IMP

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Mus musculus

14 genes annotated in mouse

Multi-species View

positive regulation of rac gtpase activity

GO:0032855

Any process that activates or increases the activity of a GTPase of the Rac family.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of rac gtpase activity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of rac gtpase activity" (in gray)

Name	Description	Probability	Func Analog Organism
Grb2	growth factor receptor bound protein 2	1.000
Itsn1	intersectin 1 (SH3 domain protein 1A)	1.000
Vav1	vav 1 oncogene	0.997
Git1	G protein-coupled receptor kinase-interactor 1	0.980
Dlg4	discs, large homolog 4 (Drosophila)	0.972
Asap1	ArfGAP with SH# domain, ankyrin repeat and PH domain1	0.943
Cbl	Casitas B-lineage lymphoma	0.942
Rac1	RAS-related C3 botulinum substrate 1	0.887
Dnm1	dynamin 1	0.885
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.819
Prkcd	protein kinase C, delta	0.745
Bcr	breakpoint cluster region	0.739
Anxa2	annexin A2	0.698
Shc1	src homology 2 domain-containing transforming protein C1	0.683
Efnb2	ephrin B2	0.655
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.648
Braf	Braf transforming gene	0.620
Nf1	neurofibromatosis 1	0.457
Ncf1	neutrophil cytosolic factor 1	0.451
Pxn	paxillin	0.440
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.439
Elmo1	engulfment and cell motility 1, ced-12 homolog (C. elegans)	0.401
Efna1	ephrin A1	0.393
Tgfb1	transforming growth factor, beta 1	0.365
Pik3ap1	phosphoinositide-3-kinase adaptor protein 1	0.352
Lrrk2	leucine-rich repeat kinase 2	0.348
Nckap1l	NCK associated protein 1 like	0.334
Grin2b	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	0.272
Inpp5d	inositol polyphosphate-5-phosphatase D	0.221
Frs2	fibroblast growth factor receptor substrate 2	0.220
Kcnab2	potassium voltage-gated channel, shaker-related subfamily, beta member 2	0.206
Apc	adenomatosis polyposis coli	0.204
Cxcr4	chemokine (C-X-C motif) receptor 4	0.197
Axin1	axin 1	0.183
Traf6	TNF receptor-associated factor 6	0.178
Cep55	centrosomal protein 55	0.177
Atp8b2	ATPase, class I, type 8B, member 2	0.171
Prkce	protein kinase C, epsilon	0.147
Gria2	glutamate receptor, ionotropic, AMPA2 (alpha 2)	0.146
Dock2	dedicator of cyto-kinesis 2	0.144
Vav2	vav 2 oncogene	0.138	Mouse Fly
Arhgap21	Rho GTPase activating protein 21	0.137
Ptk2	PTK2 protein tyrosine kinase 2	0.131
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.127
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.126
Abr	active BCR-related gene	0.121
Btk	Bruton agammaglobulinemia tyrosine kinase	0.121
Psen1	presenilin 1	0.107
Zfyve16	zinc finger, FYVE domain containing 16	0.105
Necap2	NECAP endocytosis associated 2	0.103
Itga3	integrin alpha 3	0.100
Sh3bgrl3	SH3 domain binding glutamic acid-rich protein-like 3	0.097
Sh3kbp1	SH3-domain kinase binding protein 1	0.096
Rasgrp1	RAS guanyl releasing protein 1	0.095
Arhgdia	Rho GDP dissociation inhibitor (GDI) alpha	0.095
Elmo2	engulfment and cell motility 2, ced-12 homolog (C. elegans)	0.094
Eps15	epidermal growth factor receptor pathway substrate 15	0.094
Dlg2	discs, large homolog 2 (Drosophila)	0.093
Pak1	p21 protein (Cdc42/Rac)-activated kinase 1	0.091
Ptk2b	PTK2 protein tyrosine kinase 2 beta	0.088	Rat
Cd37	CD37 antigen	0.085
Irf5	interferon regulatory factor 5	0.084
Pdcd6ip	programmed cell death 6 interacting protein	0.083
Ptpra	protein tyrosine phosphatase, receptor type, A	0.083
S100a6	S100 calcium binding protein A6 (calcyclin)	0.083
Ptpre	protein tyrosine phosphatase, receptor type, E	0.081
Sirpa	signal-regulatory protein alpha	0.080
Srgap2	SLIT-ROBO Rho GTPase activating protein 2	0.074
Crkl	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.072
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.072
Kit	kit oncogene	0.071
Ctnnb1	catenin (cadherin associated protein), beta 1	0.068
Itga4	integrin alpha 4	0.068
Rassf5	Ras association (RalGDS/AF-6) domain family member 5	0.068
Epb4.1l2	erythrocyte protein band 4.1-like 2	0.067
Prkcb	protein kinase C, beta	0.067
Htt	huntingtin	0.065
Dck	deoxycytidine kinase	0.065
Src	Rous sarcoma oncogene	0.063
Selplg	selectin, platelet (p-selectin) ligand	0.061
Itch	itchy, E3 ubiquitin protein ligase	0.061
Ccnb2	cyclin B2	0.060
Ncoa3	nuclear receptor coactivator 3	0.058
Usp12	ubiquitin specific peptidase 12	0.057
Arf3	ADP-ribosylation factor 3	0.056
Rad21	RAD21 homolog (S. pombe)	0.056
Smad3	MAD homolog 3 (Drosophila)	0.056
Coro1c	coronin, actin binding protein 1C	0.055
Fbxo11	F-box protein 11	0.053
Plp2	proteolipid protein 2	0.053
Dlgap1	discs, large (Drosophila) homolog-associated protein 1	0.053
Apaf1	apoptotic peptidase activating factor 1	0.051
Gsk3a	glycogen synthase kinase 3 alpha	0.051
Arhgef7	Rho guanine nucleotide exchange factor (GEF7)	0.051
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.049
Plcb1	phospholipase C, beta 1	0.046
Arhgap30	Rho GTPase activating protein 30	0.045	Mouse
4732456N10Rik	RIKEN cDNA 4732456N10 gene	0.044
Plaur	plasminogen activator, urokinase receptor	0.044
Blnk	B-cell linker	0.043
Lrrk1	leucine-rich repeat kinase 1	0.043
Arc	activity regulated cytoskeletal-associated protein	0.042
Dlgap4	discs, large homolog-associated protein 4 (Drosophila)	0.040
Rin1	Ras and Rab interactor 1	0.040
Fscn1	fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus)	0.039
Akt3	thymoma viral proto-oncogene 3	0.038
Nav1	neuron navigator 1	0.038
Capn2	calpain 2	0.037
Cd72	CD72 antigen	0.037
2610039C10Rik	RIKEN cDNA 2610039C10 gene	0.035
S100a11	S100 calcium binding protein A11 (calgizzarin)	0.035
Cd44	CD44 antigen	0.035
Anln	anillin, actin binding protein	0.035
Pde1b	phosphodiesterase 1B, Ca2+-calmodulin dependent	0.035
Sema4d	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	0.034
Mthfr	5,10-methylenetetrahydrofolate reductase	0.034
Pkp3	plakophilin 3	0.032
Cdk14	cyclin-dependent kinase 14	0.032
Ksr1	kinase suppressor of ras 1	0.032
Ntf3	neurotrophin 3	0.032
Lrp5	low density lipoprotein receptor-related protein 5	0.031
App	amyloid beta (A4) precursor protein	0.030
Apbb1ip	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	0.029
Map2k2	mitogen-activated protein kinase kinase 2	0.029
Abi1	abl-interactor 1	0.027
4933407C03Rik	RIKEN cDNA 4933407C03 gene	0.027
Tmem54	transmembrane protein 54	0.027
Elmo3	engulfment and cell motility 3, ced-12 homolog (C. elegans)	0.027
Ppp1r9b	protein phosphatase 1, regulatory subunit 9B	0.027
Cit	citron	0.027
Mast4	microtubule associated serine/threonine kinase family member 4	0.027
Vdr	vitamin D receptor	0.027
St14	suppression of tumorigenicity 14 (colon carcinoma)	0.027
Dok1	docking protein 1	0.026
Ikzf3	IKAROS family zinc finger 3	0.026
Iqgap1	IQ motif containing GTPase activating protein 1	0.025
Npcd	neuronal pentraxin chromo domain	0.025
Rrm2	ribonucleotide reductase M2	0.025
Numb	numb gene homolog (Drosophila)	0.025
Cdc42se1	CDC42 small effector 1	0.025
5830433M19Rik	RIKEN cDNA 5830433M19 gene	0.025
Dock5	dedicator of cytokinesis 5	0.025	Mouse Fly
Trpm2	transient receptor potential cation channel, subfamily M, member 2	0.024
Dpy19l4	dpy-19-like 4 (C. elegans)	0.024
Pyhin1	pyrin and HIN domain family, member 1	0.024
Arhgap9	Rho GTPase activating protein 9	0.023
Sh3rf1	SH3 domain containing ring finger 1	0.023
Nsf	N-ethylmaleimide sensitive fusion protein	0.022
Dock8	dedicator of cytokinesis 8	0.022
Laptm5	lysosomal-associated protein transmembrane 5	0.021
C230081A13Rik	RIKEN cDNA C230081A13 gene	0.021
Ptprc	protein tyrosine phosphatase, receptor type, C	0.021
Prc1	protein regulator of cytokinesis 1	0.021
Dock1	dedicator of cytokinesis 1	0.020	Mouse Fly
Lrp6	low density lipoprotein receptor-related protein 6	0.020
Lepr	leptin receptor	0.020
Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	0.020
Il17ra	interleukin 17 receptor A	0.020
Hip1	huntingtin interacting protein 1	0.019
Agap1	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	0.019
Epha4	Eph receptor A4	0.019
Syt1	synaptotagmin I	0.019
Palm	paralemmin	0.019
Adrbk1	adrenergic receptor kinase, beta 1	0.019
Mkl1	MKL (megakaryoblastic leukemia)/myocardin-like 1	0.019
Gab2	growth factor receptor bound protein 2-associated protein 2	0.019
Stk10	serine/threonine kinase 10	0.019
Sh3tc1	SH3 domain and tetratricopeptide repeats 1	0.019
Ppp3ca	protein phosphatase 3, catalytic subunit, alpha isoform	0.019
Ap3b1	adaptor-related protein complex 3, beta 1 subunit	0.018
Chd5	chromodomain helicase DNA binding protein 5	0.018
Ubqln4	ubiquilin 4	0.018
Cblb	Casitas B-lineage lymphoma b	0.018
Atxn7l3	ataxin 7-like 3	0.018
AI661453	expressed sequence AI661453	0.018
Snx30	sorting nexin family member 30	0.018
Arhgef6	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	0.018	Mouse
Grip1	glutamate receptor interacting protein 1	0.017
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.017
Extl3	exostoses (multiple)-like 3	0.017
Arrdc1	arrestin domain containing 1	0.017
Crk	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.017
Mad2l1	MAD2 mitotic arrest deficient-like 1 (yeast)	0.017
Nrxn1	neurexin I	0.017
Lcp1	lymphocyte cytosolic protein 1	0.017
Scn3b	sodium channel, voltage-gated, type III, beta	0.016
Esrp1	epithelial splicing regulatory protein 1	0.016
Prss8	protease, serine, 8 (prostasin)	0.016
Shank2	SH3/ankyrin domain gene 2	0.016
Gpr18	G protein-coupled receptor 18	0.016
Asap2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	0.016
Spint1	serine protease inhibitor, Kunitz type 1	0.016
Ptprj	protein tyrosine phosphatase, receptor type, J	0.016
Cpd	carboxypeptidase D	0.016
Vasp	vasodilator-stimulated phosphoprotein	0.016
Ptprs	protein tyrosine phosphatase, receptor type, S	0.016
Myo1e	myosin IE	0.016
Vav3	vav 3 oncogene	0.016
Mapk13	mitogen-activated protein kinase 13	0.015
Usp8	ubiquitin specific peptidase 8	0.015
Birc3	baculoviral IAP repeat-containing 3	0.015
Dennd1c	DENN/MADD domain containing 1C	0.015
Tjp3	tight junction protein 3	0.015
Camk2b	calcium/calmodulin-dependent protein kinase II, beta	0.015
Gab1	growth factor receptor bound protein 2-associated protein 1	0.015
Bub1	budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)	0.015
Sp100	nuclear antigen Sp100	0.015
Rgs12	regulator of G-protein signaling 12	0.015
Grm1	glutamate receptor, metabotropic 1	0.015
Rassf2	Ras association (RalGDS/AF-6) domain family member 2	0.015
Rnf144a	ring finger protein 144A	0.015
Cldn7	claudin 7	0.015
Lsp1	lymphocyte specific 1	0.015
Tuft1	tuftelin 1	0.015
Fam65b	family with sequence similarity 65, member B	0.015
Myo9a	myosin IXa	0.015
Tbkbp1	TBK1 binding protein 1	0.014
Lcp2	lymphocyte cytosolic protein 2	0.014
Cx3cl1	chemokine (C-X3-C motif) ligand 1	0.014
Gria1	glutamate receptor, ionotropic, AMPA1 (alpha 1)	0.014
Dip2b	DIP2 disco-interacting protein 2 homolog B (Drosophila)	0.014
Tyro3	TYRO3 protein tyrosine kinase 3	0.014
Grik2	glutamate receptor, ionotropic, kainate 2 (beta 2)	0.014
Erc1	ELKS/RAB6-interacting/CAST family member 1	0.014
Cyfip2	cytoplasmic FMR1 interacting protein 2	0.014
Gng13	guanine nucleotide binding protein (G protein), gamma 13	0.014
Slco2a1	solute carrier organic anion transporter family, member 2a1	0.014
Abcc5	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	0.014
Dbn1	drebrin 1	0.014
Sort1	sortilin 1	0.014
Myo1f	myosin IF	0.014
Evl	Ena-vasodilator stimulated phosphoprotein	0.014
Wipf1	WAS/WASL interacting protein family, member 1	0.014
Tmpo	thymopoietin	0.014
Rap1gds1	RAP1, GTP-GDP dissociation stimulator 1	0.014
Plxna1	plexin A1	0.014
Plekho2	pleckstrin homology domain containing, family O member 2	0.013
Spry2	sprouty homolog 2 (Drosophila)	0.013
Rhoa	ras homolog gene family, member A	0.013
Lima1	LIM domain and actin binding 1	0.013
Capg	capping protein (actin filament), gelsolin-like	0.013
Akt1	thymoma viral proto-oncogene 1	0.013
Cpne2	copine II	0.013
Chga	chromogranin A	0.013
Psd4	pleckstrin and Sec7 domain containing 4	0.013
Git2	G protein-coupled receptor kinase-interactor 2	0.013
Wdfy3	WD repeat and FYVE domain containing 3	0.013
Tmem131	transmembrane protein 131	0.013
Plxnb1	plexin B1	0.013
Gmip	Gem-interacting protein	0.012
Magi1	membrane associated guanylate kinase, WW and PDZ domain containing 1	0.012
Sh3bp1	SH3-domain binding protein 1	0.012
Crip1	cysteine-rich protein 1 (intestinal)	0.012
Pion	pigeon homolog (Drosophila)	0.012
Pip4k2a	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	0.012
Evpl	envoplakin	0.012
Pola1	polymerase (DNA directed), alpha 1	0.012
Epn2	epsin 2	0.012
Sykb	spleen tyrosine kinase	0.012
Nf2	neurofibromatosis 2	0.012
Arhgap31	Rho GTPase activating protein 31	0.012	Mouse
Tiam1	T-cell lymphoma invasion and metastasis 1	0.012	Human
Traf3	TNF receptor-associated factor 3	0.012
Gpr137b	G protein-coupled receptor 137B	0.012
Plxnc1	plexin C1	0.012
Bcl11a	B-cell CLL/lymphoma 11A (zinc finger protein)	0.011
Tmem229b	transmembrane protein 229B	0.011
Pik3r5	phosphoinositide-3-kinase, regulatory subunit 5, p101	0.011
Mid2	midline 2	0.011
Kalrn	kalirin, RhoGEF kinase	0.011	Worm
Glipr2	GLI pathogenesis-related 2	0.011
Dennd1a	DENN/MADD domain containing 1A	0.011
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.011
Clcn6	chloride channel 6	0.011
Itm2c	integral membrane protein 2C	0.011
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.011
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.011
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.011
Scnn1b	sodium channel, nonvoltage-gated 1 beta	0.011
C130098B18Rik	RIKEN cDNA C130098B18 gene	0.011
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.011
Il1rap	interleukin 1 receptor accessory protein	0.011
Sema7a	sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A	0.011
Erg	avian erythroblastosis virus E-26 (v-ets) oncogene related	0.011
Mapk3	mitogen-activated protein kinase 3	0.011
Tmem43	transmembrane protein 43	0.011
Baiap2	brain-specific angiogenesis inhibitor 1-associated protein 2	0.011
Tuba1c	tubulin, alpha 1C	0.011
Gtf3c5	general transcription factor IIIC, polypeptide 5	0.011
Cdc34	cell division cycle 34 homolog (S. cerevisiae)	0.010
Ncaph	non-SMC condensin I complex, subunit H	0.010
Rhoh	ras homolog gene family, member H	0.010
Arhgap15	Rho GTPase activating protein 15	0.010	Human
Tnk1	tyrosine kinase, non-receptor, 1	0.010
Gal3st1	galactose-3-O-sulfotransferase 1	0.010
Xpr1	xenotropic and polytropic retrovirus receptor 1	0.010
Tax1bp3	Tax1 (human T-cell leukemia virus type I) binding protein 3	0.010
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.010
Rab11fip4	RAB11 family interacting protein 4 (class II)	0.010
Stk32c	serine/threonine kinase 32C	0.010
Eif2ak4	eukaryotic translation initiation factor 2 alpha kinase 4	0.010
Ankib1	ankyrin repeat and IBR domain containing 1	0.010
Slc4a4	solute carrier family 4 (anion exchanger), member 4	0.010
Scnn1g	sodium channel, nonvoltage-gated 1 gamma	0.010
Krt19	keratin 19	0.010