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Mus musculus

20 genes annotated in mouse

mast cell activation involved in immune response

The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response.

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Gene Predictions

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Name	Description	Probability	Func Analog Organism
Cd247	CD247 antigen	0.996	Mouse
Mefv	Mediterranean fever	0.964
Csf2rb2	colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)	0.901	Mouse
Ikzf1	IKAROS family zinc finger 1	0.887
Lat	linker for activation of T cells	0.872
Tcra	T-cell receptor alpha chain	0.836
Inpp5d	inositol polyphosphate-5-phosphatase D	0.829
Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog	0.811
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.805	Mouse
Hcst	hematopoietic cell signal transducer	0.801
Ptprc	protein tyrosine phosphatase, receptor type, C	0.775
Il4	interleukin 4	0.723
Tyrobp	TYRO protein tyrosine kinase binding protein	0.658
Il2rb	interleukin 2 receptor, beta chain	0.572
Grb2	growth factor receptor bound protein 2	0.531
Rag1	recombination activating gene 1	0.527
Cd4	CD4 antigen	0.498
C5ar1	complement component 5a receptor 1	0.458
Nfam1	Nfat activating molecule with ITAM motif 1	0.423
Rgs14	regulator of G-protein signaling 14	0.413
Fyn	Fyn proto-oncogene	0.394	Mouse
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.373
Fes	feline sarcoma oncogene	0.337	Human Mouse
Msr1	macrophage scavenger receptor 1	0.326
Ptk2	PTK2 protein tyrosine kinase 2	0.306
Fcer1g	Fc receptor, IgE, high affinity I, gamma polypeptide	0.297
AF251705	cDNA sequence AF251705	0.293	Mouse
Il2	interleukin 2	0.267
Emr1	EGF-like module containing, mucin-like, hormone receptor-like sequence 1	0.259
Csf3r	colony stimulating factor 3 receptor (granulocyte)	0.245
Cd22	CD22 antigen	0.233
Pilra	paired immunoglobin-like type 2 receptor alpha	0.210
Clec4n	C-type lectin domain family 4, member n	0.206
Csf1r	colony stimulating factor 1 receptor	0.202
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.194
Hck	hemopoietic cell kinase	0.194	Mouse
Itk	IL2-inducible T-cell kinase	0.190	Mouse
Tbxas1	thromboxane A synthase 1, platelet	0.188
Il2rg	interleukin 2 receptor, gamma chain	0.183
Trem3	triggering receptor expressed on myeloid cells 3	0.179
Zap70	zeta-chain (TCR) associated protein kinase	0.177	Mouse
Pilrb1	paired immunoglobin-like type 2 receptor beta 1	0.171
Cd180	CD180 antigen	0.165
Met	met proto-oncogene	0.164
BC013712	cDNA sequence BC013712	0.162
Dok3	docking protein 3	0.162
Ifng	interferon gamma	0.141
Cd40	CD40 antigen	0.136
Ebi3	Epstein-Barr virus induced gene 3	0.133
Fcrla	Fc receptor-like A	0.132	Mouse
Fcgr1	Fc receptor, IgG, high affinity I	0.131	Mouse
Lyl1	lymphoblastomic leukemia 1	0.125
Lck	lymphocyte protein tyrosine kinase	0.123	Mouse
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.122
Siglece	sialic acid binding Ig-like lectin E	0.121
Siglec1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.114
Mmp8	matrix metallopeptidase 8	0.112
Was	Wiskott-Aldrich syndrome homolog (human)	0.112
Il10ra	interleukin 10 receptor, alpha	0.107
Fcgr4	Fc receptor, IgG, low affinity IV	0.105
Klra2	killer cell lectin-like receptor, subfamily A, member 2	0.096
Pou2f2	POU domain, class 2, transcription factor 2	0.096
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.094
Fyb	FYN binding protein	0.089
Clec4d	C-type lectin domain family 4, member d	0.087
Sfpi1	SFFV proviral integration 1	0.087
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.086
Foxf1a	forkhead box F1a	0.078
Shc1	src homology 2 domain-containing transforming protein C1	0.076
Fpr1	formyl peptide receptor 1	0.075
C1qb	complement component 1, q subcomponent, beta polypeptide	0.074
C3ar1	complement component 3a receptor 1	0.073
Myo1f	myosin IF	0.073
Slc11a1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.072
Vav1	vav 1 oncogene	0.071
F10	coagulation factor X	0.071
Irf5	interferon regulatory factor 5	0.070
Snai1	snail homolog 1 (Drosophila)	0.069
Cbl	Casitas B-lineage lymphoma	0.068
Rac2	RAS-related C3 botulinum substrate 2	0.068
Cd28	CD28 antigen	0.067
Prkce	protein kinase C, epsilon	0.066
Lair1	leukocyte-associated Ig-like receptor 1	0.066
Trem1	triggering receptor expressed on myeloid cells 1	0.064
Cd300lb	CD300 antigen like family member B	0.063	Mouse
P2rx7	purinergic receptor P2X, ligand-gated ion channel, 7	0.062
Cd300ld	CD300 molecule-like family member d	0.062	Mouse
S1pr4	sphingosine-1-phosphate receptor 4	0.061
Cd5l	CD5 antigen-like	0.061
Hmha1	histocompatibility (minor) HA-1	0.061
Ptpre	protein tyrosine phosphatase, receptor type, E	0.058
Clec4a2	C-type lectin domain family 4, member a2	0.057
Dok1	docking protein 1	0.057
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.057
Fgd3	FYVE, RhoGEF and PH domain containing 3	0.056
Calcrl	calcitonin receptor-like	0.056
Il1rn	interleukin 1 receptor antagonist	0.056
Pik3ap1	phosphoinositide-3-kinase adaptor protein 1	0.056
Cd300a	CD300A antigen	0.054
Stat6	signal transducer and activator of transcription 6	0.054
Cr2	complement receptor 2	0.054
Itgam	integrin alpha M	0.053
Cd68	CD68 antigen	0.052
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.052
4632428N05Rik	RIKEN cDNA 4632428N05 gene	0.052
Ly9	lymphocyte antigen 9	0.052
Slc15a3	solute carrier family 15, member 3	0.051
Gpr132	G protein-coupled receptor 132	0.051
Irg1	immunoresponsive gene 1	0.049
Gpr35	G protein-coupled receptor 35	0.049
Ms4a2	membrane-spanning 4-domains, subfamily A, member 2	0.049
Fpr2	formyl peptide receptor 2	0.049
F7	coagulation factor VII	0.048
Marco	macrophage receptor with collagenous structure	0.047
Mcoln2	mucolipin 2	0.046
Cnr2	cannabinoid receptor 2 (macrophage)	0.045
Tlr7	toll-like receptor 7	0.045
Apoc2	apolipoprotein C-II	0.045
Cd300lf	CD300 antigen like family member F	0.044	Mouse
Lilrb3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.044
Ncf1	neutrophil cytosolic factor 1	0.044
Ccl9	chemokine (C-C motif) ligand 9	0.044
Tifab	TRAF-interacting protein with forkhead-associated domain, family member B	0.043
Olr1	oxidized low density lipoprotein (lectin-like) receptor 1	0.043
Pik3cg	phosphoinositide-3-kinase, catalytic, gamma polypeptide	0.043
Il1b	interleukin 1 beta	0.043
Acvrl1	activin A receptor, type II-like 1	0.042
Apobr	apolipoprotein B receptor	0.041
Cd19	CD19 antigen	0.040
Clec7a	C-type lectin domain family 7, member a	0.040
Pten	phosphatase and tensin homolog	0.039
Cmklr1	chemokine-like receptor 1	0.039
Il1a	interleukin 1 alpha	0.038
Gpsm3	G-protein signalling modulator 3 (AGS3-like, C. elegans)	0.038
Aldh3b1	aldehyde dehydrogenase 3 family, member B1	0.038
Snx20	sorting nexin 20	0.037
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.037
Itgb3	integrin beta 3	0.036
Cxcr2	chemokine (C-X-C motif) receptor 2	0.036
Map4k2	mitogen-activated protein kinase kinase kinase kinase 2	0.035
Ccbp2	chemokine binding protein 2	0.035
Il7r	interleukin 7 receptor	0.034
Sit1	suppression inducing transmembrane adaptor 1	0.034
Plekho2	pleckstrin homology domain containing, family O member 2	0.034
Ifitm6	interferon induced transmembrane protein 6	0.034
Galnt6	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6	0.034
Cd177	CD177 antigen	0.033
C130050O18Rik	RIKEN cDNA C130050O18 gene	0.032
Fcer2a	Fc receptor, IgE, low affinity II, alpha polypeptide	0.032
Klrb1b	killer cell lectin-like receptor subfamily B member 1B	0.032
Arhgap4	Rho GTPase activating protein 4	0.032
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.032
Gpr97	G protein-coupled receptor 97	0.031
Ncr1	natural cytotoxicity triggering receptor 1	0.031
Skap2	src family associated phosphoprotein 2	0.031
Ms4a1	membrane-spanning 4-domains, subfamily A, member 1	0.030
Tmem106a	transmembrane protein 106A	0.030
Fas	Fas (TNF receptor superfamily member 6)	0.028
Grap2	GRB2-related adaptor protein 2	0.028
Cd7	CD7 antigen	0.028
Clec5a	C-type lectin domain family 5, member a	0.028
Abcg3	ATP-binding cassette, sub-family G (WHITE), member 3	0.028
Blk	B lymphoid kinase	0.027	Mouse
Ccr6	chemokine (C-C motif) receptor 6	0.027
Tlr8	toll-like receptor 8	0.026
Slpi	secretory leukocyte peptidase inhibitor	0.026
Ptafr	platelet-activating factor receptor	0.026
Ncf4	neutrophil cytosolic factor 4	0.026
Pxn	paxillin	0.026
B430306N03Rik	RIKEN cDNA B430306N03 gene	0.026	Mouse
Cd33	CD33 antigen	0.026
Ptpra	protein tyrosine phosphatase, receptor type, A	0.026
Cd37	CD37 antigen	0.025
Gpr182	G protein-coupled receptor 182	0.025
Hk3	hexokinase 3	0.025
Il27ra	interleukin 27 receptor, alpha	0.025
Tlr6	toll-like receptor 6	0.025
Ccl6	chemokine (C-C motif) ligand 6	0.024
Rel	reticuloendotheliosis oncogene	0.024
Cx3cr1	chemokine (C-X3-C) receptor 1	0.024
Spn	sialophorin	0.024
Cd2	CD2 antigen	0.024
Evi2b	ecotropic viral integration site 2b	0.024
Emr4	EGF-like module containing, mucin-like, hormone receptor-like sequence 4	0.024
Ptgir	prostaglandin I receptor (IP)	0.023
Slc6a4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	0.023
Sirpa	signal-regulatory protein alpha	0.023
Bcar1	breast cancer anti-estrogen resistance 1	0.023
Mb	myoglobin	0.023
P2ry13	purinergic receptor P2Y, G-protein coupled 13	0.023
Jak2	Janus kinase 2	0.022
Hlx	H2.0-like homeobox	0.022
Cyp4f18	cytochrome P450, family 4, subfamily f, polypeptide 18	0.022
Alox5ap	arachidonate 5-lipoxygenase activating protein	0.022
Dnase1l3	deoxyribonuclease 1-like 3	0.021
Laptm5	lysosomal-associated protein transmembrane 5	0.021
Aoah	acyloxyacyl hydrolase	0.021
Rasgrp4	RAS guanyl releasing protein 4	0.021	Mouse
Foxn1	forkhead box N1	0.021
Vpreb3	pre-B lymphocyte gene 3	0.021
Pou2af1	POU domain, class 2, associating factor 1	0.021
Rab3il1	RAB3A interacting protein (rabin3)-like 1	0.021
Cmah	cytidine monophospho-N-acetylneuraminic acid hydroxylase	0.021
Adamdec1	ADAM-like, decysin 1	0.021
Pde1b	phosphodiesterase 1B, Ca2+-calmodulin dependent	0.020
Fcgr2b	Fc receptor, IgG, low affinity IIb	0.020	Mouse
Igsf6	immunoglobulin superfamily, member 6	0.020
Asgr2	asialoglycoprotein receptor 2	0.020
Gda	guanine deaminase	0.020
Unc93b1	unc-93 homolog B1 (C. elegans)	0.020
Itgax	integrin alpha X	0.020
Rhoh	ras homolog gene family, member H	0.019
Sell	selectin, lymphocyte	0.019
Siglecg	sialic acid binding Ig-like lectin G	0.019
Trpv1	transient receptor potential cation channel, subfamily V, member 1	0.019
Plaur	plasminogen activator, urokinase receptor	0.019
Cd200r1	CD200 receptor 1	0.019
Bst1	bone marrow stromal cell antigen 1	0.019
Cd86	CD86 antigen	0.019
Fli1	Friend leukemia integration 1	0.018
Clec1b	C-type lectin domain family 1, member b	0.018
AB124611	cDNA sequence AB124611	0.018
1810033B17Rik	RIKEN cDNA 1810033B17 gene	0.018
Ggt5	gamma-glutamyltransferase 5	0.018
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.018
Stra8	stimulated by retinoic acid gene 8	0.018
Fasl	Fas ligand (TNF superfamily, member 6)	0.018
Ccl17	chemokine (C-C motif) ligand 17	0.018
Sdc3	syndecan 3	0.018
Sirpb1a	signal-regulatory protein beta 1A	0.017
Adora2b	adenosine A2b receptor	0.017
Cfh	complement component factor h	0.017
Hrh1	histamine receptor H1	0.017
Il13	interleukin 13	0.017
Cd80	CD80 antigen	0.017
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.017
Aif1	allograft inflammatory factor 1	0.017
Muc13	mucin 13, epithelial transmembrane	0.016
Dok2	docking protein 2	0.016
Sash3	SAM and SH3 domain containing 3	0.016
Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	0.016
Il1f9	interleukin 1 family, member 9	0.016
Lyst	lysosomal trafficking regulator	0.016
Cd14	CD14 antigen	0.016
Treml1	triggering receptor expressed on myeloid cells-like 1	0.016
Hcls1	hematopoietic cell specific Lyn substrate 1	0.016
Mmp12	matrix metallopeptidase 12	0.016
Npas2	neuronal PAS domain protein 2	0.016
Sele	selectin, endothelial cell	0.016
Epor	erythropoietin receptor	0.015
Arhgap9	Rho GTPase activating protein 9	0.015
Cfp	complement factor properdin	0.015
Bdkrb1	bradykinin receptor, beta 1	0.015
Ms4a6d	membrane-spanning 4-domains, subfamily A, member 6D	0.015
Slfn4	schlafen 4	0.015
Trpm2	transient receptor potential cation channel, subfamily M, member 2	0.015
Slc25a45	solute carrier family 25, member 45	0.015
Clec4a3	C-type lectin domain family 4, member a3	0.015
Cdk14	cyclin-dependent kinase 14	0.015
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.015
Ager	advanced glycosylation end product-specific receptor	0.015
Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.015
Folr2	folate receptor 2 (fetal)	0.015
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.015
Cd6	CD6 antigen	0.015
Acap1	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	0.015
Lat2	linker for activation of T cells family, member 2	0.015
Kcna2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.014
Pla2g2d	phospholipase A2, group IID	0.014
Tcfec	transcription factor EC	0.014
Hgf	hepatocyte growth factor	0.014
Gm14548	predicted gene 14548	0.014
Mrc1	mannose receptor, C type 1	0.014
Clec4e	C-type lectin domain family 4, member e	0.014
Ms4a7	membrane-spanning 4-domains, subfamily A, member 7	0.014
Dtx1	deltex 1 homolog (Drosophila)	0.014
Hhex	hematopoietically expressed homeobox	0.014
Pax5	paired box gene 5	0.014
Itgb2	integrin beta 2	0.014
Cd8a	CD8 antigen, alpha chain	0.014
Ccr7	chemokine (C-C motif) receptor 7	0.014
Card11	caspase recruitment domain family, member 11	0.014
P2ry6	pyrimidinergic receptor P2Y, G-protein coupled, 6	0.014
B3gnt8	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8	0.014
Klra17	killer cell lectin-like receptor, subfamily A, member 17	0.014
Pcdh12	protocadherin 12	0.013
Adap2	ArfGAP with dual PH domains 2	0.013
Cybb	cytochrome b-245, beta polypeptide	0.013
Apobec1	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	0.013
Clec10a	C-type lectin domain family 10, member A	0.013
Ccl8	chemokine (C-C motif) ligand 8	0.013
Ednrb	endothelin receptor type B	0.013
Sema6b	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B	0.013
Pax2	paired box gene 2	0.013
Pld4	phospholipase D family, member 4	0.013
Cd96	CD96 antigen	0.013
Fcrl1	Fc receptor-like 1	0.013
Kitl	kit ligand	0.012
Gp1bb	glycoprotein Ib, beta polypeptide	0.012
Kcnk13	potassium channel, subfamily K, member 13	0.012
Nos2	nitric oxide synthase 2, inducible	0.012
Litaf	LPS-induced TN factor	0.012
Il4ra	interleukin 4 receptor, alpha	0.012
Arid3a	AT rich interactive domain 3A (BRIGHT-like)	0.012
Adam8	a disintegrin and metallopeptidase domain 8	0.012
P2ry12	purinergic receptor P2Y, G-protein coupled 12	0.012
She	src homology 2 domain-containing transforming protein E	0.012
Gm11428	predicted gene 11428	0.012
P2rx1	purinergic receptor P2X, ligand-gated ion channel, 1	0.012
S1pr2	sphingosine-1-phosphate receptor 2	0.012
Zbtb46	zinc finger and BTB domain containing 46	0.012
Ciita	class II transactivator	0.012
Itgal	integrin alpha L	0.012
Ear5	eosinophil-associated, ribonuclease A family, member 5	0.012
Mmp19	matrix metallopeptidase 19	0.011
Fmnl1	formin-like 1	0.011
H2-Ob	histocompatibility 2, O region beta locus	0.011
Il6	interleukin 6	0.011
Ifngr1	interferon gamma receptor 1	0.011
Cxcr3	chemokine (C-X-C motif) receptor 3	0.011
Pkib	protein kinase inhibitor beta, cAMP dependent, testis specific	0.011
Txk	TXK tyrosine kinase	0.011	Mouse
Il15	interleukin 15	0.011
Tnf	tumor necrosis factor	0.011
Dclre1c	DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)	0.011
Tnfaip2	tumor necrosis factor, alpha-induced protein 2	0.011
Gmfg	glia maturation factor, gamma	0.011
Plcg1	phospholipase C, gamma 1	0.011
Ccl7	chemokine (C-C motif) ligand 7	0.011
Faim3	Fas apoptotic inhibitory molecule 3	0.011
Cd244	CD244 natural killer cell receptor 2B4	0.011
5430435G22Rik	RIKEN cDNA 5430435G22 gene	0.011
March1	membrane-associated ring finger (C3HC4) 1	0.011
Rassf4	Ras association (RalGDS/AF-6) domain family member 4	0.011
Sh3d19	SH3 domain protein D19	0.011
Fosl2	fos-like antigen 2	0.011
Tlr13	toll-like receptor 13	0.011
Pf4	platelet factor 4	0.011
Vipr1	vasoactive intestinal peptide receptor 1	0.011
Cxcl2	chemokine (C-X-C motif) ligand 2	0.011
H2-DMb2	histocompatibility 2, class II, locus Mb2	0.011
Ccr1	chemokine (C-C motif) receptor 1	0.011
Rasal3	RAS protein activator like 3	0.011
Pdcd1lg2	programmed cell death 1 ligand 2	0.010
Il12b	interleukin 12b	0.010
Bdnf	brain derived neurotrophic factor	0.010
Axin2	axin2	0.010
Sh3tc1	SH3 domain and tetratricopeptide repeats 1	0.010
Ifnar1	interferon (alpha and beta) receptor 1	0.010
Gna15	guanine nucleotide binding protein, alpha 15	0.010
Tmprss2	transmembrane protease, serine 2	0.010
Batf	basic leucine zipper transcription factor, ATF-like	0.010
Ccl4	chemokine (C-C motif) ligand 4	0.010
Shc3	src homology 2 domain-containing transforming protein C3	0.010
Dynlt1b	dynein light chain Tctex-type 1D	0.010
Fut4	fucosyltransferase 4	0.010
Zeb1	zinc finger E-box binding homeobox 1	0.010
Il12a	interleukin 12a	0.010
Plcb2	phospholipase C, beta 2	0.010
Fmn1	formin 1	0.010
Gjb6	gap junction protein, beta 6	0.010
Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	0.010
Stap1	signal transducing adaptor family member 1	0.010