The network for 'signal transduction in response to dna damage' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

signal transduction in response to dna damage

A cascade of processes induced by the detection of DNA damage within a cell.

Homo sapiens
Name Description Probability Func Analog Organism
TP53 tumor protein p53 1.000
BRCA1 breast cancer 1, early onset 1.000
RB1 retinoblastoma 1 0.987
CREBBP CREB binding protein 0.986
EP300 E1A binding protein p300 0.986
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.975
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.967
NBN nibrin 0.963
MAPK8 mitogen-activated protein kinase 8 0.929
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.925
MAPK14 mitogen-activated protein kinase 14 0.923
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.878
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.832
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.826
H2AFX H2A histone family, member X 0.807
MDC1 mediator of DNA-damage checkpoint 1 0.806
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.803
ATM ataxia telangiectasia mutated 0.798
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.752
GADD45A growth arrest and DNA-damage-inducible, alpha 0.750
E2F7 E2F transcription factor 7 0.748
GSK3B glycogen synthase kinase 3 beta 0.728
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.686
PAX3 paired box 3 0.681
RAD50 RAD50 homolog (S. cerevisiae) 0.677
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.645
BCAS2 breast carcinoma amplified sequence 2 0.634
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.605
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.604
XIAP X-linked inhibitor of apoptosis 0.568
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.567
TWIST1 twist homolog 1 (Drosophila) 0.557
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.532
E2F8 E2F transcription factor 8 0.511
SIRT1 sirtuin 1 0.496
WRN Werner syndrome, RecQ helicase-like 0.484
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.443
CDK2 cyclin-dependent kinase 2 0.409
POU5F1 POU class 5 homeobox 1 0.404
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.374
FANCD2 Fanconi anemia, complementation group D2 0.372
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.367
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.354
CCNE1 cyclin E1 0.342
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.330
MAPK1 mitogen-activated protein kinase 1 0.329
PGK1 phosphoglycerate kinase 1 0.323
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.321
PARP1 poly (ADP-ribose) polymerase 1 0.317
IER3 immediate early response 3 0.313
DDAH2 dimethylarginine dimethylaminohydrolase 2 0.313
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.302
CFLAR CASP8 and FADD-like apoptosis regulator 0.297
RAD18 RAD18 homolog (S. cerevisiae) 0.281
CREB1 cAMP responsive element binding protein 1 0.277
TP53BP1 tumor protein p53 binding protein 1 0.273
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.271
APAF1 apoptotic peptidase activating factor 1 0.266
CDC25A cell division cycle 25 homolog A (S. pombe) 0.265
CDC5L CDC5 cell division cycle 5-like (S. pombe) 0.256
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.256
MAP2K4 mitogen-activated protein kinase kinase 4 0.246
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 0.240
SMAD7 SMAD family member 7 0.231
FAS Fas (TNF receptor superfamily, member 6) 0.229
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.226
SETD7 SET domain containing (lysine methyltransferase) 7 0.223
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.216
BCL3 B-cell CLL/lymphoma 3 0.215
SMAD3 SMAD family member 3 0.213
OTUB1 OTU domain, ubiquitin aldehyde binding 1 0.209
DAXX death-domain associated protein 0.208
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 0.205
MAPK3 mitogen-activated protein kinase 3 0.201
SNTA1 syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) 0.193
NCOA3 nuclear receptor coactivator 3 0.186
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.175
BCL2 B-cell CLL/lymphoma 2 0.168
SMAD2 SMAD family member 2 0.166
CDK11B cyclin-dependent kinase 11B 0.166
CHEK1 CHK1 checkpoint homolog (S. pombe) 0.163
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.162
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.154
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.152
RUNX1 runt-related transcription factor 1 0.150
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.150
KAT2B K(lysine) acetyltransferase 2B 0.149
H3F3C H3 histone, family 3C 0.147
TK1 thymidine kinase 1, soluble 0.145
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.144
COASY CoA synthase 0.143
DUSP1 dual specificity phosphatase 1 0.139
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.137
SKP2 S-phase kinase-associated protein 2 (p45) 0.137
CCND3 cyclin D3 0.133
IFI16 interferon, gamma-inducible protein 16 0.132
SETD8 SET domain containing (lysine methyltransferase) 8 0.132
EPRS glutamyl-prolyl-tRNA synthetase 0.130
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.129
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.125
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
p53 CG33336 gene product from transcript CG33336-RB 0.773
imd immune deficiency 0.481
rad50 CG6339 gene product from transcript CG6339-RD 0.429
mei-9 meiotic 9 0.324
Iswi Imitation SWI 0.163
mus101 mutagen-sensitive 101 0.148
Rel Relish 0.146
CtBP C-terminal Binding Protein 0.142
Adf1 Adh transcription factor 1 0.133
Akt1 CG4006 gene product from transcript CG4006-RA 0.128
pan pangolin 0.104
pnr pannier 0.103
MTF-1 Metal response element-binding Transcription Factor-1 0.103
mus201 mutagen-sensitive 201 0.100
hay haywire 0.100
AGO2 Argonaute 2 0.099
mus205 mutagen-sensitive 205 0.090
CG4699 CG4699 gene product from transcript CG4699-RJ 0.082
ird5 immune response deficient 5 0.077
key kenny 0.076
shn schnurri 0.074
CG5524 CG5524 gene product from transcript CG5524-RA 0.074
l(1)G0007 lethal (1) G0007 0.073
stau staufen 0.071
byn brachyenteron 0.069
lea leak 0.069
RASSF8 CG5053 gene product from transcript CG5053-RA 0.068
Smr Smrter 0.068
tefu telomere fusion 0.068
hep hemipterous 0.067
Sin3A CG8815 gene product from transcript CG8815-RC 0.067
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.065
kay kayak 0.064
Ric Ras which interacts with Calmodulin 0.059
mei-41 meiotic 41 0.058
Cdc42 CG12530 gene product from transcript CG12530-RA 0.057
wee CG4488 gene product from transcript CG4488-RA 0.055
Su(var)2-HP2 CG12864 gene product from transcript CG12864-RB 0.054
stwl stonewall 0.053
debcl death executioner Bcl-2 homologue 0.052
CG10107 CG10107 gene product from transcript CG10107-RA 0.052
simj simjang 0.050
BG4 CG12297 gene product from transcript CG12297-RA 0.049
RecQ5 homolog of RecQ 0.049
Sdc Syndecan 0.048
sli slit 0.047
Dcp-1 Death caspase-1 0.046
wb wing blister 0.046
zfh1 Zn finger homeodomain 1 0.041
p38b CG7393 gene product from transcript CG7393-RA 0.041
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.041
lok loki 0.041
Dab Disabled 0.040
rpr reaper 0.040
Brca2 Breast cancer 2, early onset homolog 0.040
nbs CG6754 gene product from transcript CG6754-RC 0.039
Hr4 CG16902 gene product from transcript CG16902-RC 0.039
Mpk2 CG5475 gene product from transcript CG5475-RB 0.038
CG32685 CG32685 gene product from transcript CG32685-RC 0.038
Smg5 CG8954 gene product from transcript CG8954-RA 0.038
DNApol-eta CG7143 gene product from transcript CG7143-RA 0.038
Atg6 Autophagy-specific gene 6 0.037
Top3alpha Topoisomerase 3alpha 0.037
GATAd CG5034 gene product from transcript CG5034-RA 0.037
Dcp2 Decapping protein 2 0.036
hh hedgehog 0.036
ird1 immune response deficient 1 0.036
ari-2 ariadne 2 0.036
cav caravaggio 0.035
lid little imaginal discs 0.035
CG6015 CG6015 gene product from transcript CG6015-RA 0.035
Rac2 CG8556 gene product from transcript CG8556-RA 0.035
Bap60 Brahma associated protein 60kD 0.034
alph alphabet 0.034
X11L CG5675 gene product from transcript CG5675-RB 0.034
Ark Apaf-1-related-killer 0.033
Atg18 Autophagy-specific gene 18 0.033
kn knot 0.033
TBPH CG10327 gene product from transcript CG10327-RC 0.033
cwo clockwork orange 0.033
mus304 mutagen-sensitive 304 0.033
S6k RPS6-p70-protein kinase 0.032
crol crooked legs 0.032
mus308 mutagen-sensitive 308 0.032
caz cabeza 0.032
CG9821 CG9821 gene product from transcript CG9821-RB 0.032
CG10462 CG10462 gene product from transcript CG10462-RB 0.031
trx trithorax 0.031
CG5794 CG5794 gene product from transcript CG5794-RB 0.031
CG9772 CG9772 gene product from transcript CG9772-RB 0.030
Tfb5 CG42373 gene product from transcript CG42373-RB 0.029
Liprin-alpha CG11199 gene product from transcript CG11199-RB 0.029
NFAT NFAT homolog 0.029
Dcr-2 Dicer-2 0.029
Sema-1a CG18405 gene product from transcript CG18405-RD 0.029
slp1 sloppy paired 1 0.028
CG14023 CG14023 gene product from transcript CG14023-RB 0.028
rin rasputin 0.028
CkIalpha Casein kinase Ialpha 0.028
CG17002 CG17002 gene product from transcript CG17002-RB 0.028
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Mus musculus
Name Description Probability Func Analog Organism
Mdm2 transformed mouse 3T3 cell double minute 2 0.863
Trp53 transformation related protein 53 0.812
Rb1 retinoblastoma 1 0.477
Pten phosphatase and tensin homolog 0.440
Mdm4 transformed mouse 3T3 cell double minute 4 0.231
Brca1 breast cancer 1 0.201
Kit kit oncogene 0.148
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.063
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.062
Apc adenomatosis polyposis coli 0.061
Kitl kit ligand 0.061
Mecp2 methyl CpG binding protein 2 0.052
Trp73 transformation related protein 73 0.048
En1 engrailed 1 0.038
Cyld cylindromatosis (turban tumor syndrome) 0.038
Daxx Fas death domain-associated protein 0.035
Nbn nibrin 0.034
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.034
Smc1a structural maintenance of chromosomes 1A 0.032
Dok1 docking protein 1 0.030
Atm ataxia telangiectasia mutated homolog (human) 0.028
Rara retinoic acid receptor, alpha 0.028
Smarcd1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.027
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.025
Enah enabled homolog (Drosophila) 0.025
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.025
Mmp9 matrix metallopeptidase 9 0.025
Smc3 structural maintenace of chromosomes 3 0.024
Thbs1 thrombospondin 1 0.024
Trp63 transformation related protein 63 0.023
Mybl2 myeloblastosis oncogene-like 2 0.023
Skil SKI-like 0.022
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.021
Tgfb1 transforming growth factor, beta 1 0.020
Socs1 suppressor of cytokine signaling 1 0.020
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.020
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.020
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.019
Mcl1 myeloid cell leukemia sequence 1 0.019
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.019
Smad3 MAD homolog 3 (Drosophila) 0.019
Icam1 intercellular adhesion molecule 1 0.018
Arid1b AT rich interactive domain 1B (SWI-like) 0.018
Ddx46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.017
Mapk8 mitogen-activated protein kinase 8 0.017
Ep300 E1A binding protein p300 0.017
Ttc4 tetratricopeptide repeat domain 4 0.016
Cbl Casitas B-lineage lymphoma 0.015
S1pr2 sphingosine-1-phosphate receptor 2 0.015
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.015
Tcf7l2 transcription factor 7-like 2, T-cell specific, HMG-box 0.015
Hprt hypoxanthine guanine phosphoribosyl transferase 0.015
Gli3 GLI-Kruppel family member GLI3 0.015
Kdm2b lysine (K)-specific demethylase 2B 0.015
Slc12a2 solute carrier family 12, member 2 0.014
Gtse1 G two S phase expressed protein 1 0.014
Ccnd1 cyclin D1 0.014
Jak3 Janus kinase 3 0.014
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.014
Ctnnb1 catenin (cadherin associated protein), beta 1 0.013
Stat6 signal transducer and activator of transcription 6 0.013
Meox2 mesenchyme homeobox 2 0.013
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.013
E2f1 E2F transcription factor 1 0.013
Ar androgen receptor 0.013
Notch1 Notch gene homolog 1 (Drosophila) 0.013
Snai1 snail homolog 1 (Drosophila) 0.013
Chst8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 0.013
Fgfr1 fibroblast growth factor receptor 1 0.013
Gm3258 predicted gene 3258 0.013
Taf4a TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor 0.013
Stat3 signal transducer and activator of transcription 3 0.012
Hif1a hypoxia inducible factor 1, alpha subunit 0.012
H2-Aa histocompatibility 2, class II antigen A, alpha 0.012
Ric8 resistance to inhibitors of cholinesterase 8 homolog (C. elegans) 0.012
Hcfc1 host cell factor C1 0.012
Atxn1 ataxin 1 0.012
Ikbkap inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein 0.012
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.012
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.012
Rarg retinoic acid receptor, gamma 0.012
Socs3 suppressor of cytokine signaling 3 0.012
Rbl1 retinoblastoma-like 1 (p107) 0.012
Terf1 telomeric repeat binding factor 1 0.012
Rnf2 ring finger protein 2 0.011
Smad4 MAD homolog 4 (Drosophila) 0.011
Tmpo thymopoietin 0.011
Tnf tumor necrosis factor 0.011
Mapk11 mitogen-activated protein kinase 11 0.011
Adam17 a disintegrin and metallopeptidase domain 17 0.011
Vangl2 vang-like 2 (van gogh, Drosophila) 0.011
Gata3 GATA binding protein 3 0.011
Rnf8 ring finger protein 8 0.011
Il21r interleukin 21 receptor 0.011
2500003M10Rik RIKEN cDNA 2500003M10 gene 0.011
Psmc5 protease (prosome, macropain) 26S subunit, ATPase 5 0.011
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.011
Pax2 paired box gene 2 0.011
Hipk1 homeodomain interacting protein kinase 1 0.011
Huwe1 HECT, UBA and WWE domain containing 1 0.011
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism