IMP

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Homo sapiens

33 genes annotated in human

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regulation of defense response to virus

GO:0050688

Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of defense response to virus"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of defense response to virus" (in gray)

Name	Description	Probability	Func Analog Organism
DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.998
IFI44	interferon-induced protein 44	0.988
IFIT3	interferon-induced protein with tetratricopeptide repeats 3	0.985	Human
IFIT1	interferon-induced protein with tetratricopeptide repeats 1	0.983
EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	0.980
SP110	SP110 nuclear body protein	0.922
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.909
IFIT2	interferon-induced protein with tetratricopeptide repeats 2	0.908	Human
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.903	Fly
DDX60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	0.861
ISG15	ISG15 ubiquitin-like modifier	0.811
IFIT5	interferon-induced protein with tetratricopeptide repeats 5	0.808	Human
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.798	Fly
SAMD9	sterile alpha motif domain containing 9	0.797
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.766
IFI44L	interferon-induced protein 44-like	0.701
OAS2	2'-5'-oligoadenylate synthetase 2, 69/71kDa	0.677
IFIH1	interferon induced with helicase C domain 1	0.660	Human
STAT1	signal transducer and activator of transcription 1, 91kDa	0.639
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.636
SP100	SP100 nuclear antigen	0.551
EPSTI1	epithelial stromal interaction 1 (breast)	0.530
NMI	N-myc (and STAT) interactor	0.513
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.486	Human
MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	0.467
PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator	0.467	Human
OAS1	2',5'-oligoadenylate synthetase 1, 40/46kDa	0.415
NLRC4	NLR family, CARD domain containing 4	0.396
CREBBP	CREB binding protein	0.392
SMAD4	SMAD family member 4	0.367
PILRA	paired immunoglobin-like type 2 receptor alpha	0.365
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.354
RSAD2	radical S-adenosyl methionine domain containing 2	0.352
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.347
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.292
HERC5	hect domain and RLD 5	0.281
PLSCR1	phospholipid scramblase 1	0.258
IL4R	interleukin 4 receptor	0.256
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.255
TMEM173	transmembrane protein 173	0.242
IL23A	interleukin 23, alpha subunit p19	0.242
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.237
CHUK	conserved helix-loop-helix ubiquitous kinase	0.235	Fly
OASL	2'-5'-oligoadenylate synthetase-like	0.227
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.222
TRIM22	tripartite motif containing 22	0.214	Human
MED15	mediator complex subunit 15	0.203
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.197
MX2	myxovirus (influenza virus) resistance 2 (mouse)	0.190
PARP9	poly (ADP-ribose) polymerase family, member 9	0.180
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.160	Human
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.155
XAF1	XIAP associated factor 1	0.151
PCBP1	poly(rC) binding protein 1	0.149	Human
ATG3	ATG3 autophagy related 3 homolog (S. cerevisiae)	0.146
TRIM21	tripartite motif containing 21	0.142	Human
USP18	ubiquitin specific peptidase 18	0.131
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.128
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.113	Human
OAS3	2'-5'-oligoadenylate synthetase 3, 100kDa	0.111
GBP1	guanylate binding protein 1, interferon-inducible	0.107
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.106	Human
APOL6	apolipoprotein L, 6	0.105
TRIM39	tripartite motif containing 39	0.100	Human
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.098
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.094
MEFV	Mediterranean fever	0.093
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.092
RTP4	receptor (chemosensory) transporter protein 4	0.090
IRF9	interferon regulatory factor 9	0.087
TRAF3	TNF receptor-associated factor 3	0.086	Mouse
UBE2D4	ubiquitin-conjugating enzyme E2D 4 (putative)	0.083
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.078	Human
MAVS	mitochondrial antiviral signaling protein	0.077
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.075
WWP1	WW domain containing E3 ubiquitin protein ligase 1	0.075	Human
IRF7	interferon regulatory factor 7	0.071
RNF11	ring finger protein 11	0.070
TRIM5	tripartite motif containing 5	0.070	Human
XIAP	X-linked inhibitor of apoptosis	0.068
TRIM25	tripartite motif containing 25	0.067
DICER1	dicer 1, ribonuclease type III	0.067	Human
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.066
DAXX	death-domain associated protein	0.062
IL15	interleukin 15	0.062	Mouse
CRADD	CASP2 and RIPK1 domain containing adaptor with death domain	0.057
NOD2	nucleotide-binding oligomerization domain containing 2	0.057
CYLD	cylindromatosis (turban tumor syndrome)	0.056
TDRD7	tudor domain containing 7	0.055
ZNF263	zinc finger protein 263	0.055
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.054
CXCL10	chemokine (C-X-C motif) ligand 10	0.054
IFI27	interferon, alpha-inducible protein 27	0.053
CXCL11	chemokine (C-X-C motif) ligand 11	0.053
ZC3HAV1	zinc finger CCCH-type, antiviral 1	0.052
TYMP	thymidine phosphorylase	0.052
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.052
SAMD9L	sterile alpha motif domain containing 9-like	0.052
SCNN1B	sodium channel, nonvoltage-gated 1, beta	0.050
RANBP3	RAN binding protein 3	0.050
RIPK2	receptor-interacting serine-threonine kinase 2	0.049
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.048	Fly
CMPK2	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial	0.048
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.048	Human
CD33	CD33 molecule	0.045
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.045
IFI6	interferon, alpha-inducible protein 6	0.044
ZFYVE9	zinc finger, FYVE domain containing 9	0.043
PRKD2	protein kinase D2	0.041
PCBP2	poly(rC) binding protein 2	0.041
MOV10	Mov10, Moloney leukemia virus 10, homolog (mouse)	0.040
IFI16	interferon, gamma-inducible protein 16	0.039
HNRNPL	heterogeneous nuclear ribonucleoprotein L	0.038
TAX1BP1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.037
BIRC3	baculoviral IAP repeat containing 3	0.037
INSR	insulin receptor	0.037
FBXL15	F-box and leucine-rich repeat protein 15	0.036
CSK	c-src tyrosine kinase	0.035
HERC6	hect domain and RLD 6	0.034	Human
STX8	syntaxin 8	0.034
IRF2	interferon regulatory factor 2	0.033
NLRP3	NLR family, pyrin domain containing 3	0.032
TRIM43	tripartite motif containing 43	0.031
EPOR	erythropoietin receptor	0.031
IL15RA	interleukin 15 receptor, alpha	0.030
QKI	quaking homolog, KH domain RNA binding (mouse)	0.029
STAP2	signal transducing adaptor family member 2	0.029
IL2RB	interleukin 2 receptor, beta	0.029
WNK1	WNK lysine deficient protein kinase 1	0.027
HCFC1	host cell factor C1 (VP16-accessory protein)	0.027
PARP12	poly (ADP-ribose) polymerase family, member 12	0.027	Human
NFYC	nuclear transcription factor Y, gamma	0.027
LILRA3	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	0.027	Human
RBCK1	RanBP-type and C3HC4-type zinc finger containing 1	0.026
HK3	hexokinase 3 (white cell)	0.026
TRIM26	tripartite motif containing 26	0.026
SIGLEC7	sialic acid binding Ig-like lectin 7	0.024
TRANK1	tetratricopeptide repeat and ankyrin repeat containing 1	0.024
ELF4	E74-like factor 4 (ets domain transcription factor)	0.024
ZRANB1	zinc finger, RAN-binding domain containing 1	0.024
MBOAT7	membrane bound O-acyltransferase domain containing 7	0.024
DHX58	DEXH (Asp-Glu-X-His) box polypeptide 58	0.023
PML	promyelocytic leukemia	0.023
HIPK2	homeodomain interacting protein kinase 2	0.023
ANKRD13A	ankyrin repeat domain 13A	0.022
SMAD1	SMAD family member 1	0.022
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.022
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.022
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.021	Human
STAM2	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	0.021
ATG12	ATG12 autophagy related 12 homolog (S. cerevisiae)	0.021
ZNRF1	zinc and ring finger 1	0.021
ZNFX1	zinc finger, NFX1-type containing 1	0.020
PIAS4	protein inhibitor of activated STAT, 4	0.020
UBE2L6	ubiquitin-conjugating enzyme E2L 6	0.020
DCUN1D1	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)	0.020
DDX60L	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	0.020	Human
ATG10	ATG10 autophagy related 10 homolog (S. cerevisiae)	0.020
PTAFR	platelet-activating factor receptor	0.019
FAM46A	family with sequence similarity 46, member A	0.019
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.019
TARBP2	TAR (HIV-1) RNA binding protein 2	0.019
LAMP3	lysosomal-associated membrane protein 3	0.019
THAP11	THAP domain containing 11	0.019
CALCOCO2	calcium binding and coiled-coil domain 2	0.019
PARP14	poly (ADP-ribose) polymerase family, member 14	0.018
GBP2	guanylate binding protein 2, interferon-inducible	0.018
AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	0.018
ING2	inhibitor of growth family, member 2	0.018
CDK9	cyclin-dependent kinase 9	0.018
TRIM41	tripartite motif containing 41	0.018	Human
NBR1	neighbor of BRCA1 gene 1	0.018
IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	0.018
TNIP2	TNFAIP3 interacting protein 2	0.017
TRIM17	tripartite motif containing 17	0.017	Human
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.017
ZFP28	zinc finger protein 28 homolog (mouse)	0.017
TYK2	tyrosine kinase 2	0.017
CASP5	caspase 5, apoptosis-related cysteine peptidase	0.017	Fly
ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	0.017
EMD	emerin	0.017
SURF4	surfeit 4	0.017
NUDT18	nudix (nucleoside diphosphate linked moiety X)-type motif 18	0.017
PHF11	PHD finger protein 11	0.017
CCR1	chemokine (C-C motif) receptor 1	0.017
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.016
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.016
TRAF6	TNF receptor-associated factor 6	0.015
UBE2Z	ubiquitin-conjugating enzyme E2Z	0.015
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.015
IRS1	insulin receptor substrate 1	0.015
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.015	Fly
FKBP5	FK506 binding protein 5	0.015
TRAF5	TNF receptor-associated factor 5	0.015
GABARAP	GABA(A) receptor-associated protein	0.015
MTA2	metastasis associated 1 family, member 2	0.015
IDO1	indoleamine 2,3-dioxygenase 1	0.015
GRIP1	glutamate receptor interacting protein 1	0.014
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.014
MICA	MHC class I polypeptide-related sequence A	0.014	Human
HLA-G	major histocompatibility complex, class I, G	0.014
SIRPB1	signal-regulatory protein beta 1	0.014
TRAF3IP1	TNF receptor-associated factor 3 interacting protein 1	0.014
ELK1	ELK1, member of ETS oncogene family	0.014
IRF1	interferon regulatory factor 1	0.014
ZNF473	zinc finger protein 473	0.014
GBP4	guanylate binding protein 4	0.014
NDFIP2	Nedd4 family interacting protein 2	0.014
SKIL	SKI-like oncogene	0.014
PABPC1	poly(A) binding protein, cytoplasmic 1	0.014
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.013
NLRC5	NLR family, CARD domain containing 5	0.013
HDAC1	histone deacetylase 1	0.013
MARCH5	membrane-associated ring finger (C3HC4) 5	0.013
GABARAPL2	GABA(A) receptor-associated protein-like 2	0.013
LAP3	leucine aminopeptidase 3	0.013
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.013
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.013
MICB	MHC class I polypeptide-related sequence B	0.013
CD86	CD86 molecule	0.013
UBA7	ubiquitin-like modifier activating enzyme 7	0.013
GABARAPL1	GABA(A) receptor-associated protein like 1	0.013
RABAC1	Rab acceptor 1 (prenylated)	0.013
ZBTB48	zinc finger and BTB domain containing 48	0.013
TANK	TRAF family member-associated NFKB activator	0.013
CD300C	CD300c molecule	0.012
MYL12A	myosin, light chain 12A, regulatory, non-sarcomeric	0.012
CD40	CD40 molecule, TNF receptor superfamily member 5	0.012
AOAH	acyloxyacyl hydrolase (neutrophil)	0.012
YY1	YY1 transcription factor	0.012
ZFAND5	zinc finger, AN1-type domain 5	0.012
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.012
TFEC	transcription factor EC	0.012
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.012
APOL1	apolipoprotein L, 1	0.012
RUNX1	runt-related transcription factor 1	0.012
CYTH4	cytohesin 4	0.012
UBE2U	ubiquitin-conjugating enzyme E2U (putative)	0.012
KLF5	Kruppel-like factor 5 (intestinal)	0.012
TLR8	toll-like receptor 8	0.012
CXXC5	CXXC finger protein 5	0.012
TMEM140	transmembrane protein 140	0.012
IGSF6	immunoglobulin superfamily, member 6	0.012
IL4	interleukin 4	0.012
FPR2	formyl peptide receptor 2	0.012
IFI35	interferon-induced protein 35	0.011
DNAJA2	DnaJ (Hsp40) homolog, subfamily A, member 2	0.011
C19orf66	chromosome 19 open reading frame 66	0.011
CD274	CD274 molecule	0.011
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.011
IL18	interleukin 18 (interferon-gamma-inducing factor)	0.011
SIGLEC9	sialic acid binding Ig-like lectin 9	0.011
TRIM35	tripartite motif containing 35	0.011
SLU7	SLU7 splicing factor homolog (S. cerevisiae)	0.011
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.011	Human
SEC61A1	Sec61 alpha 1 subunit (S. cerevisiae)	0.011
RNF31	ring finger protein 31	0.011
SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	0.011
IRF5	interferon regulatory factor 5	0.011
TRIM6-TRIM34	TRIM6-TRIM34 readthrough	0.011
MR1	major histocompatibility complex, class I-related	0.011
NOD1	nucleotide-binding oligomerization domain containing 1	0.011
UBE2E1	ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)	0.011
CD300A	CD300a molecule	0.011
SUMO3	SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)	0.011
NCOA3	nuclear receptor coactivator 3	0.011
USP15	ubiquitin specific peptidase 15	0.010
CTBP2	C-terminal binding protein 2	0.010
PPP2R2B	protein phosphatase 2, regulatory subunit B, beta	0.010
RNF111	ring finger protein 111	0.010
POLH	polymerase (DNA directed), eta	0.010
TGFBR1	transforming growth factor, beta receptor 1	0.010
STAT2	signal transducer and activator of transcription 2, 113kDa	0.010
CCL8	chemokine (C-C motif) ligand 8	0.010
MARK3	MAP/microtubule affinity-regulating kinase 3	0.010
KCTD15	potassium channel tetramerisation domain containing 15	0.010
TRIM14	tripartite motif containing 14	0.010
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.010
TRIM4	tripartite motif containing 4	0.010	Human
AIM2	absent in melanoma 2	0.010
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.010
MTHFD1L	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	0.010
GCH1	GTP cyclohydrolase 1	0.010
RNF5	ring finger protein 5	0.010
TREM1	triggering receptor expressed on myeloid cells 1	0.010
SLFN12	schlafen family member 12	0.010