IMP
Process View
The network for 'signal transduction involved in dna integrity checkpoint' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
signal transduction involved in dna integrity checkpoint
A signal transduction process that contributes to a DNA integrity checkpoint.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Trp53 | transformation related protein 53 | 1.000 | |
| Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 0.994 | |
| Pten | phosphatase and tensin homolog | 0.992 | |
| Mdm2 | transformed mouse 3T3 cell double minute 2 | 0.989 | |
| Mdm4 | transformed mouse 3T3 cell double minute 4 | 0.962 | |
| Apc | adenomatosis polyposis coli | 0.938 | |
| Rb1 | retinoblastoma 1 | 0.936 | |
| Brca1 | breast cancer 1 | 0.912 | |
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.868 | |
| Col1a1 | collagen, type I, alpha 1 | 0.809 | |
| Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.784 | |
| Fgfr2 | fibroblast growth factor receptor 2 | 0.729 | |
| Brca2 | breast cancer 2 | 0.682 | |
| Kit | kit oncogene | 0.564 | |
| Cdkn1b | cyclin-dependent kinase inhibitor 1B | 0.490 | |
| Rara | retinoic acid receptor, alpha | 0.340 | |
| Skil | SKI-like | 0.336 | |
| Itgb1 | integrin beta 1 (fibronectin receptor beta) | 0.316 | |
| Daxx | Fas death domain-associated protein | 0.314 | |
| Cdkn2a | cyclin-dependent kinase inhibitor 2A | 0.309 | |
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.295 | |
| Braf | Braf transforming gene | 0.292 | |
| Thbs1 | thrombospondin 1 | 0.234 | |
| Prkdc | protein kinase, DNA activated, catalytic polypeptide | 0.232 | |
| Sfn | stratifin | 0.226 | |
| Stk11 | serine/threonine kinase 11 | 0.202 | |
| Nbn | nibrin | 0.186 | |
| Trp63 | transformation related protein 63 | 0.180 | |
| Runx1 | runt related transcription factor 1 | 0.148 | |
| Meox2 | mesenchyme homeobox 2 | 0.139 | |
| E2f1 | E2F transcription factor 1 | 0.128 | |
| Nf1 | neurofibromatosis 1 | 0.122 | |
| Hipk1 | homeodomain interacting protein kinase 1 | 0.118 | |
| Trp73 | transformation related protein 73 | 0.109 | |
| Ccnd1 | cyclin D1 | 0.108 | |
| Bcl2l11 | BCL2-like 11 (apoptosis facilitator) | 0.106 | |
| Atm | ataxia telangiectasia mutated homolog (human) | 0.103 | |
| Rxra | retinoid X receptor alpha | 0.089 | |
| Wrn | Werner syndrome homolog (human) | 0.077 | |
| Mycn | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) | 0.073 | |
| Stat3 | signal transducer and activator of transcription 3 | 0.064 | |
| Sox9 | SRY-box containing gene 9 | 0.061 | |
| Rbl1 | retinoblastoma-like 1 (p107) | 0.057 | |
| Ptch1 | patched homolog 1 | 0.054 | |
| Hif1a | hypoxia inducible factor 1, alpha subunit | 0.049 | |
| Tgfb1 | transforming growth factor, beta 1 | 0.049 | |
| Ndufv1 | NADH dehydrogenase (ubiquinone) flavoprotein 1 | 0.044 | |
| Sin3a | transcriptional regulator, SIN3A (yeast) | 0.044 | |
| Cdkn2c | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | 0.043 | |
| Cldn7 | claudin 7 | 0.043 | |
| Mybl2 | myeloblastosis oncogene-like 2 | 0.041 | |
| Vhl | von Hippel-Lindau tumor suppressor | 0.040 | |
| Esr1 | estrogen receptor 1 (alpha) | 0.037 | |
| Vdr | vitamin D receptor | 0.036 | |
| Adam17 | a disintegrin and metallopeptidase domain 17 | 0.036 | |
| Elavl1 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) | 0.036 | |
| Smad3 | MAD homolog 3 (Drosophila) | 0.035 | |
| Yap1 | yes-associated protein 1 | 0.035 | |
| Msh2 | mutS homolog 2 (E. coli) | 0.033 | |
| Nf2 | neurofibromatosis 2 | 0.032 | |
| Huwe1 | HECT, UBA and WWE domain containing 1 | 0.031 | |
| Notch1 | Notch gene homolog 1 (Drosophila) | 0.029 | |
| Rassf1 | Ras association (RalGDS/AF-6) domain family member 1 | 0.029 | |
| Dok1 | docking protein 1 | 0.029 | |
| Il6st | interleukin 6 signal transducer | 0.029 | |
| Nfya | nuclear transcription factor-Y alpha | 0.028 | |
| Gadd45a | growth arrest and DNA-damage-inducible 45 alpha | 0.028 | |
| Mmp14 | matrix metallopeptidase 14 (membrane-inserted) | 0.027 | |
| Xpa | xeroderma pigmentosum, complementation group A | 0.026 | |
| Tia1 | cytotoxic granule-associated RNA binding protein 1 | 0.026 | |
| Lig4 | ligase IV, DNA, ATP-dependent | 0.026 | |
| Smad5 | MAD homolog 5 (Drosophila) | 0.025 | |
| Ahr | aryl-hydrocarbon receptor | 0.024 | |
| Pms2 | postmeiotic segregation increased 2 (S. cerevisiae) | 0.024 | |
| Asxl1 | additional sex combs like 1 (Drosophila) | 0.024 | |
| Mlh1 | mutL homolog 1 (E. coli) | 0.024 | |
| Shh | sonic hedgehog | 0.023 | |
| Hhat | hedgehog acyltransferase | 0.022 | |
| Tsc1 | tuberous sclerosis 1 | 0.022 | |
| Gata3 | GATA binding protein 3 | 0.022 | |
| Kitl | kit ligand | 0.022 | |
| Rnf8 | ring finger protein 8 | 0.022 | |
| Hr | hairless | 0.022 | |
| Psen1 | presenilin 1 | 0.021 | |
| Lyz2 | lysozyme 2 | 0.021 | |
| Fadd | Fas (TNFRSF6)-associated via death domain | 0.020 | |
| Fbn1 | fibrillin 1 | 0.020 | |
| Crlf3 | cytokine receptor-like factor 3 | 0.020 | |
| Tcf3 | transcription factor 3 | 0.020 | |
| Timm13 | translocase of inner mitochondrial membrane 13 homolog (yeast) | 0.020 | |
| Cxcr4 | chemokine (C-X-C motif) receptor 4 | 0.020 | |
| Fas | Fas (TNF receptor superfamily member 6) | 0.020 | |
| Hoxa13 | homeobox A13 | 0.019 | |
| Smn1 | survival motor neuron 1 | 0.019 | |
| Irf6 | interferon regulatory factor 6 | 0.019 | |
| Elf3 | E74-like factor 3 | 0.019 | |
| Eif2ak2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.019 | |
| Pds5b | PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) | 0.019 | |
| Nfe2l2 | nuclear factor, erythroid derived 2, like 2 | 0.019 | |
| Itga3 | integrin alpha 3 | 0.018 |
Loading network...
Caenorhabditis elegans
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| CELE_F14D7.2 | Protein F14D7.2 | 0.013 | |
| F02D10.6 | Protein F02D10.6 | 0.013 | |
| C04B4.2 | Protein C04B4.2 | 0.012 | |
| ent-5 | Protein ENT-5 | 0.011 |
Loading network...
Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| MDM2 | Mdm2 p53 binding protein homolog (mouse) | 0.868 | |
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma | 0.651 | |
| APAF1 | apoptotic peptidase activating factor 1 | 0.574 | |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 0.569 | |
| PAX3 | paired box 3 | 0.557 | |
| RB1 | retinoblastoma 1 | 0.454 | |
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | 0.436 | |
| XIAP | X-linked inhibitor of apoptosis | 0.391 | |
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | 0.257 | |
| LRDD | leucine-rich repeats and death domain containing | 0.207 | |
| POU5F1 | POU class 5 homeobox 1 | 0.169 | |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | 0.139 | |
| NLRC4 | NLR family, CARD domain containing 4 | 0.128 | |
| PPP2R1B | protein phosphatase 2, regulatory subunit A, beta | 0.104 | |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.101 | |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.090 | |
| CASP4 | caspase 4, apoptosis-related cysteine peptidase | 0.080 | |
| CHEK2 | CHK2 checkpoint homolog (S. pombe) | 0.078 | |
| U2AF2 | U2 small nuclear RNA auxiliary factor 2 | 0.061 | |
| RAF1 | v-raf-1 murine leukemia viral oncogene homolog 1 | 0.055 | |
| FAS | Fas (TNF receptor superfamily, member 6) | 0.055 | |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.051 | |
| FADD | Fas (TNFRSF6)-associated via death domain | 0.050 | |
| POU3F2 | POU class 3 homeobox 2 | 0.047 | |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.045 | |
| IER3 | immediate early response 3 | 0.045 | |
| TP53 | tumor protein p53 | 0.045 | |
| CASP1 | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 0.042 | |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.038 | |
| SMAD7 | SMAD family member 7 | 0.037 | |
| PPP2R5A | protein phosphatase 2, regulatory subunit B', alpha | 0.036 | |
| BCL2 | B-cell CLL/lymphoma 2 | 0.030 | |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.028 | |
| DAXX | death-domain associated protein | 0.026 | |
| CCND3 | cyclin D3 | 0.025 | |
| PLRG1 | pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) | 0.021 | |
| DIABLO | diablo, IAP-binding mitochondrial protein | 0.021 | |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.021 | |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.020 | |
| BCAS2 | breast carcinoma amplified sequence 2 | 0.020 | |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.019 | |
| TELO2 | TEL2, telomere maintenance 2, homolog (S. cerevisiae) | 0.019 | |
| ATR | ataxia telangiectasia and Rad3 related | 0.017 | |
| DZIP1 | DAZ interacting protein 1 | 0.016 | |
| ELF4 | E74-like factor 4 (ets domain transcription factor) | 0.016 | |
| CASP8 | caspase 8, apoptosis-related cysteine peptidase | 0.015 | |
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 | 0.015 | |
| HDAC4 | histone deacetylase 4 | 0.015 | |
| FASLG | Fas ligand (TNF superfamily, member 6) | 0.015 | |
| SMPD1 | sphingomyelin phosphodiesterase 1, acid lysosomal | 0.015 | |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | 0.014 | |
| CASP9 | caspase 9, apoptosis-related cysteine peptidase | 0.013 | |
| NUCB2 | nucleobindin 2 | 0.013 | |
| NOD1 | nucleotide-binding oligomerization domain containing 1 | 0.013 | |
| TGIF1 | TGFB-induced factor homeobox 1 | 0.013 | |
| BANP | BTG3 associated nuclear protein | 0.013 | |
| XRCC1 | X-ray repair complementing defective repair in Chinese hamster cells 1 | 0.013 | |
| SALL2 | sal-like 2 (Drosophila) | 0.013 | |
| NOTCH1 | notch 1 | 0.012 | |
| RAC1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 0.012 | |
| UHRF2 | ubiquitin-like with PHD and ring finger domains 2 | 0.011 | |
| AXIN1 | axin 1 | 0.011 | |
| USP7 | ubiquitin specific peptidase 7 (herpes virus-associated) | 0.011 | |
| GORAB | golgin, RAB6-interacting | 0.011 | |
| PPP2R5D | protein phosphatase 2, regulatory subunit B', delta | 0.010 | |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.010 | |
| MED1 | mediator complex subunit 1 | 0.010 | |
| GNL3L | guanine nucleotide binding protein-like 3 (nucleolar)-like | 0.010 | |
| RBL2 | retinoblastoma-like 2 (p130) | 0.010 | |
| MARCKSL1 | MARCKS-like 1 | 0.010 |