IMP

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Mus musculus

3 genes annotated in mouse

myd88 independent toll like receptor signaling pathway

Any series of molecular signals generated as a consequence of binding to a toll-like receptor not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "myd88 independent toll like receptor signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "myd88 independent toll like receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.990
Ldb3	LIM domain binding 3	0.940
Igh	immunoglobulin heavy chain complex	0.926
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.925
Traf6	TNF receptor-associated factor 6	0.870
Cd19	CD19 antigen	0.855
Prkcd	protein kinase C, delta	0.816
Ikzf1	IKAROS family zinc finger 1	0.815
Myd88	myeloid differentiation primary response gene 88	0.793
Stat2	signal transducer and activator of transcription 2	0.743
Stat1	signal transducer and activator of transcription 1	0.640
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.594
Psmb9	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)	0.569
Tnf	tumor necrosis factor	0.432
Traf2	TNF receptor-associated factor 2	0.388
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.364
Birc3	baculoviral IAP repeat-containing 3	0.332
Btk	Bruton agammaglobulinemia tyrosine kinase	0.293
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.292
Tlr4	toll-like receptor 4	0.290
Prkce	protein kinase C, epsilon	0.273
Ifng	interferon gamma	0.272
Actn2	actinin alpha 2	0.252
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.223
Uba7	ubiquitin-like modifier activating enzyme 7	0.217
Src	Rous sarcoma oncogene	0.189
Blnk	B-cell linker	0.185
Bcl3	B-cell leukemia/lymphoma 3	0.179
Sfpi1	SFFV proviral integration 1	0.176
Rsad2	radical S-adenosyl methionine domain containing 2	0.175
Csf1	colony stimulating factor 1 (macrophage)	0.172
Cd79b	CD79B antigen	0.160
Ifnar1	interferon (alpha and beta) receptor 1	0.157
Il27ra	interleukin 27 receptor, alpha	0.152
Cd22	CD22 antigen	0.136
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.130
Ciita	class II transactivator	0.126
Tap2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.120
Irf4	interferon regulatory factor 4	0.113	Mouse
Lyz2	lysozyme 2	0.104
Igtp	interferon gamma induced GTPase	0.101
Sykb	spleen tyrosine kinase	0.096
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.093
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.090
Tapbp	TAP binding protein	0.090
Trim21	tripartite motif-containing 21	0.090
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.088
Tnfrsf13b	tumor necrosis factor receptor superfamily, member 13b	0.086
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.085
Pou2af1	POU domain, class 2, associating factor 1	0.083
Fas	Fas (TNF receptor superfamily member 6)	0.081
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.079
Parp10	poly (ADP-ribose) polymerase family, member 10	0.079
Ltb	lymphotoxin B	0.079
Prkcc	protein kinase C, gamma	0.078
Usp18	ubiquitin specific peptidase 18	0.076
Parp14	poly (ADP-ribose) polymerase family, member 14	0.074
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.073
Ptk2b	PTK2 protein tyrosine kinase 2 beta	0.073
Stat6	signal transducer and activator of transcription 6	0.071
Ifnar2	interferon (alpha and beta) receptor 2	0.069
Irf8	interferon regulatory factor 8	0.066	Mouse
Irf9	interferon regulatory factor 9	0.066	Mouse
Cd40	CD40 antigen	0.064	Zebrafish
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.063
Lta	lymphotoxin A	0.062
Socs1	suppressor of cytokine signaling 1	0.062
1810019J16Rik	RIKEN cDNA 1810019J16 gene	0.061
Rassf5	Ras association (RalGDS/AF-6) domain family member 5	0.060
Rtp4	receptor transporter protein 4	0.055
Tnfrsf13c	tumor necrosis factor receptor superfamily, member 13c	0.054
Traf3ip2	TRAF3 interacting protein 2	0.053
Plcg2	phospholipase C, gamma 2	0.052
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.052
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.051
Cd74	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)	0.051
H2-DMb2	histocompatibility 2, class II, locus Mb2	0.050
Irgm2	immunity-related GTPase family M member 2	0.049
Sfn	stratifin	0.049
Irf5	interferon regulatory factor 5	0.048	Mouse
Cd72	CD72 antigen	0.047
Pou2f2	POU domain, class 2, transcription factor 2	0.046
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.046
Icos	inducible T-cell co-stimulator	0.046
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.044
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.043
Cmpk2	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial	0.043
H2-DMa	histocompatibility 2, class II, locus DMa	0.042
Isg15	ISG15 ubiquitin-like modifier	0.040
Gimap1	GTPase, IMAP family member 1	0.039
Eif2ak2	eukaryotic translation initiation factor 2-alpha kinase 2	0.039
Jak3	Janus kinase 3	0.038
Tor3a	torsin family 3, member A	0.038
Plcd1	phospholipase C, delta 1	0.037
Bak1	BCL2-antagonist/killer 1	0.036
Znfx1	zinc finger, NFX1-type containing 1	0.036
Ikzf3	IKAROS family zinc finger 3	0.035
Mvp	major vault protein	0.033
Fbxw7	F-box and WD-40 domain protein 7	0.033
Tcirg1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3	0.032
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.032
Unc93b1	unc-93 homolog B1 (C. elegans)	0.032
Irgm1	immunity-related GTPase family M member 1	0.031
Trp53	transformation related protein 53	0.031
Card11	caspase recruitment domain family, member 11	0.031
Pdcd1	programmed cell death 1	0.029
Batf	basic leucine zipper transcription factor, ATF-like	0.029
Homer1	homer homolog 1 (Drosophila)	0.028
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.027
Traf3	TNF receptor-associated factor 3	0.027
Dock2	dedicator of cyto-kinesis 2	0.027
Mavs	mitochondrial antiviral signaling protein	0.027
Stat3	signal transducer and activator of transcription 3	0.025
H2-Eb1	histocompatibility 2, class II antigen E beta	0.025
Psmb8	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)	0.025
Dlgap1	discs, large (Drosophila) homolog-associated protein 1	0.025
Mx2	myxovirus (influenza virus) resistance 2	0.024
Ticam1	toll-like receptor adaptor molecule 1	0.024
Ifit1	interferon-induced protein with tetratricopeptide repeats 1	0.024
Camk2b	calcium/calmodulin-dependent protein kinase II, beta	0.023
Nfatc1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.023
Rnf31	ring finger protein 31	0.022
Ifi35	interferon-induced protein 35	0.022
Pml	promyelocytic leukemia	0.022
Zbtb7b	zinc finger and BTB domain containing 7B	0.022
Rasal3	RAS protein activator like 3	0.022
Ltbr	lymphotoxin B receptor	0.022
Adar	adenosine deaminase, RNA-specific	0.022
Shank2	SH3/ankyrin domain gene 2	0.021
Dusp2	dual specificity phosphatase 2	0.021
H2-Oa	histocompatibility 2, O region alpha locus	0.021
Ccr7	chemokine (C-C motif) receptor 7	0.021
Ikbkb	inhibitor of kappaB kinase beta	0.021
Mtap2	microtubule-associated protein 2	0.021
Psmb10	proteasome (prosome, macropain) subunit, beta type 10	0.020
Tnip1	TNFAIP3 interacting protein 1	0.020
Cblb	Casitas B-lineage lymphoma b	0.020
H2-Aa	histocompatibility 2, class II antigen A, alpha	0.020
Ikbkg	inhibitor of kappaB kinase gamma	0.020
Prkd2	protein kinase D2	0.020
Hivep2	human immunodeficiency virus type I enhancer binding protein 2	0.019
Irak1	interleukin-1 receptor-associated kinase 1	0.019
Nfkbie	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.019
Tgtp2	T-cell specific GTPase 2	0.019
Cxcl9	chemokine (C-X-C motif) ligand 9	0.019
Dlg2	discs, large homolog 2 (Drosophila)	0.019
Map3k3	mitogen-activated protein kinase kinase kinase 3	0.019
Il17ra	interleukin 17 receptor A	0.018
Sh2b3	SH2B adaptor protein 3	0.018
Laptm5	lysosomal-associated protein transmembrane 5	0.017
Prkca	protein kinase C, alpha	0.017	Mouse
Icam1	intercellular adhesion molecule 1	0.017
Ifit3	interferon-induced protein with tetratricopeptide repeats 3	0.017
Nup62-il4i1	Nup62-Il4i1 protein	0.016
Dnm1	dynamin 1	0.016
Vav1	vav 1 oncogene	0.016
Dlg3	discs, large homolog 3 (Drosophila)	0.016
Bcl6	B-cell leukemia/lymphoma 6	0.016
Grip1	glutamate receptor interacting protein 1	0.016
Ccr6	chemokine (C-C motif) receptor 6	0.016
Adcy1	adenylate cyclase 1	0.016
H2-Ab1	histocompatibility 2, class II antigen A, beta 1	0.015
Cit	citron	0.015
Spint2	serine protease inhibitor, Kunitz type 2	0.015
Hmha1	histocompatibility (minor) HA-1	0.015
Rrad	Ras-related associated with diabetes	0.015
Zbp1	Z-DNA binding protein 1	0.015
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.015
Pip4k2a	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	0.015
Il10ra	interleukin 10 receptor, alpha	0.014
Gpsm3	G-protein signalling modulator 3 (AGS3-like, C. elegans)	0.014
Tap1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.014
Actb	actin, beta	0.014
Sp100	nuclear antigen Sp100	0.014
Prkcb	protein kinase C, beta	0.014	Mouse
Ifi47	interferon gamma inducible protein 47	0.014
Gpr132	G protein-coupled receptor 132	0.014
Mx1	myxovirus (influenza virus) resistance 1	0.014
Tlr2	toll-like receptor 2	0.014
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.014
Il4ra	interleukin 4 receptor, alpha	0.014
Itga4	integrin alpha 4	0.013
Mmp9	matrix metallopeptidase 9	0.013
P2rx7	purinergic receptor P2X, ligand-gated ion channel, 7	0.013
Gbp7	guanylate binding protein 7	0.013
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.013
Tcf7	transcription factor 7, T-cell specific	0.013
Vav2	vav 2 oncogene	0.013
Cxcr5	chemokine (C-X-C motif) receptor 5	0.013
Tifa	TRAF-interacting protein with forkhead-associated domain	0.012
Plekho2	pleckstrin homology domain containing, family O member 2	0.012
Cd2	CD2 antigen	0.012
Stat5b	signal transducer and activator of transcription 5B	0.012
Hspa1b	heat shock protein 1B	0.012
Tgfb1	transforming growth factor, beta 1	0.012
Arhgef1	Rho guanine nucleotide exchange factor (GEF) 1	0.012
Bcl2	B-cell leukemia/lymphoma 2	0.012
Eno1	enolase 1, alpha non-neuron	0.012
Zeb1	zinc finger E-box binding homeobox 1	0.012
Napsa	napsin A aspartic peptidase	0.012
Map3k1	mitogen-activated protein kinase kinase kinase 1	0.012
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.012
Igk	immunoglobulin kappa chain complex	0.012
Cd27	CD27 antigen	0.012
Grin2b	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	0.012
Cxcl10	chemokine (C-X-C motif) ligand 10	0.012
Stk10	serine/threonine kinase 10	0.011
Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	0.011
Irak3	interleukin-1 receptor-associated kinase 3	0.011
Plekha2	pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2	0.011
Dennd4b	DENN/MADD domain containing 4B	0.011
Barx2	BarH-like homeobox 2	0.011
Ppfibp2	PTPRF interacting protein, binding protein 2 (liprin beta 2)	0.011
Was	Wiskott-Aldrich syndrome homolog (human)	0.011
Ccl5	chemokine (C-C motif) ligand 5	0.011
Oasl2	2'-5' oligoadenylate synthetase-like 2	0.011
Rel	reticuloendotheliosis oncogene	0.011
Dsg1a	desmoglein 1 alpha	0.011
Shank3	SH3/ankyrin domain gene 3	0.011
Smagp	small cell adhesion glycoprotein	0.010
Cd28	CD28 antigen	0.010
BC006779	cDNA sequence BC006779	0.010
Siae	sialic acid acetylesterase	0.010
Prdm1	PR domain containing 1, with ZNF domain	0.010
Rnf41	ring finger protein 41	0.010
Map3k11	mitogen-activated protein kinase kinase kinase 11	0.010
Ccrl2	chemokine (C-C motif) receptor-like 2	0.010
Inpp5d	inositol polyphosphate-5-phosphatase D	0.010
Il2rb	interleukin 2 receptor, beta chain	0.010
Ikbke	inhibitor of kappaB kinase epsilon	0.010
Pim1	proviral integration site 1	0.010