IMP

Process View

Mus musculus

15 genes annotated in mouse

Multi-species View

regulation of osteoblast proliferation

GO:0033688

Any process that modulates the frequency, rate or extent of osteoblast proliferation.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in mouse Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of osteoblast proliferation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of osteoblast proliferation" (in gray)

Name	Description	Probability	Func Analog Organism
Fgfr2	fibroblast growth factor receptor 2	0.999
Shh	sonic hedgehog	0.994
Bmp4	bone morphogenetic protein 4	0.990	Mouse
Gli3	GLI-Kruppel family member GLI3	0.989
Bcl2	B-cell leukemia/lymphoma 2	0.964
Smad4	MAD homolog 4 (Drosophila)	0.941	Mouse
Smad3	MAD homolog 3 (Drosophila)	0.919
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.894
Apc	adenomatosis polyposis coli	0.817
Fgfr1	fibroblast growth factor receptor 1	0.809
Ctnnb1	catenin (cadherin associated protein), beta 1	0.797
Smad1	MAD homolog 1 (Drosophila)	0.782	Mouse
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.716	Mouse
Prrx1	paired related homeobox 1	0.716
Arhgef11	Rho guanine nucleotide exchange factor (GEF) 11	0.670
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.564
Axin1	axin 1	0.537
Smad6	MAD homolog 6 (Drosophila)	0.536	Mouse
Nos3	nitric oxide synthase 3, endothelial cell	0.520
Lama5	laminin, alpha 5	0.491
Nf1	neurofibromatosis 1	0.455
Trp53	transformation related protein 53	0.443
Nodal	nodal	0.441
Sfrp2	secreted frizzled-related protein 2	0.423	Mouse
Pax3	paired box gene 3	0.422
Vangl2	vang-like 2 (van gogh, Drosophila)	0.402
Gata4	GATA binding protein 4	0.399	Mouse
Rxra	retinoid X receptor alpha	0.392
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.386
Hand1	heart and neural crest derivatives expressed transcript 1	0.369
Tbx3	T-box 3	0.352
Gata6	GATA binding protein 6	0.351	Mouse
Fgf8	fibroblast growth factor 8	0.333
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.331
Foxf1a	forkhead box F1a	0.310
Itga3	integrin alpha 3	0.250	Mouse
Pbx1	pre B-cell leukemia transcription factor 1	0.246
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.240
Lrp6	low density lipoprotein receptor-related protein 6	0.236	Mouse
Fgfr3	fibroblast growth factor receptor 3	0.229
Adam17	a disintegrin and metallopeptidase domain 17	0.214
Vegfa	vascular endothelial growth factor A	0.210
Pdgfb	platelet derived growth factor, B polypeptide	0.209
Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog	0.206
Nog	noggin	0.196
Ret	ret proto-oncogene	0.195
Bax	BCL2-associated X protein	0.190	Mouse
Hhex	hematopoietically expressed homeobox	0.187
Trp63	transformation related protein 63	0.182
Mapk8ip1	mitogen-activated protein kinase 8 interacting protein 1	0.176
Alx4	aristaless-like homeobox 4	0.161
Lef1	lymphoid enhancer binding factor 1	0.154
Wt1	Wilms tumor 1 homolog	0.154
Bmp7	bone morphogenetic protein 7	0.148
Ptgs2	prostaglandin-endoperoxide synthase 2	0.145
Zic3	zinc finger protein of the cerebellum 3	0.143
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.143
Jag1	jagged 1	0.136
Gli2	GLI-Kruppel family member GLI2	0.135
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.134
Fgf10	fibroblast growth factor 10	0.134
Hes1	hairy and enhancer of split 1 (Drosophila)	0.130
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.120
Erbb2ip	Erbb2 interacting protein	0.114
Ptch1	patched homolog 1	0.111
Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.110
Sox2	SRY-box containing gene 2	0.106	Mouse
Meox2	mesenchyme homeobox 2	0.101
Otx2	orthodenticle homolog 2 (Drosophila)	0.101
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.100
Col4a3	collagen, type IV, alpha 3	0.099
Lrp2	low density lipoprotein receptor-related protein 2	0.098	Mouse
P2rx7	purinergic receptor P2X, ligand-gated ion channel, 7	0.097
Runx2	runt related transcription factor 2	0.093
Notch3	Notch gene homolog 3 (Drosophila)	0.090
Sox4	SRY-box containing gene 4	0.089	Mouse
Dll1	delta-like 1 (Drosophila)	0.089
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.089
Eng	endoglin	0.088
Nynrin	NYN domain and retroviral integrase containing	0.086
Tcf21	transcription factor 21	0.085
Acvrl1	activin A receptor, type II-like 1	0.084
Tgfb2	transforming growth factor, beta 2	0.083
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.080
She	src homology 2 domain-containing transforming protein E	0.078
Lamc1	laminin, gamma 1	0.078
Tbx2	T-box 2	0.077
Wwtr1	WW domain containing transcription regulator 1	0.077
Rara	retinoic acid receptor, alpha	0.076
Pax2	paired box gene 2	0.076
Bcl6b	B-cell CLL/lymphoma 6, member B	0.076
Prkg1	protein kinase, cGMP-dependent, type I	0.075
Axin2	axin2	0.073
Msx1	homeobox, msh-like 1	0.068
Notch2	Notch gene homolog 2 (Drosophila)	0.068
Bak1	BCL2-antagonist/killer 1	0.068	Mouse
Lmna	lamin A	0.067
Kif3a	kinesin family member 3A	0.067
Itgb3	integrin beta 3	0.065
Smad7	MAD homolog 7 (Drosophila)	0.065	Mouse
Sox17	SRY-box containing gene 17	0.063	Mouse
Nes	nestin	0.063
Amotl2	angiomotin-like 2	0.063
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.062
Gsk3b	glycogen synthase kinase 3 beta	0.062
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.061
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.061
Kit	kit oncogene	0.060
Braf	Braf transforming gene	0.060
Msx2	homeobox, msh-like 2	0.059
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.058
Inpp5d	inositol polyphosphate-5-phosphatase D	0.058
Myo1f	myosin IF	0.058
Pten	phosphatase and tensin homolog	0.057
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.056
Apaf1	apoptotic peptidase activating factor 1	0.056
Ric8	resistance to inhibitors of cholinesterase 8 homolog (C. elegans)	0.056
Aplnr	apelin receptor	0.056
Ltbp1	latent transforming growth factor beta binding protein 1	0.055
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.055
Ptprb	protein tyrosine phosphatase, receptor type, B	0.055
Adcy4	adenylate cyclase 4	0.055
Pmaip1	phorbol-12-myristate-13-acetate-induced protein 1	0.054
Tgfbr2	transforming growth factor, beta receptor II	0.054
Acvr1	activin A receptor, type 1	0.053
Treml1	triggering receptor expressed on myeloid cells-like 1	0.053
Hic1	hypermethylated in cancer 1	0.052
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.052
Sox11	SRY-box containing gene 11	0.052	Mouse
Hoxa13	homeobox A13	0.052
Arhgef12	Rho guanine nucleotide exchange factor (GEF) 12	0.051
Apln	apelin	0.051
Col2a1	collagen, type II, alpha 1	0.049
P2rx1	purinergic receptor P2X, ligand-gated ion channel, 1	0.049
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.048
Bmp5	bone morphogenetic protein 5	0.047
Smad2	MAD homolog 2 (Drosophila)	0.047	Mouse
Wnt5a	wingless-related MMTV integration site 5A	0.046
Hoxd13	homeobox D13	0.046
Selp	selectin, platelet	0.046
Rarg	retinoic acid receptor, gamma	0.046
Ptk2	PTK2 protein tyrosine kinase 2	0.045
Pxn	paxillin	0.044
Lrp5	low density lipoprotein receptor-related protein 5	0.043
Nkx2-1	NK2 homeobox 1	0.043
Epas1	endothelial PAS domain protein 1	0.043
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.042
Sema3f	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.041
Gp9	glycoprotein 9 (platelet)	0.041
Foxp1	forkhead box P1	0.041
Rac1	RAS-related C3 botulinum substrate 1	0.040
Spn	sialophorin	0.040
Jun	Jun oncogene	0.040
Pofut1	protein O-fucosyltransferase 1	0.040
Lrp1	low density lipoprotein receptor-related protein 1	0.039	Mouse
Sh3bp1	SH3-domain binding protein 1	0.039
Fli1	Friend leukemia integration 1	0.039
Klf6	Kruppel-like factor 6	0.038
Isl1	ISL1 transcription factor, LIM/homeodomain	0.038
Cd151	CD151 antigen	0.037
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.036
Zeb1	zinc finger E-box binding homeobox 1	0.036
Smo	smoothened homolog (Drosophila)	0.036
Vhl	von Hippel-Lindau tumor suppressor	0.036
Notch1	Notch gene homolog 1 (Drosophila)	0.036
Bmp1	bone morphogenetic protein 1	0.035
Pthlh	parathyroid hormone-like peptide	0.034
Tdgf1	teratocarcinoma-derived growth factor 1	0.034
Dusp1	dual specificity phosphatase 1	0.034
Epha4	Eph receptor A4	0.033
Thbs1	thrombospondin 1	0.033
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.031
Tal1	T-cell acute lymphocytic leukemia 1	0.031
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.031
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.031
Sox13	SRY-box containing gene 13	0.030
Pkd1	polycystic kidney disease 1 homolog	0.030
Efnb1	ephrin B1	0.030
Sfrp1	secreted frizzled-related protein 1	0.029
Bach1	BTB and CNC homology 1	0.028
Sox7	SRY-box containing gene 7	0.028	Mouse
Gna15	guanine nucleotide binding protein, alpha 15	0.028
Ets1	E26 avian leukemia oncogene 1, 5' domain	0.028
Wnt3a	wingless-related MMTV integration site 3A	0.028
Snai1	snail homolog 1 (Drosophila)	0.028
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.028
Alx3	aristaless-like homeobox 3	0.027
Foxc1	forkhead box C1	0.027
Tln1	talin 1	0.027
Crhr2	corticotropin releasing hormone receptor 2	0.025
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.025
Rnf111	ring finger 111	0.025
Sox10	SRY-box containing gene 10	0.025	Mouse
Fgf3	fibroblast growth factor 3	0.025
Smurf1	SMAD specific E3 ubiquitin protein ligase 1	0.024
Sh2b3	SH2B adaptor protein 3	0.024
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.024
Hmha1	histocompatibility (minor) HA-1	0.024
Ctnnd1	catenin (cadherin associated protein), delta 1	0.024
Gbx2	gastrulation brain homeobox 2	0.024
Tcfap2a	transcription factor AP-2, alpha	0.024
Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.024
Was	Wiskott-Aldrich syndrome homolog (human)	0.024
Efnb2	ephrin B2	0.023
Meox1	mesenchyme homeobox 1	0.023
Tbx1	T-box 1	0.023
Creb3l1	cAMP responsive element binding protein 3-like 1	0.022
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.022
Tbxas1	thromboxane A synthase 1, platelet	0.022
Pax6	paired box gene 6	0.022
Ciita	class II transactivator	0.021
Tcf15	transcription factor 15	0.021
Ltbp3	latent transforming growth factor beta binding protein 3	0.021
Cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	0.021
Zfp36l1	zinc finger protein 36, C3H type-like 1	0.021
Itgam	integrin alpha M	0.021	Mouse
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.020
Csf3r	colony stimulating factor 3 receptor (granulocyte)	0.020
Prrx2	paired related homeobox 2	0.020
Pcdh12	protocadherin 12	0.020
Arhgef2	rho/rac guanine nucleotide exchange factor (GEF) 2	0.020
S1pr4	sphingosine-1-phosphate receptor 4	0.020
Hoxa1	homeobox A1	0.020
Alox12	arachidonate 12-lipoxygenase	0.020
Gas1	growth arrest specific 1	0.020
Lyl1	lymphoblastomic leukemia 1	0.020
Bmp2	bone morphogenetic protein 2	0.020
Foxh1	forkhead box H1	0.020
En1	engrailed 1	0.019
Rac2	RAS-related C3 botulinum substrate 2	0.019
Gpc3	glypican 3	0.019
Mmp9	matrix metallopeptidase 9	0.018
Tgfb1i1	transforming growth factor beta 1 induced transcript 1	0.018
Bptf	bromodomain PHD finger transcription factor	0.018
Fos	FBJ osteosarcoma oncogene	0.018
Slc12a2	solute carrier family 12, member 2	0.018
Cx3cr1	chemokine (C-X3-C) receptor 1	0.018
Mrc2	mannose receptor, C type 2	0.018
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.018
Inhba	inhibin beta-A	0.018
C5ar1	complement component 5a receptor 1	0.018
Foxa2	forkhead box A2	0.018
Elf4	E74-like factor 4 (ets domain transcription factor)	0.018
Klf3	Kruppel-like factor 3 (basic)	0.017
Hdac7	histone deacetylase 7	0.017
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.017
Rhoc	ras homolog gene family, member C	0.017	Mouse
Il27ra	interleukin 27 receptor, alpha	0.017
Emp2	epithelial membrane protein 2	0.017
Wwc2	WW, C2 and coiled-coil domain containing 2	0.017
Tgfa	transforming growth factor alpha	0.017
Thbd	thrombomodulin	0.017
Tspan9	tetraspanin 9	0.017
Klf7	Kruppel-like factor 7 (ubiquitous)	0.017
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.017
Flt1	FMS-like tyrosine kinase 1	0.017
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.017
Ptk7	PTK7 protein tyrosine kinase 7	0.017
Rassf5	Ras association (RalGDS/AF-6) domain family member 5	0.016
Ikzf1	IKAROS family zinc finger 1	0.016
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.016
Ikbkap	inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein	0.016
Pick1	protein interacting with C kinase 1	0.016
Rhd	Rh blood group, D antigen	0.016
Yap1	yes-associated protein 1	0.016
Mcam	melanoma cell adhesion molecule	0.016
Cux1	cut-like homeobox 1	0.016
Nckap1l	NCK associated protein 1 like	0.016
Wls	wntless homolog (Drosophila)	0.016
Etl4	enhancer trap locus 4	0.016
F2r	coagulation factor II (thrombin) receptor	0.016
Lmx1a	LIM homeobox transcription factor 1 alpha	0.016
Dok1	docking protein 1	0.015
Adamts1	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1	0.015
Klf4	Kruppel-like factor 4 (gut)	0.015
Ednrb	endothelin receptor type B	0.015
Hip1	huntingtin interacting protein 1	0.015
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.015
Nfe2	nuclear factor, erythroid derived 2	0.015
Tinagl1	tubulointerstitial nephritis antigen-like 1	0.015
Chrd	chordin	0.015
Arhgap9	Rho GTPase activating protein 9	0.015
Col4a2	collagen, type IV, alpha 2	0.014
Alx1	ALX homeobox 1	0.014
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.014
Hnf1b	HNF1 homeobox B	0.014
Ggta1	glycoprotein galactosyltransferase alpha 1, 3	0.014
Eda	ectodysplasin-A	0.014
Gp5	glycoprotein 5 (platelet)	0.014
Nrp1	neuropilin 1	0.014
Efna4	ephrin A4	0.014
Sdc3	syndecan 3	0.014
Tgm2	transglutaminase 2, C polypeptide	0.014
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.013
Fzd1	frizzled homolog 1 (Drosophila)	0.013
Eya1	eyes absent 1 homolog (Drosophila)	0.013
Vav2	vav 2 oncogene	0.013
Zfpm2	zinc finger protein, multitype 2	0.013
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.013
Sorbs3	sorbin and SH3 domain containing 3	0.013
Gja1	gap junction protein, alpha 1	0.013
App	amyloid beta (A4) precursor protein	0.013
Ksr1	kinase suppressor of ras 1	0.013
Cdh6	cadherin 6	0.013
Ctgf	connective tissue growth factor	0.013
Ceacam2	carcinoembryonic antigen-related cell adhesion molecule 2	0.013
Cxcr3	chemokine (C-X-C motif) receptor 3	0.013
Ski	ski sarcoma viral oncogene homolog (avian)	0.013
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.013
Epb4.1l2	erythrocyte protein band 4.1-like 2	0.013
Edar	ectodysplasin-A receptor	0.013
Bmper	BMP-binding endothelial regulator	0.012
Tnks1bp1	tankyrase 1 binding protein 1	0.012
Il18rap	interleukin 18 receptor accessory protein	0.012
Wisp2	WNT1 inducible signaling pathway protein 2	0.012
Hand2	heart and neural crest derivatives expressed transcript 2	0.012
Robo4	roundabout homolog 4 (Drosophila)	0.012
Kcnn4	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	0.012
Ncf1	neutrophil cytosolic factor 1	0.012
Gdnf	glial cell line derived neurotrophic factor	0.012
Wnt6	wingless-related MMTV integration site 6	0.012
Cldn5	claudin 5	0.012
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.012
Irx3	Iroquois related homeobox 3 (Drosophila)	0.012
Tbx6	T-box 6	0.012
Rb1	retinoblastoma 1	0.012
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.012
Fzd7	frizzled homolog 7 (Drosophila)	0.012
Mc5r	melanocortin 5 receptor	0.012
Itga6	integrin alpha 6	0.012	Mouse
Rarb	retinoic acid receptor, beta	0.012
Sfn	stratifin	0.012
Il10ra	interleukin 10 receptor, alpha	0.012
Lepr	leptin receptor	0.012
Hoxa11	homeobox A11	0.012
S1pr2	sphingosine-1-phosphate receptor 2	0.011
Ext1	exostoses (multiple) 1	0.011
Plat	plasminogen activator, tissue	0.011
Gata2	GATA binding protein 2	0.011	Mouse
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.011
Apoe	apolipoprotein E	0.011
Flna	filamin, alpha	0.011
Mfn2	mitofusin 2	0.011
Foxg1	forkhead box G1	0.011
Cdh5	cadherin 5	0.011
Pitx1	paired-like homeodomain transcription factor 1	0.011
Grb10	growth factor receptor bound protein 10	0.011
Epha2	Eph receptor A2	0.011
Ihh	Indian hedgehog	0.011
Ptprf	protein tyrosine phosphatase, receptor type, F	0.011
Colq	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	0.011
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.011
Cd38	CD38 antigen	0.011
Dag1	dystroglycan 1	0.011
Slc34a2	solute carrier family 34 (sodium phosphate), member 2	0.011
Sh3rf1	SH3 domain containing ring finger 1	0.011
Matn4	matrilin 4	0.011
Htt	huntingtin	0.010
Fscn1	fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus)	0.010
Sox9	SRY-box containing gene 9	0.010	Mouse
Sntb1	syntrophin, basic 1	0.010
Hoxa5	homeobox A5	0.010
Cd97	CD97 antigen	0.010
Galnt6	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6	0.010
Emx2	empty spiracles homolog 2 (Drosophila)	0.010
Skil	SKI-like	0.010
Adm	adrenomedullin	0.010
Ltb	lymphotoxin B	0.010
Nrg1	neuregulin 1	0.010
Ift88	intraflagellar transport 88 homolog (Chlamydomonas)	0.010
Id1	inhibitor of DNA binding 1	0.010
Smurf2	SMAD specific E3 ubiquitin protein ligase 2	0.010
Hoxd11	homeobox D11	0.010
Ptafr	platelet-activating factor receptor	0.010
Npr3	natriuretic peptide receptor 3	0.010