IMP

Process View

Mus musculus

17 genes annotated in mouse

granulocyte differentiation

The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "granulocyte differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "granulocyte differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
Rarg	retinoic acid receptor, gamma	0.983	Mouse
Gata1	GATA binding protein 1	0.966	Human
Rarb	retinoic acid receptor, beta	0.957	Mouse
Rxra	retinoid X receptor alpha	0.948
Ikzf1	IKAROS family zinc finger 1	0.901
Pitx2	paired-like homeodomain transcription factor 2	0.829
Rara	retinoic acid receptor, alpha	0.799
Pbx1	pre B-cell leukemia transcription factor 1	0.768
Gata4	GATA binding protein 4	0.539
Fgd1	FYVE, RhoGEF and PH domain containing 1	0.535
Mesp1	mesoderm posterior 1	0.364
Tcf4	transcription factor 4	0.338
Hoxa5	homeobox A5	0.315
Sox4	SRY-box containing gene 4	0.315
Tcf7	transcription factor 7, T-cell specific	0.314
Tbx1	T-box 1	0.305
Pax3	paired box gene 3	0.258
Tal1	T-cell acute lymphocytic leukemia 1	0.243	Human
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.240
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.234
Trp63	transformation related protein 63	0.233
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.233
Sox9	SRY-box containing gene 9	0.209
Lat	linker for activation of T cells	0.202
Hoxb3	homeobox B3	0.201
Hs1bp3	HCLS1 binding protein 3	0.190
Epor	erythropoietin receptor	0.187
Mdk	midkine	0.168
Bmp4	bone morphogenetic protein 4	0.162
Nf1	neurofibromatosis 1	0.143
Tcfap2a	transcription factor AP-2, alpha	0.135
Fgfr2	fibroblast growth factor receptor 2	0.130
Gfi1b	growth factor independent 1B	0.125
Mgea5	meningioma expressed antigen 5 (hyaluronidase)	0.124
Btk	Bruton agammaglobulinemia tyrosine kinase	0.122
Gli2	GLI-Kruppel family member GLI2	0.121
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.116
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.110
Vegfa	vascular endothelial growth factor A	0.108
Kdm2b	lysine (K)-specific demethylase 2B	0.108
Jag1	jagged 1	0.107
Foxc1	forkhead box C1	0.105
Bcl11a	B-cell CLL/lymphoma 11A (zinc finger protein)	0.103
Fli1	Friend leukemia integration 1	0.102
Hoxb4	homeobox B4	0.101
Notch2	Notch gene homolog 2 (Drosophila)	0.100
Hand2	heart and neural crest derivatives expressed transcript 2	0.100
Shh	sonic hedgehog	0.098
Hoxa2	homeobox A2	0.097
Fgf8	fibroblast growth factor 8	0.095
Plcg2	phospholipase C, gamma 2	0.092
Sp1	trans-acting transcription factor 1	0.090	Mouse
Crebbp	CREB binding protein	0.090
Tbx3	T-box 3	0.089
Emx2	empty spiracles homolog 2 (Drosophila)	0.088
Pax8	paired box gene 8	0.087
Gli3	GLI-Kruppel family member GLI3	0.082
Tgfb2	transforming growth factor, beta 2	0.081
Kdm6a	4lysine (K)-specific demethylase 6A	0.080
Il17a	interleukin 17A	0.077	Mouse
Ssbp2	single-stranded DNA binding protein 2	0.076
Gata6	GATA binding protein 6	0.074
Cd19	CD19 antigen	0.074
Duox2	dual oxidase 2	0.072
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.071
Isl1	ISL1 transcription factor, LIM/homeodomain	0.070
Msx2	homeobox, msh-like 2	0.067
Atxn1	ataxin 1	0.065
C1qa	complement component 1, q subcomponent, alpha polypeptide	0.062
Pax2	paired box gene 2	0.061
Itgb2	integrin beta 2	0.061
Efna4	ephrin A4	0.061
Zfp292	zinc finger protein 292	0.061
Jarid2	jumonji, AT rich interactive domain 2	0.057
Il17f	interleukin 17F	0.057	Mouse
Gata3	GATA binding protein 3	0.057
Cbl	Casitas B-lineage lymphoma	0.054
Flt1	FMS-like tyrosine kinase 1	0.053
Myb	myeloblastosis oncogene	0.052
Creb1	cAMP responsive element binding protein 1	0.052
Bcl2	B-cell leukemia/lymphoma 2	0.052
Gata5	GATA binding protein 5	0.050
Ttc14	tetratricopeptide repeat domain 14	0.050
Tef	thyrotroph embryonic factor	0.049
Nfe2	nuclear factor, erythroid derived 2	0.048
Sfpi1	SFFV proviral integration 1	0.048
Gsc	goosecoid homeobox	0.048
Cd247	CD247 antigen	0.047
Ep300	E1A binding protein p300	0.045
Sin3a	transcriptional regulator, SIN3A (yeast)	0.045
Sp3	trans-acting transcription factor 3	0.044
Rnf2	ring finger protein 2	0.044
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.044
Alkbh1	alkB, alkylation repair homolog 1 (E. coli)	0.043
Blnk	B-cell linker	0.042
Pou5f1	POU domain, class 5, transcription factor 1	0.041
Hr	hairless	0.041
Tcf12	transcription factor 12	0.040
Sox11	SRY-box containing gene 11	0.040
Eya1	eyes absent 1 homolog (Drosophila)	0.040
Hoxa3	homeobox A3	0.040
Hoxd3	homeobox D3	0.040
Runx1	runt related transcription factor 1	0.039	Human
Bmi1	Bmi1 polycomb ring finger oncogene	0.039
Tcf15	transcription factor 15	0.038
Card11	caspase recruitment domain family, member 11	0.037
Efnb1	ephrin B1	0.037
Hoxa9	homeobox A9	0.037
Cnot6l	CCR4-NOT transcription complex, subunit 6-like	0.037
Trp53	transformation related protein 53	0.037
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.037
Fgfr1	fibroblast growth factor receptor 1	0.036
Ar	androgen receptor	0.036
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.036
Hoxa1	homeobox A1	0.035
Ncoa1	nuclear receptor coactivator 1	0.035
Dlx1	distal-less homeobox 1	0.034
Ncor1	nuclear receptor co-repressor 1	0.034
Meis2	Meis homeobox 2	0.034
Ifitm6	interferon induced transmembrane protein 6	0.033
Tcf3	transcription factor 3	0.032
Kdr	kinase insert domain protein receptor	0.032
Bmp7	bone morphogenetic protein 7	0.031
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.030
Fgf10	fibroblast growth factor 10	0.030
S1pr4	sphingosine-1-phosphate receptor 4	0.030
Lck	lymphocyte protein tyrosine kinase	0.030
Fam76b	family with sequence similarity 76, member B	0.029
Nmu	neuromedin U	0.029
Hoxb5	homeobox B5	0.028
Tnfrsf13c	tumor necrosis factor receptor superfamily, member 13c	0.028
Prph	peripherin	0.027
Ciita	class II transactivator	0.027
Mll1	myeloid/lymphoid or mixed-lineage leukemia 1	0.027
Barx1	BarH-like homeobox 1	0.027
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.027
Klf3	Kruppel-like factor 3 (basic)	0.026
Acvr1	activin A receptor, type 1	0.026
Fuz	fuzzy homolog (Drosophila)	0.026
Rbl2	retinoblastoma-like 2	0.026
Cbfb	core binding factor beta	0.026
Fyb	FYN binding protein	0.026
Prrx2	paired related homeobox 2	0.025
Flt3	FMS-like tyrosine kinase 3	0.025
Slc16a2	solute carrier family 16 (monocarboxylic acid transporters), member 2	0.025
Hoxb6	homeobox B6	0.025
Hdac1	histone deacetylase 1	0.025
Cxcr4	chemokine (C-X-C motif) receptor 4	0.024
Fbn2	fibrillin 2	0.024
Sema5b	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.024
Dio3	deiodinase, iodothyronine type III	0.024
Rcor2	REST corepressor 2	0.024
Fbxl3	F-box and leucine-rich repeat protein 3	0.023
Pax9	paired box gene 9	0.023
Wnt6	wingless-related MMTV integration site 6	0.023
LOC100503041	PDZ domain-containing protein 7-like	0.023
Yap1	yes-associated protein 1	0.023
Slc6a4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	0.023
Ece1	endothelin converting enzyme 1	0.023
Btbd17	BTB (POZ) domain containing 17	0.022
Cbfa2t3	core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)	0.022	Human
Zmym4	zinc finger, MYM-type 4	0.022
Nckap1l	NCK associated protein 1 like	0.022
Crabp2	cellular retinoic acid binding protein II	0.022	Mouse
Dlx5	distal-less homeobox 5	0.022
Ets1	E26 avian leukemia oncogene 1, 5' domain	0.021
Hsd3b6	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6	0.021	Rat
Arid3a	AT rich interactive domain 3A (BRIGHT-like)	0.021
Ptp4a2	protein tyrosine phosphatase 4a2	0.021
Wrn	Werner syndrome homolog (human)	0.020
Pitx1	paired-like homeodomain transcription factor 1	0.020
Zfpm1	zinc finger protein, multitype 1	0.020
Pparg	peroxisome proliferator activated receptor gamma	0.020
Atp2a1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.020
Notch1	Notch gene homolog 1 (Drosophila)	0.020
Alx4	aristaless-like homeobox 4	0.020
Rbx1	ring-box 1	0.020
Dlx2	distal-less homeobox 2	0.020
Bmper	BMP-binding endothelial regulator	0.020
Smad4	MAD homolog 4 (Drosophila)	0.020
Cdh15	cadherin 15	0.020
Egfr	epidermal growth factor receptor	0.020
Sh2b3	SH2B adaptor protein 3	0.019
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.019
Ppara	peroxisome proliferator activated receptor alpha	0.019
Ankhd1	ankyrin repeat and KH domain containing 1	0.019
Zmym5	zinc finger, MYM-type 5	0.019
Foxc2	forkhead box C2	0.018
Pcid2	PCI domain containing 2	0.018
Ncf1	neutrophil cytosolic factor 1	0.018
Il4	interleukin 4	0.018
Il13	interleukin 13	0.018
Spn	sialophorin	0.018
Mapk8	mitogen-activated protein kinase 8	0.018
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.017
Arpc4	actin related protein 2/3 complex, subunit 4	0.017
Dok1	docking protein 1	0.017
Zfp322a	zinc finger protein 322A	0.017
Tgfb1	transforming growth factor, beta 1	0.017
Chd7	chromodomain helicase DNA binding protein 7	0.017
Carm1	coactivator-associated arginine methyltransferase 1	0.017
Capzb	capping protein (actin filament) muscle Z-line, beta	0.017
Rgs14	regulator of G-protein signaling 14	0.017
Cd22	CD22 antigen	0.017
Ret	ret proto-oncogene	0.017
Apoh	apolipoprotein H	0.017
Msx1	homeobox, msh-like 1	0.017
March7	membrane-associated ring finger (C3HC4) 7	0.017
Igh	immunoglobulin heavy chain complex	0.017
Igf1r	insulin-like growth factor I receptor	0.017
Aadac	arylacetamide deacetylase (esterase)	0.017
Ptprc	protein tyrosine phosphatase, receptor type, C	0.017
Nfic	nuclear factor I/C	0.017
Il2rb	interleukin 2 receptor, beta chain	0.017
Plxnd1	plexin D1	0.016
Nfia	nuclear factor I/A	0.016
Nfix	nuclear factor I/X	0.016
Cxcl12	chemokine (C-X-C motif) ligand 12	0.016
Angpt1	angiopoietin 1	0.016
Ccdc39	coiled-coil domain containing 39	0.016
Shank3	SH3/ankyrin domain gene 3	0.016
Lmo2	LIM domain only 2	0.016
Sall3	sal-like 3 (Drosophila)	0.016
Pou2af1	POU domain, class 2, associating factor 1	0.016
Inpp5d	inositol polyphosphate-5-phosphatase D	0.016
Espn	espin	0.016
Fcgr2b	Fc receptor, IgG, low affinity IIb	0.016
Prg2	proteoglycan 2, bone marrow	0.016
Smad6	MAD homolog 6 (Drosophila)	0.016
Parvg	parvin, gamma	0.016
H2-Oa	histocompatibility 2, O region alpha locus	0.016
Slc26a5	solute carrier family 26, member 5	0.015
Rbbp6	retinoblastoma binding protein 6	0.015
Efnb2	ephrin B2	0.015
Hand1	heart and neural crest derivatives expressed transcript 1	0.015
Sorbs3	sorbin and SH3 domain containing 3	0.015
Ltb	lymphotoxin B	0.015
Mta2	metastasis-associated gene family, member 2	0.015
Alx3	aristaless-like homeobox 3	0.015
Prdm16	PR domain containing 16	0.015	Human
Ngp	neutrophilic granule protein	0.015
Traf3ip2	TRAF3 interacting protein 2	0.015
Dbp	D site albumin promoter binding protein	0.015
Arid2	AT rich interactive domain 2 (ARID, RFX-like)	0.015
Otp	orthopedia homolog (Drosophila)	0.015
Krt14	keratin 14	0.014
Gas1	growth arrest specific 1	0.014
Slc4a1	solute carrier family 4 (anion exchanger), member 1	0.014
Fermt3	fermitin family homolog 3 (Drosophila)	0.014
Nfib	nuclear factor I/B	0.014
Dok2	docking protein 2	0.014
Tgfbr3	transforming growth factor, beta receptor III	0.014
Twist2	twist homolog 2 (Drosophila)	0.014
Jun	Jun oncogene	0.014
Ttr	transthyretin	0.014
Zfp148	zinc finger protein 148	0.014
Mybph	myosin binding protein H	0.014
Gypa	glycophorin A	0.014
Nkx2-4	NK2 transcription factor related, locus 4 (Drosophila)	0.014
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.014
Klf1	Kruppel-like factor 1 (erythroid)	0.014
Ebf2	early B-cell factor 2	0.014
Irf8	interferon regulatory factor 8	0.013
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.013
Ldb1	LIM domain binding 1	0.013
Map3k1	mitogen-activated protein kinase kinase kinase 1	0.013
Wac	WW domain containing adaptor with coiled-coil	0.013
Hdac2	histone deacetylase 2	0.013
Cd36	CD36 antigen	0.013
Itgal	integrin alpha L	0.013
Rac2	RAS-related C3 botulinum substrate 2	0.013
Tcf21	transcription factor 21	0.013
Ctsg	cathepsin G	0.013
Mcl1	myeloid cell leukemia sequence 1	0.013
Trim10	tripartite motif-containing 10	0.013
Mta1	metastasis associated 1	0.013
Col13a1	collagen, type XIII, alpha 1	0.013
Shc1	src homology 2 domain-containing transforming protein C1	0.013
Arid3b	AT rich interactive domain 3B (BRIGHT-like)	0.013
Hsd3b3	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3	0.013	Rat
Irs2	insulin receptor substrate 2	0.013
Cbll1	Casitas B-lineage lymphoma-like 1	0.013
Rest	RE1-silencing transcription factor	0.012
Dlgap4	discs, large homolog-associated protein 4 (Drosophila)	0.012
Wnt9b	wingless-type MMTV integration site 9B	0.012
Tax1bp3	Tax1 (human T-cell leukemia virus type I) binding protein 3	0.012
Klhl24	kelch-like 24 (Drosophila)	0.012
Arhgap9	Rho GTPase activating protein 9	0.012
Irf4	interferon regulatory factor 4	0.012
Invs	inversin	0.012
Hoxd1	homeobox D1	0.012
Vil1	villin 1	0.012
Vezf1	vascular endothelial zinc finger 1	0.012
Rasal3	RAS protein activator like 3	0.012
Ddx17	DEAD (Asp-Glu-Ala-Asp) box polypeptide 17	0.012
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.012
Gp9	glycoprotein 9 (platelet)	0.012
Rdh10	retinol dehydrogenase 10 (all-trans)	0.012
Lgals7	lectin, galactose binding, soluble 7	0.012
Pax6	paired box gene 6	0.012
Zfp36l1	zinc finger protein 36, C3H type-like 1	0.012
Lyl1	lymphoblastomic leukemia 1	0.012
Elane	elastase, neutrophil expressed	0.012
Aadat	aminoadipate aminotransferase	0.012
Il10ra	interleukin 10 receptor, alpha	0.012
Dok3	docking protein 3	0.012
Psmd5	proteasome (prosome, macropain) 26S subunit, non-ATPase, 5	0.012
Sfn	stratifin	0.012
Adra1b	adrenergic receptor, alpha 1b	0.012
Gja1	gap junction protein, alpha 1	0.012
Myod1	myogenic differentiation 1	0.011
Cdk5r2	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	0.011
Sost	sclerostin	0.011
Mxd1	MAX dimerization protein 1	0.011
Actn2	actinin alpha 2	0.011
Tecta	tectorin alpha	0.011
Vhl	von Hippel-Lindau tumor suppressor	0.011
Ermap	erythroblast membrane-associated protein	0.011
Agrp	agouti related protein	0.011
Cxcr5	chemokine (C-X-C motif) receptor 5	0.011
Apba2	amyloid beta (A4) precursor protein-binding, family A, member 2	0.011
Crabp1	cellular retinoic acid binding protein I	0.011	Mouse
Phf17	PHD finger protein 17	0.011
Sftpd	surfactant associated protein D	0.011
Meox2	mesenchyme homeobox 2	0.011
Nkx6-1	NK6 homeobox 1	0.011
Was	Wiskott-Aldrich syndrome homolog (human)	0.011
Afm	afamin	0.011
Trpm7	transient receptor potential cation channel, subfamily M, member 7	0.011
Gpr50	G-protein-coupled receptor 50	0.011
Fmnl1	formin-like 1	0.011
Prrx1	paired related homeobox 1	0.011
Cdh2	cadherin 2	0.011
Cst7	cystatin F (leukocystatin)	0.011
Sos2	son of sevenless homolog 2 (Drosophila)	0.011
Id1	inhibitor of DNA binding 1	0.011
Shd	src homology 2 domain-containing transforming protein D	0.011
Msl1	male-specific lethal 1 homolog (Drosophila)	0.011
Cd37	CD37 antigen	0.011
Mef2c	myocyte enhancer factor 2C	0.010
Cdkn1c	cyclin-dependent kinase inhibitor 1C (P57)	0.010
Acvr2b	activin receptor IIB	0.010
Stag2	stromal antigen 2	0.010
Arhgef2	rho/rac guanine nucleotide exchange factor (GEF) 2	0.010
Wdr86	WD repeat domain 86	0.010
Gsdma	gasdermin A	0.010
Akr1c6	aldo-keto reductase family 1, member C6	0.010
Ikzf2	IKAROS family zinc finger 2	0.010	Mouse
Tbx4	T-box 4	0.010
Smo	smoothened homolog (Drosophila)	0.010
Cxcr2	chemokine (C-X-C motif) receptor 2	0.010
Stat6	signal transducer and activator of transcription 6	0.010
Ms4a2	membrane-spanning 4-domains, subfamily A, member 2	0.010
Hes1	hairy and enhancer of split 1 (Drosophila)	0.010
Slc38a5	solute carrier family 38, member 5	0.010
Yy1	YY1 transcription factor	0.010
Rcor1	REST corepressor 1	0.010
Cuedc1	CUE domain containing 1	0.010
Zfhx3	zinc finger homeobox 3	0.010