IMP

Process View

Homo sapiens

26 genes annotated in human

positive regulation of interferon gamma production

Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of interferon gamma production"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of interferon gamma production" (in gray)

Name	Description	Probability	Func Analog Organism
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	1.000	Human
IL1R1	interleukin 1 receptor, type I	0.918
HLA-B	major histocompatibility complex, class I, B	0.909
HLA-F	major histocompatibility complex, class I, F	0.873	Human
B2M	beta-2-microglobulin	0.866
HLA-G	major histocompatibility complex, class I, G	0.858	Human
BTN3A2	butyrophilin, subfamily 3, member A2	0.847	Human
BTN3A3	butyrophilin, subfamily 3, member A3	0.836	Human
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.791
HLA-A	major histocompatibility complex, class I, A	0.771
SYK	spleen tyrosine kinase	0.756
HLA-C	major histocompatibility complex, class I, C	0.742	Human
BTN3A1	butyrophilin, subfamily 3, member A1	0.711	Human
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.692
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	0.681
HCK	hemopoietic cell kinase	0.632	Human
LCK	lymphocyte-specific protein tyrosine kinase	0.595	Human
HLA-E	major histocompatibility complex, class I, E	0.592	Human
MYD88	myeloid differentiation primary response gene (88)	0.497
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.421
IL23A	interleukin 23, alpha subunit p19	0.415
NLRC4	NLR family, CARD domain containing 4	0.329
BLNK	B-cell linker	0.306
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.293
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.293
TRAF1	TNF receptor-associated factor 1	0.292
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.270
CD80	CD80 molecule	0.267
CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.252
SPRR2A	small proline-rich protein 2A	0.252
DDIT3	DNA-damage-inducible transcript 3	0.248
CD247	CD247 molecule	0.248
SOCS3	suppressor of cytokine signaling 3	0.231
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.228
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.204
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.201
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.199
SH3KBP1	SH3-domain kinase binding protein 1	0.167
PTPRC	protein tyrosine phosphatase, receptor type, C	0.161
IL1RAP	interleukin 1 receptor accessory protein	0.153
PRKCQ	protein kinase C, theta	0.149
BTN2A2	butyrophilin, subfamily 2, member A2	0.139	Human
TLR2	toll-like receptor 2	0.135
MEFV	Mediterranean fever	0.130
STAT4	signal transducer and activator of transcription 4	0.116
ICAM1	intercellular adhesion molecule 1	0.108
RIN1	Ras and Rab interactor 1	0.103
GRB2	growth factor receptor-bound protein 2	0.102
TICAM2	toll-like receptor adaptor molecule 2	0.101
CD48	CD48 molecule	0.096
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.090
PHYHIPL	phytanoyl-CoA 2-hydroxylase interacting protein-like	0.087
FYN	FYN oncogene related to SRC, FGR, YES	0.083	Human
ITK	IL2-inducible T-cell kinase	0.078
NCK1	NCK adaptor protein 1	0.077
VAV1	vav 1 guanine nucleotide exchange factor	0.076
TRADD	TNFRSF1A-associated via death domain	0.074
SLA	Src-like-adaptor	0.073
LY86	lymphocyte antigen 86	0.072
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.068	Human
IL1RN	interleukin 1 receptor antagonist	0.067	Human
HCP5	HLA complex P5	0.066
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.063
BTK	Bruton agammaglobulinemia tyrosine kinase	0.063	Human
IL1R2	interleukin 1 receptor, type II	0.061
BIRC3	baculoviral IAP repeat containing 3	0.060
BTN2A1	butyrophilin, subfamily 2, member A1	0.058	Human
TRAF3IP3	TRAF3 interacting protein 3	0.058
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.058	Mouse
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.056
STAT1	signal transducer and activator of transcription 1, 91kDa	0.055
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.051
IL1B	interleukin 1, beta	0.050
LAT	linker for activation of T cells	0.047
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.046
JAK1	Janus kinase 1	0.046
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.045
HLA-DRA	major histocompatibility complex, class II, DR alpha	0.045
LY96	lymphocyte antigen 96	0.044
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.041
PLCG1	phospholipase C, gamma 1	0.040
IRF1	interferon regulatory factor 1	0.040
CD86	CD86 molecule	0.040	Human
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.038
LIF	leukemia inhibitory factor (cholinergic differentiation factor)	0.038
FGL2	fibrinogen-like 2	0.037
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.035
IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	0.034
NDP	Norrie disease (pseudoglioma)	0.034
TLR1	toll-like receptor 1	0.034	Human
JAK2	Janus kinase 2	0.033
WNT5A	wingless-type MMTV integration site family, member 5A	0.033	Mouse
CXCR4	chemokine (C-X-C motif) receptor 4	0.033
PDCD6IP	programmed cell death 6 interacting protein	0.033
WIPF1	WAS/WASL interacting protein family, member 1	0.032
PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.032
HLA-DMA	major histocompatibility complex, class II, DM alpha	0.031
GARS	glycyl-tRNA synthetase	0.031
IL10RA	interleukin 10 receptor, alpha	0.031
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.030
TPP1	tripeptidyl peptidase I	0.030
CNTF	ciliary neurotrophic factor	0.029
NOD2	nucleotide-binding oligomerization domain containing 2	0.029
IFNG	interferon, gamma	0.027
CXCL10	chemokine (C-X-C motif) ligand 10	0.025
IFITM2	interferon induced transmembrane protein 2 (1-8D)	0.025
FAS	Fas (TNF receptor superfamily, member 6)	0.025
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.024
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.024
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.023
FZD1	frizzled homolog 1 (Drosophila)	0.023	Human
NOD1	nucleotide-binding oligomerization domain containing 1	0.023
NLRP3	NLR family, pyrin domain containing 3	0.023
MTHFD2	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	0.023
BCL3	B-cell CLL/lymphoma 3	0.023	Mouse
CIITA	class II, major histocompatibility complex, transactivator	0.022
IL10	interleukin 10	0.022
TFEC	transcription factor EC	0.021
TRIM38	tripartite motif containing 38	0.021
RARRES3	retinoic acid receptor responder (tazarotene induced) 3	0.021
BBS10	Bardet-Biedl syndrome 10	0.021
IL15	interleukin 15	0.021
ARHGAP25	Rho GTPase activating protein 25	0.021
TARS	threonyl-tRNA synthetase	0.020
MS4A6A	membrane-spanning 4-domains, subfamily A, member 6A	0.020
CTSO	cathepsin O	0.020
WNT3A	wingless-type MMTV integration site family, member 3A	0.020
HSPH1	heat shock 105kDa/110kDa protein 1	0.020
CD3G	CD3g molecule, gamma (CD3-TCR complex)	0.019
IL18RAP	interleukin 18 receptor accessory protein	0.019
CCR7	chemokine (C-C motif) receptor 7	0.019
GPR18	G protein-coupled receptor 18	0.019
SH2D2A	SH2 domain containing 2A	0.019
TLR6	toll-like receptor 6	0.019	Human
ELF5	E74-like factor 5 (ets domain transcription factor)	0.019
IL6R	interleukin 6 receptor	0.018
MARS	methionyl-tRNA synthetase	0.018
TFF1	trefoil factor 1	0.018
HLA-DOA	major histocompatibility complex, class II, DO alpha	0.018
CXCL9	chemokine (C-X-C motif) ligand 9	0.018
PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	0.018
CD2AP	CD2-associated protein	0.018
GPR65	G protein-coupled receptor 65	0.018
LRMP	lymphoid-restricted membrane protein	0.018
ALOX5	arachidonate 5-lipoxygenase	0.018
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.018
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.017
MR1	major histocompatibility complex, class I-related	0.017	Human
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.017
DAPP1	dual adaptor of phosphotyrosine and 3-phosphoinositides	0.017
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.017
CD38	CD38 molecule	0.016
CYBB	cytochrome b-245, beta polypeptide	0.016
GBP2	guanylate binding protein 2, interferon-inducible	0.016
ADAM15	ADAM metallopeptidase domain 15	0.016
CD28	CD28 molecule	0.016
TRAT1	T cell receptor associated transmembrane adaptor 1	0.016
JAK3	Janus kinase 3	0.016
CD37	CD37 molecule	0.016
TNF	tumor necrosis factor	0.016
MS4A1	membrane-spanning 4-domains, subfamily A, member 1	0.016
UBASH3B	ubiquitin associated and SH3 domain containing B	0.016
IL16	interleukin 16 (lymphocyte chemoattractant factor)	0.015
SBNO2	strawberry notch homolog 2 (Drosophila)	0.015
EVI2B	ecotropic viral integration site 2B	0.015
CD79A	CD79a molecule, immunoglobulin-associated alpha	0.015
CTSS	cathepsin S	0.015
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.015
CD40	CD40 molecule, TNF receptor superfamily member 5	0.015
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.014
GIMAP4	GTPase, IMAP family member 4	0.014
NIN	ninein (GSK3B interacting protein)	0.014
CCL20	chemokine (C-C motif) ligand 20	0.014
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.014
CD1C	CD1c molecule	0.014
SH2D1A	SH2 domain containing 1A	0.014
LST1	leukocyte specific transcript 1	0.014
GTF2I	general transcription factor IIi	0.013
CSF1	colony stimulating factor 1 (macrophage)	0.013
HLA-DRB5	major histocompatibility complex, class II, DR beta 5	0.013
KMO	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	0.013
IL2RB	interleukin 2 receptor, beta	0.013
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.013
IKZF1	IKAROS family zinc finger 1 (Ikaros)	0.013
SIRPB1	signal-regulatory protein beta 1	0.013
PIK3CG	phosphoinositide-3-kinase, catalytic, gamma polypeptide	0.013
TRAF3	TNF receptor-associated factor 3	0.013
BCL2A1	BCL2-related protein A1	0.013
FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	0.013
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.013
TAPBP	TAP binding protein (tapasin)	0.012
PRKCB	protein kinase C, beta	0.012
EHF	ets homologous factor	0.012
OSM	oncostatin M	0.012
GRB7	growth factor receptor-bound protein 7	0.012
ACACA	acetyl-CoA carboxylase alpha	0.012
SOCS1	suppressor of cytokine signaling 1	0.012
CTBP2	C-terminal binding protein 2	0.012
P2RY13	purinergic receptor P2Y, G-protein coupled, 13	0.012
RNASE6	ribonuclease, RNase A family, k6	0.012
MICA	MHC class I polypeptide-related sequence A	0.012
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.012
CR1	complement component (3b/4b) receptor 1 (Knops blood group)	0.012
LRP6	low density lipoprotein receptor-related protein 6	0.012
IRF4	interferon regulatory factor 4	0.012
AIM2	absent in melanoma 2	0.012
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.012
MED28	mediator complex subunit 28	0.012
RNASEL	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	0.012
NRG1	neuregulin 1	0.012
IGJ	immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides	0.012
SH3BP2	SH3-domain binding protein 2	0.011
IARS	isoleucyl-tRNA synthetase	0.011
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.011
CD300C	CD300c molecule	0.011
CD33	CD33 molecule	0.011
TNFSF12-TNFSF13	TNFSF12-TNFSF13 readthrough	0.011
VNN2	vanin 2	0.011
ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	0.011
ADPRH	ADP-ribosylarginine hydrolase	0.011
TLR4	toll-like receptor 4	0.011	Human Mouse
MUC1	mucin 1, cell surface associated	0.011
CCR1	chemokine (C-C motif) receptor 1	0.011
IGF1	insulin-like growth factor 1 (somatomedin C)	0.011
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.011
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.011
EGFR	epidermal growth factor receptor	0.011
IL12RB1	interleukin 12 receptor, beta 1	0.011
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.010
MSR1	macrophage scavenger receptor 1	0.010
CD3D	CD3d molecule, delta (CD3-TCR complex)	0.010
AKNA	AT-hook transcription factor	0.010
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.010
NLRC5	NLR family, CARD domain containing 5	0.010
APOL3	apolipoprotein L, 3	0.010
ASNS	asparagine synthetase (glutamine-hydrolyzing)	0.010