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Mus musculus

4 genes annotated in mouse

t cell anergy

Any process contributing to anergy in T cells, a state of functional inactivation which is part of T cell tolerance induction.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "t cell anergy"

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Name	Description	Probability	Func Analog Organism
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.889
Stat3	signal transducer and activator of transcription 3	0.551
Foxp1	forkhead box P1	0.533	Mouse
Grb2	growth factor receptor bound protein 2	0.529
Tax1bp1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.485
Cyld	cylindromatosis (turban tumor syndrome)	0.422
Rac1	RAS-related C3 botulinum substrate 1	0.421
Cd3d	CD3 antigen, delta polypeptide	0.421	Mouse
Trp53	transformation related protein 53	0.417
Stat5b	signal transducer and activator of transcription 5B	0.406
Traf6	TNF receptor-associated factor 6	0.351
Zap70	zeta-chain (TCR) associated protein kinase	0.303
Fyn	Fyn proto-oncogene	0.299
Lat	linker for activation of T cells	0.298
Dvl1	dishevelled, dsh homolog 1 (Drosophila)	0.280
Lck	lymphocyte protein tyrosine kinase	0.254
Ctla4	cytotoxic T-lymphocyte-associated protein 4	0.220
Tmem64	transmembrane protein 64	0.219
Rnf11	ring finger protein 11	0.216
Crk	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.208
Shc1	src homology 2 domain-containing transforming protein C1	0.203
Cd3g	CD3 antigen, gamma polypeptide	0.188	Mouse
Cd28	CD28 antigen	0.177
Cflar	CASP8 and FADD-like apoptosis regulator	0.163
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.152
Ctsw	cathepsin W	0.133
Ndfip1	Nedd4 family interacting protein 1	0.121
Rag1	recombination activating gene 1	0.117
Cd5	CD5 antigen	0.116
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.115
Ticam1	toll-like receptor adaptor molecule 1	0.106
Ttc7	tetratricopeptide repeat domain 7	0.105
Cd6	CD6 antigen	0.102
Axin1	axin 1	0.101
Myd88	myeloid differentiation primary response gene 88	0.101
Il6st	interleukin 6 signal transducer	0.099
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.098
Smad7	MAD homolog 7 (Drosophila)	0.098
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.094
Cd27	CD27 antigen	0.092
Kit	kit oncogene	0.089
Cd2	CD2 antigen	0.088
Smad4	MAD homolog 4 (Drosophila)	0.088
Cd8b1	CD8 antigen, beta chain 1	0.086
Gzma	granzyme A	0.084
Cd19	CD19 antigen	0.080
Card11	caspase recruitment domain family, member 11	0.079
Nfatc1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.077
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.072
Itsn1	intersectin 1 (SH3 domain protein 1A)	0.071
Cd8a	CD8 antigen, alpha chain	0.070
Usp9x	ubiquitin specific peptidase 9, X chromosome	0.069
Nkd2	naked cuticle 2 homolog (Drosophila)	0.069
Dvl2	dishevelled 2, dsh homolog (Drosophila)	0.067
Rhoh	ras homolog gene family, member H	0.064
Smad1	MAD homolog 1 (Drosophila)	0.063
Smad6	MAD homolog 6 (Drosophila)	0.063
Sh2d1a	SH2 domain protein 1A	0.061
Crkl	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.061
Tbl1x	transducin (beta)-like 1 X-linked	0.057
Ahr	aryl-hydrocarbon receptor	0.057
Itk	IL2-inducible T-cell kinase	0.056
Git2	G protein-coupled receptor kinase-interactor 2	0.054
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.053
Gtf2i	general transcription factor II I	0.052
Il2rb	interleukin 2 receptor, beta chain	0.052
Apc	adenomatosis polyposis coli	0.050
Sh3kbp1	SH3-domain kinase binding protein 1	0.049
Pmepa1	prostate transmembrane protein, androgen induced 1	0.049
Purb	purine rich element binding protein B	0.049
Trp53bp1	transformation related protein 53 binding protein 1	0.048
Prdx6	peroxiredoxin 6	0.047
Cxcr6	chemokine (C-X-C motif) receptor 6	0.046
Tcra	T-cell receptor alpha chain	0.046
Kitl	kit ligand	0.045
Foxp2	forkhead box P2	0.045	Mouse
Gli2	GLI-Kruppel family member GLI2	0.044
Il27ra	interleukin 27 receptor, alpha	0.044
Arhgef7	Rho guanine nucleotide exchange factor (GEF7)	0.042
Prkcq	protein kinase C, theta	0.042
Mll1	myeloid/lymphoid or mixed-lineage leukemia 1	0.042
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.041
Fas	Fas (TNF receptor superfamily member 6)	0.040
Map3k2	mitogen-activated protein kinase kinase kinase 2	0.040
Stat6	signal transducer and activator of transcription 6	0.038
Ubc	ubiquitin C	0.038
Ralbp1	ralA binding protein 1	0.037
Smurf2	SMAD specific E3 ubiquitin protein ligase 2	0.036	Mouse
Notch1	Notch gene homolog 1 (Drosophila)	0.036
Itgb7	integrin beta 7	0.034
Gimap7	GTPase, IMAP family member 7	0.034
Arid1b	AT rich interactive domain 1B (SWI-like)	0.034
Cd2ap	CD2-associated protein	0.033
Ikbkg	inhibitor of kappaB kinase gamma	0.032
Phf2	PHD finger protein 2	0.032
Pcmtd1	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1	0.029
Gimap3	GTPase, IMAP family member 3	0.029
Smurf1	SMAD specific E3 ubiquitin protein ligase 1	0.028	Mouse
Nedd4	neural precursor cell expressed, developmentally down-regulated 4	0.028	Mouse
Stim1	stromal interaction molecule 1	0.028
Cxcr3	chemokine (C-X-C motif) receptor 3	0.027
Hmha1	histocompatibility (minor) HA-1	0.027
Meox2	mesenchyme homeobox 2	0.027
Bach2	BTB and CNC homology 2	0.026
Mpp5	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)	0.026
Ptk2	PTK2 protein tyrosine kinase 2	0.025
Tspan32	tetraspanin 32	0.025
BC021614	cDNA sequence BC021614	0.024
Tcf7	transcription factor 7, T-cell specific	0.024
Dlg3	discs, large homolog 3 (Drosophila)	0.024
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.024
Nkg7	natural killer cell group 7 sequence	0.024
Skil	SKI-like	0.024
Trp53bp2	transformation related protein 53 binding protein 2	0.024
Hhex	hematopoietically expressed homeobox	0.024
Tnfrsf18	tumor necrosis factor receptor superfamily, member 18	0.023
Tbc1d22b	TBC1 domain family, member 22B	0.023
Sorbs1	sorbin and SH3 domain containing 1	0.023
Ahcyl1	S-adenosylhomocysteine hydrolase-like 1	0.023
Ctnnb1	catenin (cadherin associated protein), beta 1	0.023
Cd7	CD7 antigen	0.023
Ptprcap	protein tyrosine phosphatase, receptor type, C polypeptide-associated protein	0.022
Nfil3	nuclear factor, interleukin 3, regulated	0.022
Flt1	FMS-like tyrosine kinase 1	0.022
Atp2b1	ATPase, Ca++ transporting, plasma membrane 1	0.022
Vangl2	vang-like 2 (van gogh, Drosophila)	0.022
Pum1	pumilio 1 (Drosophila)	0.022
Jak2	Janus kinase 2	0.021
Smad5	MAD homolog 5 (Drosophila)	0.021
Pglyrp2	peptidoglycan recognition protein 2	0.021
Add1	adducin 1 (alpha)	0.021
Fam160b1	family with sequence similarity 160, member B1	0.021
Zfp362	zinc finger protein 362	0.021
Cd3e	CD3 antigen, epsilon polypeptide	0.021
Ctnnd1	catenin (cadherin associated protein), delta 1	0.021
Ikzf1	IKAROS family zinc finger 1	0.020
Pkn2	protein kinase N2	0.020
Chd4	chromodomain helicase DNA binding protein 4	0.020
Chd9	chromodomain helicase DNA binding protein 9	0.020
Sh2d2a	SH2 domain protein 2A	0.019
Fam168a	family with sequence similarity 168, member A	0.019
Scnn1a	sodium channel, nonvoltage-gated 1 alpha	0.019
Hook3	hook homolog 3 (Drosophila)	0.019
Itgae	integrin alpha E, epithelial-associated	0.019
Cldn3	claudin 3	0.019
Pik3cb	phosphatidylinositol 3-kinase, catalytic, beta polypeptide	0.019
Cdk6	cyclin-dependent kinase 6	0.019
Wbp1	WW domain binding protein 1	0.018
Sp1	trans-acting transcription factor 1	0.018
Tmem79	transmembrane protein 79	0.018
Acap1	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	0.018
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.018
Pak1	p21 protein (Cdc42/Rac)-activated kinase 1	0.018
Gata3	GATA binding protein 3	0.018
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.017
Acly	ATP citrate lyase	0.017
4921513D23Rik	RIKEN cDNA 4921513D23 gene	0.017
Prrg2	proline-rich Gla (G-carboxyglutamic acid) polypeptide 2	0.017
Sipa1l1	signal-induced proliferation-associated 1 like 1	0.017
Rock2	Rho-associated coiled-coil containing protein kinase 2	0.017
Prkce	protein kinase C, epsilon	0.017
Traf3ip3	TRAF3 interacting protein 3	0.016
Prnp	prion protein	0.016
Ly6d	lymphocyte antigen 6 complex, locus D	0.016
Aplp2	amyloid beta (A4) precursor-like protein 2	0.016
Jak1	Janus kinase 1	0.016
Sept1	septin 1	0.016
Baz2a	bromodomain adjacent to zinc finger domain, 2A	0.016
Polr2a	polymerase (RNA) II (DNA directed) polypeptide A	0.016
Ino80d	INO80 complex subunit D	0.016
Ube4b	ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)	0.016
Atp11c	ATPase, class VI, type 11C	0.016
Hdlbp	high density lipoprotein (HDL) binding protein	0.015
Atxn2l	ataxin 2-like	0.015
Wbp2	WW domain binding protein 2	0.015
Smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.015
Arrdc1	arrestin domain containing 1	0.015
Egfr	epidermal growth factor receptor	0.015
Zswim6	zinc finger, SWIM domain containing 6	0.015
Braf	Braf transforming gene	0.015
Stat4	signal transducer and activator of transcription 4	0.015
Pard6a	par-6 (partitioning defective 6,) homolog alpha (C. elegans)	0.014
Ncoa3	nuclear receptor coactivator 3	0.014
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.014
Med15	mediator complex subunit 15	0.014
Sh2b2	SH2B adaptor protein 2	0.014
Icos	inducible T-cell co-stimulator	0.014
L3mbtl3	l(3)mbt-like 3 (Drosophila)	0.014
Ssh2	slingshot homolog 2 (Drosophila)	0.014
Pkp3	plakophilin 3	0.014
Sash3	SAM and SH3 domain containing 3	0.014
Pdcd6ip	programmed cell death 6 interacting protein	0.014
Klf3	Kruppel-like factor 3 (basic)	0.014
Tbc1d10c	TBC1 domain family, member 10c	0.013
Flnb	filamin, beta	0.013
Dock2	dedicator of cyto-kinesis 2	0.013
Gatad2b	GATA zinc finger domain containing 2B	0.013
Csnk1g1	casein kinase 1, gamma 1	0.013
Pik3c2a	phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide	0.013
Sos1	son of sevenless homolog 1 (Drosophila)	0.013
Plce1	phospholipase C, epsilon 1	0.013
Bcr	breakpoint cluster region	0.013
Sla	src-like adaptor	0.013
Vangl1	vang-like 1 (van gogh, Drosophila)	0.012
Actr1a	ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)	0.012
Ptch1	patched homolog 1	0.012
Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	0.012	Mouse
Plekhg6	pleckstrin homology domain containing, family G (with RhoGef domain) member 6	0.012
Lad1	ladinin	0.012
Mavs	mitochondrial antiviral signaling protein	0.012
Prkar1a	protein kinase, cAMP dependent regulatory, type I, alpha	0.012
Malt1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.012
Kif1b	kinesin family member 1B	0.012
Cadps2	Ca2+-dependent activator protein for secretion 2	0.012
Huwe1	HECT, UBA and WWE domain containing 1	0.012
Fermt2	fermitin family homolog 2 (Drosophila)	0.012
Mobkl1b	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.012
Ap3b1	adaptor-related protein complex 3, beta 1 subunit	0.012
Cdk19	cyclin-dependent kinase 19	0.012
Oxr1	oxidation resistance 1	0.012
Cd4	CD4 antigen	0.012
Fam193a	family with sequence similarity 193, member A	0.012
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.012
Usp3	ubiquitin specific peptidase 3	0.012
Inpp5d	inositol polyphosphate-5-phosphatase D	0.012
Ctdsp2	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2	0.012
Tmem106b	transmembrane protein 106B	0.012
Tnfaip8l2	tumor necrosis factor, alpha-induced protein 8-like 2	0.012
Pxn	paxillin	0.012
Tuba1a	tubulin, alpha 1A	0.012
Ccr7	chemokine (C-C motif) receptor 7	0.012
Prdm2	PR domain containing 2, with ZNF domain	0.011
Csde1	cold shock domain containing E1, RNA binding	0.011
Prkacb	protein kinase, cAMP dependent, catalytic, beta	0.011
Arid1a	AT rich interactive domain 1A (SWI-like)	0.011
Phf21a	PHD finger protein 21A	0.011
Spop	speckle-type POZ protein	0.011
Vav1	vav 1 oncogene	0.011
Ccny	cyclin Y	0.011
Rictor	RPTOR independent companion of MTOR, complex 2	0.011
Znrf1	zinc and ring finger 1	0.011
Ctsl	cathepsin L	0.011
Hnrnpul1	heterogeneous nuclear ribonucleoprotein U-like 1	0.011
Bbx	bobby sox homolog (Drosophila)	0.011
Eps8l2	EPS8-like 2	0.011
Mink1	misshapen-like kinase 1 (zebrafish)	0.011
Zcchc11	zinc finger, CCHC domain containing 11	0.011
Sec16a	SEC16 homolog A (S. cerevisiae)	0.011
Akt3	thymoma viral proto-oncogene 3	0.011
Txk	TXK tyrosine kinase	0.011
C230081A13Rik	RIKEN cDNA C230081A13 gene	0.011
Add3	adducin 3 (gamma)	0.011
Whsc1l1	Wolf-Hirschhorn syndrome candidate 1-like 1 (human)	0.011
Smarcc1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.011
Mark2	MAP/microtubule affinity-regulating kinase 2	0.011
Rnf103	ring finger protein 103	0.011
Csnk1d	casein kinase 1, delta	0.011
Pstpip2	proline-serine-threonine phosphatase-interacting protein 2	0.011
Eif4b	eukaryotic translation initiation factor 4B	0.011
Ankrd50	ankyrin repeat domain 50	0.011
Ep300	E1A binding protein p300	0.011
Nf2	neurofibromatosis 2	0.011
Lrmp	lymphoid-restricted membrane protein	0.011
Rps6ka3	ribosomal protein S6 kinase polypeptide 3	0.011
B230219D22Rik	RIKEN cDNA B230219D22 gene	0.011
Cpd	carboxypeptidase D	0.011
Stxbp2	syntaxin binding protein 2	0.011
Srrm2	serine/arginine repetitive matrix 2	0.011
Prrc2b	proline-rich coiled-coil 2B	0.010
Trim2	tripartite motif-containing 2	0.010
Camk1d	calcium/calmodulin-dependent protein kinase ID	0.010
Alcam	activated leukocyte cell adhesion molecule	0.010
Pten	phosphatase and tensin homolog	0.010
Dgka	diacylglycerol kinase, alpha	0.010
Lmbrd1	LMBR1 domain containing 1	0.010
Sesn3	sestrin 3	0.010
Asxl1	additional sex combs like 1 (Drosophila)	0.010
Eif4ebp2	eukaryotic translation initiation factor 4E binding protein 2	0.010
Sharpin	SHANK-associated RH domain interacting protein	0.010
Tle3	transducin-like enhancer of split 3, homolog of Drosophila E(spl)	0.010
Foxo1	forkhead box O1	0.010
Scn2a1	sodium channel, voltage-gated, type II, alpha 1	0.010
Mysm1	myb-like, SWIRM and MPN domains 1	0.010
Irak4	interleukin-1 receptor-associated kinase 4	0.010
Usp8	ubiquitin specific peptidase 8	0.010
Arhgap9	Rho GTPase activating protein 9	0.010
Slamf6	SLAM family member 6	0.010
Wbp7	WW domain binding protein 7	0.010
Prkx	protein kinase, X-linked	0.010
Arhgap31	Rho GTPase activating protein 31	0.010
Esyt2	extended synaptotagmin-like protein 2	0.010
Cd37	CD37 antigen	0.010
Bcl11b	B-cell leukemia/lymphoma 11B	0.010