.068
DUSP1 dual specificity phosphatase 1 0.068
CARD11 caspase recruitment domain family, member 11 0.067
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.067
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.066
CD86 CD86 molecule 0.065
TLR2 toll-like receptor 2 0.065
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.063
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.063
MPO myeloperoxidase 0.062
IL1R2 interleukin 1 receptor, type II 0.062
HLA-G major histocompatibility complex, class I, G 0.060
ATF4 activating transcription factor 4 (tax-responsive enhancer element B67) 0.060
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.058
CDHR2 cadherin-related family member 2 0.057
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 0.055
IL6R interleukin 6 receptor 0.055
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.055
PLAUR plasminogen activator, urokinase receptor 0.055
IL1RN interleukin 1 receptor antagonist 0.051
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 0.051
INSR insulin receptor 0.050
TRAF2 TNF receptor-associated factor 2 0.049
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.048
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.048
BTN2A2 butyrophilin, subfamily 2, member A2 0.048
PDPK1 3-phosphoinositide dependent protein kinase-1 0.048
FCN1 ficolin (collagen/fibrinogen domain containing) 1 0.048
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.047
SLAMF1 signaling lymphocytic activation molecule family member 1 0.046
IRF4 interferon regulatory factor 4 0.045
BTK Bruton agammaglobulinemia tyrosine kinase 0.045
CD1C CD1c molecule 0.045
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.045
TREM1 triggering receptor expressed on myeloid cells 1 0.045
TRIM21 tripartite motif containing 21 0.044
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.044
SIGLEC7 sialic acid binding Ig-like lectin 7 0.043
CXCL2 chemokine (C-X-C motif) ligand 2 0.042
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.040
BLNK B-cell linker 0.040
NLRP3 NLR family, pyrin domain containing 3 0.039
HK3 hexokinase 3 (white cell) 0.038
UBASH3B ubiquitin associated and SH3 domain containing B 0.037
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.037
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.036
BCL10 B-cell CLL/lymphoma 10 0.036
IFNG interferon, gamma 0.035
IRF8 interferon regulatory factor 8 0.035
PPP1R15A protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.034
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Rattus norvegicus
Name Description Probability Func Analog Organism
Igsf6 immunoglobulin superfamily, member 6 0.283
Ccl3 chemokine (C-C motif) ligand 3 0.242
Ccl2 chemokine (C-C motif) ligand 2 0.114
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.073
Tlr2 toll-like receptor 2 0.063
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.044
Akr1c18 aldo-keto reductase family 1, member C18 0.041
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.031
Cybb cytochrome b-245, beta polypeptide 0.030
Bcl2a1d B-cell leukemia/lymphoma 2 related protein A1d 0.027
Clrn3 clarin 3 0.027
Il1b interleukin 1 beta 0.024
Dnase1l3 deoxyribonuclease 1-like 3 0.023
Sell selectin L 0.023
Fos FBJ osteosarcoma oncogene 0.022
Cd44 Cd44 molecule 0.022
Cxcl3 chemokine (C-X-C motif) ligand 3 0.022
Il1a interleukin 1 alpha 0.021
Cst7 cystatin F (leukocystatin) 0.021
Cxcl2 chemokine (C-X-C motif) ligand 2 0.020
Cd247 Cd247 molecule 0.019
F2rl2 coagulation factor II (thrombin) receptor-like 2 0.019
Mmp12 matrix metallopeptidase 12 0.019
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.018
Prdm1 PR domain containing 1, with ZNF domain 0.017
Gzmk granzyme K 0.017
Musk muscle, skeletal, receptor tyrosine kinase 0.016
Cubn cubilin (intrinsic factor-cobalamin receptor) 0.016
Fcer1a Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide 0.015
Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 0.015
Tlr4 toll-like receptor 4 0.015
C5ar1 complement component 5a receptor 1 0.015
Il1r2 interleukin 1 receptor, type II 0.015
Sla src-like adaptor 0.015
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.013
Prf1 perforin 1 (pore forming protein) 0.013
Arl11 ADP-ribosylation factor-like 11 0.013
Il6 interleukin 6 0.013
Apba1 amyloid beta (A4) precursor protein-binding, family A, member 1 0.013
Gif gastric intrinsic factor 0.013
Fcn1 ficolin (collagen/fibrinogen domain containing) 1 0.013
Ccl4 chemokine (C-C motif) ligand 4 0.013
Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) 0.012
Errfi1 ERBB receptor feedback inhibitor 1 0.011
Ccr2 chemokine (C-C motif) receptor 2 0.011
Nox4 NADPH oxidase 4 0.011
Il8rb interleukin 8 receptor, beta 0.011
Xcl1 chemokine (C motif) ligand 1 0.011
Slc9a2 solute carrier family 9 (sodium/hydrogen exchanger), member 2 0.011
Dusp1 dual specificity phosphatase 1 0.011
Cd86 CD86 molecule 0.010
Mmp3 matrix metallopeptidase 3 0.010
Galr2 galanin receptor 2 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism