IMP
Process View
The network for 'negative regulation of protein ubiquitination' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
negative regulation of protein ubiquitination
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| UBE2I | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) | 0.865 | |
| SMAD7 | SMAD family member 7 | 0.849 | |
| TP53 | tumor protein p53 | 0.662 | |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.517 | |
| DAXX | death-domain associated protein | 0.517 | |
| UBC | ubiquitin C | 0.424 | |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.419 | |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.384 | |
| SMAD4 | SMAD family member 4 | 0.374 | |
| HSPA1B | heat shock 70kDa protein 1B | 0.367 | |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) | 0.347 | |
| TRAF6 | TNF receptor-associated factor 6 | 0.334 | |
| HUWE1 | HECT, UBA and WWE domain containing 1 | 0.321 | |
| DTX3L | deltex 3-like (Drosophila) | 0.314 | |
| RNF11 | ring finger protein 11 | 0.266 | |
| MAP3K7 | mitogen-activated protein kinase kinase kinase 7 | 0.246 | |
| SMAD1 | SMAD family member 1 | 0.200 | |
| HSPA1A | heat shock 70kDa protein 1A | 0.200 | |
| SMAD5 | SMAD family member 5 | 0.173 | |
| UBE2D1 | ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) | 0.156 | |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 0.145 | |
| USP7 | ubiquitin specific peptidase 7 (herpes virus-associated) | 0.134 | |
| MBD1 | methyl-CpG binding domain protein 1 | 0.128 | |
| SUMO1 | SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) | 0.118 | |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.117 | |
| TRIM21 | tripartite motif containing 21 | 0.116 | |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.114 | |
| BAG3 | BCL2-associated athanogene 3 | 0.114 | |
| NOXA1 | NADPH oxidase activator 1 | 0.114 | |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.111 | |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.110 | |
| SP110 | SP110 nuclear body protein | 0.107 | |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.105 | |
| TAB2 | TGF-beta activated kinase 1/MAP3K7 binding protein 2 | 0.103 | |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.103 | |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.102 | |
| DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 0.101 | |
| POU3F2 | POU class 3 homeobox 2 | 0.099 | |
| ZRANB1 | zinc finger, RAN-binding domain containing 1 | 0.095 | |
| ZNF496 | zinc finger protein 496 | 0.091 | |
| UHRF2 | ubiquitin-like with PHD and ring finger domains 2 | 0.089 | |
| CDC27 | cell division cycle 27 homolog (S. cerevisiae) | 0.087 | |
| GSK3B | glycogen synthase kinase 3 beta | 0.085 | |
| HSPA4 | heat shock 70kDa protein 4 | 0.084 | |
| SMAD3 | SMAD family member 3 | 0.079 | |
| MED15 | mediator complex subunit 15 | 0.079 | |
| POU5F1 | POU class 5 homeobox 1 | 0.078 | |
| FBXW11 | F-box and WD repeat domain containing 11 | 0.076 | |
| SPRY4 | sprouty homolog 4 (Drosophila) | 0.075 | |
| PARD6B | par-6 partitioning defective 6 homolog beta (C. elegans) | 0.066 | |
| PARD6A | par-6 partitioning defective 6 homolog alpha (C. elegans) | 0.065 | |
| PTEN | phosphatase and tensin homolog | 0.065 | |
| ZNF263 | zinc finger protein 263 | 0.065 | |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.064 | |
| RNF111 | ring finger protein 111 | 0.062 | |
| WWP2 | WW domain containing E3 ubiquitin protein ligase 2 | 0.061 | |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide | 0.060 | |
| ARIH2 | ariadne homolog 2 (Drosophila) | 0.060 | |
| CCNB1 | cyclin B1 | 0.059 | |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.055 | |
| PAX3 | paired box 3 | 0.055 | |
| HSPA8 | heat shock 70kDa protein 8 | 0.054 | |
| PRKCZ | protein kinase C, zeta | 0.054 | |
| SMAD2 | SMAD family member 2 | 0.051 | |
| HERC2 | hect domain and RLD 2 | 0.051 | |
| PML | promyelocytic leukemia | 0.050 | |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.049 | |
| ATG3 | ATG3 autophagy related 3 homolog (S. cerevisiae) | 0.049 | |
| ARRB1 | arrestin, beta 1 | 0.049 | |
| PARD6G | par-6 partitioning defective 6 homolog gamma (C. elegans) | 0.048 | |
| TRIM5 | tripartite motif containing 5 | 0.046 | |
| CHORDC1 | cysteine and histidine-rich domain (CHORD) containing 1 | 0.045 | |
| IRAK1 | interleukin-1 receptor-associated kinase 1 | 0.045 | |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.044 | |
| UBE2D4 | ubiquitin-conjugating enzyme E2D 4 (putative) | 0.044 | |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4 | 0.044 | |
| SKP2 | S-phase kinase-associated protein 2 (p45) | 0.044 | |
| SIAH1 | seven in absentia homolog 1 (Drosophila) | 0.043 | |
| SETDB1 | SET domain, bifurcated 1 | 0.042 | |
| IKBKB | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 0.041 | |
| PRKCB | protein kinase C, beta | 0.041 | |
| PRKCA | protein kinase C, alpha | 0.041 | |
| NCOA3 | nuclear receptor coactivator 3 | 0.041 | |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | 0.040 | |
| EGFR | epidermal growth factor receptor | 0.040 | |
| ATG12 | ATG12 autophagy related 12 homolog (S. cerevisiae) | 0.040 | |
| CBL | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 0.040 | |
| FLNB | filamin B, beta | 0.039 | |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 0.039 | |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) | 0.039 | |
| SLC39A7 | solute carrier family 39 (zinc transporter), member 7 | 0.038 | |
| ELK1 | ELK1, member of ETS oncogene family | 0.038 | |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.038 | |
| UBE2N | ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) | 0.038 | |
| YWHAH | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | 0.037 | |
| CFL1 | cofilin 1 (non-muscle) | 0.037 | |
| CDCP1 | CUB domain containing protein 1 | 0.037 | |
| NCL | nucleolin | 0.036 | |
| IRF7 | interferon regulatory factor 7 | 0.035 | |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.035 |
Loading network...
Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Per2 | period homolog 2 (Drosophila) | 0.901 | |
| Cry2 | cryptochrome 2 (photolyase-like) | 0.810 | |
| Arntl | aryl hydrocarbon receptor nuclear translocator-like | 0.523 | |
| Psen1 | presenilin 1 | 0.369 | |
| Clock | circadian locomotor output cycles kaput | 0.251 | |
| Iigp1 | interferon inducible GTPase 1 | 0.192 | |
| Shh | sonic hedgehog | 0.129 | |
| Ncoa3 | nuclear receptor coactivator 3 | 0.121 | |
| Ywhaz | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.116 | |
| Aim2 | absent in melanoma 2 | 0.107 | |
| Usp18 | ubiquitin specific peptidase 18 | 0.099 | |
| Wnt3a | wingless-related MMTV integration site 3A | 0.089 | |
| Arrb1 | arrestin, beta 1 | 0.080 | |
| Notch1 | Notch gene homolog 1 (Drosophila) | 0.079 | |
| Trp53 | transformation related protein 53 | 0.079 | |
| Gbp3 | guanylate binding protein 3 | 0.066 | |
| Ifih1 | interferon induced with helicase C domain 1 | 0.065 | |
| Rpgrip1l | Rpgrip1-like | 0.063 | |
| Oasl2 | 2'-5' oligoadenylate synthetase-like 2 | 0.063 | |
| Kdm2b | lysine (K)-specific demethylase 2B | 0.062 | |
| Irf9 | interferon regulatory factor 9 | 0.062 | |
| Lrrk2 | leucine-rich repeat kinase 2 | 0.059 | |
| Ywhab | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | 0.048 | |
| Arrb2 | arrestin, beta 2 | 0.044 | |
| Ptrf | polymerase I and transcript release factor | 0.042 | |
| Gclm | glutamate-cysteine ligase, modifier subunit | 0.042 | |
| Rarg | retinoic acid receptor, gamma | 0.042 | |
| Irgm2 | immunity-related GTPase family M member 2 | 0.038 | |
| Casp4 | caspase 4, apoptosis-related cysteine peptidase | 0.036 | |
| Crk | v-crk sarcoma virus CT10 oncogene homolog (avian) | 0.036 | |
| Igtp | interferon gamma induced GTPase | 0.036 | |
| Per1 | period homolog 1 (Drosophila) | 0.035 | |
| Ifit1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.033 | |
| Wnt4 | wingless-related MMTV integration site 4 | 0.033 | |
| Gli3 | GLI-Kruppel family member GLI3 | 0.032 | |
| Pax2 | paired box gene 2 | 0.031 | |
| Axin1 | axin 1 | 0.030 | |
| Wnt10b | wingless related MMTV integration site 10b | 0.030 | |
| Sgol2 | shugoshin-like 2 (S. pombe) | 0.030 | |
| Fgf8 | fibroblast growth factor 8 | 0.029 | |
| Smad6 | MAD homolog 6 (Drosophila) | 0.029 | |
| Ywhaq | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide | 0.028 | |
| Use1 | unconventional SNARE in the ER 1 homolog (S. cerevisiae) | 0.028 | |
| Hspa8 | heat shock protein 8 | 0.027 | |
| Gdnf | glial cell line derived neurotrophic factor | 0.027 | |
| Ywhae | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 0.027 | |
| Csnk1e | casein kinase 1, epsilon | 0.027 | |
| Dkk1 | dickkopf homolog 1 (Xenopus laevis) | 0.026 | |
| Ncstn | nicastrin | 0.026 | |
| Usp2 | ubiquitin specific peptidase 2 | 0.024 | |
| Ric8 | resistance to inhibitors of cholinesterase 8 homolog (C. elegans) | 0.024 | |
| ND6 | NADH dehydrogenase subunit 6 | 0.024 | |
| Casp1 | caspase 1 | 0.024 | |
| Pou3f1 | POU domain, class 3, transcription factor 1 | 0.024 | |
| Cdx1 | caudal type homeobox 1 | 0.024 | |
| Rtp4 | receptor transporter protein 4 | 0.023 | |
| Irgm1 | immunity-related GTPase family M member 1 | 0.023 | |
| Kpna1 | karyopherin (importin) alpha 1 | 0.023 | |
| Pthlh | parathyroid hormone-like peptide | 0.022 | |
| Ror2 | receptor tyrosine kinase-like orphan receptor 2 | 0.022 | |
| Irf7 | interferon regulatory factor 7 | 0.022 | |
| Sap18 | Sin3-associated polypeptide 18 | 0.021 | |
| Ifit3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.021 | |
| Amhr2 | anti-Mullerian hormone type 2 receptor | 0.021 | |
| Lhx1 | LIM homeobox protein 1 | 0.020 | |
| Stat1 | signal transducer and activator of transcription 1 | 0.020 | |
| Ptch1 | patched homolog 1 | 0.020 | |
| Kl | klotho | 0.019 | |
| Tgtp2 | T-cell specific GTPase 2 | 0.019 | |
| Cacybp | calcyclin binding protein | 0.019 | |
| Aph1a | anterior pharynx defective 1a homolog (C. elegans) | 0.018 | |
| Sh3bp1 | SH3-domain binding protein 1 | 0.017 | |
| Ccne1 | cyclin E1 | 0.017 | |
| Cdk5r2 | cyclin-dependent kinase 5, regulatory subunit 2 (p39) | 0.017 | |
| Ikbkap | inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein | 0.017 | |
| Fbxl3 | F-box and leucine-rich repeat protein 3 | 0.017 | |
| Foxm1 | forkhead box M1 | 0.017 | |
| Ccna2 | cyclin A2 | 0.017 | |
| Rnf19a | ring finger protein 19A | 0.017 | |
| Psmb10 | proteasome (prosome, macropain) subunit, beta type 10 | 0.017 | |
| T | brachyury | 0.016 | |
| Ccne2 | cyclin E2 | 0.016 | |
| Chmp2a | chromatin modifying protein 2A | 0.016 | |
| Setdb1 | SET domain, bifurcated 1 | 0.016 | |
| En1 | engrailed 1 | 0.016 | |
| Wnt9a | wingless-type MMTV integration site 9A | 0.016 | |
| Ppp2ca | protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform | 0.016 | |
| Notch2 | Notch gene homolog 2 (Drosophila) | 0.016 | |
| Skil | SKI-like | 0.016 | |
| Atg12 | autophagy-related 12 (yeast) | 0.016 | |
| Cdk5r1 | cyclin-dependent kinase 5, regulatory subunit 1 (p35) | 0.015 | |
| Src | Rous sarcoma oncogene | 0.015 | |
| H2-Q7 | histocompatibility 2, Q region locus 7 | 0.015 | |
| Per3 | period homolog 3 (Drosophila) | 0.015 | |
| Cdk2 | cyclin-dependent kinase 2 | 0.015 | |
| Rnf2 | ring finger protein 2 | 0.015 | |
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.015 | |
| Iqcb1 | IQ calmodulin-binding motif containing 1 | 0.014 | |
| Parp14 | poly (ADP-ribose) polymerase family, member 14 | 0.014 | |
| Bmp4 | bone morphogenetic protein 4 | 0.014 |