IMP

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Danio rerio

20 genes annotated in zebrafish

cell surface receptor signaling pathway involved in heart development

Any series of molecular signals initiated by the binding of a receptor on the surface of a cell to a physiological ligand, which contributes to the progression of the heart over time.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cell surface receptor signaling pathway involved in heart development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cell surface receptor signaling pathway involved in heart development" (in gray)

Name	Description	Probability	Func Analog Organism
tbx1	T-box 1	1.000	Zebrafish
bmp4	bone morphogenetic protein 4	0.996
ndr2	nodal-related 2	0.994
tbx16	T-box gene 16	0.989
ntla	no tail a	0.986
chd	chordin	0.970
bmp2b	bone morphogenetic protein 2b	0.967	Human Zebrafish
lft1	lefty1	0.965
wnt5b	wingless-type MMTV integration site family, member 5b	0.959	Mouse
has2	hyaluronan synthase 2	0.946
twist1a	twist1a	0.931
flh	floating head	0.926
fn1	fibronectin 1	0.919
lft2	lefty2	0.895
sox32	SRY-box containing gene 32	0.830	Mouse
tbx6	T-box gene 6	0.825	Zebrafish
oep	one-eyed pinhead	0.824
pkd2	polycystic kidney disease 2	0.785
tbx5a	T-box 5a	0.781	Zebrafish
gro1	groucho 1	0.756
hand2	heart and neural crest derivatives expressed transcript 2	0.748	Mouse
tbx2a	T-box gene 2a	0.720	Zebrafish
cxcr4a	chemokine (C-X-C motif) receptor 4a	0.659
dharma	dharma	0.636
sox17	SRY-box containing gene 17	0.623	Mouse
dkk1b	dickkopf 1b	0.605	Mouse
mespa	mesoderm posterior a	0.600	Mouse
gli2a	GLI-Kruppel family member GLI2a	0.600
wnt11	wingless-type MMTV integration site family, member 11	0.600
fli1a	friend leukemia integration 1a	0.582
axin1	axin 1	0.554
shha	sonic hedgehog a	0.524
fgf17	fibroblast growth factor 17	0.523
gli1	GLI-Kruppel family member 1	0.522
dact2	dapper homolog 2, antagonist of beta-catenin (xenopus)	0.510
bmp2a	bone morphogenetic protein 2a	0.478	Human Zebrafish
ndr1	nodal-related 1	0.467	Zebrafish
wnt2bb	wingless-type MMTV integration site family, member 2Bb	0.438
cyp26c1	cytochrome P450, family 26, subfamily C, polypeptide 1	0.429
mib	mind bomb	0.423
ptch1	patched 1	0.396
tbx2b	T-box 2b	0.388	Zebrafish
fbln1	fibulin 1	0.372
twist3	twist3	0.358
kdrl	kinase insert domain receptor like	0.351
pcdh8	protocadherin 8	0.350
fzd7a	frizzled homolog 7a	0.324
ephb4b	eph receptor B4b	0.311
dlc	deltaC	0.309
admp	anti-dorsalizing morphogenic protein	0.308	Zebrafish
wnt11r	wingless-type MMTV integration site family, member 11, related	0.306
foxh1	forkhead box H1	0.290
bmp7a	bone morphogenetic protein 7a	0.288
vangl2	vang-like 2 (van gogh, Drosophila)	0.285
plcg1	phospholipase C, gamma 1	0.278
fzd5	frizzled homolog 5	0.263	Zebrafish
tbx18	T-box 18	0.261	Zebrafish
nkx2.5	NK2 transcription factor related 5	0.257
cdh2	cadherin 2, neuronal	0.246
lamb1a	laminin, beta 1a	0.245
fzd7b	frizzled homolog 7b	0.244	Zebrafish
wls	wntless homolog (Drosophila)	0.238
dhrs3a	dehydrogenase/reductase (SDR family) member 3a	0.225
notch2	notch homolog 2	0.225
spaw	southpaw	0.221
nfatc1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.220
etv2	ets variant gene 2	0.216
notch1b	notch homolog 1b	0.215	Human Mouse
smo	smoothened homolog (Drosophila)	0.212
bambia	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a	0.211
her1	hairy-related 1	0.210
dusp6	dual specificity phosphatase 6	0.206
nog1	noggin 1	0.198
notch3	notch homolog 3	0.196
foxd5	forkhead box D5	0.188
otx1a	orthodenticle homolog 1a	0.184
gro2	groucho 2	0.177
tbx20	T-box 20	0.171	Zebrafish
sfrp1a	secreted frizzled-related protein 1a	0.167
bon	bonnie and clyde	0.162
wnt10a	wingless-type MMTV integration site family, member 10a	0.161
her7	hairy and enhancer of split related-7	0.158
gata4	GATA-binding protein 4	0.157
smad9	MAD homolog 9 (Drosophila)	0.146	Zebrafish
edn1	endothelin 1	0.143
lama5	laminin, alpha 5	0.143
mmp2	matrix metalloproteinase 2	0.142
hsp47	heat shock protein 47	0.139
cdh1	cadherin 1, epithelial	0.138
rerea	arginine-glutamic acid dipeptide (RE) repeats a	0.130
msxd	muscle segment homeobox D	0.130
klf4	Kruppel-like factor 4	0.127
snai1b	snail homolog 1b (Drosophila)	0.122	Mouse
jag1b	jagged 1b	0.121	Human Mouse
foxa2	forkhead box A2	0.115
lmo4a	LIM domain only 4a	0.112
klf2a	Kruppel-like factor 2a	0.110
lhx1b	LIM homeobox 1b	0.109
foxa3	forkhead box A3	0.109
fzd8b	frizzled homolog 8b	0.109	Zebrafish
gata2a	GATA-binding protein 2a	0.108
cdh5	cadherin 5	0.103
smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.101
tnnt2a	troponin T2a, cardiac	0.099
foxi1	forkhead box I1	0.098
hmgcrb	3-hydroxy-3-methylglutaryl-Coenzyme A reductase b	0.097
plekha7	pleckstrin homology domain containing, family A member 7	0.093
drl	draculin	0.093
ptgs1	prostaglandin-endoperoxide synthase 1	0.091
fgf8a	fibroblast growth factor 8 a	0.090
dvl2	dishevelled, dsh homolog 2 (Drosophila)	0.090	Fly
gata5	GATA-binding protein 5	0.089
nkx1.2la	NK1 transcription factor related 2-like,a	0.088
rarga	retinoic acid receptor gamma a	0.087
rest	RE1-silencing transcription factor	0.087
foxn4	forkhead box N4	0.087
foxj1a	forkhead box J1a	0.086
igf1rb	insulin-like growth factor 1b receptor	0.086
fgf3	fibroblast growth factor 3	0.083
wnt4a	wingless-type MMTV integration site family, member 4a	0.082
pard6gb	par-6 partitioning defective 6 homolog gamma B (C. elegans)	0.081
aplnrb	apelin receptor b	0.079
twist2	twist2	0.079
fgfr4	fibroblast growth factor receptor 4	0.078
fzd10	frizzled homolog 10	0.078	Zebrafish
brd2a	bromodomain-containing 2a	0.077
twist1b	twist1b	0.077
nppa	natriuretic peptide precursor A	0.076
med12	mediator of RNA polymerase II transcription, subunit 12 homolog	0.075
vent	ventral expressed homeobox	0.074
jag2	jagged 2	0.073
hhex	hematopoietically expressed homeobox	0.073
tcf7l1a	transcription factor 7-like 1a (T-cell specific, HMG-box)	0.072
aplnra	apelin receptor a	0.072
wif1	wnt inhibitory factor 1	0.071
nkd1	naked cuticle homolog 1 (Drosophila)	0.071
tll1	tolloid-like 1	0.070
sulf1	sulfatase 1	0.070
mespb	mesoderm posterior b	0.070	Mouse
gpc4	glypican 4	0.069
runx1	runt-related transcription factor 1	0.068
osr1	odd-skipped related 1 (Drosophila)	0.068
frzb	frizzled-related protein	0.067	Zebrafish
dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.066
hapln1a	hyaluronan and proteoglycan link protein 1a	0.065
spry4	sprouty (Drosophila) homolog 4	0.063
runx2b	runt-related transcription factor 2b	0.061
tcf7	transcription factor 7 (T-cell specific, HMG-box)	0.061
bmper	BMP binding endothelial regulator	0.061
tbx24	T-box 24	0.061	Zebrafish
lpp	LIM domain containing preferred translocation partner in lipoma	0.061
neo1	neogenin 1	0.060
plod1a	procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a	0.060
spns2	spinster homolog 2 (Drosophila)	0.060
tgfb2	transforming growth factor, beta 2	0.059
rargb	retinoic acid receptor, gamma b	0.057
myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.056
fbn2b	fibrillin 2b	0.055
lama4	laminin, alpha 4	0.055
og9x	OG9 homeobox gene	0.055
pitx2	paired-like homeodomain transcription factor 2	0.054
gsc	goosecoid	0.054	Zebrafish
vcana	versican a	0.054
msxc	muscle segment homeobox C	0.052
ptch2	patched 2	0.050
eif4e1b	eukaryotic translation initiation factor 4e 1b	0.050
mapk3	mitogen-activated protein kinase 3	0.050
bmpr1aa	bone morphogenetic protein receptor, type 1aa	0.049
gdf6b	growth differentiation factor 6b	0.049	Zebrafish
tgfb3	transforming growth factor, beta 3	0.048
eve1	even-skipped-like1	0.048
gata6	GATA-binding protein 6	0.048
id1	inhibitor of DNA binding 1	0.047
cldng	claudin g	0.046
alcamb	activated leukocyte cell adhesion molecule b	0.045
ihha	Indian hedgehog homolog a	0.043	Zebrafish
hoxa2b	homeo box A2b	0.042
gbx2	gastrulation brain homeo box 2	0.042
nanos3	nanos homolog 3	0.042
pea3	ETS-domain transcription factor pea3	0.042
her12	hairy-related 12	0.042
tmpoa	thymopoietin a	0.041
otx1b	orthodenticle homolog 1b	0.041
chrna2a	cholinergic receptor, nicotinic, alpha polypeptide 2a (neuronal)	0.040
gata1a	GATA binding protein 1a	0.040
waca	WW domain containing adaptor with coiled-coil a	0.040
pbx4	pre-B-cell leukemia transcription factor 4	0.040
gli2b	GLI-Kruppel family member GLI2b	0.038
znf703	zinc finger protein 703	0.038
wnt9b	wingless-type MMTV integration site family, member 9B	0.038
fgf10a	fibroblast growth factor 10a	0.038
fzd9b	frizzled homolog 9b	0.038	Zebrafish
mos	v-mos Moloney murine sarcoma viral oncogene homolog	0.038
ednra	endothelin receptor type A	0.037
wnt8a	wingless-type MMTV integration site family, member 8a	0.037
six4a	sine oculis homeobox homolog 4a	0.037
sim2	single-minded homolog 2 (Drosophila)	0.036
col8a1a	collagen, type VIII, alpha 1a	0.034
fgf4	fibroblast growth factor 4	0.034
ets1a	v-ets erythroblastosis virus E26 oncogene homolog 1a	0.034
scd	stearoyl-CoA desaturase (delta-9-desaturase)	0.034
smad3b	MAD, mothers against decapentaplegic homolog 3b (Drosophila)	0.034	Zebrafish
snai1a	snail homolog 1a (Drosophila)	0.034	Mouse
dlx3b	distal-less homeobox gene 3b	0.033
eomesa	eomesodermin homolog a	0.033	Zebrafish
hspb1	heat shock protein, alpha-crystallin-related, 1	0.033
msxb	muscle segment homeobox B	0.032
cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.031
wnt9a	wingless-type MMTV integration site family, member 9A	0.031
bmp3	bone morphogenetic protein 3	0.031	Zebrafish
hoxa11a	homeo box A11a	0.031
hey2	hairy/enhancer-of-split related with YRPW motif 2	0.031
foxd3	forkhead box D3	0.030
gpr126	G protein-coupled receptor 126	0.029
msgn1	mesogenin 1	0.029
ptenb	phosphatase and tensin homolog B (mutated in multiple advanced cancers 1)	0.029
p4ha2	procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2	0.028
cdx4	caudal type homeo box transcription factor 4	0.027
ccna1	cyclin A1	0.027
rxrbb	retinoid x receptor, beta b	0.027
prtga	protogenin homolog a (Gallus gallus)	0.026
pou5f1	POU domain, class 5, transcription factor 1	0.026
tmem88a	transmembrane protein 88 a	0.026
shdb	Src homology 2 domain containing transforming protein D, b	0.025
LOC100000687	signal peptide, CUB and EGF-like domain-containing protein 3-like	0.025
etv5b	ets variant 5b	0.025
tp63	tumor protein p63	0.025
six4b	sine oculis homeobox homolog 4b	0.025
hesx1	homeo box (expressed in ES cells) 1	0.025
has3	hyaluronan synthase 3	0.024	Zebrafish
ncor1	nuclear receptor co-repressor 1	0.024
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.024
evx1	even-skipped homeobox 1	0.024
six4.3	sine oculis homeobox homolog 4.3	0.024
hmx1	H6 homeo box 1	0.024
pggt1b	protein geranylgeranyltransferase type I, beta subunit	0.024
ephb3a	eph receptor B3a	0.024
hoxb1b	homeo box B1b	0.023
hmx4	H6 family homeobox 4	0.023
acvr1b	activin A receptor, type IB	0.023
hspb12	heat shock protein, alpha-crystallin-related, b12	0.023
il17rd	interleukin 17 receptor D	0.023
sesn1	sestrin 1	0.023
prickle1a	prickle-like 1 (Drosophila) a	0.022
wnt10b	wingless-type MMTV integration site family, member 10b	0.022
grem2	gremlin 2, cysteine knot superfamily	0.022
sp5l	Sp5 transcription factor-like	0.021
frem3	Fras1 related extracellular matrix 3	0.020
hspb7	heat shock protein family, alpha-crystallin-related, b7	0.020
scrib	scribbled homolog (Drosophila)	0.020
mef2cb	myocyte enhancer factor 2cb	0.020
ankrd6	ankyrin repeat domain 6	0.020
fzd2	frizzled homolog 2	0.020
plekhh1	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	0.020
wnt3a	wingless-type MMTV integration site family, member 3A	0.020	Human
lama1	laminin, alpha 1	0.019
tbpl2	TATA box binding protein like 2	0.019
hoxa13b	homeo box A13b	0.019
rarab	retinoic acid receptor, alpha b	0.019
mapk1	mitogen-activated protein kinase 1	0.019
dbx1b	developing brain homeobox 1b	0.019
smad5	MAD homolog 5 (Drosophila)	0.019
rxrga	retinoid x receptor, gamma a	0.019
npy8ar	neuropeptide Y receptor Y8a	0.019
spon2a	spondin 2a, extracellular matrix protein	0.019
barx2	BarH-like homeobox 2	0.018
arl4ab	ADP-ribosylation factor-like 4ab	0.018
hoxa13a	homeo box A13a	0.018
si:dkeyp-68f6.1	si:dkeyp-68f6.1	0.018
epb4.1l4	erythrocyte protein band 4.1-like 4	0.018
kif7	kinesin family member 7	0.018
tbx5b	T-box 5b	0.018
hoxa1a	homeo box A1a	0.018
gatsl2	GATS protein-like 2	0.017
osr2	odd-skipped related 2 (Drosophila)	0.017
erg	v-ets erythroblastosis virus E26 oncogene like (avian)	0.017
chsy1	chondroitin sulfate synthase 1	0.017
dld	deltaD	0.017
rbfox2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.017
gbx1	gastrulation brain homeobox 1	0.016
skia	nuclear oncoprotein skia	0.016
acvr1l	activin A receptor, type I like	0.016
crip2	cysteine-rich protein 2	0.016
si:ch211-235f6.2	si:ch211-235f6.2	0.015
acta1b	actin, alpha 1b, skeletal muscle	0.015
emx3	empty spiracles homeobox 3	0.015
lrrc6	leucine rich repeat containing 6	0.015
asb2b	ankyrin repeat and SOCS box-containing 2b	0.015
dlx5a	distal-less homeobox gene 5a	0.015
plagl2	pleiomorphic adenoma gene-like 2	0.015
runx3	runt-related transcription factor 3	0.015
zp2.2	zona pellucida glycoprotein 2.2	0.015
gata3	GATA-binding protein 3	0.015
crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.015	Zebrafish
gsdf	gonadal somatic cell derived factor	0.015
supt6h	suppressor of Ty 6 homolog	0.015
satb2	SATB homeobox 2	0.014
hapln3	hyaluronan and proteoglycan link protein 3	0.014
b3gnt7	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7	0.014
lamc1	laminin, gamma 1	0.014
tmem2	transmembrane protein 2	0.014
ism1	isthmin 1	0.014
spry2	sprouty homolog 2	0.014
trim3a	tripartite motif-containing 3a	0.014
mll	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.014
axin2	axin 2 (conductin, axil)	0.014
shmt2	serine hydroxymethyltransferase 2 (mitochondrial)	0.014
lfng	lunatic fringe homolog	0.014
mesp2	mesoderm posterior 2 homolog (mouse)	0.013
cbfb	core-binding factor, beta subunit	0.013
cftr	cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7)	0.013
pld1a	phospholipase D1a	0.013
hoxd11a	homeo box D11a	0.013
ippk	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	0.013
si:dkey-11e23.5	si:dkey-11e23.5	0.013
lmna	lamin A	0.013
znfl2a	zinc finger-like gene 2a	0.013
tp53	tumor protein p53	0.013
zgc:111821	zgc:111821	0.013
wu:fk76c08	wu:fk76c08	0.013
uts2a	urotensin 2, alpha	0.013
trpv4	transient receptor potential cation channel, subfamily V, member 4	0.013
lhx8a	LIM homeobox 8a	0.012
znf503	zinc finger protein 503	0.012
pcdh18b	protocadherin 18b	0.012
disp1	dispatched homolog 1 (Drosophila)	0.012
btg1	B-cell translocation gene 1	0.012
tgfbi	transforming growth factor, beta-induced	0.012
her5	hairy-related 5	0.012
epha2	eph receptor A2	0.012
ptgs2a	prostaglandin-endoperoxide synthase 2a	0.012
aldh1a2	aldehyde dehydrogenase 1 family, member A2	0.012
zgc:55877	zgc:55877	0.012
pax9	paired box gene 9	0.012
klf4a	Kruppel-like transcription factor 4a	0.011
pias4a	protein inhibitor of activated STAT, 4a	0.011
nkx2.3	NK2 transcription factor related 3	0.011
acvr2b	activin receptor IIb	0.011
rasl11b	RAS-like, family 11, member B	0.011
cmlc1	cardiac myosin light chain-1	0.011
zgc:55888	zgc:55888	0.011
npnt	nephronectin	0.011
cd99l2	CD99 antigen-like 2	0.011
nnr	nanor	0.011
col27a1a	collagen, type XXVII, alpha 1a	0.011
ntf7	neurotrophin 7	0.011
apln	apelin	0.011
myl7	myosin, light polypeptide 7, regulatory	0.011
efna5a	ephrin A5a	0.011
ntn1b	netrin 1b	0.011
cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.011
sepn1	selenoprotein N, 1	0.011
cx44.2	connexin 44.2	0.011
dzip1	DAZ interacting protein 1	0.011
mxtx2	mix-type homeobox gene 2	0.011
vmhcl	ventricular myosin heavy chain-like	0.011
s1pr2	sphingosine-1-phosphate receptor 2	0.010
LOC566708	FL cytokine receptor-like	0.010
vox	ventral homeobox	0.010
cx30.3	connexin 30.3	0.010
fli1b	friend leukemia integration 1b	0.010
cldnd	claudin d	0.010
igf1	insulin-like growth factor 1	0.010
mta3	metastasis associated family, member 3	0.010
mllt11	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11	0.010
popdc1	popeye domain containing 1	0.010
ved	ventrally expressed dharma/bozozok antagonist	0.010