IMP

Process View

Homo sapiens

3 genes annotated in human

t cell homeostasis

The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "t cell homeostasis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "t cell homeostasis" (in gray)

Name	Description	Probability	Func Analog Organism
BCL2L1	BCL2-like 1	0.999
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.921	Mouse
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.916
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.885
BID	BH3 interacting domain death agonist	0.704
BAK1	BCL2-antagonist/killer 1	0.565
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.559
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.557
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.437
FASLG	Fas ligand (TNF superfamily, member 6)	0.430
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.409
CDK2	cyclin-dependent kinase 2	0.373
BAD	BCL2-associated agonist of cell death	0.269
BAX	BCL2-associated X protein	0.251	Mouse
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.248
FAS	Fas (TNF receptor superfamily, member 6)	0.243	Mouse
KPNA1	karyopherin alpha 1 (importin alpha 5)	0.206
NOXA1	NADPH oxidase activator 1	0.193
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.187
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.178
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.174	Mouse
BCL2	B-cell CLL/lymphoma 2	0.156	Mouse
INSR	insulin receptor	0.134
CFLAR	CASP8 and FADD-like apoptosis regulator	0.124
IL2RB	interleukin 2 receptor, beta	0.116
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.106
PXMP2	peroxisomal membrane protein 2, 22kDa	0.101
STAT5A	signal transducer and activator of transcription 5A	0.100	Mouse
FADD	Fas (TNFRSF6)-associated via death domain	0.097	Mouse
RNF144B	ring finger protein 144B	0.090
RB1	retinoblastoma 1	0.089
SH3RF1	SH3 domain containing ring finger 1	0.088
PRKCZ	protein kinase C, zeta	0.086	Human
ENG	endoglin	0.081
ARNT	aryl hydrocarbon receptor nuclear translocator	0.078
BCL2L2	BCL2-like 2	0.066
CAV1	caveolin 1, caveolae protein, 22kDa	0.066
HPCAL4	hippocalcin like 4	0.066
JAK2	Janus kinase 2	0.060
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.059	Mouse
RNR2	l-rRNA	0.057
PICK1	protein interacting with PRKCA 1	0.055
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.054
SOCS3	suppressor of cytokine signaling 3	0.054
FSTL1	follistatin-like 1	0.053
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	0.053
BECN1	beclin 1, autophagy related	0.053
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.052
NAF1	nuclear assembly factor 1 homolog (S. cerevisiae)	0.051
TSC22D1	TSC22 domain family, member 1	0.051
IRF2	interferon regulatory factor 2	0.050
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.050
CD247	CD247 molecule	0.049
JAK1	Janus kinase 1	0.048
NUMB	numb homolog (Drosophila)	0.045
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.045
APAF1	apoptotic peptidase activating factor 1	0.043
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.043
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.043
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.042
NCOA7	nuclear receptor coactivator 7	0.042
AKT3	v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)	0.041	Human
CDCP1	CUB domain containing protein 1	0.040
ZNF71	zinc finger protein 71	0.040
SMG1	SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)	0.037
BIK	BCL2-interacting killer (apoptosis-inducing)	0.037
STAP2	signal transducing adaptor family member 2	0.037
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.037
ARNTL	aryl hydrocarbon receptor nuclear translocator-like	0.035
MAPT	microtubule-associated protein tau	0.035
BBC3	BCL2 binding component 3	0.035
NMT2	N-myristoyltransferase 2	0.034
PDPK1	3-phosphoinositide dependent protein kinase-1	0.032
PRKCB	protein kinase C, beta	0.032
CCL14	chemokine (C-C motif) ligand 14	0.031
SH2D1A	SH2 domain containing 1A	0.031
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.031
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.030
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.030
CARD11	caspase recruitment domain family, member 11	0.030
TGFBR1	transforming growth factor, beta receptor 1	0.029
TGFB3	transforming growth factor, beta 3	0.027
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.027
CASP6	caspase 6, apoptosis-related cysteine peptidase	0.026
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.025
PPP3R1	protein phosphatase 3, regulatory subunit B, alpha	0.024
RPS8	ribosomal protein S8	0.024
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.024
DCTN1	dynactin 1	0.023
TP53BP2	tumor protein p53 binding protein, 2	0.022
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.022
CCDC115	coiled-coil domain containing 115	0.022
MAPK1	mitogen-activated protein kinase 1	0.021
FYN	FYN oncogene related to SRC, FGR, YES	0.021
CCND3	cyclin D3	0.020
LCK	lymphocyte-specific protein tyrosine kinase	0.020
STAT5B	signal transducer and activator of transcription 5B	0.020	Mouse
PRMT2	protein arginine methyltransferase 2	0.020
RARA	retinoic acid receptor, alpha	0.020
IRS2	insulin receptor substrate 2	0.020
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.019
ZHX1	zinc fingers and homeoboxes 1	0.019
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.019
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.019
ASXL1	additional sex combs like 1 (Drosophila)	0.019
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.019
SNF8	SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)	0.018
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.018
BCAR1	breast cancer anti-estrogen resistance 1	0.018
BCL10	B-cell CLL/lymphoma 10	0.018
CD2	CD2 molecule	0.018
FAM129A	family with sequence similarity 129, member A	0.017
AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	0.017
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.017
PTPN13	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	0.017
EPOR	erythropoietin receptor	0.017
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	0.017
ARRB2	arrestin, beta 2	0.017
STK10	serine/threonine kinase 10	0.016
E2F2	E2F transcription factor 2	0.016
THBS1	thrombospondin 1	0.016
AIP	aryl hydrocarbon receptor interacting protein	0.016
RPL5	ribosomal protein L5	0.016
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.016
ITK	IL2-inducible T-cell kinase	0.016
GHR	growth hormone receptor	0.016
ZBP1	Z-DNA binding protein 1	0.016
PYCARD	PYD and CARD domain containing	0.015
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.015
CYBA	cytochrome b-245, alpha polypeptide	0.015
GNB2L1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	0.015
FKBP8	FK506 binding protein 8, 38kDa	0.015
PABPC3	poly(A) binding protein, cytoplasmic 3	0.015
CCHCR1	coiled-coil alpha-helical rod protein 1	0.015
IL32	interleukin 32	0.015
CREBBP	CREB binding protein	0.015
TRIM9	tripartite motif containing 9	0.015
TMEM160	transmembrane protein 160	0.015
GRB10	growth factor receptor-bound protein 10	0.015
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	0.015
CDT1	chromatin licensing and DNA replication factor 1	0.015
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.015
LLGL1	lethal giant larvae homolog 1 (Drosophila)	0.014
ACTB	actin, beta	0.014
KLF9	Kruppel-like factor 9	0.014
TGFBR3	transforming growth factor, beta receptor III	0.014
MTHFD1	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	0.014
IRF4	interferon regulatory factor 4	0.014
RPS3A	ribosomal protein S3A	0.014
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.014
BCL2A1	BCL2-related protein A1	0.014
TRIB3	tribbles homolog 3 (Drosophila)	0.014
TXNIP	thioredoxin interacting protein	0.014
PLEKHO1	pleckstrin homology domain containing, family O member 1	0.014
ARHGAP4	Rho GTPase activating protein 4	0.014
BMP2	bone morphogenetic protein 2	0.014
LLGL2	lethal giant larvae homolog 2 (Drosophila)	0.014
NACA	nascent polypeptide-associated complex alpha subunit	0.014
F11R	F11 receptor	0.014
DEF6	differentially expressed in FDCP 6 homolog (mouse)	0.014
POFUT1	protein O-fucosyltransferase 1	0.013
PASK	PAS domain containing serine/threonine kinase	0.013
AP1S1	adaptor-related protein complex 1, sigma 1 subunit	0.013
VPS36	vacuolar protein sorting 36 homolog (S. cerevisiae)	0.013
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.013
IFNAR2	interferon (alpha, beta and omega) receptor 2	0.013
LRRK2	leucine-rich repeat kinase 2	0.013
DIABLO	diablo, IAP-binding mitochondrial protein	0.013
BIRC3	baculoviral IAP repeat containing 3	0.013
MFNG	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.013
STK17B	serine/threonine kinase 17b	0.013
MYO1D	myosin ID	0.013
POLR1B	polymerase (RNA) I polypeptide B, 128kDa	0.013
NCF1	neutrophil cytosolic factor 1	0.013
CD3G	CD3g molecule, gamma (CD3-TCR complex)	0.013
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.013
DUSP6	dual specificity phosphatase 6	0.013
CUX1	cut-like homeobox 1	0.013
PLEKHF2	pleckstrin homology domain containing, family F (with FYVE domain) member 2	0.013
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.012
SORBS2	sorbin and SH3 domain containing 2	0.012
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.012
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.012
TPM3	tropomyosin 3	0.012
MLKL	mixed lineage kinase domain-like	0.012
MAPK8	mitogen-activated protein kinase 8	0.012
PEBP4	phosphatidylethanolamine-binding protein 4	0.012
CSPG4	chondroitin sulfate proteoglycan 4	0.012
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.012
PRKCQ	protein kinase C, theta	0.012	Human
VHL	von Hippel-Lindau tumor suppressor	0.012
CAPN1	calpain 1, (mu/I) large subunit	0.012
PNMA1	paraneoplastic antigen MA1	0.012
CDC25B	cell division cycle 25 homolog B (S. pombe)	0.012
SESN2	sestrin 2	0.012
EIF4B	eukaryotic translation initiation factor 4B	0.012
CCNB1	cyclin B1	0.012
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.012
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.012
MBD4	methyl-CpG binding domain protein 4	0.012
IFNG	interferon, gamma	0.012
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.012
PTK6	PTK6 protein tyrosine kinase 6	0.012
SCIN	scinderin	0.012
BTG1	B-cell translocation gene 1, anti-proliferative	0.011
ZFYVE1	zinc finger, FYVE domain containing 1	0.011
MAP2K1	mitogen-activated protein kinase kinase 1	0.011
NFATC1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.011
APOA1	apolipoprotein A-I	0.011
ALDOA	aldolase A, fructose-bisphosphate	0.011
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.011
APP	amyloid beta (A4) precursor protein	0.011
IRS1	insulin receptor substrate 1	0.011
EPAS1	endothelial PAS domain protein 1	0.011
GLRX3	glutaredoxin 3	0.011
HUWE1	HECT, UBA and WWE domain containing 1	0.011
SAMD4B	sterile alpha motif domain containing 4B	0.011
ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	0.011
TRAF1	TNF receptor-associated factor 1	0.011
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.011
BTK	Bruton agammaglobulinemia tyrosine kinase	0.011
CITED1	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1	0.011
SH2D2A	SH2 domain containing 2A	0.011
CD80	CD80 molecule	0.011
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.011
EEF2K	eukaryotic elongation factor-2 kinase	0.011
KLRG1	killer cell lectin-like receptor subfamily G, member 1	0.011
COTL1	coactosin-like 1 (Dictyostelium)	0.011
SPNS1	spinster homolog 1 (Drosophila)	0.011
NFATC2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.011
POLR2C	polymerase (RNA) II (DNA directed) polypeptide C, 33kDa	0.011
EIF2S3	eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa	0.011
ZNF511	zinc finger protein 511	0.011
EP300	E1A binding protein p300	0.011
BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	0.011
PRKCE	protein kinase C, epsilon	0.011
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.010
XIAP	X-linked inhibitor of apoptosis	0.010
STK17A	serine/threonine kinase 17a	0.010
BICD1	bicaudal D homolog 1 (Drosophila)	0.010
PTCD2	pentatricopeptide repeat domain 2	0.010
PAWR	PRKC, apoptosis, WT1, regulator	0.010
TRPC1	transient receptor potential cation channel, subfamily C, member 1	0.010
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.010
PPP2R4	protein phosphatase 2A activator, regulatory subunit 4	0.010
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.010
PRTFDC1	phosphoribosyl transferase domain containing 1	0.010
PIK3IP1	phosphoinositide-3-kinase interacting protein 1	0.010
JUN	jun proto-oncogene	0.010
DENND5A	DENN/MADD domain containing 5A	0.010
SOCS1	suppressor of cytokine signaling 1	0.010
SETDB1	SET domain, bifurcated 1	0.010
DDIT4	DNA-damage-inducible transcript 4	0.010
PNPLA3	patatin-like phospholipase domain containing 3	0.010
NRP1	neuropilin 1	0.010
IL1RAP	interleukin 1 receptor accessory protein	0.010
LTK	leukocyte receptor tyrosine kinase	0.010