IMP

Process View

Homo sapiens

22 genes annotated in human

extrinsic apoptotic signaling pathway in absence of ligand

A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "extrinsic apoptotic signaling pathway in absence of ligand"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "extrinsic apoptotic signaling pathway in absence of ligand" (in gray)

Name	Description	Probability	Func Analog Organism
BCL2	B-cell CLL/lymphoma 2	1.000
BCL2L1	BCL2-like 1	0.999	Human Mouse
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.991
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.985
TAL1	T-cell acute lymphocytic leukemia 1	0.971
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.970	Mouse
BAX	BCL2-associated X protein	0.965	Human Mouse
HSPA1B	heat shock 70kDa protein 1B	0.931
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.870	Human
BAD	BCL2-associated agonist of cell death	0.834
FAS	Fas (TNF receptor superfamily, member 6)	0.832	Mouse
BID	BH3 interacting domain death agonist	0.774
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.621	Mouse
EGFR	epidermal growth factor receptor	0.609	Human
IL1R1	interleukin 1 receptor, type I	0.589
B2M	beta-2-microglobulin	0.514
CFLAR	CASP8 and FADD-like apoptosis regulator	0.501
CXCL10	chemokine (C-X-C motif) ligand 10	0.475	Human
PML	promyelocytic leukemia	0.437
HSPA1A	heat shock 70kDa protein 1A	0.406
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.391
CXCL2	chemokine (C-X-C motif) ligand 2	0.376
FADD	Fas (TNFRSF6)-associated via death domain	0.373	Mouse
CRADD	CASP2 and RIPK1 domain containing adaptor with death domain	0.373
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.373
TRADD	TNFRSF1A-associated via death domain	0.342
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.336
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.276
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.240
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.231
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.226
BIRC2	baculoviral IAP repeat containing 2	0.201
TRAF1	TNF receptor-associated factor 1	0.197
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.188
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.182
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.168
APAF1	apoptotic peptidase activating factor 1	0.139
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.135
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.132
IL1B	interleukin 1, beta	0.127
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.126
IL4R	interleukin 4 receptor	0.125
BAG3	BCL2-associated athanogene 3	0.122	Mouse
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.120
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.118
GSK3B	glycogen synthase kinase 3 beta	0.115	Mouse
MAPK14	mitogen-activated protein kinase 14	0.113
IL8	interleukin 8	0.113
TRAF2	TNF receptor-associated factor 2	0.110
CXCL11	chemokine (C-X-C motif) ligand 11	0.102	Human
IL1R2	interleukin 1 receptor, type II	0.102
MAPK7	mitogen-activated protein kinase 7	0.101
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.095
TNF	tumor necrosis factor	0.093
IFITM3	interferon induced transmembrane protein 3 (1-8U)	0.085
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.083
BAK1	BCL2-antagonist/killer 1	0.081	Human
MAP2K5	mitogen-activated protein kinase kinase 5	0.080	Rat
DNAJB1	DnaJ (Hsp40) homolog, subfamily B, member 1	0.077
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.076
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.074
DAXX	death-domain associated protein	0.073
XIAP	X-linked inhibitor of apoptosis	0.073
IL6	interleukin 6 (interferon, beta 2)	0.072
CXCL5	chemokine (C-X-C motif) ligand 5	0.062	Human
HSPB1	heat shock 27kDa protein 1	0.060
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.059
BCL2A1	BCL2-related protein A1	0.058	Human
HSPB8	heat shock 22kDa protein 8	0.055
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.055
MAPK1	mitogen-activated protein kinase 1	0.055
CXCL3	chemokine (C-X-C motif) ligand 3	0.053	Human
THBS1	thrombospondin 1	0.053
FASLG	Fas ligand (TNF superfamily, member 6)	0.052
BIRC3	baculoviral IAP repeat containing 3	0.049
PF4	platelet factor 4	0.048
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.047
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.046
CCL4	chemokine (C-C motif) ligand 4	0.046
JUP	junction plakoglobin	0.044
CCL8	chemokine (C-C motif) ligand 8	0.043
STIP1	stress-induced-phosphoprotein 1	0.042
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.041
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.041
IL2RG	interleukin 2 receptor, gamma	0.041
PLCG1	phospholipase C, gamma 1	0.039
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.039
FGF2	fibroblast growth factor 2 (basic)	0.037
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	0.037
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.037
GRB7	growth factor receptor-bound protein 7	0.036
EIF4G3	eukaryotic translation initiation factor 4 gamma, 3	0.036
AXIN1	axin 1	0.036
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.035
CCL20	chemokine (C-C motif) ligand 20	0.035
BANP	BTG3 associated nuclear protein	0.034
IFI27	interferon, alpha-inducible protein 27	0.033	Human
PTK6	PTK6 protein tyrosine kinase 6	0.033
BIK	BCL2-interacting killer (apoptosis-inducing)	0.031
PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	0.031	Human
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.031
KLF13	Kruppel-like factor 13	0.029
ASRGL1	asparaginase like 1	0.028
DPP4	dipeptidyl-peptidase 4	0.027
BBC3	BCL2 binding component 3	0.027
RIPK3	receptor-interacting serine-threonine kinase 3	0.026
IL1RN	interleukin 1 receptor antagonist	0.026	Human
KAT2B	K(lysine) acetyltransferase 2B	0.026
ANKS1B	ankyrin repeat and sterile alpha motif domain containing 1B	0.025
STAT2	signal transducer and activator of transcription 2, 113kDa	0.025
FOXO1	forkhead box O1	0.024
APP	amyloid beta (A4) precursor protein	0.024
HLA-G	major histocompatibility complex, class I, G	0.024
RIPK2	receptor-interacting serine-threonine kinase 2	0.023
APC	adenomatous polyposis coli	0.023
FRS2	fibroblast growth factor receptor substrate 2	0.023
IFNG	interferon, gamma	0.023
RNF144B	ring finger protein 144B	0.023
BAG1	BCL2-associated athanogene	0.022
CXCL9	chemokine (C-X-C motif) ligand 9	0.022	Human
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.022
STK11	serine/threonine kinase 11	0.021
CTTNBP2NL	CTTNBP2 N-terminal like	0.021
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.021
LAPTM4A	lysosomal protein transmembrane 4 alpha	0.021
CD320	CD320 molecule	0.021
MAGEA2	melanoma antigen family A, 2	0.020
IL1A	interleukin 1, alpha	0.020	Human Mouse
PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	0.020
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.020	Human
ATM	ataxia telangiectasia mutated	0.019
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.019
ZFP36L1	zinc finger protein 36, C3H type-like 1	0.018
CXCR3	chemokine (C-X-C motif) receptor 3	0.018
UBD	ubiquitin D	0.018
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.018
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.018
INSR	insulin receptor	0.018
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.018	Mouse
PDK1	pyruvate dehydrogenase kinase, isozyme 1	0.018
PF4V1	platelet factor 4 variant 1	0.018	Human
SOCS3	suppressor of cytokine signaling 3	0.018
IFI44L	interferon-induced protein 44-like	0.018
LAMP2	lysosomal-associated membrane protein 2	0.017
TBX5	T-box 5	0.017
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.017
IL7R	interleukin 7 receptor	0.017
TP53BP2	tumor protein p53 binding protein, 2	0.017
DUSP9	dual specificity phosphatase 9	0.017
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.016
MAGEH1	melanoma antigen family H, 1	0.016
IL11	interleukin 11	0.016
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.016
HBB	hemoglobin, beta	0.016
CSF3	colony stimulating factor 3 (granulocyte)	0.016
SQSTM1	sequestosome 1	0.016
SMG6	Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)	0.016
VAV3	vav 3 guanine nucleotide exchange factor	0.016
DLG3	discs, large homolog 3 (Drosophila)	0.015
CXCL13	chemokine (C-X-C motif) ligand 13	0.015
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.015
PSEN1	presenilin 1	0.015
ABL2	v-abl Abelson murine leukemia viral oncogene homolog 2	0.015
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.015	Human
DIABLO	diablo, IAP-binding mitochondrial protein	0.014
VDAC1	voltage-dependent anion channel 1	0.014
BCL2L2	BCL2-like 2	0.014	Human
PI3	peptidase inhibitor 3, skin-derived	0.014
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.014
CCL5	chemokine (C-C motif) ligand 5	0.014
CCL2	chemokine (C-C motif) ligand 2	0.013
CCL7	chemokine (C-C motif) ligand 7	0.013
CTBP1	C-terminal binding protein 1	0.013
PPP2R5D	protein phosphatase 2, regulatory subunit B', delta	0.013
FST	follistatin	0.013
TRO	trophinin	0.013
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.013
APOL1	apolipoprotein L, 1	0.013
CRYAB	crystallin, alpha B	0.012
PPP5C	protein phosphatase 5, catalytic subunit	0.012
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.012	Human
ZBTB16	zinc finger and BTB domain containing 16	0.012
STRADA	STE20-related kinase adaptor alpha	0.011
OAS2	2'-5'-oligoadenylate synthetase 2, 69/71kDa	0.011
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.011
KIAA1967	KIAA1967	0.011
OLR1	oxidized low density lipoprotein (lectin-like) receptor 1	0.011
EFNA1	ephrin-A1	0.011
MAPK3	mitogen-activated protein kinase 3	0.011
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.011
RBCK1	RanBP-type and C3HC4-type zinc finger containing 1	0.011
NR5A1	nuclear receptor subfamily 5, group A, member 1	0.011
LAMP3	lysosomal-associated membrane protein 3	0.011
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.011
LDLR	low density lipoprotein receptor	0.011
CD83	CD83 molecule	0.011
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.011
CDH5	cadherin 5, type 2 (vascular endothelium)	0.011
HUWE1	HECT, UBA and WWE domain containing 1	0.011
STAT5A	signal transducer and activator of transcription 5A	0.011
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.011
OASL	2'-5'-oligoadenylate synthetase-like	0.011
MYL6	myosin, light chain 6, alkali, smooth muscle and non-muscle	0.011
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.010
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.010
NRG1	neuregulin 1	0.010
SFN	stratifin	0.010
DLG2	discs, large homolog 2 (Drosophila)	0.010
DAPP1	dual adaptor of phosphotyrosine and 3-phosphoinositides	0.010
CD274	CD274 molecule	0.010
IL1RAP	interleukin 1 receptor accessory protein	0.010