IMP

Process View

Mus musculus

4 genes annotated in mouse

positive regulation of type i interferon mediated signaling pathway

Any process that increases the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of type i interferon mediated signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of type i interferon mediated signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
Psmb9	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)	0.912
Irf9	interferon regulatory factor 9	0.877	Mouse
Stat1	signal transducer and activator of transcription 1	0.791
Ifit3	interferon-induced protein with tetratricopeptide repeats 3	0.784
Usp18	ubiquitin specific peptidase 18	0.763
Stat2	signal transducer and activator of transcription 2	0.690
Igtp	interferon gamma induced GTPase	0.672
Irgm2	immunity-related GTPase family M member 2	0.668
Uba7	ubiquitin-like modifier activating enzyme 7	0.660
Irgm1	immunity-related GTPase family M member 1	0.599
Trim21	tripartite motif-containing 21	0.535
Isg15	ISG15 ubiquitin-like modifier	0.502
Ifit1	interferon-induced protein with tetratricopeptide repeats 1	0.435
Oasl2	2'-5' oligoadenylate synthetase-like 2	0.403
Gbp7	guanylate binding protein 7	0.307
Rtp4	receptor transporter protein 4	0.299
Bcl3	B-cell leukemia/lymphoma 3	0.284
Dhx58	DEXH (Asp-Glu-X-His) box polypeptide 58	0.275
Ifi47	interferon gamma inducible protein 47	0.269
Parp14	poly (ADP-ribose) polymerase family, member 14	0.266
Trim30a	tripartite motif-containing 30A	0.255
Rsad2	radical S-adenosyl methionine domain containing 2	0.240
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.239
Ifi44	interferon-induced protein 44	0.232
Unc93b1	unc-93 homolog B1 (C. elegans)	0.199
Gbp2	guanylate binding protein 2	0.162
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.147
Irf7	interferon regulatory factor 7	0.143
Irf8	interferon regulatory factor 8	0.141	Mouse
Tor3a	torsin family 3, member A	0.124
Traf3	TNF receptor-associated factor 3	0.120
Sfpi1	SFFV proviral integration 1	0.118
Gbp3	guanylate binding protein 3	0.116
Ifi35	interferon-induced protein 35	0.111
Iigp1	interferon inducible GTPase 1	0.110
Casp8	caspase 8	0.107
Parp10	poly (ADP-ribose) polymerase family, member 10	0.107
Myd88	myeloid differentiation primary response gene 88	0.104
Ifih1	interferon induced with helicase C domain 1	0.101
Oas1a	2'-5' oligoadenylate synthetase 1A	0.100
BC006779	cDNA sequence BC006779	0.094
Tgtp2	T-cell specific GTPase 2	0.091
Ifi27l2a	interferon, alpha-inducible protein 27 like 2A	0.090
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.089
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.089
1810019J16Rik	RIKEN cDNA 1810019J16 gene	0.086
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.082
Fas	Fas (TNF receptor superfamily member 6)	0.076
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.072
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.071
Sp100	nuclear antigen Sp100	0.067
Ifnar2	interferon (alpha and beta) receptor 2	0.067
Pml	promyelocytic leukemia	0.065
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.065
Plcg2	phospholipase C, gamma 2	0.063
Tap2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.063
Cmpk2	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial	0.062
Traf2	TNF receptor-associated factor 2	0.060
Ikzf1	IKAROS family zinc finger 1	0.059
Oas2	2'-5' oligoadenylate synthetase 2	0.059
Mx1	myxovirus (influenza virus) resistance 1	0.058
Ddx58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.058
Eif2ak2	eukaryotic translation initiation factor 2-alpha kinase 2	0.058
Cd72	CD72 antigen	0.053
Cxcl10	chemokine (C-X-C motif) ligand 10	0.051
Trim30d	tripartite motif-containing 30D	0.050
Znfx1	zinc finger, NFX1-type containing 1	0.049
Irf5	interferon regulatory factor 5	0.048	Mouse
Ddx60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	0.047
Ms4a4c	membrane-spanning 4-domains, subfamily A, member 4C	0.047
H2-DMb2	histocompatibility 2, class II, locus Mb2	0.046
Batf	basic leucine zipper transcription factor, ATF-like	0.046
Tapbp	TAP binding protein	0.046
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.044
Irf1	interferon regulatory factor 1	0.043	Mouse
Ccl5	chemokine (C-C motif) ligand 5	0.041
Zbp1	Z-DNA binding protein 1	0.041
AW112010	expressed sequence AW112010	0.041
Oas1b	2'-5' oligoadenylate synthetase 1B	0.040
Samhd1	SAM domain and HD domain, 1	0.039
Cxcl9	chemokine (C-X-C motif) ligand 9	0.037
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.037
Parp12	poly (ADP-ribose) polymerase family, member 12	0.037
Cd74	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)	0.036
Parp9	poly (ADP-ribose) polymerase family, member 9	0.036
Oasl1	2'-5' oligoadenylate synthetase-like 1	0.036
Cd7	CD7 antigen	0.035
Ifnar1	interferon (alpha and beta) receptor 1	0.035
Rnf31	ring finger protein 31	0.035
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.035
Ube2l6	ubiquitin-conjugating enzyme E2L 6	0.035
Prkcd	protein kinase C, delta	0.035
Cd79b	CD79B antigen	0.034
Cd274	CD274 antigen	0.034
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.034
Dock2	dedicator of cyto-kinesis 2	0.034
Tnfrsf13b	tumor necrosis factor receptor superfamily, member 13b	0.032
Stat3	signal transducer and activator of transcription 3	0.032
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.031
Ticam1	toll-like receptor adaptor molecule 1	0.031
Cd40	CD40 antigen	0.030
Traf6	TNF receptor-associated factor 6	0.029
H2-DMa	histocompatibility 2, class II, locus DMa	0.029
Adar	adenosine deaminase, RNA-specific	0.029
Stat6	signal transducer and activator of transcription 6	0.029
Psmb8	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)	0.028
Fgfr2	fibroblast growth factor receptor 2	0.027
Slfn2	schlafen 2	0.027
Il27ra	interleukin 27 receptor, alpha	0.027
Il10ra	interleukin 10 receptor, alpha	0.027
Epsti1	epithelial stromal interaction 1 (breast)	0.025
Ifi203	interferon activated gene 203	0.024
Mx2	myxovirus (influenza virus) resistance 2	0.024
Cd37	CD37 antigen	0.023
Lgals3bp	lectin, galactoside-binding, soluble, 3 binding protein	0.023
Trim25	tripartite motif-containing 25	0.023
H2-Eb1	histocompatibility 2, class II antigen E beta	0.023
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.022
Prkd2	protein kinase D2	0.022
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.022
H2-Aa	histocompatibility 2, class II antigen A, alpha	0.022
Tmem173	transmembrane protein 173	0.020
Tapbpl	TAP binding protein-like	0.020
Tmem106a	transmembrane protein 106A	0.020
Pyhin1	pyrin and HIN domain family, member 1	0.020
Ikbkg	inhibitor of kappaB kinase gamma	0.019
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.019
D14Ertd668e	DNA segment, Chr 14, ERATO Doi 668, expressed	0.019
Apobec3	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3	0.019
Plac8	placenta-specific 8	0.019
Lgals9	lectin, galactose binding, soluble 9	0.019
Gbp6	guanylate binding protein 6	0.018
Birc3	baculoviral IAP repeat-containing 3	0.018
Casp7	caspase 7	0.018
Slamf8	SLAM family member 8	0.018
Apobec1	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	0.018
Bcl6	B-cell leukemia/lymphoma 6	0.018
H2-M3	histocompatibility 2, M region locus 3	0.017
Dtx3l	deltex 3-like (Drosophila)	0.017
Ncoa3	nuclear receptor coactivator 3	0.017
Il18bp	interleukin 18 binding protein	0.017
Nmi	N-myc (and STAT) interactor	0.017
Icam1	intercellular adhesion molecule 1	0.017
Trp53	transformation related protein 53	0.017
Siae	sialic acid acetylesterase	0.016
Herc6	hect domain and RLD 6	0.016
Itgal	integrin alpha L	0.016
Erap1	endoplasmic reticulum aminopeptidase 1	0.015
Serpina3g	serine (or cysteine) peptidase inhibitor, clade A, member 3G	0.015
Rnf135	ring finger protein 135	0.015
Sykb	spleen tyrosine kinase	0.015
C920025E04Rik	RIKEN cDNA C920025E04 gene	0.015
Traf3ip2	TRAF3 interacting protein 2	0.015
Blnk	B-cell linker	0.015
Bak1	BCL2-antagonist/killer 1	0.015
Efnb2	ephrin B2	0.014
Ciita	class II transactivator	0.014
Ikzf3	IKAROS family zinc finger 3	0.014
Irak4	interleukin-1 receptor-associated kinase 4	0.014
BC013712	cDNA sequence BC013712	0.014
Ikbke	inhibitor of kappaB kinase epsilon	0.014
Tcirg1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3	0.014
H2-Ke6	H2-K region expressed gene 6	0.014
Celsr1	cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)	0.014
Bst2	bone marrow stromal cell antigen 2	0.014
Rdh10	retinol dehydrogenase 10 (all-trans)	0.013
Hhex	hematopoietically expressed homeobox	0.013
Jak3	Janus kinase 3	0.013
Mnda	myeloid cell nuclear differentiation antigen	0.013
Hck	hemopoietic cell kinase	0.013
Myo1g	myosin IG	0.013
Nfatc1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.013
H2-Q8	histocompatibility 2, Q region locus 8	0.013
Igh	immunoglobulin heavy chain complex	0.013
Tab2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.013
Plekha2	pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2	0.013
Gata3	GATA binding protein 3	0.013
Trim26	tripartite motif-containing 26	0.013
Parp4	poly (ADP-ribose) polymerase family, member 4	0.013
Ripk3	receptor-interacting serine-threonine kinase 3	0.013
Aco1	aconitase 1	0.013
Ep300	E1A binding protein p300	0.013
Tnfsf10	tumor necrosis factor (ligand) superfamily, member 10	0.012
Samd9l	sterile alpha motif domain containing 9-like	0.012
Fadd	Fas (TNFRSF6)-associated via death domain	0.012	Human
Lyl1	lymphoblastomic leukemia 1	0.012
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.012
Zbtb48	zinc finger and BTB domain containing 48	0.012
H2-T24	histocompatibility 2, T region locus 24	0.012
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.012
Aim1	absent in melanoma 1	0.012
Abcd1	ATP-binding cassette, sub-family D (ALD), member 1	0.012
Ap1g2	adaptor protein complex AP-1, gamma 2 subunit	0.012
Trim34a	tripartite motif-containing 34A	0.012
Smo	smoothened homolog (Drosophila)	0.012
Rarg	retinoic acid receptor, gamma	0.012
Tti1	Tel2 interacting protein 1 homolog (S. pombe)	0.012
Rac2	RAS-related C3 botulinum substrate 2	0.012
Tnip1	TNFAIP3 interacting protein 1	0.011
Tmem55a	transmembrane protein 55A	0.011
Thap2	THAP domain containing, apoptosis associated protein 2	0.011
Pou2af1	POU domain, class 2, associating factor 1	0.011
Irf4	interferon regulatory factor 4	0.011	Mouse
Psmb10	proteasome (prosome, macropain) subunit, beta type 10	0.011
Map3k3	mitogen-activated protein kinase kinase kinase 3	0.011
Mif4gd	MIF4G domain containing	0.011
Il17ra	interleukin 17 receptor A	0.011
Gsdmd	gasdermin D	0.011
Arl3	ADP-ribosylation factor-like 3	0.011
Il4ra	interleukin 4 receptor, alpha	0.011
Stat5a	signal transducer and activator of transcription 5A	0.011
Etv6	ets variant gene 6 (TEL oncogene)	0.011
Dom3z	DOM-3 homolog Z (C. elegans)	0.011
Rnpepl1	arginyl aminopeptidase (aminopeptidase B)-like 1	0.011
Stk10	serine/threonine kinase 10	0.010
Zfp36	zinc finger protein 36	0.010
Zfp644	zinc finger protein 644	0.010
Vav2	vav 2 oncogene	0.010
H2-Ab1	histocompatibility 2, class II antigen A, beta 1	0.010
Pvrl2	poliovirus receptor-related 2	0.010
Map3k1	mitogen-activated protein kinase kinase kinase 1	0.010
Gbp10	guanylate-binding protein 10	0.010
Sfrp1	secreted frizzled-related protein 1	0.010
Zc3hav1	zinc finger CCCH type, antiviral 1	0.010
Gne	glucosamine	0.010
Ikbkb	inhibitor of kappaB kinase beta	0.010
Oas3	2'-5' oligoadenylate synthetase 3	0.010
Pik3ap1	phosphoinositide-3-kinase adaptor protein 1	0.010
Ltb	lymphotoxin B	0.010
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.010
Vav1	vav 1 oncogene	0.010
Rps6ka1	ribosomal protein S6 kinase polypeptide 1	0.010