The network for 'cd4 positive alpha beta t cell activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cd4 positive alpha beta t cell activation

The change in morphology and behavior of a CD4-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.

Mus musculus
Name Description Probability Func Analog Organism
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 1.000
Stat3 signal transducer and activator of transcription 3 0.999
Tnf tumor necrosis factor 0.997
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.996
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.996
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.991
Stat5a signal transducer and activator of transcription 5A 0.991
Lepr leptin receptor 0.983
Lef1 lymphoid enhancer binding factor 1 0.966
Stat5b signal transducer and activator of transcription 5B 0.964
Jak2 Janus kinase 2 0.949
Foxp3 forkhead box P3 0.936
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.925
Il4ra interleukin 4 receptor, alpha 0.912
Socs1 suppressor of cytokine signaling 1 0.893
Stat6 signal transducer and activator of transcription 6 0.892
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.882
Cd40 CD40 antigen 0.838
Runx1 runt related transcription factor 1 0.822
Fas Fas (TNF receptor superfamily member 6) 0.822
Irf9 interferon regulatory factor 9 0.794
Ccl2 chemokine (C-C motif) ligand 2 0.780
Cish cytokine inducible SH2-containing protein 0.773
Bcl3 B-cell leukemia/lymphoma 3 0.753
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.744
Gli2 GLI-Kruppel family member GLI2 0.728
Irf5 interferon regulatory factor 5 0.706
Gata6 GATA binding protein 6 0.692
Gata4 GATA binding protein 4 0.691
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.671
Batf basic leucine zipper transcription factor, ATF-like 0.623
Mxd1 MAX dimerization protein 1 0.614
Socs3 suppressor of cytokine signaling 3 0.590
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.578
Nckap1l NCK associated protein 1 like 0.577
Creb1 cAMP responsive element binding protein 1 0.563
Stat2 signal transducer and activator of transcription 2 0.558
Ikzf1 IKAROS family zinc finger 1 0.549
Ccr2 chemokine (C-C motif) receptor 2 0.544
Rarg retinoic acid receptor, gamma 0.530
Tgfb1 transforming growth factor, beta 1 0.524
Batf3 basic leucine zipper transcription factor, ATF-like 3 0.513
Cd44 CD44 antigen 0.500
Ccl12 chemokine (C-C motif) ligand 12 0.476
Hic1 hypermethylated in cancer 1 0.474
Sfpi1 SFFV proviral integration 1 0.469
Kit kit oncogene 0.458
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.450
Rxra retinoid X receptor alpha 0.443
Twist2 twist homolog 2 (Drosophila) 0.442
Atxn1 ataxin 1 0.416
Hhex hematopoietically expressed homeobox 0.402
Foxp1 forkhead box P1 0.394
Cd19 CD19 antigen 0.392
Ccr7 chemokine (C-C motif) receptor 7 0.387
Ifng interferon gamma 0.382
Ptgir prostaglandin I receptor (IP) 0.379
Bcl2 B-cell leukemia/lymphoma 2 0.371
Csf1 colony stimulating factor 1 (macrophage) 0.366
Il6st interleukin 6 signal transducer 0.362
Traf1 TNF receptor-associated factor 1 0.353
Ccl4 chemokine (C-C motif) ligand 4 0.340
Itga3 integrin alpha 3 0.336
Icam1 intercellular adhesion molecule 1 0.331
Ccl7 chemokine (C-C motif) ligand 7 0.330
Irf4 interferon regulatory factor 4 0.328
Traf6 TNF receptor-associated factor 6 0.325
Il27ra interleukin 27 receptor, alpha 0.307
Fgf10 fibroblast growth factor 10 0.307
Myd88 myeloid differentiation primary response gene 88 0.304
Thra thyroid hormone receptor alpha 0.303
Slc39a4 solute carrier family 39 (zinc transporter), member 4 0.300
Ifnar2 interferon (alpha and beta) receptor 2 0.299
Zfpm2 zinc finger protein, multitype 2 0.290
Ccr1 chemokine (C-C motif) receptor 1 0.290
Sfn stratifin 0.288
Tcf7 transcription factor 7, T-cell specific 0.281
Rag1 recombination activating gene 1 0.280
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.277
Nf1 neurofibromatosis 1 0.275
Cd86 CD86 antigen 0.271
Csf2 colony stimulating factor 2 (granulocyte-macrophage) 0.270
Hdac7 histone deacetylase 7 0.262
Tnfrsf18 tumor necrosis factor receptor superfamily, member 18 0.257
Rc3h1 RING CCCH (C3H) domains 1 0.257
Foxn1 forkhead box N1 0.254
Selp selectin, platelet 0.252
Il10 interleukin 10 0.252
Sox7 SRY-box containing gene 7 0.250
Tgfbr2 transforming growth factor, beta receptor II 0.236
Il2rb interleukin 2 receptor, beta chain 0.228
Il12b interleukin 12b 0.228
Ccl3 chemokine (C-C motif) ligand 3 0.220
Ptprc protein tyrosine phosphatase, receptor type, C 0.219
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.212
Lag3 lymphocyte-activation gene 3 0.211
Clec4d C-type lectin domain family 4, member d 0.209
Plcg1 phospholipase C, gamma 1 0.208
Lyz2 lysozyme 2 0.207
Il10ra interleukin 10 receptor, alpha 0.205
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
IL4R interleukin 4 receptor 0.903
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.568
IL8 interleukin 8 0.310
NCOR2 nuclear receptor corepressor 2 0.285
CCR5 chemokine (C-C motif) receptor 5 0.241
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.201
CCL4 chemokine (C-C motif) ligand 4 0.140
LIN9 lin-9 homolog (C. elegans) 0.121
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.119
ICAM1 intercellular adhesion molecule 1 0.114
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.103
IL2RG interleukin 2 receptor, gamma 0.096
CCL8 chemokine (C-C motif) ligand 8 0.077
CXCL9 chemokine (C-X-C motif) ligand 9 0.077
TRAF1 TNF receptor-associated factor 1 0.067
CCL22 chemokine (C-C motif) ligand 22 0.057
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.050
CCL5 chemokine (C-C motif) ligand 5 0.047
CCR7 chemokine (C-C motif) receptor 7 0.047
CCL2 chemokine (C-C motif) ligand 2 0.046
CXCL10 chemokine (C-X-C motif) ligand 10 0.042
MEOX1 mesenchyme homeobox 1 0.042
RARA retinoic acid receptor, alpha 0.041
PPARA peroxisome proliferator-activated receptor alpha 0.038
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.033
IL4 interleukin 4 0.033
IL1B interleukin 1, beta 0.032
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.030
NR2E3 nuclear receptor subfamily 2, group E, member 3 0.029
CXCL11 chemokine (C-X-C motif) ligand 11 0.027
IL23A interleukin 23, alpha subunit p19 0.027
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.027
NLK nemo-like kinase 0.025
RXRA retinoid X receptor, alpha 0.024
DPP4 dipeptidyl-peptidase 4 0.024
PDZD11 PDZ domain containing 11 0.023
IL7R interleukin 7 receptor 0.022
SOCS3 suppressor of cytokine signaling 3 0.022
CCL13 chemokine (C-C motif) ligand 13 0.019
NCOA1 nuclear receptor coactivator 1 0.018
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.017
BCL3 B-cell CLL/lymphoma 3 0.016
CCL19 chemokine (C-C motif) ligand 19 0.015
CXCL13 chemokine (C-X-C motif) ligand 13 0.013
HDAC9 histone deacetylase 9 0.013
CD40 CD40 molecule, TNF receptor superfamily member 5 0.012
CXCL2 chemokine (C-X-C motif) ligand 2 0.011
IFNG interferon, gamma 0.010
IL2RB interleukin 2 receptor, beta 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cd5 Cd5 molecule 0.046
Gimap4 GTPase, IMAP family member 4 0.037
Cd2 Cd2 molecule 0.031
Epn1 Epsin 1 0.029
Ccl5 chemokine (C-C motif) ligand 5 0.028
Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.026
Rcsd1 RCSD domain containing 1 0.023
Gja4 gap junction protein, alpha 4 0.022
Eif3i eukaryotic translation initiation factor 3, subunit I 0.021
Hdac7 histone deacetylase 7 0.020
Il2rg interleukin 2 receptor, gamma 0.020
Lck lymphocyte-specific protein tyrosine kinase 0.020
Stat6 signal transducer and activator of transcription 6 0.019
Tgfbr2 transforming growth factor, beta receptor II 0.019
Il2rb interleukin 2 receptor, beta 0.018
Sh2d1a SH2 domain protein 1A 0.016
Pecam1 platelet/endothelial cell adhesion molecule 1 0.015
Rxra retinoid X receptor alpha 0.015
Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.015
Cdgap Cdc42 GTPase-activating protein 0.015
Cd3g CD3 molecule, gamma 0.015
Ruvbl1 RuvB-like 1 (E. coli) 0.014
Mrps34 mitochondrial ribosomal protein S34 0.014
Mapk7 mitogen-activated protein kinase 7 0.014
Ict1 immature colon carcinoma transcript 1 0.013
Rps6ka1 ribosomal protein S6 kinase polypeptide 1 0.013
Psd4 pleckstrin and Sec7 domain containing 4 0.013
Smad7 SMAD family member 7 0.013
Sh3tc1 SH3 domain and tetratricopeptide repeats 1 0.012
Ncr3 natural cytotoxicity triggering receptor 3 0.012
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.012
Mrps7 mitochondrial ribosomal protein S7 0.012
Hmha1 histocompatibility (minor) HA-1 0.012
Glycam1 glycosylation dependent cell adhesion molecule 1 0.012
Anpep alanyl (membrane) aminopeptidase 0.012
Dchs1 dachsous 1 (Drosophila) 0.012
Spn sialophorin 0.012
Rhoh ras homolog gene family, member H 0.012
Hdac1l histone deacetylase 1-like 0.012
Plekhg2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 0.012
Mrps5 mitochondrial ribosomal protein S5 0.012
Ddr1 discoidin domain receptor tyrosine kinase 1 0.012
Arhgap4 Rho GTPase activating protein 4 0.011
Ccl21 chemokine (C-C motif) ligand 21 0.011
Tfeb transcription factor EB 0.011
Egfl7 EGF-like-domain, multiple 7 0.011
Dctn4 dynactin 4 0.011
Nfic nuclear factor I/C 0.011
Faim3 Fas apoptotic inhibitory molecule 3 0.011
Serpinb6b serine (or cysteine) peptidase inhibitor, clade B, member 6b 0.011
Rara retinoic acid receptor, alpha 0.011
Zfml zinc finger, matrin-like 0.011
Cxcl10 chemokine (C-X-C motif) ligand 10 0.011
Gata2 GATA binding protein 2 0.011
Prpf4b PRP4 pre-mRNA processing factor 4 homolog B (yeast) 0.011
Skap1 src kinase associated phosphoprotein 1 0.010
Secp43 tRNA selenocysteine associated protein 0.010
Ogt O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 0.010
Dll4 delta-like 4 (Drosophila) 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism