The network for 'regulation of fibroblast proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of fibroblast proliferation

Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells.

Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 1.000
Bcl2 B-cell leukemia/lymphoma 2 0.977
Pten phosphatase and tensin homolog 0.971
Gli3 GLI-Kruppel family member GLI3 0.942
Pbx1 pre B-cell leukemia transcription factor 1 0.912
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.877
Rara retinoic acid receptor, alpha 0.867
Fgfr2 fibroblast growth factor receptor 2 0.812
Apc adenomatosis polyposis coli 0.763
Lepr leptin receptor 0.703
Egfr epidermal growth factor receptor 0.685
Bax BCL2-associated X protein 0.581
Pax3 paired box gene 3 0.573
C1qa complement component 1, q subcomponent, alpha polypeptide 0.548
Ptgs2 prostaglandin-endoperoxide synthase 2 0.543
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.529
Rxra retinoid X receptor alpha 0.517
Smad3 MAD homolog 3 (Drosophila) 0.514
Prrx1 paired related homeobox 1 0.510
Jun Jun oncogene 0.462
Vhl von Hippel-Lindau tumor suppressor 0.450
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.446
Nos3 nitric oxide synthase 3, endothelial cell 0.438
Tgfb1 transforming growth factor, beta 1 0.421
Csf1 colony stimulating factor 1 (macrophage) 0.400
C1qc complement component 1, q subcomponent, C chain 0.387
Skil SKI-like 0.375
Mapk8 mitogen-activated protein kinase 8 0.364
Fgfr1 fibroblast growth factor receptor 1 0.353
Shh sonic hedgehog 0.337
Kit kit oncogene 0.298
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.298
Fos FBJ osteosarcoma oncogene 0.277
Mcl1 myeloid cell leukemia sequence 1 0.273
Trp63 transformation related protein 63 0.272
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.261
Btg2 B-cell translocation gene 2, anti-proliferative 0.254
Maff v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) 0.250
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.247
Apoe apolipoprotein E 0.246
Ccnd1 cyclin D1 0.243
Sox10 SRY-box containing gene 10 0.235
Hoxa9 homeobox A9 0.231
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.231
Polr2a polymerase (RNA) II (DNA directed) polypeptide A 0.228
Ret ret proto-oncogene 0.228
Ccnd2 cyclin D2 0.227
Egr1 early growth response 1 0.226
Stat3 signal transducer and activator of transcription 3 0.219
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.218
Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha 0.215
Notch2 Notch gene homolog 2 (Drosophila) 0.215
Sox9 SRY-box containing gene 9 0.190
Zfp36 zinc finger protein 36 0.189
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.176
Spry4 sprouty homolog 4 (Drosophila) 0.170
Rb1 retinoblastoma 1 0.168
Gadd45b growth arrest and DNA-damage-inducible 45 beta 0.165
Mdm2 transformed mouse 3T3 cell double minute 2 0.161
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.161
Esr1 estrogen receptor 1 (alpha) 0.160
Atf3 activating transcription factor 3 0.159
Ntf3 neurotrophin 3 0.157
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.155
Mdm4 transformed mouse 3T3 cell double minute 4 0.152
Gli2 GLI-Kruppel family member GLI2 0.152
Nrg1 neuregulin 1 0.149
Vdr vitamin D receptor 0.148
Bmp4 bone morphogenetic protein 4 0.148
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.146
Lep leptin 0.143
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.142
Tcf21 transcription factor 21 0.142
Myc myelocytomatosis oncogene 0.140
Fgf8 fibroblast growth factor 8 0.138
Klf4 Kruppel-like factor 4 (gut) 0.137
Gdf1 growth differentiation factor 1 0.136
Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 0.134
Wnt5a wingless-related MMTV integration site 5A 0.131
Adamts1 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 0.130
Acvr1 activin A receptor, type 1 0.129
Vegfa vascular endothelial growth factor A 0.127
Bak1 BCL2-antagonist/killer 1 0.127
Lif leukemia inhibitory factor 0.125
Thbs1 thrombospondin 1 0.120
Lmna lamin A 0.116
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.112
Pax6 paired box gene 6 0.110
Pvr poliovirus receptor 0.108
Mark4 MAP/microtubule affinity-regulating kinase 4 0.108
Cbl Casitas B-lineage lymphoma 0.104
C1qb complement component 1, q subcomponent, beta polypeptide 0.102
Nodal nodal 0.100
Cdk1 cyclin-dependent kinase 1 0.099
Nfe2l2 nuclear factor, erythroid derived 2, like 2 0.097
Fgf10 fibroblast growth factor 10 0.095
Ednrb endothelin receptor type B 0.095
Hbegf heparin-binding EGF-like growth factor 0.094
Lyz2 lysozyme 2 0.094
Egr2 early growth response 2 0.094
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
C09B9.4 Protein C09B9.4 0.012
ikke-1 Protein IKKE-1 0.011
T05A7.6 Protein T05A7.6 0.011
F09C12.8 Protein F09C12.8 0.011
K11C4.1 Protein K11C4.1 0.010
F37A8.1 Protein F37A8.1 0.010
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.992
CDK2 cyclin-dependent kinase 2 0.972
RING1 ring finger protein 1 0.942
RB1 retinoblastoma 1 0.932
E2F1 E2F transcription factor 1 0.895
NAMPT nicotinamide phosphoribosyltransferase 0.694
VEGFA vascular endothelial growth factor A 0.589
AXL AXL receptor tyrosine kinase 0.475
RNF2 ring finger protein 2 0.453
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.424
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.346
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.312
RBL2 retinoblastoma-like 2 (p130) 0.286
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.281
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.276
APLF aprataxin and PNKP like factor 0.270
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.263
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.256
TFDP1 transcription factor Dp-1 0.247
DTX3L deltex 3-like (Drosophila) 0.237
CCNE1 cyclin E1 0.232
CBX8 chromobox homolog 8 0.223
CCND1 cyclin D1 0.222
NRP1 neuropilin 1 0.193
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.187
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.184
CDK6 cyclin-dependent kinase 6 0.155
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.154
PARP14 poly (ADP-ribose) polymerase family, member 14 0.151
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.143
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.140
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.137
RBBP8 retinoblastoma binding protein 8 0.130
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.128
E2F4 E2F transcription factor 4, p107/p130-binding 0.125
IGF2R insulin-like growth factor 2 receptor 0.105
CKS1B CDC28 protein kinase regulatory subunit 1B 0.093
TP53 tumor protein p53 0.090
CBX7 chromobox homolog 7 0.085
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.085
CBX6 chromobox homolog 6 0.085
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 0.083
PGF placental growth factor 0.081
PARP9 poly (ADP-ribose) polymerase family, member 9 0.078
PLAUR plasminogen activator, urokinase receptor 0.071
BMI1 BMI1 polycomb ring finger oncogene 0.068
CCND2 cyclin D2 0.068
EGFR epidermal growth factor receptor 0.067
MAX MYC associated factor X 0.065
LIN9 lin-9 homolog (C. elegans) 0.059
CCND3 cyclin D3 0.056
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.054
TFF1 trefoil factor 1 0.053
LIG4 ligase IV, DNA, ATP-dependent 0.051
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.048
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.047
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.046
SKP2 S-phase kinase-associated protein 2 (p45) 0.046
RYBP RING1 and YY1 binding protein 0.045
PLAT plasminogen activator, tissue 0.043
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.042
RBL1 retinoblastoma-like 1 (p107) 0.042
PDGFA platelet-derived growth factor alpha polypeptide 0.041
ALDOA aldolase A, fructose-bisphosphate 0.040
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.039
KLF6 Kruppel-like factor 6 0.039
CCNA2 cyclin A2 0.039
LGALS8 lectin, galactoside-binding, soluble, 8 0.038
ENO1 enolase 1, (alpha) 0.038
LIN54 lin-54 homolog (C. elegans) 0.037
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.037
PLAU plasminogen activator, urokinase 0.036
SKIL SKI-like oncogene 0.036
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.035
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.035
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.035
RXRA retinoid X receptor, alpha 0.032
JUNB jun B proto-oncogene 0.031
KRT5 keratin 5 0.030
PNKP polynucleotide kinase 3'-phosphatase 0.030
STAT1 signal transducer and activator of transcription 1, 91kDa 0.030
FZD1 frizzled homolog 1 (Drosophila) 0.030
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.028
E2F3 E2F transcription factor 3 0.028
PGK1 phosphoglycerate kinase 1 0.028
CTSB cathepsin B 0.028
BCL3 B-cell CLL/lymphoma 3 0.027
NFIL3 nuclear factor, interleukin 3 regulated 0.027
RNF144B ring finger protein 144B 0.027
UBE2B ubiquitin-conjugating enzyme E2B (RAD6 homolog) 0.027
IGFBP5 insulin-like growth factor binding protein 5 0.026
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.026
CDK4 cyclin-dependent kinase 4 0.026
CXCR4 chemokine (C-X-C motif) receptor 4 0.026
MAFF v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) 0.026
COL11A2 collagen, type XI, alpha 2 0.026
E2F6 E2F transcription factor 6 0.025
SIRT1 sirtuin 1 0.024
MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.024
ITGB1BP3 integrin beta 1 binding protein 3 0.024
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism